The DOI matches its Crossref record; 115 of the 115 references it cites were found in a registry or an index.
The establishment of spemann's organizer and patterning of the vertebrate embryo
Open accessAbstract
Molecular studies have begun to unravel the sequential cell-cell signalling events that establish the dorsal-ventral, or 'back-to-belly', axis of vertebrate animals. In Xenopus and zebrafish, these events start with the movement of membrane vesicles associated with dorsal determinants. This mediates the induction of mesoderm by generating gradients of growth factors. Dorsal mesoderm then becomes a signalling centre, the Spemann's organizer, which secretes several antagonists of growth-factor signalling. Recent studies have led to new models for the regulation of cell-cell signalling during development, which may also apply to the homeostasis of adult tissues.
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“For example, overexpression of Xwnt8, Dsh, β-catenin or dominant-negative GSK3 can induce secondary axis formation.56”
From Wnt signal transduction pathways (2008) · cites this paper as [56]
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Cites
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XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus Embryos
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The Spemann Organizer Signal noggin Binds and Inactivates Bone Morphogenetic Protein 4
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Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction
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Cited by
Sorted by citations
Wnt signal transduction pathways
Komiya, Y., & Habas, R. (2008) · Organogenesis · doi:10.4161/org.4.2.5851 · Cited by 1,528
MicroRNA control of signal transduction
Inui, M., Martello, G., & Piccolo, S. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2868 · Cited by 1,272
Mapping Wnt/β-catenin signaling during mouse development and in colorectal tumors
Maretto, S., Cordenonsi, M., Dupont, S., Braghetta, P., Broccoli, V., Hassan, A. B., Volpin, D., Bressan, G. M., & Piccolo, S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0434590100 · Cited by 759
Morphogen gradient interpretation
Gurdon, J. B., & Bourillot, P.-Y. (2001) · Nature · doi:10.1038/35101500 · Cited by 746
DORSAL-VENTRAL PATTERNING AND NEURAL INDUCTION IN XENOPUS EMBRYOS
De Robertis, E. M., & Kuroda, H. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.011403.154124 · Cited by 671
Metadata
- Authors
- De Robertis, E. M., Larraín, J., Oelgeschläger, M., & Wessely, O.
- Affiliations
- Howard Hughes Medical Institute (US)
- Venue
- Nature Reviews Genetics
- Published
- 2000-12
- Volume
- 1
- Issue
- 3
- Pages
- 171-181
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- PMC
- PMC2291143
- OpenAlex
- W1533376056
- Cited by
- 429
- References
- 115
- Citations by year
- 2026: 3 · 2025: 10 · 2024: 8 · 2023: 8 · 2022: 9 · 2021: 11 · 2020: 16 · 2019: 7 · 2018: 6 · 2017: 13 · 2016: 13 · 2015: 13 · 2014: 18 · 2013: 9 · 2012: 18
- FWCI
- 2.06
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Genetics (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R37HD021502)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Planarian Biology and Electrostimulation
- Keywords
- Spemann's organizer, dorsal-ventral axis, embryonic patterning, cell-to-cell communication, mesoderm induction, growth factor gradients, Xenopus, zebrafish, tissue homeostasis
- MeSH terms
- Amino Acid Sequence, Animals, Glycoproteins, Molecular Sequence Data, Vertebrates, Sequence Homology, Amino Acid, Body Patterning, Intercellular Signaling Peptides and Proteins
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