Cited by 953Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model OrganismsCancer-related Molecular Pathways

The DOI matches its Crossref record; 95 of the 96 references it cites were found in a registry or an index.

The age of cancer

DePinho, Ronald A.·2000·Nature

DOI 10.1038/35041694

Open this paper in CoChat — free account

Abstract

A striking link exists between advanced age and increased incidence of cancer. Here I review how several of the age-related molecular and physiological changes might act in concert to promote cancer, and in particular epithelial carcinogenesis. Experimental data indicate that the aged, cancer-prone phenotype might represent the combined pathogenetic effects of mutation load, epigenetic regulation, telomere dysfunction and altered stromal milieu. Further verification of the role of these effects should in turn lead to the design of effective therapeutics for the treatment and prevention of cancer in the aged.

Integrity signals

Registry

Crossref · 10.1038/35041694

Cites

95 of 95 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The hallmarks of cancer
Hanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219
Aging: a theory based on free radical and radiation chemistry
Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567
A biomarker that identifies senescent human cells in culture and in aging skin in vivo.
Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., & Pereira-Smith, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9363 · Cited by 7,477
Specific Association of Human Telomerase Activity with Immortal Cells and Cancer
Kim, N. W., Piatyszek, M. A., Prowse, K. R., Harley, C. B., West, M. D., Ho, P. L. C., Coviello, G. M., Wright, W. E., Weinrich, S. L., & Shay, J. W. (1994) · Science · doi:10.1126/science.7605428 · Cited by 7,091
Genetic Alterations during Colorectal-Tumor Development
Vogelstein, B., Fearon, E. R., Hamilton, S. R., Kern, S. E., Preisinger, A. C., Leppert, M., de Vries-Smits, A. M. M., & Bos, J. L. (1988) · New England Journal of Medicine · doi:10.1056/nejm198809013190901 · Cited by 6,704
The Clonal Evolution of Tumor Cell Populations: Acquired genetic lability permits stepwise selection of variant sublines and underlies tumor progression.
Nowell, P. C. (1976) · Science · doi:10.1126/science.959840 · Cited by 6,471
Oxidants, antioxidants, and the degenerative diseases of aging.
Ames, B. N., Shigenaga, M. K., & Hagen, T. M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.7915 · Cited by 5,958
Telomeres shorten during ageing of human fibroblasts
Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., & Lowe, S. W. (1997) · Cell · doi:10.1016/s0092-8674(00)81902-9 · Cited by 5,218
Lessons from hereditary colorectal cancer
Kinzler, K. W., & Vogelstein, B. (1996) · Cell · doi:10.1016/s0092-8674(00)81333-1 · Cited by 4,919

Flagged first, then by citations

Show all 96 references

1 of the 96 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

Vijg, J. & Dolle, M. E. T. in Handbook of the Biology of Ageing 5th edn (eds Masoro, E. J. & Austad, S. N.) (Academic, in the press).

Sorted by citations

Items 401–500 of 953

Use of and Attitudes and Knowledge about Pap Smears among Women in Kuwait
Hammasi, K. E., Samir, O., Kettaneh, S., Al-Fadli, A., & Thalib, L. (2009) · Journal of Women s Health · doi:10.1089/jwh.2008.1227 · Cited by 31
Overexpression of matrix metalloproteinase 1 in dermal fibroblasts from DNA repair-deficient/cancer-prone xeroderma pigmentosum group C patients
Fréchet, M., Warrick, E., Vioux, C., Chevallier, O., Spatz, A., Benhamou, S., Sarasin, A. R., Bernerd, F., & Magnaldo, T. (2008) · Oncogene · doi:10.1038/onc.2008.153 · Cited by 34
Synthesis of Oligonucleotides Containing Fapy·dG (N6-(2-Deoxy-α,β- d -erythropentofuranosyl)-2,6-diamino-4-hydroxy-5-formamidopyrimidine) Using a 5‘-Dimethoxytrityl Dinucleotide Phosphoramidite
Jiang, Y. L., Wiederholt, C. J., Patro, J. N., Haraguchi, K., & Greenberg, M. M. (2004) · The Journal of Organic Chemistry · doi:10.1021/jo048253o · Cited by 31
Alcoholics show reduced telomere length in the oesophagus
Aida, J., Yokoyama, A., Izumiyama, N., Nakamura, K., Ishikawa, N., Poon, S. S. S., Fujiwara, M., Sawabe, M., Matsuura, M., Arai, T., et al. (2010) · The Journal of Pathology · doi:10.1002/path.2817 · Cited by 30
Telomere Dysfunction and DNA Damage Checkpoints in Diseases and Cancer of the Gastrointestinal Tract
Rudolph, K. L., Hartmann, D., & Opitz, O. G. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.07.037 · Cited by 32
Laparoscopy-Assisted Gastrectomy in Patients Older Than 80
Yamada, H., Kojima, K., Inokuchi, M., Kawano, T., & Sugihara, K. (2009) · Journal of Surgical Research · doi:10.1016/j.jss.2009.01.032 · Cited by 30
Mechanisms of murine dendritic cell antitumor dysfunction in aging
Grolleau‐Julius, A., Close, L. A., Harning, E. K., & Yung, R. L. (2008) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-008-0636-9 · Cited by 30
Role of methylation of the hMLH1 gene promoter in the development of gastric and colorectal carcinoma in the elderly
Arai, T., Kasahara, I., Sawabe, M., Honma, N., Aida, J., & Tabubo, K. (2010) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/j.1447-0594.2010.00590.x · Cited by 30
Mannan-binding lectin (MBL) in women with tumours of the reproductive system
Świerzko, A. S., Florczak, K., Cedzyński, M., Szemraj, J., Wydra, D. G., Bąk‐Romaniszyn, L., Emerich, J., & Sułowska, Z. (2006) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-006-0250-7 · Cited by 29
Order of genetic events is critical determinant of aberrations in chromosome count and structure
Fauth, C., O’Hare, M. J., Lederer, G., Jat, P., & Speicher, M. R. (2004) · Genes Chromosomes and Cancer · doi:10.1002/gcc.20051 · Cited by 28
MicroRNA and Senescence: The Senectome, Integration and Distributed Control
Bilsland, A. E., Revie, J., & Keith, W. N. (2013) · Critical Reviews™ in Oncogenesis · doi:10.1615/critrevoncog.2013007197 · Cited by 30
Effect of Unrealistic Optimism, Perceived Control Over Disease, and Experience With Female Cancer on Behavioral Intentions of Israeli Women to Undergo Screening Tests
Barnoy, S., Bar‐Tal, Y., & Treister, L. (2003) · Cancer Nursing · doi:10.1097/00002820-200310000-00004 · Cited by 29
Telomere dysfunction: a new player in radiation sensitivity
Genescà, A., Martín, M., Latre, L., Soler, D., Pampalona, J., & Tusell, L. (2006) · BioEssays · doi:10.1002/bies.20501 · Cited by 33
Structural Alterations in Breast Stromal and Epithelial DNA: The Influence of 8,5-cyclo-2-Deoxyadenosine
Anderson, K. M., Jaruga, P., Ramsey, C. R., Gilman, N. K., Green, V. M., Rostad, S. W., Emerman, J. T., Dizdaroğlu, M., & Malins, D. C. (2006) · Cell Cycle · doi:10.4161/cc.5.11.2816 · Cited by 29
The flexible evolutionary anchorage-dependent Pardee's restriction point of mammalian cells. How its deregulation may lead to cancer
David-Pfeuty, T. (2005) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2005.08.008 · Cited by 29
Transient Activation of the ALT Pathway in Human Primary Fibroblasts Exposed to High-LET Radiation
Berardinelli, F., Antoccia, A., Cherubini, R., Nadal, V. D., Gerardi, S., Cirrone, G. A. P., Tanzarella, C., & Sgura, A. (2010) · Radiation Research · doi:10.1667/rr2127.1 · Cited by 29
A BAC transgenic reporter recapitulates in vivo regulation of human telomerase reverse transcriptase in development and tumorigenesis
Jia, W., Wang, S., Horner, J. W., Wang, N., Wang, H., Gunther, E. J., DePinho, R. A., & Zhu, J. (2011) · The FASEB Journal · doi:10.1096/fj.10-173989 · Cited by 23
Self-citation
PTCH1+/− Dermal Fibroblasts Isolated from Healthy Skin of Gorlin Syndrome Patients Exhibit Features of Carcinoma Associated Fibroblasts
Valin, A., Barnay‐Verdier, S., Robert, T., Ripoche, H., Brellier, F., Chevallier, O., Avril, M., & Magnaldo, T. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004818 · Cited by 32
Human fibroblasts expressing hTERT show remarkable karyotype stability even after exposure to ionizing radiation
Pirzio, L. M., Freulet-Marrière, M.-A., Bai, Y., Fouladi, B., Murnane, J. P., Sabatier, L., & Desmaze, C. (2004) · Cytogenetic and Genome Research · doi:10.1159/000077470 · Cited by 29
A base-modified PNA–graphene oxide platform as a turn-on fluorescence sensor for the detection of human telomeric repeats
Sabale, P. M., George, J. T., & Srivatsan, S. G. (2014) · Nanoscale · doi:10.1039/c4nr00878b · Cited by 28
Fattigation-platform nanoparticles using apo-transferrin stearic acid as a core for receptor-oriented cancer targeting
Amin, H. H., Meghani, N. M., Park, C., Nguyen, V. H., Tran, T. T. D., Tran, P. H. L., & Lee, B. (2017) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2017.08.014 · Cited by 29
Changes in telomere length with aging in human neurons and glial cells revealed by quantitative fluorescence in situ hybridization analysis
Tomita, K., Aida, J., Izumiyama‐Shimomura, N., Nakamura, K., Ishikawa, N., Matsuda, Y., Arai, T., Ishiwata, T., Kumasaka, T., Takahashi‐Fujigasaki, J., et al. (2018) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.13500 · Cited by 32
Stress signaling in cancer
Murakami, S., Noguchi, T., Takeda, K., & Ichijo, H. (2007) · Cancer Science · doi:10.1111/j.1349-7006.2007.00551.x · Cited by 30
Telomeres and telomere dynamics: relevance to cancers of the GI tract
Basu, N., Skinner, H. G., Litzelman, K., Vanderboom, R. J., Baichoo, E., & Boardman, L. A. (2013) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/17474124.2013.848790 · Cited by 29
Age-promoted creation of a pro-cancer microenvironment by inflammation: pathogenesis of dyscoordinated feedback control
Schwartsburd, P. M. (2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.08.003 · Cited by 29
Genetic Control of Stem Cells: Implications for Aging
Zant, G. E. V. (2003) · International Journal of Hematology · doi:10.1007/bf02982600 · Cited by 28
Aging and immunotherapies: New horizons for the golden ages
Hamilton, J. A. G., & Henry, C. J. (2020) · Aging and Cancer · doi:10.1002/aac2.12014 · Cited by 28
Chromosomal instability and telomere lengths of each chromosomal arm measured by Q-FISH in human fibroblast strains prior to replicative senescence
Takubo, K., Aida, J., Izumiyama, N., Ishikawa, N., Fujiwara, M., Poon, S. S. S., Kondo, H., Kammori, M., Matsuura, M., Sawabe, M., et al. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2010.08.007 · Cited by 27
Independent Generation and Characterization of a C2‘-Oxidized Abasic Site in Chemically Synthesized Oligonucleotides
Kim, J. C., Weledji, Y. N., & Greenberg, M. M. (2004) · The Journal of Organic Chemistry · doi:10.1021/jo049033d · Cited by 27
Muscular dystrophies share pathogenetic mechanisms with muscle sarcomas
Fanzani, A., Monti, E., Donato, R., & Sorci, G. (2013) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2013.07.001 · Cited by 29
Telomere crisis in kidney epithelial cells promotes the acquisition of a microRNA signature retrieved in aggressive renal cell carcinomas
Castro‐Vega, L. J., Jouravleva, K., Liu-Bordes, W.-Y., Martinez, C., Gestraud, P., Hupé, P., Servant, N., Albaud, B., Gentien, D., Gad, S., et al. (2013) · Carcinogenesis · doi:10.1093/carcin/bgt029 · Cited by 25
Evolution, developmental plasticity, and metabolic disease
Kuzawa, C. W., Gluckman, P. D., Hanson, M. A., & Beedle, A. S. (2007) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780199207466.003.0019 · Cited by 27
Preimplantational embryo development and incidence of blastomere apoptosis in bovine somatic cell nuclear transfer embryos reconstructed with long-term cultured donor cells
Jang, G., Eulsoon, P. A. R. K., Cho, J., Bhuiyan, M. M. U., Lee, B.-C., Kang, S., & Hwang, W. S. (2004) · Theriogenology · doi:10.1016/j.theriogenology.2003.11.022 · Cited by 27
c-Myb and C/EBPβ regulate OPN and other senescence-associated secretory phenotype factors
Flanagan, K. C., Alspach, E., Pazolli, E., Parajuli, S. P., Ren, Q., Arthur, L., TAPIA-CONYER, R. C., & Stewart, S. A. (2017) · Oncotarget · doi:10.18632/oncotarget.22940 · Cited by 29
Genomic instability and cancer: lessons from Drosophila
Gerlach, S. U., & Herranz, H. (2020) · Open Biology · doi:10.1098/rsob.200060 · Cited by 27
Can Peto’s paradox be used as the null hypothesis to identify the role of evolution in natural resistance to cancer? A critical review
Ducasse, H., Újvári, B., Solary, É., Vittecoq, M., Arnal, A., Bernex, F., Pirot, N., Missé, D., Bonhomme, F., Renaud, F., et al. (2015) · BMC Cancer · doi:10.1186/s12885-015-1782-z · Cited by 30
The inflammatory network: bridging senescent stroma and epithelial tumorigenesis
Shan, W. (2009) · Frontiers in bioscience · doi:10.2741/3511 · Cited by 26
Lifestyle, diet, and disease: comparative perspectives on the determinants of chronic health risks
Leonard, W. R. (2007) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780199207466.003.0020 · Cited by 26
Imaging the life and death of tumors in living subjects: Preclinical PET imaging of proliferation and apoptosis
Nguyen, Q., & Aboagye, E. O. (2010) · Integrative Biology · doi:10.1039/c0ib00066c · Cited by 25
Chemiluminescence detection of telomere DNA in human cells on a membrane by using fluorescein-5-isothiocyanate-labeled primers
Yamasuji, M., Shibata, T., Kabashima, T., & Kai, M. (2011) · Analytical Biochemistry · doi:10.1016/j.ab.2011.01.047 · Cited by 25
On the gene expression landscape of cancer
González, A., Leon, D. A., Perera, Y., & Perez, R. (2023) · PLoS ONE · doi:10.1371/journal.pone.0277786 · Cited by 26
Increasing longevity and life satisfaction: is there a catch to living longer?
Nemitz, J. (2021) · Journal of Population Economics · doi:10.1007/s00148-021-00836-3 · Cited by 29
Connexins, important players in the dissemination of prostate cancer cells
Boucher, J., Monvoisin, A., Vix, J., Mesnil, M., Thuringer, D., Debiais, F., & Cronier, L. (2017) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2017.06.020 · Cited by 25
Is telomere erosion a mechanism of species extinction?
Stindl, R. (2004) · Journal of Experimental Zoology Part B Molecular and Developmental Evolution · doi:10.1002/jez.b.20006 · Cited by 25
Effect of host age on tumor growth rate in rodents
Vladimir, N. (2006) · Frontiers in bioscience · doi:10.2741/1808 · Cited by 25
Influence of thehTERTrs2736100 polymorphism on telomere length in gastric cancer
Choi, B. J. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i31.9328 · Cited by 25
Harnessing hypoxia as an evolutionary driver of complex multicellularity
Hammarlund, E. U. (2020) · Interface Focus · doi:10.1098/rsfs.2019.0101 · Cited by 25
Low prevalence of p53, p16INK4aand Ha-ras tumour-specific mutations in low-graded actinic keratosis
Nindl, I., Gottschling, M., Krawtchenko, N., Lehmann, M., Röwert‐Huber, J., Eberle, J., Stockfleth, E., & Forschner, T. (2007) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2007.07857.x · Cited by 24
Role of Oxygen in Cancer: Looking Beyond Hypoxia
López‐Lázaro, M. (2009) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/187152009788451806 · Cited by 24
Genetic variation of acquired structural chromosomal aberrations
Vodička, P., Mušák, Ľ., Vodičková, Ľ., Vodenková, S., Catalano, C., Kroupa, M., Naccarati, A., Polívková, Z., Vymetalkova, V. P., Försti, A., et al. (2018) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2018.05.014 · Cited by 24
Alterations in composition of immune cells and impairment of anti-tumor immune response in aged oral cancer-bearing mice
Sekido, K., Tomihara, K., Tachinami, H., Heshiki, W., Sakurai, K., Moniruzzaman, R., Imaue, S., Fujiwara, K., & Noguchi, M. (2019) · Oral Oncology · doi:10.1016/j.oraloncology.2019.104462 · Cited by 23
Age-Related Changes of Gene Expression Profiles in Drosophila
Bordet, G., Lodhi, N., Kossenkov, A. V., & Tulin, A. V. (2021) · Genes · doi:10.3390/genes12121982 · Cited by 23
Soluble Klotho, a Potential Biomarker of Chronic Kidney Disease–Mineral Bone Disorders Involved in Healthy Ageing: Lights and Shadows
Martín-Vírgala, J., Martín-Carro, B., Fernández-Villabrille, S., Ruiz-Torres, M., Gómez‐Alonso, C., Rodríguez-García, M., Martín, J. L. F., Alonso‐Montes, C., Panizo, S., Cannata-Andía, J. B., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031843 · Cited by 24
CD44v6 in developing, dysplastic and malignant oral epithelia
Rautava, J., Soukka, T., Inki, P., Leimola‐Virtanen, R., Saloniemi, I., Happonen, R., & Heikinheimo, K. (2003) · Oral Oncology · doi:10.1016/s1368-8375(02)00140-9 · Cited by 23
Anti-Aging and Biomedicine: Critical Studies on the Pursuit of Maintaining, Revitalizing and Enhancing Aging Bodies
Kampf, A., & Botelho, L. (2009) · Medicine Studies · doi:10.1007/s12376-009-0021-9 · Cited by 24
Protein Binding Has a Large Effect on Radical Mediated DNA Damage
Peng, X., Pigli, Y. Z., Rice, P. A., & Greenberg, M. M. (2008) · Journal of the American Chemical Society · doi:10.1021/ja805440v · Cited by 23
Ageing gender-specific "Biomarkers of Homeostasis", to protect ourselves against the diseases of the old age
Berghella, A. M., Contasta, I., Marulli, G., D’Innocenzo, C., Garofalo, F., Gizzi, F., Bartolomucci, M., Laglia, G., Valeri, M., Gizzi, M., et al. (2014) · Immunity & Ageing · doi:10.1186/1742-4933-11-3 · Cited by 23
An investigation of the association of genetic susceptibility risk with somatic mutation burden in breast cancer
Zhu, B., Mukherjee, A., Machiela, M. J., Song, L., Hua, X., Shi, J., García‐Closas, M., Chanock, S. J., & Chatterjee, N. (2016) · British Journal of Cancer · doi:10.1038/bjc.2016.223 · Cited by 23
Clinicopathological characteristics of Epstein-Barr virus-positive gastric cancer in Latvia
Gašenko, E., Isajevs, S., Camargo, M. C., Offerhaus, G. J. A., Poļaka, I., Gulley, M. L., Škapars, R., Sīviņš, A., Kojalo, I., Kiršners, A., et al. (2019) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000001521 · Cited by 23
Non-Thermal Plasma Induces Antileukemic Effect Through mTOR Ubiquitination
Kim, S., Kim, H. J., Kim, H. J., & Kim, C. (2020) · Cells · doi:10.3390/cells9030595 · Cited by 23
A single‐nucleotide polymorphism in the XPG gene, and tumour stage, grade, and clinical course in patients with nonmuscle‐invasive neoplasms of the urinary bladder
Sakano, S., Kumar, R., Larsson, P., Onelöv, E., Adolfsson, J., Steineck, G., & Hemminki, K. (2005) · British Journal of Urology · doi:10.1111/j.1464-410x.2005.05994.x · Cited by 23
Synthesis, DNA Polymerase Incorporation, and Enzymatic Phosphate Hydrolysis of Formamidopyrimidine Nucleoside Triphosphates
Imoto, S., Patro, J. N., Jiang, Y. L., Oka, N., & Greenberg, M. M. (2006) · Journal of the American Chemical Society · doi:10.1021/ja065525r · Cited by 23
A comprehensive leukemia database: integration of cytogenetics, molecular genetics and microarray data with clinical information, cytomorphology and immunophenotyping
Dugas, M., Schoch, C., Schnittger, S., Haferlach, T., Danhauser-riedl, S., Hiddemann, W., Messerer, D., & Überla, K. (2001) · Leukemia · doi:10.1038/sj.leu.2402301 · Cited by 23
Cancer Immunotherapy in Older Patients
Marrone, K. A., & Forde, P. M. (2017) · The Cancer Journal · doi:10.1097/ppo.0000000000000268 · Cited by 22
Integration of Enzymatic Labeling with Single-Molecule Detection for Sensitive Quantification of Diverse DNA Damages
Zhang, Y., Hua, R.-N., & Zhang, C. (2020) · Analytical Chemistry · doi:10.1021/acs.analchem.9b04547 · Cited by 22
Time-programmed activation of dual polyprodrugs for synergistic cascade oxidation-chemotherapy
Liu, Y., Jiang, M., Tu, Y., Wang, K., Zong, Q., & Yuan, Y. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121136 · Cited by 22
Impact of chronologic age in the elderly with gastric cancer
Lee, S. R., Kim, H. O., & Yoo, C. H. (2012) · Journal of the Korean Surgical Society · doi:10.4174/jkss.2012.82.4.211 · Cited by 22
Internet Delivery of PREP-Based Relationship Education for At-Risk Couples
Loew, B. A., RHOADES, G. K., Markman, H. J., Stanley, S. M., Pacifici, C., White, L., & Delaney, R. (2012) · Journal of Couple & Relationship Therapy · doi:10.1080/15332691.2012.718968 · Cited by 22
Signs of proinflammatory/genotoxic switch (adipogenotoxicosis) in mammary fat of breast cancer patients: Role of menopausal status, estrogens and hyperglycemia
Berstein, L. M., Ковалевский, А. Ю., Евгеньевна, П. Т., Kotov, A. V., Kovalenko, I. G., Tsyrlina, E. V., Leenman, E. E., Revskoĭ, S. I., Семиглазов, В. Ф., & Pozharisski, K. M. (2007) · International Journal of Cancer · doi:10.1002/ijc.22552 · Cited by 24
IGF axis and other factors in HPV-related and HPV-unrelated carcinogenesis (Review)
Durzyńska, J. (2014) · Oncology Reports · doi:10.3892/or.2014.3505 · Cited by 22
Innovative CODAS Algorithm for q-Rung Orthopair Fuzzy Information and Cancer Risk Assessment
Kausar, R., Farid, H. M. A., Riaz, M., & Bilgin, N. G. (2023) · Symmetry · doi:10.3390/sym15010205 · Cited by 21
Self-Renewal Signalling in Presenescent Tetraploid IMR90 Cells
Huna, A., Salmiņa, K., Jascenko, E., Duburs, G., Inashkina, I., & Erenpreisa, J. A. (2011) · Journal of Aging Research · doi:10.4061/2011/103253 · Cited by 23
hTERT promoter polymorphism, -1327C>T, is associated with the risk of epithelial cancer
Iizuka, T., Sawabe, M., Takubo, K., Liu, M., Homma, Y., Suzuki, M., & Arai, T. (2013) · SpringerPlus · doi:10.1186/2193-1801-2-249 · Cited by 21
Novel technologies for cancer biomarker discovery: Humoral proteomics
Shoshan, S. H., & Admon, A. (2007) · Cancer Biomarkers · doi:10.3233/cbm-2007-3305 · Cited by 21
Gero-Oncology Nursing Research
Kagan, S. H. (2004) · Oncology nursing forum · doi:10.1188/04.onf.293-299 · Cited by 21
Development Potential of Transgenic Somatic Cell Nuclear Transfer Embryos According to Various Factors of Donor Cell
Cho, J., Bhuiyan, M. M. U., Shin, S.-T., Eulsoon, P. A. R. K., Jang, G., Kang, S., Lee, B.-C., & Hwang, W. S. (2004) · Journal of Veterinary Medical Science · doi:10.1292/jvms.66.1567 · Cited by 21
Expression level of Wnt signaling components possibly influences the biological behavior of colorectal cancer in different age groups
Seidler, H. B. K., Utsuyama, M., Nagaoka, S., Takemura, T., Kitagawa, M., & Hirokawa, K. (2004) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2003.12.004 · Cited by 21
Multiclass classification for skin cancer profiling based on the integration of heterogeneous gene expression series
Gálvez, J. M., Castillo-Secilla, D., Herrera, L. J., Román, B. S., Valenzuela, O., Ortuño, F. M., & Rojas, I. (2018) · PLoS ONE · doi:10.1371/journal.pone.0196836 · Cited by 20
Changes in Pancreatic Senescence Mediate Pancreatic Diseases
Li, K., Bian, J., Xiao, Y., Wang, D., Han, L., He, C., Gong, L., & Wang, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043513 · Cited by 20
Biomarkers of UVB radiation-related senescent fibroblasts
Qiang, M., & Dai, Z. (2024) · Scientific Reports · doi:10.1038/s41598-023-51058-4 · Cited by 23
Genome-Wide Analysis of Yeast Aging
Sutphin, G. L., Olsen, B., Kennedy, B. K., & Kaeberlein, M. R. (2011) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-007-2561-4_12 · Cited by 21
Beneficial Autoimmunity at Body Surfaces – Immune Surveillance and Rapid Type 2 Immunity Regulate Tissue Homeostasis and Cancer
Dalessandri, T., & Strid, J. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00347 · Cited by 23
Molecular and chemical genetic approaches to developmental origins of aging and disease in zebrafish
Sasaki, T., & Kishi, S. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.04.030 · Cited by 22
Overexpression of eIF-5A2 in mice causes accelerated organismal aging by increasing chromosome instability
Chen, M., Huang, J., Deng, H. K., Dong, S.-S., Deng, W., Tsang, S. L., Huen, M. S. Y., Chen, L., Tong, Z., Zhu, G., et al. (2011) · BMC Cancer · doi:10.1186/1471-2407-11-199 · Cited by 20
Ultraviolet responses of Gorlin syndrome primary skin cells
Brellier, F., Valin, A., Chevallier, O., Gorry, P., Avril, M.-F., & Magnaldo, T. (2008) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2008.08650.x · Cited by 20
Senescence-Dependent MutSα Dysfunction Attenuates Mismatch Repair
Chang, I. Y., Jin, M., Yoon, S. P., Youn, C.-K., Yoon, Y. A., Moon, S.-P., Hyun, J. W., Jun, J. Y., & You, H. J. (2008) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-07-0380 · Cited by 20
The number of dysfunctional telomeres in a cell: one amplifies; more than one translocate
Tusell, L., Soler, D., Agostini, M., Pampalona, J., & Genescà, A. (2008) · Cytogenetic and Genome Research · doi:10.1159/000167818 · Cited by 20
Overexpression of Klotho Inhibits HELF Fibroblasts SASP-related Protumoral Effects on Non-small Cell Lung Cancer Cells
Chen, B., Liang, Y., Chen, L., Wei, Y., Li, Y., Zhao, W., & Wu, J. (2018) · Journal of Cancer · doi:10.7150/jca.23967 · Cited by 20
Effect of azoxymethane and curcumin on transcriptional levels of cyclooxygenase-1 and -2 during initiation of colon carcinogenesis
Kwon, Y., & Magnuson, B. A. (2006) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520600825216 · Cited by 20
The search for Methuselah
Partridge, B., & Hall, W. (2007) · EMBO Reports · doi:10.1038/sj.embor.7401069 · Cited by 20
The Presence of Telomere Fusion in Sporadic Colon Cancer Independently of Disease Stage, TP53/KRAS Mutation Status, Mean Telomere Length, and Telomerase Activity
Tanaka, H., Beam, M. J., & Caruana, K. (2014) · Neoplasia · doi:10.1016/j.neo.2014.08.009 · Cited by 19
How Does Chronobiology Contribute to the Development of Diseases in Later Life
Stowe, T. A., & McClung, C. A. (2023) · Clinical Interventions in Aging · doi:10.2147/cia.s380436 · Cited by 20
Aptamer Conjugate-Based Ratiometric Fluorescent Probe for Precise Imaging of Therapy-Induced Cancer Senescence
Wang, L., Li, J., Zhao, Z., Xia, Y., Xie, Y., Hong, D., Liu, Y., & Tan, W. (2023) · Analytical Chemistry · doi:10.1021/acs.analchem.3c03435 · Cited by 20
Nanomedicine And Nanotheranostics: Special Focus on Imaging of Anticancer Drugs Induced Cardiac Toxicity
Setia, A., Challa, R. R., Vallamkonda, B., Satti, P., Mehata, A. K., Priya, V., Kumar, S., V, & Muthu, M. S. (2024) · Nanotheranostics · doi:10.7150/ntno.96846 · Cited by 20
Multiparameter analyses of cell cycle regulatory proteins in human breast cancer: A key to definition of separate pathways in tumorigenesis
Landberg, G. (2002) · Advances in cancer research · doi:10.1016/s0065-230x(02)84002-7 · Cited by 19
Radiation-induced chromosome breaks in ataxia-telangiectasia cells remain open
Martı́n, M., Genescà, A., Latre, L., Ribas, M., Miró, R., Egozcue, J., & Tusell, L. (2003) · International Journal of Radiation Biology · doi:10.1080/0955300031000089601 · Cited by 19
Emergence of new infectious diseases
Woolhouse, M. E. J., & Antia, R. (2007) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780199207466.003.0016 · Cited by 19
Aging and cancer in transgenic and mutant mice
Anisimov, V. N. (2003) · Frontiers in bioscience · doi:10.2741/1122 · Cited by 19
Somatic recombination in adult tissues: What is there to learn?
Siudeja, K., & Bardin, A. J. (2016) · Fly · doi:10.1080/19336934.2016.1249073 · Cited by 20
Recent Advances in Strategies for Imaging Detection and Intervention of Cellular Senescence
Li, J., Bi, Z., Wang, L., Xia, Y., Xie, Y., & Liu, Y. (2022) · ChemBioChem · doi:10.1002/cbic.202200364 · Cited by 19

Authors: DePinho, R. A.
Affiliations: Harvard University (US)
Corresponding author: DePinho, Ronald A.
ORCID: DePinho, Ronald A.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2000-11
Volume: 408
Issue: 6809
Pages: 248-254
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/35041694
OpenAlex: W1552282019
Cited by: 951
References: 96
Citations by year: 2026: 10 · 2025: 17 · 2024: 28 · 2023: 28 · 2022: 19 · 2021: 34 · 2020: 19 · 2019: 29 · 2018: 29 · 2017: 35 · 2016: 19 · 2015: 38 · 2014: 41 · 2013: 38 · 2012: 36
FWCI: 3.79
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Keywords: aging, cancer incidence, epithelial carcinogenesis, mutational burden, epigenetic regulation, telomere dysfunction, tumor microenvironment, cancer prevention
MeSH terms: Aging, Animals, Humans, Neoplasms, Incidence, Telomere, Genome, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The age of cancer

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks