Cited by 181Developmental Biology and Gene RegulationNeurogenesis and neuroplasticity mechanismsAxon Guidance and Neuronal Signaling

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Defects in pathfinding by cranial neural crest cells in mice lacking the neuregulin receptor ErbB4

Golding, Jon P., Trainor, Paul, Krumlauf, Robb, Gassmann, Martin·2000·Nature Cell Biology

DOI 10.1038/35000058

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Abstract

Mouse embryos with a loss-of-function mutation in the gene encoding the receptor tyrosine kinase ErbB4 exhibit misprojections of cranial sensory ganglion afferent axons. Here we analyse ErbB4-deficient mice, and find that morphological differences between wild-type and mutant cranial ganglia correlate with aberrant migration of a subpopulation of hindbrain-derived cranial neural crest cells within the paraxial mesenchyme environment. In transplantation experiments using new grafting techniques in cultured mouse embryos, we determine that this phenotype is non-cell-autonomous: wild-type and mutant neural crest cells both migrate in a pattern consistent with the host environment, deviating from their normal pathway only when transplanted into mutant embryos. ErbB4 signalling events within the hindbrain therefore provide patterning information to cranial paraxial mesenchyme that is essential for the proper migration of neural crest cells.

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The Molecular Biology of Axon Guidance
Tessier‐Lavigne, M., & Goodman, C. S. (1996) · Science · doi:10.1126/science.274.5290.1123 · Cited by 3,311
Multiple essential functions of neuregulin in development
Meyer, D., & Birchmeier, C. (1995) · Nature · doi:10.1038/378386a0 · Cited by 1,273
Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor
Gassmann, M., Casagranda, F., Orioli, D., Simon, H. H., Lai, C., Klein, R., & Lemke, G. (1995) · Nature · doi:10.1038/378390a0 · Cited by 1,151
Patterning the Vertebrate Neuraxis
Lumsden, A., & Krumlauf, R. K. (1996) · Science · doi:10.1126/science.274.5290.1109 · Cited by 1,142
Conversion of Xenopus Ectoderm into Neurons by NeuroD, a Basic Helix-Loop-Helix Protein
Lee, J. E., Hollenberg, S. M., Snider, L., Turner, D. L., Lipnick, N., & Weintraub, H. (1995) · Science · doi:10.1126/science.7754368 · Cited by 1,023
[22] Detection of messenger RNA by in Situ hybridization to tissue sections and whole mounts
Wilkinson, D. G., & Nieto, M. A. (1993) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(93)25025-w · Cited by 794
Sox10, a Novel Transcriptional Modulator in Glial Cells
Kuhlbrodt, K., Herbarth, B., Sock, E., Hermans-Borgmeyer, I., & Wegner, M. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-01-00237.1998 · Cited by 781
neurogenin1 Is Essential for the Determination of Neuronal Precursors for Proximal Cranial Sensory Ganglia
Ma, Q., Chen, Z., Barrantes, I. D. B., de la Pompa, J. L., & Anderson, D. J. (1998) · Neuron · doi:10.1016/s0896-6273(00)80988-5 · Cited by 735
Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family.
Plowman, G. D., Culouscou, J., Whitney, G. S., Green, J. M., Carlton, G. W., Foy, L., NEUBAUER, M., & SHOYAB, M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.1746 · Cited by 714
Contributions of placodal and neural crest cells to avian cranial peripheral ganglia
D'amico‐Martel, A., & Noden, D. M. (1983) · American Journal of Anatomy · doi:10.1002/aja.1001660406 · Cited by 708
Segmental origin and migration of neural crest cells in the hindbrain region of the chick embryo
Lumsden, A., Sprawson, N., & Graham, A. (1991) · Development · doi:10.1242/dev.113.4.1281 · Cited by 634
Transcription factor AP-2 is expressed in neural crest cell lineages during mouse embryogenesis.Preprint
Mitchell, P. J., Timmons, P. M., Hébert, J. M., Rigby, P. W. J., & Tjian, R. (1991) · Genes & Development · doi:10.1101/gad.5.1.105 · Cited by 593
Expression and interactions of the two closely related homeobox genes Phox2a and Phox2b during neurogenesis
Pattyn, A., Morin, X., Cremer, H., Goridis, C., & Brunet, J. (1997) · Development · doi:10.1242/dev.124.20.4065 · Cited by 582
An analysis of the migratory behavior of avian cephalic neural crest cells
Noden, D. M. (1975) · Developmental Biology · doi:10.1016/0012-1606(75)90318-8 · Cited by 498
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Wang, H. U., & Anderson, D. J. (1997) · Neuron · doi:10.1016/s0896-6273(00)81240-4 · Cited by 479
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Schuurmans, C. J., Gradwohl, G., Morin, X., Dierich, A., LeMeur, M., Goridis, C., & Guillemot, F. (1998) · Neuron · doi:10.1016/s0896-6273(00)80989-7 · Cited by 444
Eph receptors and ephrins: effectors of morphogenesis
Holder, N., & Klein, R. (1999) · Development · doi:10.1242/dev.126.10.2033 · Cited by 443
Heregulin induces tyrosine phosphorylation of HER4/p180erbB4
Plowman, G. D., Green, J. M., Culouscou, J., Carlton, G. W., Rothwell, V. M., & Buckley, S. D. (1993) · Nature · doi:10.1038/366473a0 · Cited by 441
Isoform-specific expression and function of neuregulin
Meyer, D., Yamaai, T., Garratt, A. N., Sonnenberg-Riethmacher, E., Kane, D. J., Theill, L. E., & Birchmeier, C. (1997) · Development · doi:10.1242/dev.124.18.3575 · Cited by 395
Neuregulin-3 (NRG3): A novel neural tissue-enriched protein that binds and activates ErbB4
Zhang, D., Sliwkowski, M. X., Mark, M. R., Frantz, G. D., Akita, R. W., Sun, Y., Hillan, K. J., Crowley, C. W., Brush, J., & Godowski, P. J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.18.9562 · Cited by 383
The EphA4 and EphB1 receptor tyrosine kinases and ephrin-B2 ligand regulate targeted migration of branchial neural crest cells
Smith, A., Robinson, V., Patel, K., & Wilkinson, D. G. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00255-7 · Cited by 350
Cranial paraxial mesoderm and neural crest cells of the mouse embryo: co-distribution in the craniofacial mesenchyme but distinct segregation in branchial arches
Trainor, P. A., & Tam, P. (1995) · Development · doi:10.1242/dev.121.8.2569 · Cited by 341
Eph receptors and ephrins in neural development
O’Leary, D. D. M., & Wilkinson, D. G. (1999) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(99)80008-7 · Cited by 329
Neuregulin-4: a novel growth factor that acts through the ErbB-4 receptor tyrosine kinase
Harari, D., Tzahar, E., Romano, J., Shelly, M., Pierce, J., Andrews, G. C., & Yarden, Y. (1999) · Oncogene · doi:10.1038/sj.onc.1202631 · Cited by 318
Epidermal Growth Factor-related Peptides Activate Distinct Subsets of ErbB Receptors and Differ in Their Biological Activities
Beerli, R. R., & Hynes, N. E. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.11.6071 · Cited by 308
Evidence for collapsin-1 functioning in the control of neural crest migration in both trunk and hindbrain regions
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Plasticity in mouse neural crest cells reveals a new patterning role for cranial mesoderm
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Segmental migration of the hindbrain neural crest does not arise from its segmental generation
Sechrist, J. W., Serbedzija, G. N., Scherson, T. Y., Fraser, S. E., & Bronner-Fraser, M. E. (1993) · Development · doi:10.1242/dev.118.3.691 · Cited by 206
Cross-regulation in the mouse HoxB complex: the expression of Hoxb2 in rhombomere 4 is regulated by Hoxb1.Preprint
Maconochie, M. K., Nonchev, S., Studer, M., Chan, S.-K., Pöpperl, H., Sham, M. H., Mann, R. S., & Krumlauf, R. K. (1997) · Genes & Development · doi:10.1101/gad.11.14.1885 · Cited by 200
Differential distribution patterns of CRABP I and CRABP II transcripts during mouse embryogenesis
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Ectopic expression of Hoxa-1 in the zebrafish alters the fate of the mandibular arch neural crest and phenocopies a retinoic acid-induced phenotype
Alexandre, D., Clarke, J. D. W., Oxtoby, E., Yan, Y., Jowett, T., & Holder, N. (1996) · Development · doi:10.1242/dev.122.3.735 · Cited by 198
Cranial paraxial mesoderm: regionalisation of cell fate and impact on craniofacial development in mouse embryos
Trainor, P. A., Tan, S., & Tam, P. (1994) · Development · doi:10.1242/dev.120.9.2397 · Cited by 184
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Retinoic acid stage-dependently alters the migration pattern and identity of hindbrain neural crest cells
Lee, Y. M., Osumi, N., Ninomiya, Y., Moon, C.-K., Eriksson, U., & Eto, K. (1995) · Development · doi:10.1242/dev.121.3.825 · Cited by 158
Homeotic Transformation of Rhombomere Identity After Localized Hoxb1 Misexpression
Bell, E. J. D. H., Wingate, R. J. T., & Lumsden, A. (1999) · Science · doi:10.1126/science.284.5423.2168 · Cited by 150
The Distribution of Collapsin-1 mRNA in the Developing Chick Nervous System
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Heparin-binding EGF-like growth factor interacts with mouse blastocysts independently of ErbB1: a possible role for heparan sulfate proteoglycans and ErbB4 in blastocyst implantation
Paria, B. C., Elenius, K., Klagsbrun, M., & Dey, S. K. (1999) · Development · doi:10.1242/dev.126.9.1997 · Cited by 135
X-chromosome activity of the mouse primordial germ cells revealed by the expression of an X-linked lacZ transgene
Tam, P., Zhou, S. X., & Tan, S. (1994) · Development · doi:10.1242/dev.120.10.2925 · Cited by 126
Rhombomeric origin and rostrocaudal reassortment of neural crest cells revealed by intravital microscopy
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Neuregulins and neuregulin receptors in neural development
Gassmann, M., & Lemke, G. (1997) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(97)80125-0 · Cited by 118
[10] Isolation and culture of whole postimplantation embryos and germ layer derivatives
Sturm, K. S., & Tam, P. (1993) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(93)25013-r · Cited by 114
The Role of kreisler in Segmentation during Hindbrain Development
Manzanares, M., Trainor, P. A., Nonchev, S., Ariza‐McNaughton, L., Brodie, J., Gould, A. P., Marshall, H., Morrison, A., Kwan, C.-T., Sham, M. H., et al. (1999) · Developmental Biology · doi:10.1006/dbio.1999.9318 · Cited by 104
A Paraxial Exclusion Zone Creates Patterned Cranial Neural Crest Cell Outgrowth Adjacent to Rhombomeres 3 and 5
Farlie, P. G., Kerr, R., Thomas, P., Symes, T., Minichiello, J., Hearn, C. J., & Newgreen, D. F. (1999) · Developmental Biology · doi:10.1006/dbio.1999.9332 · Cited by 88
Late effects of retinoic acid on neural crest and aspects of rhombomere identity
Gale, E. A., Prince, V., Lumsden, A., Clarke, J., Holder, N., & Maden, M. (1996) · Development · doi:10.1242/dev.122.3.783 · Cited by 82
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Ulupınar, E., Datwani, A., Behar, O., Fujisawa, H., & Erzurumlu, R. S. (1999) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1999.0747 · Cited by 61
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Helbling, P. M., Tran, C. T., & Brändli, A. W. (1998) · Mechanisms of Development · doi:10.1016/s0925-4773(98)00148-8 · Cited by 61
Rhombomere rotation reveals that multiple mechanisms contribute to the segmental pattern of hindbrain neural crest migration
Sechrist, J. W., Scherson, T. Y., & Bronner-Fraser, M. E. (1994) · Development · doi:10.1242/dev.120.7.1777 · Cited by 55
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Golding, J. P., Tidcombe, H., Tsoni, S. V., & Gassmann, M. (1999) · Developmental Biology · doi:10.1006/dbio.1999.9497 · Cited by 27
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Axon repulsion during peripheral nerve segmentation
Keynes, R. J., Jaques, K., & Cook, G. M. W. (1991) · Development · doi:10.1242/dev.113.supplement_2.131 · Cited by 14
Cell Grafting and Labeling in Postimplantation Mouse Embryos
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Authors: Golding, J. P., Trainor, P., Krumlauf, R., & Gassmann, M.
Affiliations: National Institute for Medical Research (GB)
Corresponding author: Gassmann, Martin
ORCID: Golding, Jon P.
Trainor, Paul
Krumlauf, Robb
Gassmann, Martin
Venue: Nature Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2000-01-14
Volume: 2
Issue: 2
Pages: 103-109
ISSN: 1465-7392 (ISSN-L)
1476-4679
DOI: 10.1038/35000058
OpenAlex: W1979586311
Cited by: 181
References: 51
Citations by year: 2026: 3 · 2024: 9 · 2023: 8 · 2022: 4 · 2021: 4 · 2020: 5 · 2019: 9 · 2018: 7 · 2017: 4 · 2016: 2 · 2015: 3 · 2014: 5 · 2013: 6 · 2012: 7
FWCI: 5.42
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Cell Biology (publishedVersion)
PubMed (publishedVersion)
Funders: Core Research for Evolutional Science and Technology
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
Keywords: ErbB4, cranial neural crest cells, neural crest migration, cranial sensory ganglia, axon guidance, hindbrain patterning, receptor tyrosine kinase
MeSH terms: Animals, Branchial Region, Cell Movement, Ear, Embryonic Induction, Mesoderm, Mice, Mutant Strains, Neural Crest, Neurons, Rhombencephalon, Signal Transduction, Tissue Transplantation, Ganglia, Sensory, Body Patterning, Receptor Protein-Tyrosine Kinases, Neuregulins, Mice, ErbB Receptors, Receptor, ErbB-4

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Defects in pathfinding by cranial neural crest cells in mice lacking the neuregulin receptor ErbB4

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