Cited by 1,606Adipose Tissue and MetabolismRegulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

A role for brown adipose tissue in diet-induced thermogenesis

Rothwell, Nancy J., Stock, Michael J.·1979·Nature

DOI 10.1038/281031a0

Open this paper in CoChat — free account

Abstract

Measurement of energy balance during voluntary overeating in rats unequivocally establishes the quantitative importance of diet-induced thermogenesis in energy balance. Like cold-induced thermogenesis, this form of heat production involves changes in the activity of the sympathetic nervous system and brown adipose tissue which suggest that this tissue may determine metabolic efficiency and resistance to obesity.

Integrity signals

Registry

Crossref · 10.1038/281031a0

Cites

30 of 30 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The Composition of Foods
McCance, R. A., & Widdowson, E. M. (1960) · Biblioteca Digital (Real Academia Nacional de Medicina) · Cited by 971
Nonshivering thermogenesis in the rat. II. Measurements of blood flow with microspheres point to brown adipose tissue as the dominant site of the calorigenesis induced by noradrenaline
Foster, D. O., & Frydman, M. L. (1978) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y78-015 · Cited by 652
An easy colorimetric micromethod for routine determination of free fatty acids in plasma
Falholt, K., Lund, B., & FALHOLT, W. (1973) · Clinica Chimica Acta · doi:10.1016/0009-8981(73)90016-8 · Cited by 636
Dietary obesity in adult rats: Similarities to hypothalamic and human obesity syndromes
Sclafani, A. J., & Springer, D. (1976) · Physiology & Behavior · doi:10.1016/0031-9384(76)90109-8 · Cited by 616
The distribution of brown adipose tissue in the human.
Heaton, J. M. (1972) · PubMed · Cited by 606
The energy cost of fat and protein deposition in the rat
Pullar, J. D., & Webster, A. J. F. (1977) · British Journal Of Nutrition · doi:10.1079/bjn19770039 · Cited by 382
Stimulation of the sympathetic nervous system during sucrose feeding
Young, J. B., & Landsberg, L. (1977) · Nature · doi:10.1038/269615a0 · Cited by 331
Reduced thermogenesis in obesity
Jung, R. T., Shetty, P. S., James, W. P. T., Barrand, M. A., & Callingham, B. A. (1979) · Nature · doi:10.1038/279322a0 · Cited by 293
Cellular Thermogenesis
Himms‐Hagen, J. (1976) · Annual Review of Physiology · doi:10.1146/annurev.ph.38.030176.001531 · Cited by 282
Thermoregulation and non-shivering thermogenesis in the genetically obese (ob/ob) mouse
Trayhurn, P., & James, W. P. T. (1978) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00584859 · Cited by 254

Flagged first, then by citations

Show all 30 references

Research works printed but not linked: 15

Lofti, M. thesis, London Univ. (1977).
Tulp, O. et al. Am. J. clin. Nutr. 30, 621 (1977).
Gurr, M. I., Mawson, R., Rothwell, N. J. & Stock, M. J. J. Physiol., Lond. 291, 60P (1979).
Sims, E. A. H. et al. Rec. Prog. Horm. Res. 29, 457–496 (1973).
Blaxter, K. L. in Obesity in Perspective (ed. Bray, G. A.) DHEW Pub. No. (NIH) 75–708, 127–136 (1973).
Rothwell, N. J. & Stock, M. J. J. Physiol., Lond. 276, 60P–61P (1977).
Rothwell, N. J. & Stock, M. J. J. Physiol., Lond. 291, 59P (1979).
Djazayery, A., Miller, D. S. & Stock, M. J. Nutr. Metab. (in the press).
Rothwell, N. J. & Stock, M. J. J. comp. Physiol. Psychol. (in the press).
Stock, M. J. J. Physiol., Lond. (in the press).
Jansky, L., Bartunkova, R. & Zeisberger, E. Physiol. Bohemoslov. 16, 366–372 (1967).
Hull, D. & Hardman, M. J. in Brown Adipose Tissue (ed. Lindberg, O.) (Elsevier, New York, 1970).
Danforth, E. et al. Clin. Res. 23, 573A (1975).
Heaton, J. M. J. Anat. 112, 35–39 (1972).
Evans, E. & Miller, D. S. Proc. Nutr. Soc. 36, 136A (1977).

Sorted by citations

Items 501–600 of 999

Short photoperiod stimulates brown adipose tissue growth and thermogenesis but not norepinephrine turnover in Syrian hamsters
McElroy, J. F., & Wade, G. N. (1986) · Physiology & Behavior · doi:10.1016/0031-9384(86)90238-6 · Cited by 53
Less Body Fat Accumulation with D-Psicose Diet versus D-Fructose Diet.
Matsuo, T., Baba, Y., HASHIGUCHI, M., Takeshita, K., Izumori, K., & Suzuki, H. (2001) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.30.55 · Cited by 53
Mitochondrial proton leak in brown adipose tissue mitochondria of Ucp1 -deficient mice is GDP insensitive
Monemdjou, S., Kozak, L. P., & Harper, M. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.276.6.e1073 · Cited by 53
Brown fat, thermogenesis and physiological birth in a marsupial
Loudon, A. S. I., Rothwell, N. J., & Stock, M. J. (1985) · Comparative Biochemistry and Physiology Part A Physiology · doi:10.1016/0300-9629(85)90912-0 · Cited by 53
Self-citation
Evidence for masking of brown adipose tissue mitochondrial GDP-binding sites in response to fasting in rats made obese by dietary manipulation. Effects of reversion to standard diet
Puigserver, P., Lladó, I., Palou, A., & Gianotti, M. (1991) · Biochemical Journal · doi:10.1042/bj2790575 · Cited by 53
Body fat accumulation is greater in rats fed a beef tallow diet than in rats fed a safflower or soybean oil diet
Matsuo, T., Takeuchi, H., Suzuki, H., & Suzuki, M. (2002) · Asia Pacific Journal of Clinical Nutrition · doi:10.1046/j.1440-6047.2002.00299.x · Cited by 52
The mitochondrial uncoupling protein: structural and genetic studies.
Ricquier, D., & Bouillaud, F. (1997) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(08)61003-x · Cited by 52
Contributions of White and Brown Adipose Tissues to the Circadian Regulation of Energy Metabolism
Heyde, I., Begemann, K., & Oster, H. (2021) · Endocrinology · doi:10.1210/endocr/bqab009 · Cited by 60
Brown Adipose Tissue: Activation and Metabolism in Humans
Hachemi, I., & U-Din, M. (2023) · Endocrinology and Metabolism · doi:10.3803/enm.2023.1659 · Cited by 58
The impact of cafeteria diet feeding on physiology and anxiety-related behaviour in male and female Sprague–Dawley rats of different ages
Warneke, W., Klaus, S., Fink, H., Langley‐Evans, S. C., & Voigt, J. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.11.016 · Cited by 56
Piceatannol exhibits anti‐inflammatory effects on macrophages interacting with adipocytes
Yamamoto, T., Li, Y., Hanafusa, Y., Yeh, Y., Maruki‐Uchida, H., Kawakami, S., Sai, M., Goto, T., Ito, T., & Kawada, T. (2016) · Food Science & Nutrition · doi:10.1002/fsn3.366 · Cited by 52
Energy balance of laying hens selected on residual food consumption
Gabarrou, J.-F., Geraert, P., François, N., Guillaumin, S., PICARD, M., & Bordas, A. (1998) · British Poultry Science · doi:10.1080/00071669889439 · Cited by 52
Mitochondria of adult human brown adipose tissue contain a 32 000-Mr uncoupling protein
Bouillaud, F., Combes‐George, M., & Ricquier, D. (1983) · Bioscience Reports · doi:10.1007/bf01120989 · Cited by 52
Palmityl-CoA oxidase: Detection in several guinea pig tissues and peroxisomal localisation in mucosa of small intestine
Small, G. M., Brolly, D., & Connock, M. J. (1980) · Life Sciences · doi:10.1016/0024-3205(80)90441-5 · Cited by 52
Factors affecting brown adipose tissue activity in animals and man
Ricquier, D., & Mory, G. (1984) · Clinics in Endocrinology and Metabolism · doi:10.1016/s0300-595x(84)80035-3 · Cited by 52
Human Thermoregulatory Responses to Acute Cold Stress with Special Reference to Water Immersion
Toner, M. M., & McArdle, W. D. (1996) · Comprehensive physiology · doi:10.1002/cphy.cp040117 · Cited by 52
Brown adipose tissue and aging
Lecoultre, V., & Ravussin, É. (2010) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e328341221e · Cited by 50
Feline obesity - prevalence, risk factors, pathogenesis, associated conditions and assessment: a review
Tarkošová, D., Story, M. M., Rand, J. S., & Svoboda, M. (2016) · Veterinární Medicína · doi:10.17221/145/2015-vetmed · Cited by 58
Differential effects of diet composition and timing of feeding behavior on rat brown adipose tissue and skeletal muscle peripheral clocks
de Goede, P., Sen, S., Oosterman, J. E., Foppen, E., Jansen, R., la Fleur, S. E., Challet, É., & Kalsbeek, A. (2017) · Neurobiology of Sleep and Circadian Rhythms · doi:10.1016/j.nbscr.2017.09.002 · Cited by 51
Redox control of non-shivering thermogenesis
Lettieri‐Barbato, D. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.04.002 · Cited by 52
Physiological Regulation of Body Weight and the Issue of Obesity
Keesey, R. E. (1989) · Medical Clinics of North America · doi:10.1016/s0025-7125(16)30689-7 · Cited by 51
The part played by variation of energy expenditure in the regulation of energy balance
Hervey, G. R., & Tobin, G. (1982) · Proceedings of The Nutrition Society · doi:10.1079/pns19820024 · Cited by 51
Regulation of energy balanc: studies on gnetic, hypothalamic and dietary obesity
Bray, G. A. (1982) · Proceedings of The Nutrition Society · doi:10.1079/pns19820018 · Cited by 51
Diet-induced changes in sympathoadrenal activity: Implications for thermogenesis
Landsberg, L., & Young, J. B. (1981) · Life Sciences · doi:10.1016/0024-3205(81)90352-0 · Cited by 50
L-Arginine improves multiple physiological parameters in mice exposed to diet-induced metabolic disturbances
Clemmensen, C., Madsen, A. N., Smajilovic, S., Holst, B., & Bräuner-Osborne, H. (2012) · Amino Acids · doi:10.1007/s00726-011-1199-1 · Cited by 49
Activation of Pregnane X Receptor by Pregnenolone 16 α-carbonitrile Prevents High-Fat Diet-Induced Obesity in AKR/J Mice
Ma, Y., & Liu, D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038734 · Cited by 52
Gender effects on adrenergic receptor expression and lipolysis in white adipose tissue of rats.
Lladó, I., Rodriguez-Cuenca, S., Pujol, E., Monjo, M., Estrany, M., Roca, P., & Palou, A. (2002) · Obesity Research · doi:10.1038/oby.2002.41 · Cited by 53
Dietary strategies for the prevention of obesity
Jebb, S. A. (2005) · Proceedings of The Nutrition Society · doi:10.1079/pns2005429 · Cited by 52
Characteristics of Thermogenesis, Obesity, and Longevity in the LA/N-cp Rat
Tulp, O. L. (1990) · ILAR Journal · doi:10.1093/ilar.32.3.32 · Cited by 50
Protein kinase A induces UCP1 expression in specific adipose depots to increase energy expenditure and improve metabolic health
Dickson, L. M., Gandhi, S., Layden, B. T., Cohen, R., & Wicksteed, B. L. (2016) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00114.2016 · Cited by 51
Shared PPARα/γ Target Genes Regulate Brown Adipocyte Thermogenic Function
Shen, Y., Su, Y., Silva, F. J., Weller, A. H., Sostre‐Colón, J., Titchenell, P. M., Steger, D. J., Seale, P., & Soccio, R. E. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.02.032 · Cited by 50
The thermogenic properties of ephedrine/ methylxanthine mixtures: animal studies
Dulloo, A. G., & Miller, D. (1986) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/43.3.388 · Cited by 50
Decerebration activates thermogenesis in the rat.
Rothwell, N. J., Stock, M. J., & Thexton, A. J. (1983) · The Journal of Physiology · doi:10.1113/jphysiol.1983.sp014836 · Cited by 50
Self-citation
Effect of High Fat Diets on the Thermogenic Activity of Brown Adipose Tissue in Cold-Acclimated Mice
Mercer, S. W., & Trayhurn, P. (1984) · Journal of Nutrition · doi:10.1093/jn/114.6.1151 · Cited by 50
Pathophysiology of Childhood Obesity
Rosenbaum, M. S., & Leibel, R. L. (1988) · Advances in Pediatrics · doi:10.1016/s0065-3101(24)00174-9 · Cited by 51
Brown adipose tissue after ventromedial hypothalamic lesions in rats
Saito, M., Minokoshi, Y., & Shimazu, T. (1985) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1985.248.1.e20 · Cited by 50
Molecular Mechanisms of Vaspin Action – From Adipose Tissue to Skin and Bone, from Blood Vessels to the Brain
Weiner, J., Zieger, K., Pippel, J., & Heiker, J. T. (2018) · Advances in experimental medicine and biology · doi:10.1007/5584_2018_241 · Cited by 49
Integration of sensory information via central thermoregulatory leptin targets
Rezai-Zadeh, K. P., & Münzberg, H. (2013) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.02.014 · Cited by 52
In Vivo Noninvasive Detection of Brown Adipose Tissue through Intermolecular Zero-Quantum MRI
Branca, R. T., Zhang, L., Warren, W. S., Auerbach, E. J., Khanna, A., Degan, S., Uǧurbil, K., & Maronpot, R. R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074206 · Cited by 49
Identification of Brown Adipose Tissue Using MR Imaging in a Human Adult With Histological and Immunohistochemical Confirmation
Reddy, N. L., Jones, T. A., Wayte, S. C., Adesanya, O., Sankar, S., Yeo, Y. C., Tripathi, G., McTernan, P. G., Randeva, H. S., Kumar, S., et al. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-2036 · Cited by 49
Nitrogen and energy requirements of the short-tailed fruit bat (Carollia perspicillata): fruit bats are not nitrogen constrained
Delorme, M., & Thomas, D. W. (1996) · Journal of Comparative Physiology B · doi:10.1007/bf02337887 · Cited by 49
Radioligand binding studies of the atypical β3‐adrenergic receptor in rat brown adipose tissue using [3H]CGP 12177
Muzzin, P., Revelli, J. P., Fraser, C. M., & Giacobino, J. (1992) · FEBS Letters · doi:10.1016/0014-5793(92)80046-j · Cited by 49
Kaempferia parviflora extract increases energy consumption through activation of BAT in mice
Yoshino, S., Kim, M., Awa, R., Kuwahara, H., Kano, Y., & Kawada, T. (2014) · Food Science & Nutrition · doi:10.1002/fsn3.144 · Cited by 48
Protein kinase Cβ deficiency attenuates obesity syndrome of ob/ob mice by promoting white adipose tissue remodeling
Huang, W., Bansode, R. R., Bal, N. C., Mehta, M., & Mehta, K. D. (2011) · Journal of Lipid Research · doi:10.1194/jlr.m019687 · Cited by 47
Overfeeding Over 24 Hours Does Not Activate Brown Adipose Tissue in Humans
Schlögl, M., Piaggi, P., Thiyyagura, P., Reiman, E. M., Chen, K., Lutrin, C. L., Krakoff, J. A., & Thearle, M. S. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-2387 · Cited by 48
Is thermogenesis a significant causal factor in preventing the “globesity” epidemic?
Hansen, J. C., Gilman, A. P., & Odland, J. Ø. (2010) · Medical Hypotheses · doi:10.1016/j.mehy.2010.02.033 · Cited by 51
Capsinoids activate brown adipose tissue (BAT) with increased energy expenditure associated with subthreshold 18-fluorine fluorodeoxyglucose uptake in BAT-positive humans confirmed by positron emission tomography scan
Sun, L., Camps, S. G., Goh, H. J., Govindharajulu, P., Schaefferkoetter, J. D., Townsend, D. W., Verma, S. K., Velan, S. S., Sun, L., Sze, S. K., et al. (2018) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqx025 · Cited by 48
In the absence of UCP1-mediated diet-induced thermogenesis, obesity is augmented even in the obesity-resistant 129S mouse strain
Luijten, I. H. N., Feldmann, H. M., von Essen, G., Cannon, B., & Nedergaard, J. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00020.2019 · Cited by 52
Temperature- and capsaicin-sensitive nerve fibers in brown adipose tissue attenuate thermogenesis in the rat
Osaka, T., Kobayashi, A., Namba, Y., Ezaki, O., Inoue, S., Kimura, S., & Lee, T. H. (1998) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s004240050743 · Cited by 48
Non-malignant FDG uptake in infradiaphragmatic adipose tissue: a new site of physiological tracer biodistribution characterised by PET/CT
Bar‐Shalom, R., Gaitini, D. E., Keidar, Z., & Israel, O. (2004) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-004-1506-0 · Cited by 46
Changes in lipid metabolism in diet-induced obesity
Triscari, J. M., Nauss-Karol, C., Levin, B. E., & Sullivan, A. C. (1985) · Metabolism · doi:10.1016/0026-0495(85)90198-2 · Cited by 48
Evidence for the presence of brown adipose tissue in the pig
Dauncey, M. J., Wooding, F. B. P., & Ingram, D. L. (1981) · Research in Veterinary Science · doi:10.1016/s0034-5288(18)32525-6 · Cited by 48
Inhibition by vasodilators of noradrenaline and vasoconstrictor-mediated, but not skeletal muscle contraction-induced oxygen uptake in the perfused rat hindlimb; implications for non-shivering thermogenesis in muscle tissue
Colquhoun, E. Q., Hettiarachchi, M., Ye, J., Rattigan, S., & Clark, M. G. (1990) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(90)90610-x · Cited by 48
Visceral adipose tissue: emerging role of gluco‐ and mineralocorticoid hormones in the setting of cardiometabolic alterations
Boscaro, M., Giacchetti, G., & Ronconi, V. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06597.x · Cited by 49
JAK2 promotes brown adipose tissue function and is required for diet- and cold-induced thermogenesis in mice
Shi, S. Y., Zhang, W., Luk, C. T., Sivasubramaniyam, T., Brunt, J. J., Schroer, S. A., Desai, H. R., Majerski, A., & Woo, M. (2015) · Diabetologia · doi:10.1007/s00125-015-3786-2 · Cited by 47
Comparative analysis of the digestive efficiency and nitrogen and energy requirements of the phyllostomid fruit-bat ( Artibeus jamaicensis ) and the pteropodid fruit-bat ( Rousettus aegyptiacus )
Delorme, M., & Thomas, D. W. (1999) · Journal of Comparative Physiology B · doi:10.1007/s003600050202 · Cited by 43
Adipose tissue development during early life: novel insights into energy balance from small and large mammals
Symonds, M. E., Pope, M., & Budge, H. (2012) · Proceedings of The Nutrition Society · doi:10.1017/s0029665112000584 · Cited by 49
Control of energy balance in relation to energy intake and energy expenditure in animals and man: an ecological perspective
Stubbs, R. J., & Tolkamp, B. J. (2006) · British Journal Of Nutrition · doi:10.1079/bjn20041361 · Cited by 49
Sarcolipin is a novel regulator of muscle metabolism and obesity
Maurya, S. K., & Periasamy, M. (2015) · Pharmacological Research · doi:10.1016/j.phrs.2015.10.020 · Cited by 46
Fundamental mechanisms of thermogenesis
Ricquier, D. (2006) · Comptes Rendus Biologies · doi:10.1016/j.crvi.2005.10.010 · Cited by 47
Visualization of interscapular brown adipose tissue using (99m)Tc-tetrofosmin in pediatric patients.
Fukuchi, K., Ono, Y., Nakahata, Y., Okada, Y., Hayashida, K., & Ishida, Y. (2003) · PubMed · Cited by 45
Body Weight and Composition in Laboratory Rats: Effects of Diets with High or Low Protein Concentrations
Donald, P., Pitts, G. C., & Pohl, S. L. (1981) · Science · doi:10.1126/science.7444462 · Cited by 47
Brown adipose tissue of rats with obesity-inducing ventromedial hypothalamic lesions
Hogan, S. L., Coscina, D. V., & Himms‐Hagen, J. (1982) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1982.243.4.e338 · Cited by 47
Effects of Dietary Essential Fatty Acids on Active Thermogenin Content in Rat Brown Adipose Tissue
Nedergaard, J., Becker, W., & Cannon, B. (1983) · Journal of Nutrition · doi:10.1093/jn/113.9.1717 · Cited by 47
Adrenergic mechanisms in the metabolic adaptation to fasting and feeding: Effects of phlorizin on diet-induced changes in sympathoadrenal activity in the rat
Landsberg, L., Greff, L., Gunn, S., & Young, J. B. (1980) · Metabolism · doi:10.1016/0026-0495(80)90022-0 · Cited by 47
PDE3 and PDE4 Isozyme-Selective Inhibitors Are Both Required for Synergistic Activation of Brown Adipose Tissue
Kraynik, S. M., Miyaoka, R. S., & Beavo, J. A. (2013) · Molecular Pharmacology · doi:10.1124/mol.112.084145 · Cited by 46
Activation of β3-adrenoceptors increases in vivo free fatty acid uptake and utilization in brown but not white fat depots in high-fat-fed rats
Warner, A., Kjellstedt, A., Carreras, A., Böttcher, G., Peng, X., Seale, P., Oakes, N. D., & Lindén, D. (2016) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00204.2016 · Cited by 46
An emerging role for epigenetic regulation of Pgc-1α expression in environmentally stimulated brown adipose thermogenesis
Gill, J. A., & Merrill, M. A. L. (2017) · Current Zoology · doi:10.1093/eep/dvx009 · Cited by 48
Appetite Disturbance and the Problems of Overweight
Blundell, J. E. (1990) · Drugs · doi:10.2165/00003495-199000393-00003 · Cited by 46
UCP1 protein: The molecular hub of adipose organ plasticity
Cinti, S. (2016) · Biochimie · doi:10.1016/j.biochi.2016.09.008 · Cited by 46
Does Brown Adipose Tissue (BAT) Have a Role in the Physiology or Treatment of Human Obesity?
Himms‐Hagen, J. (2001) · Reviews in Endocrine and Metabolic Disorders · doi:10.1023/a:1011856617047 · Cited by 45
Augmenting energy expenditure by mitochondrial uncoupling: A role of AMP-activated protein kinase
Klaus, S., Keipert, S., Rossmeisl, M., & Kopecky, J. (2012) · Genes & Nutrition · doi:10.1007/s12263-011-0260-8 · Cited by 44
Contribution of brown adipose tissue activity to the control of energy balance by GLP-1 receptor signalling in mice
Heppner, K. M., Marks, S., Holland, J., Ottaway, N., Smiley, D., DiMarchi, R. D., & Pérez–Tilve, D. (2015) · Diabetologia · doi:10.1007/s00125-015-3651-3 · Cited by 46
Neuronal Control of Adaptive Thermogenesis
Yang, X., & Ruan, H. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00149 · Cited by 47
Thermogenic adipocytes: From cells to physiology and medicine
Díaz, M. B., Herzig, S., & Vegiopoulos, A. (2014) · Metabolism · doi:10.1016/j.metabol.2014.07.002 · Cited by 45
Brown adipose tissue (BAT) specific vaspin expression is increased after obesogenic diets and cold exposure and linked to acute changes in DNA-methylation
Weiner, J., Rohde, K., Krause, K., Zieger, K., Klöting, N., Kralisch, S., Kovacs, P. L., Stümvoll, M., Blüher, M., Böttcher, Y., et al. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.03.004 · Cited by 44
Effects of capsaicin and isothiocyanate on thermogenesis of interscapular brown adipose tissue in rats.
Yoshida, T., Yoshioka, K., Wakabayashi, Y., Nishioka, H., & Kondo, M. (1988) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.34.587 · Cited by 44
Norepinephrine stimulates the expression of fibroblast growth factor 2 in rat brown adipocyte primary culture.
Yamashita, H., Sato, N., Kizaki, T., Oh-ishi, S., Segawa, M., Saitoh, D., Ohira, Y., & Ohno, H. (1995) · PubMed · Cited by 44
Adrenal Glucocorticoids Regulate Adipsin Gene Expression in Genetically Obese Mice
Spiegelman, B. M., Lowell, B. B., Napolitano, A., Dubuc, P. U., Barton, D. E., Francke, U., Groves, D. L., Cook, K. S., & Flier, J. S. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)94260-2 · Cited by 44
Thermogenesis in diabetes-obesity syndromes in mutant mice
Coleman, D. (1982) · Diabetologia · doi:10.1007/bf00283754 · Cited by 44
Modulation in vivo of β-adrenergic-receptor subtypes in rat brown adipose tissue by the thermogenic agonist Ro 16–8714
Revelli, J. P., Muzzin, P., & Giacobino, J. (1992) · Biochemical Journal · doi:10.1042/bj2860743 · Cited by 44
Regulation of metabolism by cGMP
Pfeifer, A., Kilić, A., & Hoffmann, L. S. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.06.001 · Cited by 47
Contrasting effects of cold acclimation versus obesogenic diets on chemerin gene expression in brown and brite adipose tissues
Hansen, I. R., Jansson, K. M., Cannon, B., & Nedergaard, J. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.09.003 · Cited by 43
Pharmacological Approaches for the Treatment of Obesity
Fern??ndez-L??pez, J.-A., Remesar, X., Foz, M., & Alemany, M. (2002) · Drugs · doi:10.2165/00003495-200262060-00005 · Cited by 42
Diet-Induced Thermogenesis
Rothwell, N. J., & Stock, M. J. (1983) · Springer eBooks · doi:10.1007/978-94-011-6032-2_7 · Cited by 43
Self-citation
The Genetics of Brown Adipocyte Induction in White Fat Depots
Kozak, L. P. (2011) · Frontiers in Endocrinology · doi:10.3389/fendo.2011.00064 · Cited by 41
Novel Aspects of Brown Adipose Tissue Biology
Heeren, J., & Münzberg, H. (2012) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2012.11.004 · Cited by 43
Reduced Brown Adipose Tissue Thermogenesis of Obese Rats After Ovariectomy.
Yoshioka, K., Yoshida, T., Wakabayashi, Y., Nishioka, H., & Kondo, M. (1988) · Endocrinologia Japonica · doi:10.1507/endocrj1954.35.537 · Cited by 42
Development of Compensatory Thermogenesis in Response to Overfeeding in Hypothyroid Rats1
Curcio, C., Lopes, A. M., Ribeiro, M. O., Francoso, O. A., Carvalho, S. D., Lima, F. B., Bicudo, J. E. P. W., & Bianco, A. C. (1999) · Endocrinology · doi:10.1210/endo.140.8.6906 · Cited by 42
Neural and vascular provisions of rat interscapular brown adipose tissue
Nnodim, J. O., & Lever, J. D. (1988) · American Journal of Anatomy · doi:10.1002/aja.1001820309 · Cited by 42
WIdespread increases in regional hypothalamic neuropeptide Y levels in acute cold-exposed rats
McCarthy, H. D., Kilpatrick, A. P., Trayhurn, P., & Williams, G. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90388-v · Cited by 41
Integration of energy intake and expenditure in animals and man: The autonomic and adrenal hypothesis
Bray, G. A. (1984) · Clinics in Endocrinology and Metabolism · doi:10.1016/s0300-595x(84)80036-5 · Cited by 42
Synergistic effect of polymorphisms of uncoupling protein 1 and β3-adrenergic receptor genes on autonomic nervous system activity
Shihara, N., Yasuda, K., Moritani, T., Ue, H., Uno, M., Adachi, T., Nunoi, K., Seino, Y., Yamada, Y., & Tsuda, K. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801629 · Cited by 42
The Association between Trp64Arg Polymorphism of the β3-Adrenergic Receptor and Autonomic Nervous System Activity1
Shihara, N., Yasuda, K., Moritani, T., Ue, H., Adachi, T., Tanaka, H., Tsuda, K., & Seino, Y. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.5.5701 · Cited by 42
Central effects of neuropeptide Y with emphasis on its role in obesity and diabetes
Turton, M. D., O’Shea, D., & Bloom, S. R. (1997) · Elsevier eBooks · doi:10.1016/b978-012304990-2/50003-2 · Cited by 42
Socio-cultural determinants of child mortality in Southern Peru: Including some methodological considerations
de Meer, K., Bergman, R., & Kusner, J. S. (1993) · Social Science & Medicine · doi:10.1016/0277-9536(93)90016-w · Cited by 42
Sympathoadrenal System
Landsberg, L., & Young, J. B. (1985) · Springer eBooks · doi:10.1007/978-1-4684-4817-7_6 · Cited by 42
A new, powerful player in lipoprotein metabolism: brown adipose tissue
Bartelt, A., Merkel, M., & Heeren, J. (2012) · Journal of Molecular Medicine · doi:10.1007/s00109-012-0858-3 · Cited by 45
Melatonin multiple effects on brown adipose tissue molecular machinery
de Souza, C. A. P., Gallo, C. C., de Camargo, L. S., de Carvalho, P. V. V., Olesçuck, I. F., Macedo, F. P., da Cunha, F. M., Cipolla‐Neto, J., & do Amaral, F. G. (2018) · Journal of Pineal Research · doi:10.1111/jpi.12549 · Cited by 41
Lipid Regulators of Thermogenic Fat Activation
Park, H., He, A., & Lodhi, I. J. (2019) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2019.07.020 · Cited by 42

Authors: Rothwell, N. J., & Stock, M. J.
Affiliations: University of London (GB)
ORCID: Rothwell, Nancy J.
Stock, Michael J.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1979-09
Volume: 281
Issue: 5726
Pages: 31-35
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/281031a0
OpenAlex: W1972836378
Cited by: 1,606
References: 30
Citations by year: 2026: 11 · 2025: 8 · 2024: 22 · 2023: 22 · 2022: 22 · 2021: 34 · 2020: 42 · 2019: 36 · 2018: 37 · 2017: 41 · 2016: 38 · 2015: 46 · 2014: 46 · 2013: 52 · 2012: 39
FWCI: 75.55
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Research Explorer (The University of Manchester) (publishedVersion)
Research Explorer (The University of Manchester) (submittedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: brown adipose tissue, diet-induced thermogenesis, energy balance, sympathetic nervous system, cold-induced thermogenesis, obesity resistance, metabolic efficiency, rats
MeSH terms: Animals, Body Temperature Regulation, Adipose Tissue, Brown, Diet, Disease Models, Animal, Energy Metabolism, Humans, Lipid Mobilization, Male, Norepinephrine, Obesity, Oxygen Consumption, Sympathetic Nervous System, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

A role for brown adipose tissue in diet-induced thermogenesis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks