Cited by 429Developmental Biology and Gene RegulationWnt/β-catenin signaling in development and cancerPlanarian Biology and Electrostimulation

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The establishment of spemann's organizer and patterning of the vertebrate embryo

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De Robertis, E. M., Larraín, J., Oelgeschläger, M., Wessely, O.·2000·Nature Reviews Genetics

DOI 10.1038/35042039PMC PMC2291143

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Abstract

Molecular studies have begun to unravel the sequential cell-cell signalling events that establish the dorsal-ventral, or 'back-to-belly', axis of vertebrate animals. In Xenopus and zebrafish, these events start with the movement of membrane vesicles associated with dorsal determinants. This mediates the induction of mesoderm by generating gradients of growth factors. Dorsal mesoderm then becomes a signalling centre, the Spemann's organizer, which secretes several antagonists of growth-factor signalling. Recent studies have led to new models for the regulation of cell-cell signalling during development, which may also apply to the homeostasis of adult tissues.

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Authors: De Robertis, E. M., Larraín, J., Oelgeschläger, M., & Wessely, O.
Affiliations: Howard Hughes Medical Institute (US)
ORCID: Oelgeschläger, M.
Wessely, O.
Venue: Nature Reviews Genetics
Publisher: Springer Science and Business Media LLC
Published: 2000-12
Volume: 1
Issue: 3
Pages: 171-181
ISSN: 1471-0056 (ISSN-L)
1471-0064
DOI: 10.1038/35042039
PMC: PMC2291143
OpenAlex: W1533376056
Cited by: 429
References: 115
Citations by year: 2026: 3 · 2025: 10 · 2024: 8 · 2023: 8 · 2022: 9 · 2021: 11 · 2020: 16 · 2019: 7 · 2018: 6 · 2017: 13 · 2016: 13 · 2015: 13 · 2014: 18 · 2013: 9 · 2012: 18
FWCI: 2.06
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Genetics (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Eunice Kennedy Shriver National Institute of Child Health and Human Development (R37HD021502)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Planarian Biology and Electrostimulation
Keywords: Spemann's organizer, dorsal-ventral axis, embryonic patterning, cell-to-cell communication, mesoderm induction, growth factor gradients, Xenopus, zebrafish, tissue homeostasis
MeSH terms: Amino Acid Sequence, Animals, Glycoproteins, Molecular Sequence Data, Vertebrates, Sequence Homology, Amino Acid, Body Patterning, Intercellular Signaling Peptides and Proteins

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The establishment of spemann's organizer and patterning of the vertebrate embryo

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