The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Human Zw10 and ROD are mitotic checkpoint proteins that bind to kinetochores
Abstract
Here we show that human Zeste White 10 (Zw10) and Rough deal (Rod) are new components of the mitotic checkpoint, as cells lacking these proteins at kinetochores fail to arrest in mitosis when exposed to microtubule inhibitors. Checkpoint failure and premature mitotic exit may explain why cells defective for hZw10 and hRod divide with lagging chromosomes. As Zw10 and Rod are not conserved in yeast, our data, combined with an accompanying study of Drosophila Zw10 and Rod, indicate that metazoans may require an elaborate spindle checkpoint to monitor complex kinetochore functions.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“the kinetochore-associated protein (KNTC1), a regulator of the mitotic checkpoint70,71, which demonstrated moderate to strong lethal effects when knocked out in almost every cell line except for those with a KRAS G12V allele”
From The origins and genetic interactions of KRAS mutations are allele- and tissue-specific (2021) · cites this paper as [70]
Citations
Cites
Mutations of mitotic checkpoint genes in human cancers
Cahill, D. P., Lengauer, C., Yu, J., Riggins, G. J., Willson, J. K. V., Markowitz, S. D., Kinzler, K. W., & Vogelstein, B. (1998) · Nature · doi:10.1038/32688 · Cited by 1,490
Feedback control of mitosis in budding yeast
Li, R., & Murray, A. W. (1991) · Cell · doi:10.1016/0092-8674(81)90015-5 · Cited by 1,174
S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function
Hoyt, M. A., Totis, L., & Roberts, B. T. (1991) · Cell · doi:10.1016/0092-8674(81)90014-3 · Cited by 1,138
Association of Spindle Assembly Checkpoint Component XMAD2 with Unattached Kinetochores
Chen, R., Waters, J. C., Salmon, E. D., & Murray, A. W. (1996) · Science · doi:10.1126/science.274.5285.242 · Cited by 783
How Cells Get the Right Chromosomes
Nicklas, R. B. (1997) · Science · doi:10.1126/science.275.5300.632 · Cited by 619
Identification of a Human Mitotic Checkpoint Gene: hsMAD2
Li, Y., & Benezra, R. (1996) · Science · doi:10.1126/science.274.5285.246 · Cited by 597
Taylor, S. S., & McKeon, F. (1997) · Cell · doi:10.1016/s0092-8674(00)80255-x · Cited by 540
Human T Cell Leukemia Virus Type 1 Oncoprotein Tax Targets the Human Mitotic Checkpoint Protein MAD1
Jin, D., Spencer, F. A., & Jeang, K.-T. (1998) · Cell · doi:10.1016/s0092-8674(00)81148-4 · Cited by 525
Rieder, C. L., Schultz, A., Cole, R. W., & Sluder, G. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.127.5.1301 · Cited by 506
Rieder, C. L., & Alexander, S. P. H. (1990) · The Journal of Cell Biology · doi:10.1083/jcb.110.1.81 · Cited by 488
Flagged first, then by citations
Cited by
Sorted by citations
Items 201–219 of 219
Characterization of TRAPPC11 and GOSR2 mutations in human fibroblasts
Prematilake, K. (2016) · Spectrum Research Repository (Concordia University)
Hayati, S. (2018) · Rutgers University Community Repository (Rutgers University) · doi:10.7282/t3m61pr8
The contribution of discoidin domain receptor 1 to the pathogenesis of diffuse large B cell lymphoma
Margielewska, S. (2018) · University of Birmingham Institutional Research Archive (University of Birmingham)
Gaurav, S., Ranjan, R., Kuldeep, J., Dhiman, K., Mahapatra, P. P., Ashish, Siddiqi, M. I., & Ahmed, S. (2020) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2020.129739
Walczak, C. (2007) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.1087311.540330
Compton, D. A. (2002) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.1003370.36455
Jackson, P. K. (2004) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.1021812.247725
Melo, A. P. C., Teixeira, H. M. P., Coelho, R. S., Silva, H. D. S., Silva, R. R., Alcântara‐Neves, N. M., Costa, G. N. D. O., Barreto, M. L., Costa, R. D. S., Pinto, L. C., et al. (2025) · Gene · doi:10.1016/j.gene.2025.149219
On evolutionary conservation of mitotic checkpoint signaling
van Gogh, I. J. A. (2010) · Utrecht University Repository (Utrecht University)
Zhou, M., Duan, L., Chen, J., Li, Y., Yin, Z., Song, S., Cao, Y., Luo, P., Hu, F., Yang, G., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26681953
Zhou, M., Duan, L., Chen, J., Li, Y., Yin, Z., Song, S., Cao, Y., Luo, P., Hu, F., Yang, G., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26681956
Zhou, M., Duan, L., Chen, J., Li, Y., Yin, Z., Song, S., Cao, Y., Luo, P., Hu, F., Yang, G., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26681950
Fidelity-Ensuring Consistency of Mitosis is Safeguarded by the 53BP1-USP28-p53 PathwayPreprint
Shulman, A., Ozaki, K., Chang, L. R., Hoong, E., & Tsou, M.-F. B. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.03.16.712228
RSK2 et Greatwall, deux AGC kinases actrices de la mitose
Brioudes, E. (2010) · theses.fr (ABES) · doi:10.70675/4302c889ze763z4585zbe22zf4152ff1631c
Li, Y.-F., Weng, C., & Wang, M. (2026) · World Journal of Gastroenterology · doi:10.3748/wjg.118071
Guo, X., Tang, J., Li, H., Mao, S., Tang, Y.-X., Tang, Z.-Z., & Gong, L. (2026) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/j.jpet.2026.104964
Metadata
- Authors
- Chan, G. K. T., Jablonski, S. A., Starr, D. A., Goldberg, M. L., & Yen, T. J.
- Affiliations
- Fox Chase Cancer Center (US)
- University of Colorado Boulder (US)
- Cornell University (US)
- Corresponding author
- Yen, T. J.
- Venue
- Nature Cell Biology
- Published
- 2000-11-14
- Volume
- 2
- Issue
- 12
- Pages
- 944-947
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- OpenAlex
- W1540858422
- Cited by
- 217
- References
- 31
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 6 · 2023: 7 · 2022: 6 · 2021: 2 · 2020: 10 · 2019: 5 · 2018: 8 · 2017: 5 · 2016: 6 · 2015: 3 · 2014: 5 · 2013: 8 · 2012: 2
- FWCI
- 5.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (P30CA006927, CA06927)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- ZW10, rods, spindle assembly checkpoint, kinetochore, microtubule inhibitors, mitotic arrest, lagging chromosomes, chromosome segregation, Drosophila, animal evolution
- MeSH terms
- Binding Sites, Chromosomal Proteins, Non-Histone, HeLa Cells, Humans, Microscopy, Fluorescence, Microtubules, Mitosis, Spindle Apparatus, Protein Binding, Nocodazole, Kinetochores, Cell Cycle Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
