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Role for interleukin-3 in mast-cell and basophil development and in immunity to parasites

Lantz, Chris S., Boesiger, Jurg, Song, Chang Ho, Mach, Nicolas, Kobayashi, Takahiko, Mulligan, Richard C., Nawa, Yukifumi, Dranoff, Glenn, Galli, Stephen J.·1998·Nature
DOI 10.1038/32190
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Abstract

The cytokine interleukin-3 (IL-3), which can be derived from T cells and other sources, is a potentially important link between the immune and haematopoietic systems. IL-3 may be particularly critical for the development, survival and function of tissue mast cells and blood basophils, which are thought to be important effector cells in immunity to parasites and other immunological responses, such as allergic reactions. Here we show, using IL-3-deficient mice, that IL-3 is not essential for the generation of mast cells or basophils under physiological conditions, but that it does contribute to increased numbers of tissue mast cells, enhanced basophil production, and immunity in mice infected with the nematode Stronglyoides venezuelensis. Parasite expulsion and mast-cell development are impaired even more severely in IL-3-deficient mice that also show a marked reduction in signalling by c-kit. These findings establish a role for IL-3 in immunity to parasites and indicate that one of the functions of IL-3 in host defence against infection is to expand populations of haematopoietic effector cells.

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Research works printed but not linked: 30

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Cited by

Metadata

Authors
Lantz, C. S., Boesiger, J., Song, C. H., Mach, N., Kobayashi, T., Mulligan, R. C., Nawa, Y., Dranoff, G., & Galli, S. J.
Venue
Nature
Publisher
Springer Science and Business Media LLC
Published
1998-03
Volume
392
Issue
6671
Pages
90-93
ISSN
  • 0028-0836
  • 1476-4687
DOI
10.1038/32190
Cited by
474
References
0
Language
en
Licence
www.springer.com/tdm (tdm)

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