Human Zw10 and ROD are mitotic checkpoint proteins that bind to kinetochores
Abstract
Here we show that human Zeste White 10 (Zw10) and Rough deal (Rod) are new components of the mitotic checkpoint, as cells lacking these proteins at kinetochores fail to arrest in mitosis when exposed to microtubule inhibitors. Checkpoint failure and premature mitotic exit may explain why cells defective for hZw10 and hRod divide with lagging chromosomes. As Zw10 and Rod are not conserved in yeast, our data, combined with an accompanying study of Drosophila Zw10 and Rod, indicate that metazoans may require an elaborate spindle checkpoint to monitor complex kinetochore functions.
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KNTC1 demonstrated moderate to strong lethal effects when knocked out in almost every cell line except for those with a KRAS G12V allele.
“the kinetochore-associated protein (KNTC1), a regulator of the mitotic checkpoint70,71, which demonstrated moderate to strong lethal effects when knocked out in almost every cell line except for those with a KRAS G12V allele”
From The origins and genetic interactions of KRAS mutations are allele- and tissue-specific (2021) · cites this paper as [70]
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- Authors
- Chan, G. K. T., Jablonski, S. A., Starr, D. A., Goldberg, M. L., & Yen, T. J.
- Affiliations
- Fox Chase Cancer Center (US)
- University of Colorado Boulder (US)
- Cornell University (US)
- Corresponding author
- Yen, T. J.
- Venue
- Nature Cell Biology
- Published
- 2000-11-14
- Volume
- 2
- Issue
- 12
- Pages
- 944-947
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- OpenAlex
- W1540858422
- Cited by
- 217
- References
- 31
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 6 · 2023: 7 · 2022: 6 · 2021: 2 · 2020: 10 · 2019: 5 · 2018: 8 · 2017: 5 · 2016: 6 · 2015: 3 · 2014: 5 · 2013: 8 · 2012: 2
- FWCI
- 5.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (P30CA006927, CA06927)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- ZW10, rods, spindle assembly checkpoint, kinetochore, microtubule inhibitors, mitotic arrest, lagging chromosomes, chromosome segregation, Drosophila, animal evolution
- MeSH terms
- Binding Sites, Chromosomal Proteins, Non-Histone, HeLa Cells, Humans, Microscopy, Fluorescence, Microtubules, Mitosis, Spindle Apparatus, Protein Binding, Nocodazole, Kinetochores, Cell Cycle Proteins
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