Cited by 521Signaling Pathways in DiseaseProtein Structure and DynamicsGenomics and Chromatin Dynamics

Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA

Chen, Lin, Glover, J. N. Mark, Hogan, Patrick G., Rao, Anjana, Harrison, Stephen C.·1998·Nature

Abstract

The nuclear factor of activated T cells (NFAT) and the AP-1 heterodimer, Fos-Jun, cooperatively bind a composite DNA site and synergistically activate the expression of many immune-response genes. A 2.7-A-resolution crystal structure of the DNA-binding domains of NFAT, Fos and Jun, in a quaternary complex with a DNA fragment containing the distal antigen-receptor response element from the interleukin-2 gene promoter, shows an extended interface between NFAT and AP-1, facilitated by the bending of Fos and DNA. The tight association of the three proteins on DNA creates a continuous groove for the recognition of 15 base pairs.

Integrity signals

Registry

Crossref · 10.1038/32100

Cites

44 of 44 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Chen, L., Glover, J. N. M., Hogan, P. G., Rao, A., & Harrison, S. C.
Affiliations
  • Harvard University (US)
  • Howard Hughes Medical Institute (US)
Corresponding author
  • Chen, Lin
  • Harrison, Stephen C.
Venue
Nature
Published
1998-03
Volume
392
Issue
6671
Pages
42-48
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
OpenAlex
W1847275787
Cited by
521
References
44
Citations by year
2026: 7 · 2025: 11 · 2024: 14 · 2023: 11 · 2022: 11 · 2021: 14 · 2020: 12 · 2019: 18 · 2018: 4 · 2017: 12 · 2016: 15 · 2015: 15 · 2014: 15 · 2013: 9 · 2012: 17
FWCI
13.95
Type
journal article
Language
en
Open access
closed
Locations
  • Nature (publishedVersion)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords
NFAT, FOS, c-Jun, DNA-binding domain, AP-1, transcription factor-DNA complex, interleukin-2 promoter, protein-DNA interactions, quaternary complex, protein-protein interfaces
MeSH terms
Amino Acid Sequence, Animals, Binding Sites, DNA, DNA-Binding Proteins, Gene Expression Regulation, Humans, Models, Molecular, Molecular Sequence Data, Mutation, Nuclear Proteins, Protein Conformation, Recombinant Proteins, T-Lymphocytes, Transcription Factors, Transcription, Genetic, Proto-Oncogene Proteins c-jun, Proto-Oncogene Proteins c-fos, Crystallography, X-Ray, Transcription Factor AP-1, NFATC Transcription Factors, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review