Cited by 240Mast cells and histamineT-cell and B-cell ImmunologyFood Allergy and Anaphylaxis Research

Widespread Immunological Functions of Mast Cells: Fact or Fiction?

Open access
Rodewald, Hans-Reimer, Feyerabend, Thorsten B.·2012·Immunity

Abstract

Immunological functions of mast cells are currently considered to be much broader than the original role of mast cells in IgE-driven allergic disease. The spectrum of proposed mast cell functions includes areas as diverse as the regulation of innate and adaptive immune responses, protective immunity against viral, microbial, and parasitic pathogens, autoimmunity, tolerance to graft rejection, promotion of or protection from cancer, wound healing, angiogenesis, cardiovascular diseases, diabetes, obesity, and others. The vast majority of in vivo mast cell data have been based on mast cell-deficient Kit mutant mice. However, work in new mouse mutants with unperturbed Kit function, which have a surprisingly normal immune system, has failed to corroborate some key immunological aspects, formerly attributed to mast cells. Here, we consider the implications of these recent developments for the state of the field as well as for future work, aiming at deciphering the physiological functions of mast cells.

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Crossref · 10.1016/j.immuni.2012.07.007

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Authors
Rodewald, H.-R., & Feyerabend, T. B.
Affiliations
German Cancer Research Center (DE)
Corresponding author
Rodewald, Hans-Reimer
Venue
Immunity
Publisher
Elsevier BV
Published
2012-07
Volume
37
Issue
1
Pages
13-24
ISSN
1074-7613 (ISSN-L)
OpenAlex
W2033723439
Cited by
240
References
118
Citations by year
2026: 8 · 2025: 9 · 2024: 7 · 2023: 10 · 2022: 13 · 2021: 13 · 2020: 17 · 2019: 20 · 2018: 15 · 2017: 18 · 2016: 16 · 2015: 29 · 2014: 38 · 2013: 25 · 2012: 2
FWCI
2.77
Type
journal article
Language
en
Open access
Locations
  • Immunity (publishedVersion)
  • PubMed (publishedVersion)
Funders
European Research Council
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
Keywords
mast cells, mast cell function, mast cell-deficient mice, innate immunity, adaptive immunity, autoimmunity, graft tolerance, cancer, wound healing, angiogenesis, cardiovascular disease, diabetes mellitus, obesity, allergic diseases, IgE
MeSH terms
Animals, Humans, Immunity, Mast Cells, Mutation, Proto-Oncogene Proteins c-kit, Mice

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