The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Intracellular injections of EGTA block induction of hippocampal long-term potentiation
Abstract
Hippocampal long-term potentiation (LTP) is a remarkably stable facilitation of synaptic responses resulting from very brief trains of high-frequency stimulation. Because of its persistence and modest induction conditions, LTP represents a promising candidate for a substrate of memory. Some progress has been made in localizing the changes responsible for the effect; for example, it has been shown that LTP is not accompanied by changes in the fibre volleys of the test afferents or by generalized alterations of the dendrites of their target cells. However, it is unknown whether the potentiation is due to pre- or postsynaptic changes and there is evidence in favour of each (for example, see refs 5, 6). We now report that intracellular injections of the calcium chelator EGTA block the development of LTP. These results strongly suggest that LTP is caused by a modification of the postsynaptic neurone and that its induction depends on the level of free calcium.
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“loading postsynaptic cells with the Ca2+ chelator EGTA blocked LTP (176), suggesting that Ca2+ is necessary for LTP.”
From Synaptic memory and CaMKII (2023) · cites this paper as [176]
Citations
Cites
Bliss, T. V. P., & Gardner-Medwin, A. R. (1973) · The Journal of Physiology · doi:10.1113/jphysiol.1973.sp010274 · Cited by 7,424
A calcium-activated hyperpolarization follows repetitive firing in hippocampal neurons
Hotson, J. R., & Prince, D. A. (1980) · Journal of Neurophysiology · doi:10.1152/jn.1980.43.2.409 · Cited by 569
Dunwiddie, T. V., & LYNCH, G. S. (1978) · The Journal of Physiology · doi:10.1113/jphysiol.1978.sp012239 · Cited by 479
Self-citationAlger, B. E., & Nicoll, R. A. (1980) · Science · doi:10.1126/science.7444438 · Cited by 421
Afterpotential generation in hippocampal pyramidal cells.
Wong, R. K. S., & Prince, D. A. (1981) · Journal of Neurophysiology · doi:10.1152/jn.1981.45.1.86 · Cited by 391
Long-term potentiation of the perforant path in vivo is associated with increased glutamate release
DOLPHIN, A. C., Errington, M. L., & Bliss, T. V. P. (1982) · Nature · doi:10.1038/297496a0 · Cited by 389
Andersen, P. N., Sundberg, S. H., Sveen, O., Swann, J. W., & Wigström, H. (1980) · The Journal of Physiology · doi:10.1113/jphysiol.1980.sp013256 · Cited by 366
Effects of EGTA on the Calcium-Activated Afterhyperpolarization in Hippocampal CA3 Pyramidal Cells
Schwartzkroin, P. A., & Stafstrom, C. E. (1980) · Science · doi:10.1126/science.6777871 · Cited by 275
Dunwiddie, T. V., & LYNCH, G. S. (1979) · Brain Research · doi:10.1016/0006-8993(79)90377-9 · Cited by 234
Self-citationMicromolar Calcium Stimulates Proteolysis and Glutamate Binding in Rat Brain Synaptic Membranes
Baudry, M., Bundman, M. C., Smith, E. K., & LYNCH, G. S. (1981) · Science · doi:10.1126/science.7015504 · Cited by 181
Self-citationRegulation of glutamate receptors by cations
Baudry, M., & LYNCH, G. S. (1979) · Nature · doi:10.1038/282748a0 · Cited by 151
Self-citationBaudry, M., & LYNCH, G. S. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.4.2298 · Cited by 146
Self-citationSynaptic transmission is required for initiation of long-term potentiation
Dunwiddie, T. V., Madison, D. V., & LYNCH, G. S. (1978) · Brain Research · doi:10.1016/0006-8993(78)90293-7 · Cited by 124
Self-citationLYNCH, G. S., Halpain, S., & Baudry, M. (1982) · Brain Research · doi:10.1016/0006-8993(82)90908-8 · Cited by 118
Self-citationIncrease in glutamate receptors following repetitive electrical stimulation in hippocampal slices
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Self-citationVargas, F., Greenbaum, L. M., & Costa, E. (1980) · Neuropharmacology · doi:10.1016/0028-3908(80)90072-6 · Cited by 33
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Research works printed but not linked: 2
- Bliss, T. V. P. & Lomo, T. J. Physiol., Lond. 232, 331–356 (1973). · DOI · Paper page
- Lee, K., Oliver, M., Schottler, F. & Lynch, G. in Electrical Activity in Isolated Mammalian CNS Preparations (eds Kerkut, G. & Wheal, H. V.) 189–212 (Academic, New York, 1981).
Cited by
Sorted by citations
A synaptic model of memory: long-term potentiation in the hippocampus
Bliss, T. V. P., & Collingridge, G. L. (1993) · Nature · doi:10.1038/361031a0 · Cited by 11,566
Malenka, R. C., & Bear, M. F. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.012 · Cited by 3,968
Long-Term Potentiation--A Decade of Progress?
Malenka, R. C., & Nicoll, A. R. A. (1999) · Science · doi:10.1126/science.285.5435.1870 · Cited by 2,729
THE HEME OXYGENASE SYSTEM:A Regulator of Second Messenger Gases
Maines, M. D. (1997) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.37.1.517 · Cited by 2,489
Long-Term Potentiation and Memory
Lynch, M. A. (2004) · Physiological Reviews · doi:10.1152/physrev.00014.2003 · Cited by 2,074
Metadata
- Authors
- Lynch, G., Larson, J., Kelso, S., Barrionuevo, G., & Schottler, F.
- Affiliations
- University of California, Irvine (US)
- ORCID
- Lynch, Gary
- Venue
- Nature
- Published
- 1983-10
- Volume
- 305
- Issue
- 5936
- Pages
- 719-721
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2031739172
- Cited by
- 1,116
- References
- 16
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 11 · 2023: 7 · 2022: 10 · 2021: 9 · 2020: 9 · 2019: 25 · 2018: 18 · 2017: 14 · 2016: 16 · 2015: 19 · 2014: 17 · 2013: 19 · 2012: 28
- FWCI
- 6.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- long-term potentiation, hippocampus, EGTA, calcium chelation, intracellular injection, free calcium, synaptic plasticity, memory substrate, high-frequency stimulation
- MeSH terms
- Animals, Calcium, Egtazic Acid, Electric Stimulation, Ethylene Glycols, Evoked Potentials, Hippocampus, Membrane Potentials, Time Factors, Rats
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