Inverse relationship between brown fat thermogenesis and meal size: The thermostatic control of food intake revisited
Abstract
This study examines a new hypothesis whereby heat production from brown fat in response to eating may serve as a feedback signal for satiety. To test this hypothesis, in vitro respiration rate of brown adipose tissue (BAT) was determined in relation to the voluntary caloric intake of the preceding test meal. This relationship was examined as a function of meal composition and of obesity. It was found that in rats fed a high fat diet, as well as in two types of obese rats (VMH and Zucker), respiration rate per 100 mg tissue was significantly reduced, and energy intake of the preceding test meal increased compared to rats receiving a low fat diet or to respective lean rats. These data lend support to a brown fat mediated thermostatic hypothesis for the control of food intake.
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Meal-associated thermogenesis exists.
“It has been demonstrated by several groups that there is a meal‐associated thermogenesis 101, 102, 103.”
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- Authors
- Glick, Z.
- Affiliations
- Harbor–UCLA Medical Center (US)
- Corresponding author
- Glick, Zvi
- Venue
- Physiology & Behavior
- Publisher
- Elsevier BV
- Published
- 1982-12
- Volume
- 29
- Issue
- 6
- Pages
- 1137-1140
- ISSN
- 0031-9384 (ISSN-L)
- OpenAlex
- W2088603277
- Cited by
- 35
- References
- 48
- Citations by year
- 2024: 2 · 2020: 4 · 2019: 1 · 2018: 4 · 2015: 1
- FWCI
- 5.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Physiology & Behavior (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- brown adipose tissue, thermogenesis, meal size, satiety, food intake regulation, thermostat control, high-fat diet, obesity, Zucker rats, meal composition
- MeSH terms
- Animals, Body Temperature Regulation, Body Weight, Adipose Tissue, Brown, Energy Intake, Eating, Female, Rats, Inbred Strains, Respiration, Rats
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