The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
DREAM is a Ca2+-regulated transcriptional repressor
Open accessAbstract
Fluxes in amounts of intracellular calcium ions are important determinants of gene expression. So far, Ca2+-regulated kinases and phosphatases have been implicated in changing the phosphorylation status of key transcription factors and thereby modulating their function,. In addition, direct effectors of Ca2+-induced gene expression have been suggested to exist in the nucleus, although no such effectors have been identified yet. Expression of the human prodynorphin gene, which is involved inmemory acquisition and pain,, is regulated through its downstream regulatory element (DRE) sequence, which acts as a location-dependent gene silencer. Here we isolate a new transcriptional repressor, DRE-antagonist modulator (DREAM), which specifically binds to the DRE. DREAM contains four Ca2+-binding domains of the EF-hand type. Upon stimulation by Ca2+, DREAM's ability to bind to the DRE and its repressor function are prevented. Mutation of the EF-hands abolishes the response of DREAM to Ca2+. In addition to the prodynorphin promoter, DREAM represses transcription from the early response gene c-fos. Thus, DREAM represents the first known Ca2+-binding protein to function as a DNA-binding transcriptional regulator.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Differential activation of transcription factors induced by Ca2+ response amplitude and duration
Dolmetsch, R. E., Lewis, R. S., Goodnow, C. C., & Healy, J. I. (1997) · Nature · doi:10.1038/386855a0 · Cited by 1,752
Differential activation of transcription factors induced by Ca2+ response amplitude and duration
Dolmetsch, R. E., Lewis, R. S., Goodnow, C. C., & Healy, J. I. (1997) · Nature · doi:10.1038/40912 · Cited by 1,521
CREB: a Ca 2+ -Regulated Transcription Factor Phosphorylated by Calmodulin-Dependent Kinases
Sheng, M., Thompson, M. A., & Greenberg, M. E. (1991) · Science · doi:10.1126/science.1646483 · Cited by 1,488
Calcium Signaling in Neurons: Molecular Mechanisms and Cellular Consequences
Ghosh, A., & Greenberg, M. E. (1995) · Science · doi:10.1126/science.7716515 · Cited by 1,407
Regulation of Gene Expression in Hippocampal Neurons by Distinct Calcium Signaling Pathways
Bading, H., Ginty, D. D., & Greenberg, M. E. (1993) · Science · doi:10.1126/science.8097060 · Cited by 1,157
Role of ion flux in the control of c-fos expression
Morgan, J. I., & Curran, T. (1986) · Nature · doi:10.1038/322552a0 · Cited by 998
Distinct functions of nuclear and cytoplasmic calcium in the control of gene expression
Hardingham, G. E., Chawla, S., Johnson, C. M., & Bading, H. (1997) · Nature · doi:10.1038/385260a0 · Cited by 729
Translocation of calmodulin to the nucleus supports CREB phosphorylation in hippocampal neurons
Deisseroth, K., Heist, E. K., & Tsien, R. W. (1998) · Nature · doi:10.1038/32448 · Cited by 653
Transcriptional autoregulation of the proto-oncogene fos
Sassone-Corsi, P., Sisson, J. C., & Verma, I. M. (1988) · Nature · doi:10.1038/334314a0 · Cited by 595
Recoverin: a Calcium Sensitive Activator of Retinal Rod Guanylate Cyclase
Dizhoor, A. M., Ray, S., Kumar, S., Niemi, G., Spencer, M., Brolley, D., Walsh, K. A., Philipov, P. P., Hurley, J. B., & Stryer, L. (1991) · Science · doi:10.1126/science.1672047 · Cited by 571
Cited by
Greer, P. L., & Greenberg, M. E. (2008) · Neuron · doi:10.1016/j.neuron.2008.09.002 · Cited by 661
Neuronal Activity-Regulated Gene Transcription in Synapse Development and Cognitive Function
West, A. E., & Greenberg, M. E. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005744 · Cited by 532
Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling
Burgoyne, R. D. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2093 · Cited by 527
Ca2+/CaM-Dependent Kinases: From Activation to Function
Hook, S. S., & Means, A. R. (2001) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.41.1.471 · Cited by 482
The neuronal calcium sensor family of Ca2+-binding proteins
BURGOYNE, R. D., & WEISS, J. L. (2001) · Biochemical Journal · doi:10.1042/bj3530001 · Cited by 444
Metadata
- Authors
- Carrión, A. M., Link, W. A., Ledo, F., Mellström, B., & Naranjo, J. R.
- Venue
- Nature
- Published
- 1999-03
- Volume
- 398
- Issue
- 6722
- Pages
- 80-84
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1625124567
- Cited by
- 573
- References
- 19
- FWCI
- 11.85
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: DREAM is a Ca2+-regulated transcriptional repressor. https://app.cochat.ai/papers/10.1038/18044
- The paper
- Carrión, A. M., Link, W. A., Ledo, F., Mellström, B., & Naranjo, J. R. (1999). DREAM is a Ca2+-regulated transcriptional repressor. Nature. https://doi.org/10.1038/18044
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
