The age of cancer

DePinho, Ronald A.·2000·Nature

DOI 10.1038/35041694

Cited by (953)

Items 301–400 of 953

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Low skeletal muscle mass is associated with increased hospital expenditure in patients undergoing cancer surgery of the alimentary tract
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Cell signaling in aging and apoptosis
Yousin Suh · 2002 · Mechanisms of Ageing and Development
Detection of novel germline mutations for breast cancer in non‐ BRCA 1/2 families
Fatima Aloraifi, Trudi McDevitt, Rui Martiniano, Jonah McGreevy, Russell Lewis McLaughlin, Chris M. Egan, Nuala Cody, Marie Meany, Elaine M. Kenny, Andrew Green et al. · 2015 · FEBS Journal
Q‐FISH analysis of telomere and chromosome instability in the oesophagus with and without squamous cell carcinoma in situ
Kaiyo Takubo, Masahiro Fujita, Naotaka Izumiyama, Kenichi Nakamura, Naoshi Ishikawa, Steven S.S. Poon, Mutsunori Fujiwara, Motoji Sawabe, Masaaki Matsuura, Heike Irmgard Grabsch et al. · 2010 · The Journal of Pathology
Modeling prostate cancer: a perspective on transgenic mouse models
Varinder Jeet, Pamela Joan Russell, Aparajita Khatri · 2010 · Cancer and Metastasis Reviews
The programmed aging paradigm: How we get old
Giacinto Libertini · 2014 · Biochemistry (Moscow)
Fasting and fasting-mimicking diets for chemotherapy augmentation
Sebastian Brandhorst · 2021 · GeroScience
Pathogen evolution in a vaccinated world
Andrew F. Read, Margaret J. Mackinnon · 2007 · Oxford University Press eBooks
Long telomeres in peripheral blood leukocytes are associated with an increased risk of soft tissue sarcoma
Hui Xie, Xifeng Wu, Shui Wang, David W. Chang, Raphael E. Pollock, Dina Chelouche Lev, Jian Hong Gu · 2013 · Cancer
Potential of telomerase activation in extending health span and longevity
Bruno Bernardes de Jesus, Marı́a A. Blasco · 2012 · Current Opinion in Cell Biology
Spatial constraints govern competition of mutant clones in human epidermis
Magnus Lynch, Clare Lynch, Emma E. Craythorne, Kifayathullah Liakath‐Ali, Raj Mallipeddi, Juliet N. Barker, Fiona M. Watt · 2017 · Nature Communications
Age-specific changes in expression, activity, and activation of the c-Jun NH2-terminal kinase and p38 mitogen-activated protein kinases by methyl methanesulfonate in rats
Yousin Suh · 2001 · Mechanisms of Ageing and Development
Telomere length heterogeneity and chromosome instability
Arturo Londoño‐Vallejo · 2004 · Cancer Letters
Telomerase: biology and phase I trials
Lloyd R. Kèlland · 2001 · The Lancet Oncology
Anthracycline chemotherapy‐mediated vascular dysfunction as a model of accelerated vascular aging
Zachary Stephen Clayton, David A. Hutton, Sophia A. Mahoney, Douglas R. Seals · 2021 · Aging and Cancer
Selective anti-cancer agents as anti-aging drugs
Mikhail V. Blagosklonny · 2013 · Cancer Biology & Therapy
The ecology and evolution of antibiotic-resistant bacteria
Carl T. Bergstrom, Michael Feldgarden · 2007 · Oxford University Press eBooks
Myc—Is this the oncogene from Hell?
Laura Soucek, Gérard I. Evan · 2002 · Cancer Cell
Towards a systemic paradigm in carcinogenesis: linking epigenetics and genetics
Ernesto Burgio, Lucia Migliore · 2014 · Molecular Biology Reports
Postoperative complications in the oldest old gastric cancer patients
Hiroyuki Yamada, Tsuyoshi Shinohara, Masashi Takeshita, Tetsuya Umesaki, Yoshiro Fujimori, Kiyofumi Yamagishi · 2013 · International Journal of Surgery
The senescent microenvironment promotes the emergence of heterogeneous cancer stem-like cells
Luis Jaime Castro‐Vega, Karina Jouravleva, Paola Ortíz-Montero, Win-Yan Liu-Bordes, Jorge Luis Galeano, Martha Liliana Romero, Tatiana G. Popova, Silvia Bacchetti, Jean‐Paul Vernot, Arturo Londoño‐Vallejo · 2015 · Carcinogenesis
Variation of global DNA methylation levels with age and in autistic children
Shui‐Ying Tsang, Tanveer Ahmad, Flora W. K. Mat, Cunyou Zhao, Shifu Xiao, Kun Xia, Hong Xue · 2016 · Human Genomics
Enhanced human papillomavirus type 8 oncogene expression levels are crucial for skin tumorigenesis in transgenic mice
Martin Hufbauer, Daliborka Lazić, Baki Akgũl, Janet L. Brandsma, Herbert Pfister, Soenke Jan Weissenborn · 2010 · Virology
Peto's paradox and the hallmarks of cancer: constructing an evolutionary framework for understanding the incidence of cancer
Leonard Nunney, Brian Michael Muir · 2015 · Philosophical Transactions of the Royal Society B Biological Sciences
Age-dependent methylation of ESR1 gene in prostate cancer
Long‐Cheng Li, Hiroaki Shiina, Masao Deguchi, Hong Zhao, Steven T. Okino, Christopher J. Kane, Peter R. Carroll, Miko Igawa, Rajvir Dahiya · 2004 · Biochemical and Biophysical Research Communications
Involvement of Rel/NF-κB transcription factors in senescence
Karo Gosselin, Corinne Abbadie · 2003 · Experimental Gerontology
Mutant and genetically modified mice as models for studying the relationship between aging and carcinogenesis
Vladimir Nikolaevich Anisimov · 2001 · Mechanisms of Ageing and Development
Progressive senescence programs induce intrinsic vulnerability to aging-related female breast cancer
Huiru Bai, Xiaoqin Liu, Mei‐Zhen Lin, Yuan Meng, Ruolan Tang, Yajing Guo, Nan Li, Michael F. Clarke, Shang Cai · 2024 · Nature Communications
Senescence, NK cells, and cancer: navigating the crossroads of aging and disease
Marina Gergues, Rafijul Bari, Sharmila Koppisetti, Anna Gosiewska, Lin Kang, ROBERT J. HARIRI · 2025 · Frontiers in Immunology
Prediction models for endometrial cancer for the general population or symptomatic women: A systematic review
Maaike Alblas, Kimberley Velt, Nora Pashayan, Martin Widschwendter, Ewout Willem Steyerberg, Yvonne Vergouwe · 2018 · Critical Reviews in Oncology/Hematology
The population genetics of multistage carcinogenesis
Leonard Nunney · 2003 · Proceedings of the Royal Society B Biological Sciences
Tumor development: Haploinsufficiency and local network assembly
Lubomir B. Smilenov · 2005 · Cancer Letters
Short telomeres in an oral precancerous lesion: Q‐FISH analysis of leukoplakia
Junko Aida, Takanori Kobayashi, Takashi Saku, Masatsune Yamaguchi, Naotaka Shimomura, Kenichi Nakamura, Naoshi Ishikawa, Satoshi Maruyama, Jun Cheng, Steven S.S. Poon et al. · 2011 · Journal of Oral Pathology and Medicine
Insulin-Like Growth Factors and Insulin: At the Crossroad Between Tumor Development and Longevity
Ruslan Novosyadlyy, Derek LeRoith · 2012 · The Journals of Gerontology Series A
Metabolic regulation of Sirtuins upon fasting and the implication for cancer
Yueming Zhu, Yufan Yan, David R. Gius, Athanassios Vassilopoulos · 2013 · Current Opinion in Oncology
Implications of quantum metabolism and natural selection for the origin of cancer cells and tumor progression
P. C. W. Davies, Lloyd Demetrius, Jack A. Tuszyński · 2012 · AIP Advances
Role of chromosomal aberrations in clonal diversity and progression of acute myeloid leukemia
Tilmann Bochtler, Stefan Fröhling, A. Krämer · 2015 · Leukemia
A Critical Examination of the “Bad Luck” Explanation of Cancer Risk
Andrii I. Rozhok, Geoffrey M. Wahl, James V. DeGregori · 2015 · Cancer Prevention Research
ROS-Mediated 15-Hydroxyprostaglandin Dehydrogenase Degradation via Cysteine Oxidation Promotes NAD+-Mediated Epithelial-Mesenchymal Transition
Weixuan Wang, Yadong Hu, Xiaofei Wang, Qingtao Wang, Haiteng Deng · 2018 · Cell chemical biology
CuAAC ensembled 1,2,3-triazole linked nanogels for targeted drug delivery: a review
Gurleen Singh, Ather Majeed, Riddima Singh, Nancy George, Gurjaspreet Singh, Sofia Gupta, Harminder Singh, Gurpreet Kaur, Jandeep Singh · 2023 · RSC Advances
Possible interventions to modify aging
Giacinto Libertini, Nicola Ferrara · 2016 · Biochemistry (Moscow)
The Relevance of Mouse Models to Understanding the Development and Progression of Human Breast Cancer
Donald Craig Allred, Daniel Medina · 2008 · Journal of Mammary Gland Biology and Neoplasia
Aging is associated with increased clonogenic potential in rat liver in vivo
Daniela Pasciu, Stefania Montisci, Marianna Greco, Silvia Doratiotto, Sabrina Pitzalis, P. Pani, Sergio Laconi, Ezio Laconi · 2006 · Aging Cell
Empirical Evidence for Various Evolutionary Hypotheses on Species Demonstrating Increasing Mortality with Increasing Chronological Age in the Wild
Giacinto Libertini · 2008 · The Scientific World JOURNAL
Proteomic Identification of Insulin-like Growth Factor-binding Protein-6 Induced by Sublethal H2O2 Stress from Human Diploid Fibroblasts
Lifang Xie, George Tsaprailis, Qin M. Chen · 2005 · Molecular & Cellular Proteomics
Cancer genomics: promises and complexities.
Wei Zhang, Pilar M. Labordé, Kevin R. Coombes, Donald A. Berry, Stanley R. Hamilton · 2001 · PubMed
Aging-associated increase of gelsolin for apoptosis resistance
Jeong Soo Ahn, Ik‐Soon Jang, Duk-In Kim, Kyung A. Cho, Yong Hoon Park, Kyungtae Kim, Chung Sil Kwak, Sang Chul Park · 2003 · Biochemical and Biophysical Research Communications
WEE1 murine deficiency induces hyper-activation of APC/C and results in genomic instability and carcinogenesis
Athanassios Vassilopoulos, Yohei Tominaga, H-Seok Kim, Tyler J. Lahusen, B Li, Hongtao Yu, David R. Gius, C-X Deng · 2014 · Oncogene
Effects of Recloning on the Efficiency of Production of .ALPHA.1,3-Galactosyltransferase Knockout Pigs
Tatsuya FUJIMURA, Hiroshi MURAKAMI, Mayuko Kurome, Yoichi Takahagi, Tamotsu Shigehisa, Hiroshi Nagashima · 2008 · Journal of Reproduction and Development
Quantitative fluorescence in situ hybridization measurement of telomere length in skin with/without sun exposure or actinic keratosis
Hiroyuki Ikeda, Junko Aida, Atsushi Hatamochi, Yoichiro Hamasaki, Naotaka Izumiyama‐Shimomura, Kenichi Nakamura, Naoshi Ishikawa, Steven S.S. Poon, Mutsunori Fujiwara, Ken‐ichiro Tomita et al. · 2013 · Human Pathology
Transient ALT activation protects human primary cells from chromosome instability induced by low chronic oxidative stress
Elisa Coluzzi, Rossella Buonsante, Stefano Leone, Anthony J. Asmar, Kelley L. Miller, Daniela Cimini, Antonella Sgura · 2017 · Scientific Reports
Genomic stability and functional activity may be lost in telomerase-transduced human CD8+ T lymphocytes
Marco W.J. Schreurs, Mario A. J. A. Hermsen, Ramon I. Klein Geltink, Kirsten B. J. Scholten, Antoinette A. T. P. Brink, Esther W. Taanman-Kueter, Marianne Tijssen, Chris J.L.M. Meijer, Bauke Ylstra, Gerrit A. Meijer et al. · 2005 · Blood
A role for cellular senescence in birth timing
Jeeyeon M. Cha, David Michael Aronoff · 2017 · Cell Cycle
The Genomic Health of Human Pluripotent Stem Cells: Genomic Instability and the Consequences on Nuclear Organization
Marianne P. Henry, J. Ross Hawkins, Jennifer Boyle, Joanna M. Bridger · 2019 · Frontiers in Genetics
How hormones mediate trade-offs in human health and disease
Richard G. Bribiescas, Peter T. Ellison · 2007 · Oxford University Press eBooks
Chemical Carcinogens as Foreign Bodies and Some Pitfalls Regarding Cancer Immune Surveillance
Thomas J. F. Blankenstein, Zhihai Qin · 2003 · Advances in cancer research
The impact of DNA damage, genetic mutation and cellular responses on cancer prevention, longevity and aging: observations in humans and mice
Paul Hasty · 2004 · Mechanisms of Ageing and Development
Redox Control of Zinc Finger Proteins
M. A. Baldwin, Christopher C. Benz · 2002 · Methods in enzymology on CD-ROM/Methods in enzymology
Noncanonical and mortality-defining toxicities of CAR T cell therapy
Kai Rejeski, Joshua Aiden Hill, Saurabh Dahiya, Michael David Jain · 2025 · Nature Medicine
DNA methylation abnormalities at gene promoters are extensive and variable in the elderly and phenocopy cancer cells
Hannah E. Gautrey, Sanne D. Otterdijk, H. Cordell, J. Mathers, G. Strathdee · 2014 · The FASEB Journal
Effect of additional surgery after noncurative endoscopic submucosal dissection for early gastric cancer
Kohei Yamanouchi, Shinichi Ogata, Yasuhisa Sakata, Nanae Tsuruoka, Ryo Shimoda, Atsushi Nakayama, Takashi Akutagawa, Shimpei Shirai, Eri Takeshita, Koji Yamamoto et al. · 2015 · Endoscopy International Open
Immunotherapy with Listeria reduces metastatic breast cancer in young and old mice through different mechanisms
Arthee Jahangir, Dinesh Chandra, Wilber Quispe‐Tintaya, Manisha Singh, Benson Chellakkan Selvanesan, Claudia Gravekamp · 2017 · OncoImmunology
Enhanced inflammation and attenuated tumor suppressor pathways are associated with oncogene‐induced lung tumors in aged mice
Neha Parikh, Ryan Lane Shuck, Mihai Gagea, Lanlan Shen, Lawrence A. Donehower · 2017 · Aging Cell
Guillain–Barré syndrome in patients treated with immune checkpoint inhibitors
Qianqian Fan, Yang Hu, Xiang Wang, Bin Zhao · 2021 · Journal of Neurology
Focus on the Complex Interconnection between Cancer, Narcolepsy and Other Neurodegenerative Diseases: A Possible Case of Orexin-Dependent Inverse Comorbidity
Maria Paola Mogavero, Alessandro Silvani, Lourdes M. DelRosso, Michele Salemi, Raffaele Ferri · 2021 · Cancers
CD90/Thy‐1 is preferentially expressed on blast cells of high risk acute myeloid leukaemias*
Francesco Buccisano, Francesca Maria Rossi, Adriano Venditti, Giovanni Del Poeta, Maria Christina Cox, Elisabetta Abruzzese, Maurizio Rupolo, Massimiliano Berretta, Massimo Degan, Stefania Russo et al. · 2004 · British Journal of Haematology
Hepatitis B virus X protein overcomes oncogenic RAS‐induced senescence in human immortalized cells
Naoki Oishi, Khurts Shilagardi, Yasunari Nakamoto, Masao Honda, Shuichi Kaneko, Seishi Murakami · 2007 · Cancer Science
A mouse model of Werner Syndrome: what can it tell us about aging and cancer?
Sandy S. Chang · 2004 · The International Journal of Biochemistry & Cell Biology
Aging: past, present and future
Mikhail V. Blagosklonny, Judith Campisi, David A. Sinclair · 2009 · Aging
Over-expression of hTERT in CHO K1 results in decreased apoptosis and reduced serum dependency
Francesco Crea, Donatella Sarti, Francesco Falciani B, Mohamed Al‐Rubeai · 2005 · Journal of Biotechnology
Cause of Death in Patients With Well‐Differentiated Thyroid Carcinoma
Nigel J P Beasley, Paul G. Walfish, Ian Witterick, Jeremy L. Freeman · 2001 · The Laryngoscope
Role of Src-specific phosphorylation site on focal adhesion kinase for senescence-associated apoptosis resistance
S. J. Ryu, Kyung‐A Cho, Yoon Sin Oh, Se Chang Park · 2006 · APOPTOSIS
Molecular Mechanism of Inositol Hexaphosphate-mediated Apoptosis in Human Malignant Glioblastoma T98G Cells
Surajit Karmakar, Naren Lal Banik, Swapan K. Ray · 2007 · Neurochemical Research
Association of p53 polymorphisms and colorectal cancer: Modulation of risk and progression
Enzo Mammano, Claudio Belluco, Massimiliano Bonafè, Fabiola Olivieri, Elena Mugianesi, Cristiana Barbi, Michele Mishto, Marco Cosci, Claudio Franceschi, M. Lise et al. · 2008 · European Journal of Surgical Oncology
Loss of heterozygosity and histone hypoacetylation of the PINX1 gene are associated with reduced expression in gastric carcinoma
Tomohiro Kondo, Naohide Oue, Yoshitsugu Mitani, Hiroki Kuniyasu, Tsuyoshi Noguchi, Kazuya Kuraoka, Hirofumi Nakayama, Wataru Yasui · 2005 · Oncogene
Telomerase and telomere dynamics in ageing and cancer: current status and future directions
F. Sampedro Camarena, G. Cano Serral, Frederic Sampedro · 2007 · Clinical & Translational Oncology
Those dam-aged telomeres!
Lea A. Harrington · 2003 · Current Opinion in Genetics & Development
Between Scylla and Charybdis: p53 links tumor suppression and aging
Campisi, Judith · 2002 · Mechanisms of Ageing and Development
Tenascin-C patterns and splice variants in actinic keratosis and cutaneous squamous cell carcinoma
Chantip Dang, Marc Gottschling, Joachim Röwert, Tobias Forschner, Eggert Stockfleth, Ingo Nindl · 2006 · British Journal of Dermatology
pH and redox dual-responsive copolymer micelles with surface charge reversal for co-delivery of all-trans-retinoic acid and paclitaxel for cancer combination chemotherapy
Yanqiu Zhang, Lianjun Peng, Jiahui Chu, Ming Zhang, Lizhu Sun, Bin Zhong, Qiyong Wu · 2018 · International Journal of Nanomedicine
Recent Advances and Impact of Chemotherapeutic and Antiangiogenic Nanoformulations for Combination Cancer Therapy
Amit Kumar Rajora, Divyashree Ravishankar, Hongbo Zhang, Jessica M. Rosenholm · 2020 · Pharmaceutics
Telomere shortening in breast cancer correlates with the pathological features of tumor progression
Makoto Kammori, YOSHIYUKI SUGISHITA, Takahiro Okamoto, Makio Kobayashi, Kazuko Yamazaki, Emiko Yamada, Tetsu Yamada · 2015 · Oncology Reports
Skin tumor formation in human papillomavirus 8 transgenic mice is associated with a deregulation of oncogenic miRNAs and their tumor suppressive targets
Martin Hufbauer, Daliborka Lazić, Markus Reinartz, Baki Akgũl, Herbert Pfister, Sönke Jan Weißenborn · 2011 · Journal of Dermatological Science
Different outcomes of telomere-dependent anaphase bridges
Laura Tusell, Judit Pampalona, David Soler, Cristina Frías-López, Anna Genescà · 2010 · Biochemical Society Transactions
Cancer After Heart Transplantation: A 25-year Single-center Perspective
Jan M. Van Keer, Walter Droogné, Johan Van Cleemput, Gábor Vörös, Filip Rega, Bart P. Meyns, Stefan P. Janssens, Johan Vanhaecke · 2016 · Transplantation Proceedings
Von selbstorganisierenden Polymeren zu Nanohybrid- und Biomaterialien
Stephan Förster, Thomas Plantenberg · 2002 · Angewandte Chemie
Are Age-Associated Diseases an Integral Part of Aging?
Edward J. Masoro · 2005 · Elsevier eBooks
The biology of senescence: potential for prevention of disease
James L. Kirkland · 2002 · Clinics in Geriatric Medicine
The relationship between apoptosis and aging
Bin Lü, Hong‐Duo Chen, Hong-Guang Hong-Guang · 2012 · Advances in Bioscience and Biotechnology
Age-Related Genomic Hypomethylation
Igor P. Pogribny, B. F. Vanyushin · 2009 · Springer eBooks
Evolutionary Explanations of the “Actuarial Senescence in the Wild” and of the “State of Senility”
Giacinto Libertini · 2006 · The Scientific World JOURNAL
Clonal diversity revealed by morphoproteomic and copy number profiles of single prostate cancer cells at diagnosis
Paymaneh D. Malihi, Michael Morikado, Lisa M. Welter, Sandy T Liu, Eric T. Miller, Radu M. Cadaneanu, Beatrice S Knudsen, Michael S. Lewis, Anders Carlsson, Carmen Ruiz Velasco et al. · 2017 · Convergent Science Physical Oncology
B cells with aberrant activation of Notch1 signaling promote Treg and Th2 cell–dominant T-cell responses via IL-33
Hiroshi Arima, Momoko Nishikori, Yasuyuki Otsuka, Wataru Kishimoto, Kiyotaka Izumi, Koubun Yasuda, Tomohiro Yoshimoto, Akifumi Takaori‐Kondo · 2018 · Blood Advances
Suicidal function of DNA methylation in age-related genome disintegration
Alexander L. Mazin · 2009 · Ageing Research Reviews
The role of telomeres in predicting individual radiosensitivity of patients with cancer in the era of personalized radiotherapy
Céline Mirjolet, Romain Boidot, Sébastien Saliques, François Ghiringhelli, P. Maingon, G. Créhange · 2015 · Cancer Treatment Reviews
On evolutionary origin of cancer.
A. V. Lichtenstein · 2005 · Cancer Cell International
An integrative theory for cancer (Review)
Guopei Luo, Na Liu · 2018 · International Journal of Molecular Medicine
Management of immunotherapy toxicities in older adults
Shruti Bhandari, Amitoj Singh Gill, Cesar A. Perez, Dharamvir Jain · 2018 · Seminars in Oncology
Sirtuins in Hematological Aging and Malignancy
Mendel Roth, Zhiqiang Wang, Wenyong Chen · 2013 · Critical Reviews™ in Oncogenesis