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Cited by 593Neural and Behavioral Psychology StudiesMemory and Neural MechanismsNeural dynamics and brain function

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Neural Activity in the Primate Prefrontal Cortex during Associative Learning

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Asaad, Wael F, Rainer, Gregor, Miller, Earl K·1998·Neuron
DOI 10.1016/s0896-6273(00)80658-3
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Abstract

The prefrontal (PF) cortex has been implicated in the remarkable ability of primates to form and rearrange arbitrary associations rapidly. This ability was studied in two monkeys, using a task that required them to learn to make specific saccades in response to particular cues and then repeatedly reverse these responses. We found that the activity of individual PF neurons represented both the cues and the associated responses, perhaps providing a neural substrate for their association. Furthermore, during learning, neural activity conveyed the direction of the animals' impending responses progressively earlier within each successive trial. The final level of activity just before the response, however, was unaffected by learning. These results suggest a role for the PF cortex in learning arbitrary cue-response associations, an ability critical for complex behavior.

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  • Increased activity of bilateral ventrolateral prefrontal cortex (PMv/IFG) in the dual-task condition before training suggests that dual-task conditions may require greater control over stimulus-response mapping rules, even when the mappings are spatially compatible.

    “The increased activity of bilateral ventrolateral prefrontal cortex (PMv/IFG) in our dual-task condition before training suggests that dual-task conditions may require greater control over stimulus-response mapping rules, even in cases in which the mappings are spatially compatible.”

    From The Neural Correlates of Motor Skill Automaticity (2005) · cites this paper as Asaad et al., 1998

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Metadata

Authors
Asaad, W. F., Rainer, G., & Miller, E. K.
Affiliations
  • Massachusetts Institute of Technology (US)
  • Max Planck Society (DE)
Corresponding author
Miller, Earl K
ORCID
Venue
Neuron
Publisher
Elsevier BV
Published
1998-12
Volume
21
Issue
6
Pages
1399-1407
ISSN
0896-6273 (ISSN-L)
DOI
10.1016/s0896-6273(00)80658-3
OpenAlex
W1993129834
Cited by
593
References
3
Citations by year
2026: 9 · 2025: 20 · 2024: 16 · 2023: 16 · 2022: 20 · 2021: 17 · 2020: 17 · 2019: 14 · 2018: 17 · 2017: 25 · 2016: 24 · 2015: 26 · 2014: 21 · 2013: 23 · 2012: 26
FWCI
11.68
Type
journal article
Language
en
Open access
Licence
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
Funders
National Institute of Neurological Disorders and Stroke (NS35145-02)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
prefrontal cortex, associative learning, reversal learning, single-unit activity, neural coding, monkeys, response timing
MeSH terms
Animals, Association Learning, Brain Mapping, Eye Movements, Functional Laterality, Macaca mulatta, Neurons, Reaction Time, Restraint, Physical, Saccades, Prefrontal Cortex

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