Cited by 953Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model OrganismsCancer-related Molecular Pathways

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The age of cancer

DePinho, Ronald A.·2000·Nature

DOI 10.1038/35041694

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Abstract

A striking link exists between advanced age and increased incidence of cancer. Here I review how several of the age-related molecular and physiological changes might act in concert to promote cancer, and in particular epithelial carcinogenesis. Experimental data indicate that the aged, cancer-prone phenotype might represent the combined pathogenetic effects of mutation load, epigenetic regulation, telomere dysfunction and altered stromal milieu. Further verification of the role of these effects should in turn lead to the design of effective therapeutics for the treatment and prevention of cancer in the aged.

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Vijg, J. & Dolle, M. E. T. in Handbook of the Biology of Ageing 5th edn (eds Masoro, E. J. & Austad, S. N.) (Academic, in the press).

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Authors: DePinho, R. A.
Affiliations: Harvard University (US)
Corresponding author: DePinho, Ronald A.
ORCID: DePinho, Ronald A.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2000-11
Volume: 408
Issue: 6809
Pages: 248-254
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/35041694
OpenAlex: W1552282019
Cited by: 951
References: 96
Citations by year: 2026: 10 · 2025: 17 · 2024: 28 · 2023: 28 · 2022: 19 · 2021: 34 · 2020: 19 · 2019: 29 · 2018: 29 · 2017: 35 · 2016: 19 · 2015: 38 · 2014: 41 · 2013: 38 · 2012: 36
FWCI: 3.79
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Keywords: aging, cancer incidence, epithelial carcinogenesis, mutational burden, epigenetic regulation, telomere dysfunction, tumor microenvironment, cancer prevention
MeSH terms: Aging, Animals, Humans, Neoplasms, Incidence, Telomere, Genome, Mice

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