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Effects of sleep and arousal on the processing of visual information in the cat
Abstract
Single units in the cat lateral geniculate nucleus and primary visual cortex show changes in both spontaneous and visually evoked firing as a function of the state of wakefulness. On arousal spontaneous firing is smoother and often reduced, whereas evoked responses are usually enhanced; the result is an increase in the signal-to-noise ratio. Single- and double-label 2-deoxyglucose autoradiographs show further that slow-wave sleep differentially depresses visually evoked activity in the deeper layers of the visual cortex.
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“Variations in behavioral state strongly affect the magnitude of evoked cortical activity.”
From Waking state: rapid variations modulate neural and behavioral responses (2015) · cites this paper as Livingstone and Hubel, 1981
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“Gain modulation mechanisms are also robustly engaged by changes in internal state32–35.”
From Mechanisms underlying gain modulation in the cortex (2020) · cites this paper as [35]
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Cites
Receptive fields, binocular interaction and functional architecture in the cat’s visual cortex
Hubel, D. H., & Wiesel, T. N. (1962) · The Journal of Physiology · doi:10.1113/jphysiol.1962.sp006837 · Cited by 13,680
Self-citationReceptive fields and functional architecture of monkey striate cortex
Hubel, D. H., & Wiesel, T. N. (1968) · The Journal of Physiology · doi:10.1113/jphysiol.1968.sp008455 · Cited by 6,685
Self-citationSokoloff, L., Reivich, M., Kennedy, C., Rosiers, M. H. D., Patlak, C. S., Pettigrew, K. D., Sakurada, O., & Shinohara, M. (1977) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1977.tb10649.x · Cited by 6,000
RECEPTIVE FIELDS AND FUNCTIONAL ARCHITECTURE IN TWO NONSTRIATE VISUAL AREAS (18 AND 19) OF THE CAT
Hubel, D. H., & Wiesel, T. N. (1965) · Journal of Neurophysiology · doi:10.1152/jn.1965.28.2.229 · Cited by 2,615
Self-citationDISCHARGE PATTERNS AND FUNCTIONAL ORGANIZATION OF MAMMALIAN RETINA
Kuffler, S. W. (1953) · Journal of Neurophysiology · doi:10.1152/jn.1953.16.1.37 · Cited by 2,609
Visual properties of neurons in inferotemporal cortex of the Macaque.
Gross, C. G., Rocha‐Miranda, C. E., & Bender, D. B. (1972) · Journal of Neurophysiology · doi:10.1152/jn.1972.35.1.96 · Cited by 1,488
Moore, R. Y., & Bloom, F. E. (1979) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.02.030179.000553 · Cited by 1,378
Summation and inhibition in the frog's retina
Barlow, H. B. (1953) · The Journal of Physiology · doi:10.1113/jphysiol.1953.sp004829 · Cited by 912
Dorsal raphe neurons: depression of firing during sleep in cats
McGinty, D., & Harper, R. M. (1976) · Brain Research · doi:10.1016/0006-8993(76)90480-7 · Cited by 900
Foote, S. L., Aston-Jones, G., & Bloom, F. E. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.5.3033 · Cited by 857
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Research works printed but not linked: 7
- Maffei, L. & Rizzolatti, C. T. Arch. ital. Biol. 103, 609–622 (1965).
- Murata, K. & Kameda, K. Arch. ital. Biol. 101, 306–331 (1963).
- Akimoto, H., Saito, Y. & Nakamura, Y. Neurophysiologie und Psychophysik des visuellen Systems (eds Jung, R. & Kornhuber, H.) 363–374 (Springer, Berlin, 1961).
- Evarts, E. V. in Colloque International sur les Aspects Anatomo-fonctionnels de la Physiologie du Sommeil, 189–212 (Éditions du Centre National de la Recherche Scientifique, Paris, 1965).
- Mollica, A., Moruzzi, G. & Naquet, R. EEG J. 5, 571–584 (1953).
- Schlag, J. L'activité Spontanée des Cellules du Système Nerveux Central (Editions Arscia, Bruxelles, 1959).
- Beniot, O. J. Physiol., Paris 56, 259–262 (1964).
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Silva, T. O. (2013) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
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Metadata
- Authors
- Livingstone, M. S., & Hubel, D. H.
- Affiliations
- Harvard University (US)
- Venue
- Nature
- Published
- 1981-06
- Volume
- 291
- Issue
- 5816
- Pages
- 554-561
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2029325913
- Cited by
- 583
- References
- 41
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 15 · 2023: 9 · 2022: 6 · 2021: 5 · 2020: 6 · 2019: 8 · 2018: 5 · 2017: 12 · 2016: 12 · 2015: 18 · 2014: 9 · 2013: 12 · 2012: 5
- FWCI
- 10.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ns007848-19, 5r01ey000605-43)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- sleep, arousal, visual processing, lateral geniculate nucleus, primary visual cortex, single-unit activity, spontaneous firing, visual evoked potentials, signal-to-noise ratio, slow-wave sleep, 2-deoxyglucose autoradiography, cats
- MeSH terms
- Action Potentials, Animals, Arousal, Autoradiography, Axonal Transport, Carbon Radioisotopes, Cats, Deoxyglucose, Evoked Potentials, Geniculate Bodies, Sleep, Tritium, Vision, Ocular, Visual Cortex, Visual Perception
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