Cited by 414Genomics and Chromatin DynamicsDevelopmental Biology and Gene RegulationEpigenetics and DNA Methylation

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Segmental distribution of bithorax complex proteins during Drosophila development

Beachy, Philip A., Helfand, Stephen L., Hogness, David S.·1985·Nature

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Abstract

The Ubx and bxd transcription units comprise a single functional domain in the bithorax complex of Drosophila melanogaster. The segmental distributions and nuclear localization of proteins encoded by the Ubx unit have been determined by immunofluorescence staining with antibodies raised against a fusion protein containing Ubx coding sequences. Wild-type and mutant distributions are consistent with a model in which the protein-coding functions of the domain derive from the Ubx unit and are regulated by the bxd unit.

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The reinforcement-extinction process of selector gene activity: a positive feed-back loop and cell-cell interactions in Ultrabithorax patterning
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Authors: Beachy, P. A., Helfand, S. L., & Hogness, D. S.
Affiliations: Stanford Medicine (US)
ORCID: Beachy, Philip A.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1985-02
Volume: 313
Issue: 6003
Pages: 545-551
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/313545a0
OpenAlex: W2041519679
Cited by: 413
References: 51
Citations by year: 2026: 3 · 2025: 1 · 2024: 2 · 2023: 14 · 2021: 2 · 2020: 3 · 2019: 1 · 2018: 4 · 2017: 1 · 2016: 3 · 2015: 5 · 2014: 5 · 2013: 4
FWCI: 23.20
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Keywords: bithorax complex, Ubx, Drosophila melanogaster, developmental gene expression, nuclear localization, homeotic genes, transcriptional regulation, segmental distribution
MeSH terms: Animals, Antibodies, Base Sequence, Cell Nucleus, Drosophila melanogaster, Fluorescent Antibody Technique, Gene Expression Regulation, Larva, Models, Genetic, Morphogenesis, Transcription Factors, Transcription, Genetic

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Segmental distribution of bithorax complex proteins during Drosophila development

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