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A role for brown adipose tissue in diet-induced thermogenesis
Abstract
Measurement of energy balance during voluntary overeating in rats unequivocally establishes the quantitative importance of diet-induced thermogenesis in energy balance. Like cold-induced thermogenesis, this form of heat production involves changes in the activity of the sympathetic nervous system and brown adipose tissue which suggest that this tissue may determine metabolic efficiency and resistance to obesity.
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“It has been proposed that differential responses to DIT may account for the large individual differences in weight gain in response to overfeeding and thus contribute to the development of obesity 49.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [49]
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Metadata
- Authors
- Rothwell, N. J., & Stock, M. J.
- Affiliations
- University of London (GB)
- Venue
- Nature
- Published
- 1979-09
- Volume
- 281
- Issue
- 5726
- Pages
- 31-35
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1972836378
- Cited by
- 1,606
- References
- 30
- Citations by year
- 2026: 11 · 2025: 8 · 2024: 22 · 2023: 22 · 2022: 22 · 2021: 34 · 2020: 42 · 2019: 36 · 2018: 37 · 2017: 41 · 2016: 38 · 2015: 46 · 2014: 46 · 2013: 52 · 2012: 39
- FWCI
- 75.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- brown adipose tissue, diet-induced thermogenesis, energy balance, sympathetic nervous system, cold-induced thermogenesis, obesity resistance, metabolic efficiency, rats
- MeSH terms
- Animals, Body Temperature Regulation, Adipose Tissue, Brown, Diet, Disease Models, Animal, Energy Metabolism, Humans, Lipid Mobilization, Male, Norepinephrine, Obesity, Oxygen Consumption, Sympathetic Nervous System, Rats
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