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Intracellular injections of EGTA block induction of hippocampal long-term potentiation

Lynch, Gary, Larson, John, Kelso, Stephen, Barrionuevo, German, Schottler, Frank·1983·Nature

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Abstract

Hippocampal long-term potentiation (LTP) is a remarkably stable facilitation of synaptic responses resulting from very brief trains of high-frequency stimulation. Because of its persistence and modest induction conditions, LTP represents a promising candidate for a substrate of memory. Some progress has been made in localizing the changes responsible for the effect; for example, it has been shown that LTP is not accompanied by changes in the fibre volleys of the test afferents or by generalized alterations of the dendrites of their target cells. However, it is unknown whether the potentiation is due to pre- or postsynaptic changes and there is evidence in favour of each (for example, see refs 5, 6). We now report that intracellular injections of the calcium chelator EGTA block the development of LTP. These results strongly suggest that LTP is caused by a modification of the postsynaptic neurone and that its induction depends on the level of free calcium.

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Authors: Lynch, G., Larson, J., Kelso, S., Barrionuevo, G., & Schottler, F.
Affiliations: University of California, Irvine (US)
ORCID: Lynch, Gary
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1983-10
Volume: 305
Issue: 5936
Pages: 719-721
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/305719a0
OpenAlex: W2031739172
Cited by: 1,116
References: 16
Citations by year: 2026: 6 · 2025: 9 · 2024: 11 · 2023: 7 · 2022: 10 · 2021: 9 · 2020: 9 · 2019: 25 · 2018: 18 · 2017: 14 · 2016: 16 · 2015: 19 · 2014: 17 · 2013: 19 · 2012: 28
FWCI: 6.65
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords: long-term potentiation, hippocampus, EGTA, calcium chelation, intracellular injection, free calcium, synaptic plasticity, memory substrate, high-frequency stimulation
MeSH terms: Animals, Calcium, Egtazic Acid, Electric Stimulation, Ethylene Glycols, Evoked Potentials, Hippocampus, Membrane Potentials, Time Factors, Rats

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Intracellular injections of EGTA block induction of hippocampal long-term potentiation

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