Cited by 7,847Tuberculosis Research and EpidemiologyGenomics and Phylogenetic StudiesMycobacterium research and diagnosis

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Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence

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Cole, S. T., Brosch, R., Parkhill, J., Garnier, T., Churcher, C., Harris, D., Gordon, S. V., Eiglmeier, K., Gas, S., Barry, C. E., Tekaia, F., Badcock, K., Basham, D., Brown, D., Chillingworth, T., Connor, R., Davies, R., Devlin, K., Feltwell, T., Gentles, S., Hamlin, N., Holroyd, S., Hornsby, T., Jagels, K., Krogh, A., McLean, J., Moule, S., Murphy, L., Oliver, K., Osborne, J., Quail, M. A., Rajandream, M.-A., Rogers, J., Rutter, S., Seeger, K., Skelton, J., Squares, R., Squares, S., Sulston, J. E., Taylor, K., Whitehead, S., Barrell, B. G.·1998·Nature

DOI 10.1038/31159

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Abstract

Countless millions of people have died from tuberculosis, a chronic infectious disease caused by the tubercle bacillus. The complete genome sequence of the best-characterized strain of Mycobacterium tuberculosis, H37Rv, has been determined and analysed in order to improve our understanding of the biology of this slow-growing pathogen and to help the conception of new prophylactic and therapeutic interventions. The genome comprises 4,411,529 base pairs, contains around 4,000 genes, and has a very high guanine + cytosine content that is reflected in the biased amino-acid content of the proteins. M. tuberculosis differs radically from other bacteria in that a very large portion of its coding capacity is devoted to the production of enzymes involved in lipogenesis and lipolysis, and to two new families of glycine-rich proteins with a repetitive structure that may represent a source of antigenic variation.

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Authors: Cole, S. T., Brosch, R., Parkhill, J., Garnier, T., Churcher, C., Harris, D., Gordon, S. V., Eiglmeier, K., Gas, S., Barry, C. E., Tekaia, F., Badcock, K., Basham, D., Brown, D., Chillingworth, T., Connor, R., Davies, R., Devlin, K., Feltwell, T., Gentles, S., Hamlin, N., Holroyd, S., Hornsby, T., Jagels, K., Krogh, A., McLean, J., Moule, S., Murphy, L., Oliver, K., Osborne, J., Quail, M. A., Rajandream, M.-A., Rogers, J., Rutter, S., Seeger, K., Skelton, J., Squares, R., Squares, S., Sulston, J. E., Taylor, K., Whitehead, S., & Barrell, B. G.
Affiliations: Institut Pasteur (FR)
Wellcome Sanger Institute (GB)
National Institutes of Health (US)
Technical University of Denmark (DK)
Corresponding author: Barrell, B. G.
ORCID: Cole, S. T.
Brosch, R.
Parkhill, J.
Harris, D.
Gordon, S. V.
Eiglmeier, K.
Barry, C. E.
Tekaia, F.
Davies, R.
Feltwell, T.
Krogh, A.
Murphy, L.
Oliver, K.
Quail, M. A.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1998-06
Volume: 393
Issue: 6685
Pages: 537-544
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/31159
OpenAlex: W2158023121
Cited by: 7,847
References: 53
Citations by year: 2026: 124 · 2025: 173 · 2024: 157 · 2023: 209 · 2022: 188 · 2021: 233 · 2020: 220 · 2019: 235 · 2018: 259 · 2017: 257 · 2016: 259 · 2015: 312 · 2014: 385 · 2013: 340 · 2012: 318
FWCI: 249.58
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Research Explorer (The University of Manchester) (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
Funders: American Heart Association
Wellcome Trust
Medical Research Council Canada
National Institutes of Health
Medical Research Council
National Institute of Allergy and Infectious Diseases (Z01AI000783)
Brookhaven National Laboratory
Topics: Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
Health Sciences › Medicine › Epidemiology › Mycobacterium research and diagnosis
Keywords: Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv, complete genome sequence, genome analysis, GC content, amino acid composition, lipogenesis, lipolysis, glycine-rich proteins, antigenic variation, tuberculosis pathogenesis, tuberculosis treatment
MeSH terms: Chromosome Mapping, Chromosomes, Bacterial, Drug Resistance, Microbial, Humans, Molecular Sequence Data, Mycobacterium tuberculosis, Tuberculosis, Genome, Bacterial, Sequence Analysis, DNA, Lipid Metabolism

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Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence

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