The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Defects in pathfinding by cranial neural crest cells in mice lacking the neuregulin receptor ErbB4
Abstract
Mouse embryos with a loss-of-function mutation in the gene encoding the receptor tyrosine kinase ErbB4 exhibit misprojections of cranial sensory ganglion afferent axons. Here we analyse ErbB4-deficient mice, and find that morphological differences between wild-type and mutant cranial ganglia correlate with aberrant migration of a subpopulation of hindbrain-derived cranial neural crest cells within the paraxial mesenchyme environment. In transplantation experiments using new grafting techniques in cultured mouse embryos, we determine that this phenotype is non-cell-autonomous: wild-type and mutant neural crest cells both migrate in a pattern consistent with the host environment, deviating from their normal pathway only when transplanted into mutant embryos. ErbB4 signalling events within the hindbrain therefore provide patterning information to cranial paraxial mesenchyme that is essential for the proper migration of neural crest cells.
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“Loss of Erbb4 function in mice has been shown to cause defects in hindbrain cranial neural crest cell pathfinding, including a caudal elongation of the trigeminal and geniculate ganglia [77].”
From Self-domestication in Homo sapiens: Insights from comparative genomics (2017) · cites this paper as [77]
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Cites
The Molecular Biology of Axon Guidance
Tessier‐Lavigne, M., & Goodman, C. S. (1996) · Science · doi:10.1126/science.274.5290.1123 · Cited by 3,311
Multiple essential functions of neuregulin in development
Meyer, D., & Birchmeier, C. (1995) · Nature · doi:10.1038/378386a0 · Cited by 1,273
Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor
Gassmann, M., Casagranda, F., Orioli, D., Simon, H. H., Lai, C., Klein, R., & Lemke, G. (1995) · Nature · doi:10.1038/378390a0 · Cited by 1,151
Patterning the Vertebrate Neuraxis
Lumsden, A., & Krumlauf, R. K. (1996) · Science · doi:10.1126/science.274.5290.1109 · Cited by 1,142
Conversion of Xenopus Ectoderm into Neurons by NeuroD, a Basic Helix-Loop-Helix Protein
Lee, J. E., Hollenberg, S. M., Snider, L., Turner, D. L., Lipnick, N., & Weintraub, H. (1995) · Science · doi:10.1126/science.7754368 · Cited by 1,023
[22] Detection of messenger RNA by in Situ hybridization to tissue sections and whole mounts
Wilkinson, D. G., & Nieto, M. A. (1993) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(93)25025-w · Cited by 794
Sox10, a Novel Transcriptional Modulator in Glial Cells
Kuhlbrodt, K., Herbarth, B., Sock, E., Hermans-Borgmeyer, I., & Wegner, M. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-01-00237.1998 · Cited by 781
Ma, Q., Chen, Z., Barrantes, I. D. B., de la Pompa, J. L., & Anderson, D. J. (1998) · Neuron · doi:10.1016/s0896-6273(00)80988-5 · Cited by 735
Plowman, G. D., Culouscou, J., Whitney, G. S., Green, J. M., Carlton, G. W., Foy, L., NEUBAUER, M., & SHOYAB, M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.1746 · Cited by 714
Contributions of placodal and neural crest cells to avian cranial peripheral ganglia
D'amico‐Martel, A., & Noden, D. M. (1983) · American Journal of Anatomy · doi:10.1002/aja.1001660406 · Cited by 708
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Metadata
- Authors
- Golding, J. P., Trainor, P., Krumlauf, R., & Gassmann, M.
- Affiliations
- National Institute for Medical Research (GB)
- Corresponding author
- Gassmann, Martin
- Venue
- Nature Cell Biology
- Published
- 2000-01-14
- Volume
- 2
- Issue
- 2
- Pages
- 103-109
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- OpenAlex
- W1979586311
- Cited by
- 181
- References
- 51
- Citations by year
- 2026: 3 · 2024: 9 · 2023: 8 · 2022: 4 · 2021: 4 · 2020: 5 · 2019: 9 · 2018: 7 · 2017: 4 · 2016: 2 · 2015: 3 · 2014: 5 · 2013: 6 · 2012: 7
- FWCI
- 5.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Core Research for Evolutional Science and Technology
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Keywords
- ErbB4, cranial neural crest cells, neural crest migration, cranial sensory ganglia, axon guidance, hindbrain patterning, receptor tyrosine kinase
- MeSH terms
- Animals, Branchial Region, Cell Movement, Ear, Embryonic Induction, Mesoderm, Mice, Mutant Strains, Neural Crest, Neurons, Rhombencephalon, Signal Transduction, Tissue Transplantation, Ganglia, Sensory, Body Patterning, Receptor Protein-Tyrosine Kinases, Neuregulins, Mice, ErbB Receptors, Receptor, ErbB-4
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