Widespread Immunological Functions of Mast Cells: Fact or Fiction?
Open accessAbstract
Immunological functions of mast cells are currently considered to be much broader than the original role of mast cells in IgE-driven allergic disease. The spectrum of proposed mast cell functions includes areas as diverse as the regulation of innate and adaptive immune responses, protective immunity against viral, microbial, and parasitic pathogens, autoimmunity, tolerance to graft rejection, promotion of or protection from cancer, wound healing, angiogenesis, cardiovascular diseases, diabetes, obesity, and others. The vast majority of in vivo mast cell data have been based on mast cell-deficient Kit mutant mice. However, work in new mouse mutants with unperturbed Kit function, which have a surprisingly normal immune system, has failed to corroborate some key immunological aspects, formerly attributed to mast cells. Here, we consider the implications of these recent developments for the state of the field as well as for future work, aiming at deciphering the physiological functions of mast cells.
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Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
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Evidence that Meningeal mast cells can worsen stroke pathology in mice.
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“effects through the release of potent inflammatory mediators, such as histamine, proteases, chemotactic factors, and cytokines [8].”
Background
- Authors
- Rodewald, H.-R., & Feyerabend, T. B.
- Affiliations
- German Cancer Research Center (DE)
- Corresponding author
- Rodewald, Hans-Reimer
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2012-07
- Volume
- 37
- Issue
- 1
- Pages
- 13-24
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2033723439
- Cited by
- 240
- References
- 118
- Citations by year
- 2026: 8 · 2025: 9 · 2024: 7 · 2023: 10 · 2022: 13 · 2021: 13 · 2020: 17 · 2019: 20 · 2018: 15 · 2017: 18 · 2016: 16 · 2015: 29 · 2014: 38 · 2013: 25 · 2012: 2
- FWCI
- 2.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- Funders
- European Research Council
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
- Keywords
- mast cells, mast cell function, mast cell-deficient mice, innate immunity, adaptive immunity, autoimmunity, graft tolerance, cancer, wound healing, angiogenesis, cardiovascular disease, diabetes mellitus, obesity, allergic diseases, IgE
- MeSH terms
- Animals, Humans, Immunity, Mast Cells, Mutation, Proto-Oncogene Proteins c-kit, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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