Student or educator? Sign up with your school email and get 6 months of Pro free.
Cited by 434

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Remission in models of type 1 diabetes by gene therapy using a single-chain insulin analogue

Open access
Lee, Hyun Chul, Kim, Su-Jin, Kim, Kyung-Sup, Shin, Hang-Cheol, Yoon, Ji-Won·2000·Nature

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1038/35044106This paper is marked retracted.

Cites

1 of 1 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 1 references

Research works printed but not linked: 27

  1. Levine, F. & Leibowitz, G. Towards gene therapy of diabetes mellitus. Mol. Med. Today 5, 165–171 (1999). · DOI
  2. Yoon, J. W. & Jun, H. S. in Encyclopedia of Immunology (eds Roitt, I. M. & Delves, P. J.) 2nd edn, 1390–1398 (Academic, London, 1998). · doi:10.1006/rwei.1999.0355
  3. Schranz, D. B. & Lernmark, A. Immunology in diabetes: an update. Diab. Metab. Rev. 14, 3–29 (1998). · DOI
  4. Tisch, R. & McDevitt, H. Insulin-dependent diabetes mellitus. Cell 85, 291–297 (1996). · DOI · Paper page
  5. Bach, J. F. Insulin-dependent diabetes mellitus as a β cell targeted disease of immunoregulation. J. Autoimmun. 8, 439–463 (1995). · DOI
  6. Rossini, A. A., Greiner, D. L., Friedman, H. P. & Mordes, J. P. Immunopathogenesis of diabetes mellitus. Diabetes Rev. 1, 43–75 (1993).
  7. The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. New Engl. J. Med. 329, 977–986 (1993). · DOI · Paper page
  8. Cuif, M. H., Doiron, B. & Kahn, A. Insulin and cyclic AMP act at different levels on transcription of the L-type pyruvate kinase gene. FEBS Lett. 417, 81–84 (1997). · DOI
  9. Chen, R., Doiron, B. & Kahn, A. Glucose responsiveness of a reporter gene transduced into hepatocytic cells using a retroviral vector. FEBS Lett. 365, 223–226 (1995). · DOI
  10. Cuif, M. H., Porteu, A., Kahn, A. & Vaulont, S. Exploration of a liver-specific, glucose/insulin-responsive promoter in transgenic mice. J. Biol. Chem. 268, 13769–13772 (1993). · DOI
  11. Bergot, M. O., Diaz-Guerra, M. J., Puzenat, N., Raymondjean, M. & Kahn, A. Cis-regulation of the L-type pyruvate kinase gene promoter by glucose, insulin and cyclic AMP. Nucleic Acids Res. 20, 1871–1877 (1992). · DOI · Paper page
  12. Muzyczka, N. Use of adeno-associated virus as a general transduction vector for mammalian cells. Curr. Top. Microbiol. Immunol. 158, 97–129 (1992).
  13. Clark, K. R., Liu, X., McGrath, J. P. & Johnson, P. R. Highly purified recombinant adeno-associated virus vectors are biologically active and free of detectable helper and wild-type viruses. Hum. Gene Ther. 10, 1031–1039 (1999). · DOI · Paper page
  14. Samulski, R. J. Adeno-associated virus: integration at a specific chromosomal locus. Curr. Opin. Genet. Dev. 3, 74–80 (1993). · DOI · Paper page
  15. Giraud, C., Winocour, E. & Berns, K. I. Site-specific integration by adeno-associated virus is directed by a cellular DNA sequence. Proc. Natl Acad. Sci. USA 91, 10039–10043 (1994). · DOI · Paper page
  16. Kotin, R. M., Linden, R. M. & Berns, K. I. Characterization of a preferred site on human chromosome 19q for integration of adeno-associated virus DNA by non-homologous recombination. EMBO J. 11, 5071–5078 (1992). · DOI · Paper page
  17. Cameron, N. E., Cotter, M. A. & Low, P. A. Nerve blood flow in early experimental diabetes in rats: relation to conduction deficits. Am. J. Physiol. 261, E1–E8 (1991).
  18. Studier, F. W., Rosenberg, A. H., Dunn, J. J. & Dubendorff, J. W. Use of T7 RNA polymerase to direct expression of cloned genes. Methods Enzymol. 185, 60–89 (1990). · DOI · Paper page
  19. Pollet, R. J., Standaert, M. L. & Haase, B. A. Insulin binding to the human lymphocyte receptor. Evaluation of the negative cooperativity model. J. Biol. Chem. 252, 5828–5834 (1977). · DOI · Paper page
  20. Roth, J. Assay of peptide hormones using cell receptors: application to insulin and to human growth hormone. Methods Enzymol. 37, 66–82 (1975). · doi:10.1016/s0076-6879(75)37006-7
  21. Frost, S. C. & Lane, M. D. Evidence for the involvement of vicinal sulfhydryl groups in insulin-activated hexose transport by 3T3-L1 adipocytes. J. Biol. Chem. 260, 2646–2652 (1985). · DOI · Paper page
  22. Heath, W. F. et al. (A-C-B) human proinsulin, a novel insulin agonist and intermediate in the synthesis of biosynthetic human insulin. J. Biol. Chem. 267, 419–425 (1992). · DOI
  23. Yoon, J. W., Lesniak, M. A., Fussganger, R. & Notkins, A. L. Genetic differences in susceptibility of pancreatic β-cells to virus-induced diabetes mellitus. Nature 264, 178–180 (1976). · DOI
  24. Ma, Z. et al. Effect of hemoglobin- and Perflubron-based oxygen carriers on common clinical laboratory tests. Clin. Chem. 43, 1732–1737 (1997). · doi:10.1093/clinchem/43.9.1732
  25. Yoon, J. W., Rodrigues, M. M., Currier, C. & Notkins, A. Long-term complications of virus-induced diabetes mellitus in mice. Nature 296, 566–569 (1982). · DOI
  26. Yoon, J. W. et al. Control of autoimmune diabetes in NOD mice by GAD expression or suppression in cells. Science 284, 1183–1187 (1999). · DOI · Paper page
  27. Hirasawa, K. Possible role of macrophage-derived soluble mediators in the pathogenesis of EMC virus-induced diabetes in mice. J. Virol. 71, 4024–4031 (1997). · DOI

Cited by

See all 434

Metadata

Authors
Lee, H. C., Kim, S.-J., Kim, K.-S., Shin, H.-C., & Yoon, J.-W.
Venue
Nature
Published
2000-11-23
Volume
408
Issue
6811
Pages
483-488
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
OpenAlex
W2078325631
Cited by
434
References
1
FWCI
22.82
Type
journal article
Language
en
Status
Retracted
Open access
green
Licence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Remission in models of type 1 diabetes by gene therapy using a single-chain insulin analogue. https://app.cochat.ai/papers/10.1038/35044106
The paper
Lee, H. C., Kim, S.-J., Kim, K.-S., Shin, H.-C., & Yoon, J.-W. (2000). Remission in models of type 1 diabetes by gene therapy using a single-chain insulin analogue. Nature. https://doi.org/10.1038/35044106

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.