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Cited by 822Neural dynamics and brain functionNeural and Behavioral Psychology StudiesMemory and Neural Mechanisms

The DOI matches its Crossref record; 26 of the 27 references it cites were found in a registry or an index.

Neuronal correlates of parametric working memory in the prefrontal cortex

Romo, Ranulfo, Brody, Carlos D., Hernández, Adrián, Lemus, Luis·1999·Nature
DOI 10.1038/20939
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Abstract

Humans and monkeys have similar abilities to discriminate the difference in frequency between two mechanical vibrations applied sequentially to the fingertips. A key component of this sensory task is that the second stimulus is compared with the trace left by the first (base) stimulus, which must involve working memory. Where and how is this trace held in the brain? This question was investigated by recording from single neurons in the prefrontal cortex of monkeys while they performed the somatosensory discrimination task. Here we describe neurons in the inferior convexity of the prefrontal cortex whose discharge rates varied, during the delay period between the two stimuli, as a monotonic function of the base stimulus frequency. We describe this as 'monotonic stimulus encoding', and we suggest that the result may generalize: monotonic stimulus encoding may be the basic representation of one-dimensional sensory stimulus quantities in working memory. Thus we predict that other behavioural tasks that require ordinal comparisons between scalar analogue stimuli would give rise to monotonic responses similar to those reported here.

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Crossref · 10.1038/20939

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Citations

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Research works printed but not linked: 4

  1. Fuster, J. M. The Prefrontal Cortex 2nd edn(Raven, New York, (1989).
  2. Salinas, E., Hernández, A., Zainos, A., Lemus, L. & Romo, R. Cortical recoding of sensory stimuli during somatosensory discrimination. Soc. Neurosci. Abstr. 24, 1126 (1998).
  3. Ross, S. M. Introduction to Probability for Scientists and Engineers(Wiley, New York, (1987).
  4. Press, W., Teukolsky, S. A., Vettering, W. T. & Flannery, B. P. Numerical Recipes in C 2nd edn(Cambridge Univ. Press, Cambridge, U.K., (1992).

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Metadata

Authors
Romo, R., Brody, C. D., Hernández, A., & Lemus, L.
Affiliations
Universidad Nacional Autónoma de México (MX)
Corresponding author
Romo, Ranulfo
ORCID
Venue
Nature
Publisher
Springer Science and Business Media LLC
Published
1999-06
Volume
399
Issue
6735
Pages
470-473
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
DOI
10.1038/20939
OpenAlex
W2101620490
Cited by
822
References
27
Citations by year
2026: 26 · 2025: 30 · 2024: 35 · 2023: 35 · 2022: 34 · 2021: 43 · 2020: 36 · 2019: 35 · 2018: 37 · 2017: 42 · 2016: 29 · 2015: 31 · 2014: 34 · 2013: 34 · 2012: 35
FWCI
9.48
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Nature (publishedVersion)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
working memory, prefrontal cortex, single-unit recording, somatosensory discrimination, ordinal comparison, delay period
MeSH terms
Animals, Discrimination Learning, Humans, Macaca mulatta, Memory, Short-Term, Neurons, Prefrontal Cortex

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