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A role for brown adipose tissue in diet-induced thermogenesis

Rothwell, Nancy J., Stock, Michael J.·1979·Nature

DOI 10.1038/281031a0

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Abstract

Measurement of energy balance during voluntary overeating in rats unequivocally establishes the quantitative importance of diet-induced thermogenesis in energy balance. Like cold-induced thermogenesis, this form of heat production involves changes in the activity of the sympathetic nervous system and brown adipose tissue which suggest that this tissue may determine metabolic efficiency and resistance to obesity.

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Authors: Rothwell, N. J., & Stock, M. J.
Affiliations: University of London (GB)
ORCID: Rothwell, Nancy J.
Stock, Michael J.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1979-09
Volume: 281
Issue: 5726
Pages: 31-35
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/281031a0
OpenAlex: W1972836378
Cited by: 1,606
References: 30
Citations by year: 2026: 11 · 2025: 8 · 2024: 22 · 2023: 22 · 2022: 22 · 2021: 34 · 2020: 42 · 2019: 36 · 2018: 37 · 2017: 41 · 2016: 38 · 2015: 46 · 2014: 46 · 2013: 52 · 2012: 39
FWCI: 75.55
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Research Explorer (The University of Manchester) (publishedVersion)
Research Explorer (The University of Manchester) (submittedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: brown adipose tissue, diet-induced thermogenesis, energy balance, sympathetic nervous system, cold-induced thermogenesis, obesity resistance, metabolic efficiency, rats
MeSH terms: Animals, Body Temperature Regulation, Adipose Tissue, Brown, Diet, Disease Models, Animal, Energy Metabolism, Humans, Lipid Mobilization, Male, Norepinephrine, Obesity, Oxygen Consumption, Sympathetic Nervous System, Rats

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A role for brown adipose tissue in diet-induced thermogenesis

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