Cited by 1,777Leprosy Research and TreatmentGenomics and Phylogenetic StudiesResearch on Leishmaniasis Studies

The DOI matches its Crossref record; 49 of the 50 references it cites were found in a registry or an index.

Massive gene decay in the leprosy bacillus.

Open access

Cole, S. T., Eiglmeier, K., Parkhill, J., James, K. D., Thomson, N. R., Wheeler, P. R., Honoré, N., Garnier, T., Churcher, C., Harris, D., Mungall, K., Basham, D., Brown, D., Chillingworth, T., Connor, R., Davies, R. M., Devlin, K., Duthoy, S., Feltwell, T., Fraser, A., Hamlin, N., Holroyd, S., Hornsby, T., Jagels, K., Lacroix, C., Maclean, J., Moule, S., Murphy, L., Oliver, K., Quail, M. A., Rajandream, M.-A., Rutherford, K. M., Rutter, S., Seeger, K., Simon, S., Simmonds, M., Skelton, J., Squares, R., Squares, S., Stevens, K., Taylor, K., Whitehead, S., Woodward, J. R., Barrell, B. G.·2001·Nature

DOI 10.1038/35059006

Open this paper in CoChat — free account

Abstract

Leprosy, a chronic human neurological disease, results from infection with the obligate intracellular pathogen Mycobacterium leprae, a close relative of the tubercle bacillus. Mycobacterium leprae has the longest doubling time of all known bacteria and has thwarted every effort at culture in the laboratory. Comparing the 3.27-megabase (Mb) genome sequence of an armadillo-derived Indian isolate of the leprosy bacillus with that of Mycobacterium tuberculosis (4.41 Mb) provides clear explanations for these properties and reveals an extreme case of reductive evolution. Less than half of the genome contains functional genes but pseudogenes, with intact counterparts in M. tuberculosis, abound. Genome downsizing and the current mosaic arrangement appear to have resulted from extensive recombination events between dispersed repetitive sequences. Gene deletion and decay have eliminated many important metabolic activities including siderophore production, part of the oxidative and most of the microaerophilic and anaerobic respiratory chains, and numerous catabolic systems and their regulatory circuits.

Integrity signals

Registry

Crossref · 10.1038/35059006

Cites

49 of 49 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
Cole, S. T., Brosch, R., Parkhill, J., Garnier, T., Churcher, C., Harris, D., Gordon, S. V., Eiglmeier, K., Gas, S., Barry, C. E., et al. (1998) · Nature · doi:10.1038/31159 · Cited by 7,847
Self-citation
Artemis: sequence visualization and annotation
Rutherford, K. M., Parkhill, J., Crook, J., Horsnell, T., Rice, P., Rajandream, M., & Barrell, B. (2000) · Bioinform. · doi:10.1093/bioinformatics/16.10.944 · Cited by 3,295
Self-citation
The genome sequence of Rickettsia prowazekii and the origin of mitochondria
Andersson, S. G. E., Zomorodipour, A., Andersson, J. O., Sicheritz-Pontén, T., Alsmark, U. C. M., Podowski, R. M., Näslund, A. K., Eriksson, A.-S., Winkler, H. H., & Kurland, C. G. (1998) · Nature · doi:10.1038/24094 · Cited by 1,697
Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase
McKinney, J. D., zu Bentrup, K. H., Muñoz‐Elías, E. J., Miczák, A., Chen, B., Chan, W.-T., Swenson, D. L., Sacchettini, J. C., Jacobs, W. R., & Russell, D. G. (2000) · Nature · doi:10.1038/35021074 · Cited by 1,361
A new DNA sequence assembly program
Bonfield, J., Smith, K. F., & Staden, R. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.24.4992 · Cited by 978
Issues in searching molecular sequence databases
Altschul, S. F., Boguski, M. S., Gish, W. R., & Wootton, J. C. (1994) · Nature Genetics · doi:10.1038/ng0294-119 · Cited by 773
Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice
Cox, J. S., Chen, B., McNeil, M., & Jacobs, W. R. (1999) · Nature · doi:10.1038/47042 · Cited by 746
The Envelope Layers of Mycobacteria with Reference to their Pathogenicity
Daffé, M., & Draper, P. (1997) · Advances in microbial physiology/Advances in Microbial Physiology · doi:10.1016/s0065-2911(08)60016-8 · Cited by 727
Complete DNA sequence of a serogroup A strain of Neisseria meningitidis Z2491
Parkhill, J., Achtman, M., James, K., Bentley, S. D., Churcher, C. M., Klee, S. R., Morelli, G., Basham, D., Brown, D., Chillingworth, T., et al. (2000) · Nature · doi:10.1038/35006655 · Cited by 699
Self-citation
A Novel Mycolic Acid Cyclopropane Synthetase Is Required for Cording, Persistence, and Virulence of Mycobacterium tuberculosis
Glickman, M. S., Cox, J. S., & Jacobs, W. R. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80250-6 · Cited by 656

Flagged first, then by citations

Show all 50 references

1 of the 50 references couldn’t be matched to a known paper.

Research works printed but not linked: 3

World Health Organization in WHO Weekly Epidemiological Record 73, 40 (1998).
Hansen, G. H. A. Undersogelser angaende spedalskhedens aasager. Norsk Magazin for Laegervidenskaben 4 (Suppl.), 1–88 (1874).
Shephard, C. C. in Leprosy (ed. Hastings, R. C.) 269–286 (Churchill Livingstone, Edinburgh, 1985).

Sorted by citations

Items 801–900 of 1,000

Comparative proteomics of the Mycobacterium leprae binding protein myelin P0: its implication in leprosy and other neurodegenerative diseases
Vardhini, D., Suneetha, S. K., Ahmed, N., Joshi, D. S. M., Karuna, S., Magee, X., Vijayalakshmi, D. S. R., Sridhar, V., Karunakar, K. V., Archelos, J. J., et al. (2003) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2003.11.001 · Cited by 28
Hemoglobins: Diversity of structures and functions
Kosmachevskaya, O. V., & Topunov, A. F. (2009) · Applied Biochemistry and Microbiology · doi:10.1134/s0003683809060015 · Cited by 28
Nystatin Biosynthesis and Transport: nysH and nysG Genes Encoding a Putative ABC Transporter System in Streptomyces noursei ATCC 11455 Are Required for Efficient Conversion of 10-Deoxynystatin to Nystatin
Sletta, H., Borgos, S. E., Bruheim, P., Sekurova, O. N., Grasdalen, H., Aune, R., Ellingsen, T. E., & Zotchev, S. B. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.11.4576-4583.2005 · Cited by 28
Advances in the diagnosis and treatment of leprosy
Katoch, V. M. (2002) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399402004763 · Cited by 28
Oxygen and Nitrate Respiration in Streptomyces coelicolor A3(2)
Sawers, R. G., Falke, D., & Fischer, M. (2016) · Advances in microbial physiology/Advances in Microbial Physiology · doi:10.1016/bs.ampbs.2016.02.004 · Cited by 28
The Diversity and Importance of Microbial Cytochromes P450
Kelly, S. L., Kelly, D. E., Jackson, C. J., Warrilow, A. G. S., & Lamb, D. C. (2007) · Springer eBooks · doi:10.1007/0-387-27447-2_13 · Cited by 28
Tempo and mode of early gene loss in endosymbiotic bacteria from insects
Delmotte, F., Rispe, C., Schaber, J., Silva, F. J., & Moya, A. (2006) · BMC Evolutionary Biology · doi:10.1186/1471-2148-6-56 · Cited by 28
Leprosy: current diagnostic and treatment approaches
Ustianowski, A., & Lockwood, D. N. J. (2003) · Current Opinion in Infectious Diseases · doi:10.1097/00001432-200310000-00008 · Cited by 28
Optimized DNA Preparation from MycobacteriaPreprint
Käser, M., Ruf, M., Hauser, J., & Pluschke, G. (2010) · Cold Spring Harbor Protocols · doi:10.1101/pdb.prot5408 · Cited by 28
Challenges and advances in serological and molecular tests to aid leprosy diagnosis
Lopes-Luz, L., Saavedra, D. P., Fogaça, M. B. T., Bührer-Sékula, S., & Stefani, M. M. D. A. (2023) · Experimental Biology and Medicine · doi:10.1177/15353702231209422 · Cited by 27
Multibacillary leprosy patients with high and persistent serum antibodies to leprosy IDRI diagnostic-1/LID-1: higher susceptibility to develop type 2 reactions
Mizoguti, D. D. F., Hungria, E. M., Freitas, A. A., Oliveira, R. M., Cardoso, L. P. V., Costa, M. B., Sousa, A. L. M., Duthie, M. S., & Stefani, M. M. A. (2015) · Memórias do Instituto Oswaldo Cruz · doi:10.1590/0074-02760150198 · Cited by 27
Recognition of DNA Supercoil Geometry by Mycobacterium tuberculosis Gyrase
Ashley, R. E., Blower, T. R., Berger, J. M., & Osheroff, N. (2017) · Biochemistry · doi:10.1021/acs.biochem.7b00681 · Cited by 27
New insights in the pathogenesis and genetics of leprosy
Gulia, A., Fried, I., & Massone, C. (2010) · F1000 Medicine Reports · doi:10.3410/m2-30 · Cited by 27
Simple sequence repeats in mycobacterial genomes
Sreenu, V. B., Kumar, P., Nagaraju, J., & Nagarajaram, H. A. (2007) · Journal of Biosciences · doi:10.1007/s12038-007-0002-7 · Cited by 27
Genetics of Peptidoglycan Biosynthesis
Pavelka, M. S., Mahapatra, S., & Crick, D. C. (2014) · Microbiology Spectrum · doi:10.1128/microbiolspec.mgm2-0034-2013 · Cited by 27
Characterization of the major formamidopyrimidine-DNA glycosylase homolog inMycobacterium tuberculosisand its linkage to variable tandem repeats
Olsen, I., Balasingham, S. V., Davidsen, T., Debebe, E., Rødland, E. A., van Soolingen, D., Kremer, K., Alseth, I., & Tønjum, T. (2009) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2009.00562.x · Cited by 27
The Mycoplasma fermentans prophage φMFV1: genome organization, mobility and variable expression of an encoded surface protein
Röske, K., Calcutt, M. J., & Wise, K. S. (2004) · Molecular Microbiology · doi:10.1111/j.1365-2958.2004.04087.x · Cited by 27
Search for Mycobacterium leprae in wild mammals
Pedrini, S., Rosa, P. S., Medri, Í. M., Mourão, G. M., Bagagli, E., & Lopes, C. A. D. M. (2010) · The Brazilian Journal of Infectious Diseases · doi:10.1016/s1413-8670(10)70010-6 · Cited by 27
Meet the Herod bug
Knight, J. (2001) · Nature · doi:10.1038/35083744 · Cited by 27
Databases and software for the comparison of prokaryotic genomes
Field, D., Feil, E. J., & Wilson, G. A. (2005) · Microbiology · doi:10.1099/mic.0.28006-0 · Cited by 27
B-subunit of Phosphate-specific Transporter fromMycobacterium tuberculosis Is a Thermostable ATPase
Sarin, J., Aggarwal, S., Chaba, R., Varshney, G. C., & Chakraborti, P. K. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105401200 · Cited by 27
Immunology taught by Darwin
Phillips, R. E. (2002) · Nature Immunology · doi:10.1038/ni1102-987 · Cited by 27
Protein targets for structure-based anti-Mycobacterium tuberculosis drug discovery
Lou, Z., & Zhang, X. (2010) · Protein & Cell · doi:10.1007/s13238-010-0057-3 · Cited by 27
The Erp protein is anchored at the surface by a carboxy-terminal hydrophobic domain and is important for cell-wall structure inMycobacterium smegmatis
Kocíncová, D., Sondén, B., Mendonça-Lima, L., Gicquel, B., & Reyrat, J. (2004) · FEMS Microbiology Letters · doi:10.1016/s0378-1097(03)00964-9 · Cited by 27
Expression and Purification of an Active Form of the Mycobacterium leprae DNA Gyrase and Its Inhibition by Quinolones
Matrat, S., Petrella, S., Cambau, E., Sougakoff, W., Jarlier, V., & Aubry, A. (2007) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01282-06 · Cited by 27
Paradoxical conservation of a set of three cellulose-targeting genes in Mycobacterium tuberculosis complex organisms
Medie, F. M., Salah, I. B., Drancourt, M., & Henrissat, B. (2010) · Microbiology · doi:10.1099/mic.0.037812-0 · Cited by 27
The impact of comparative genomics on infectious disease research
Zhang, R., & Zhang, C. (2006) · Microbes and Infection · doi:10.1016/j.micinf.2005.11.019 · Cited by 27
Differential gene expression of pathogens inside infected hosts
Jansen, A., & Yu, J. (2006) · Current Opinion in Microbiology · doi:10.1016/j.mib.2006.01.003 · Cited by 27
Mycobacterium tuberculosis: a model system for structural genomics
Smith, C. V., & Sacchettini, J. C. (2003) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2003.10.004 · Cited by 27
Identification of a Mycothiol-Dependent Nitroreductase from Mycobacterium tuberculosis
Negri, A., Javidnia, P. E., Mu, R., Zhang, X., Vendôme, J., Gold, B. S., Roberts, J., Barman, D., Ioerger, T. R., Sacchettini, J. C., et al. (2018) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.7b00111 · Cited by 28
Transitional genomes and nutritional role reversals identified for dual symbionts of adelgids (Aphidoidea: Adelgidae)
Dial, D. T., Weglarz, K. M., Aremu, A. O., Havill, N. P., Pearson, T. A., Burke, G. R., & von Dohlen, C. D. (2021) · The ISME Journal · doi:10.1038/s41396-021-01102-w · Cited by 26
Construction and Analysis of the Complete Genome Sequence of Leprosy Agent Mycobacterium lepromatosis
Silva, F. J., Santos-García, D., Zheng, X., Zhang, L., & Han, X. Y. (2022) · Microbiology Spectrum · doi:10.1128/spectrum.01692-21 · Cited by 26
Introduction to Evolutionary Genomics
Saitou, N. (2013) · Computational biology · doi:10.1007/978-1-4471-5304-7 · Cited by 26
Bacterial-induced cell reprogramming to stem cell-like cells: new premise in host–pathogen interactions
Hess, S., & Rambukkana, A. (2014) · Current Opinion in Microbiology · doi:10.1016/j.mib.2014.11.021 · Cited by 26
Desafios na era pós genômica para o desenvolvimento de testes laboratoriais para o diagnóstico da hanseníase
Stefani, M. M. D. A. (2008) · Revista da Sociedade Brasileira de Medicina Tropical · doi:10.1590/s0037-86822008000700018 · Cited by 26
Evaluation of various cytokines elicited during antigen-specific recall as potential risk indicators for the differential development of leprosy
Sampaio, L. H. F., de Sousa, A. L. M., Barcelos, M. C., Reed, S. G., Stefani, M. M. A., & Duthie, M. S. (2011) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-011-1462-0 · Cited by 26
Cryptic plasmids of Mycobacterium avium: Tn552 to the rescue
Kirby, C., Waring, A., Griffin, T. J., Falkinham, J. O., Grindley, N. D. F., & Derbyshire, K. M. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.02729.x · Cited by 26
The role of multiple SOS boxes upstream of the Mycobacterium tuberculosis lexA gene – identification of a novel DNA-damage-inducible gene
Dullaghan, E. M., Brooks, P. C., & Davis, E. O. (2002) · Microbiology · doi:10.1099/00221287-148-11-3609 · Cited by 26
Mycobacterium leprae interactions with the host cell: recent advances.
Barker, L. P. (2006) · PubMed · Cited by 26
Feline leprosy due to Candidatus ‘Mycobacterium lepraefelis’: Further clinical and molecular characterisation of eight previously reported cases and an additional 30 cases
O'Brien, C. R., Malík, R., Globan, M., Reppas, G., McCowan, C., & Fyfe, J. (2017) · Journal of Feline Medicine and Surgery · doi:10.1177/1098612x17706470 · Cited by 26
Essential Nucleoid Associated Protein mIHF (Rv1388) Controls Virulence and Housekeeping Genes in Mycobacterium tuberculosis
Odermatt, N. T., Sala, C., Benjak, A., & Cole, S. T. (2018) · Scientific Reports · doi:10.1038/s41598-018-32340-2 · Cited by 26
Self-citation
Functional Annotation of Putative Aminoglycoside Antibiotic Modifying Proteins in Mycobacterium tuberculosis H37Rv.
Draker, K.-A., Boehr, D. D., Elowe, N. H., NOGA, T. J., & Wright, G. D. (2003) · The Journal of Antibiotics · doi:10.7164/antibiotics.56.135 · Cited by 26
Nitrogen Metabolism and Nitrogen Control in Corynebacteria: Variations of a Common Theme
Walter, B., Hänßler, E., Kalinowski, J., & Burkovski, A. (2006) · Microbial Physiology · doi:10.1159/000096468 · Cited by 26
Use of Protein Microarrays To Define the Humoral Immune Response in Leprosy Patients and Identification of Disease-State-Specific Antigenic Profiles
Groathouse, N. A., Amin, A. G., Marques, M. A. M., Spencer, J. S., GELBER, R. H., Knudson, D. L., Belisle, J. T., Brennan, P. J., & Slayden, R. A. (2006) · Infection and Immunity · doi:10.1128/iai.00041-06 · Cited by 26
Structural and Functional Characteristics of Homing Endonucleases
Guhan, N., & Muniyappa, K. (2003) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/713609235 · Cited by 26
Protein Histidine Kinase
Matthews, H. R., & Chan, K. (2003) · Humana Press eBooks · doi:10.1385/1-59259-059-4:171 · Cited by 26
Leprosy frequency in the world, 1999-2010
Penna, M. L. F., & Penna, G. O. (2012) · Memórias do Instituto Oswaldo Cruz · doi:10.1590/s0074-02762012000900002 · Cited by 25
Chimpanzees used for medical research shed light on the pathoetiology of leprosy
Suzuki, K., Tanigawa, K., Kawashima, A., Miyamura, T., & Ishii, N. (2011) · Future Microbiology · doi:10.2217/fmb.11.97 · Cited by 25
Iron Acquisition in Mycobacterium avium subsp. paratuberculosis
Wang, J., Moolji, J., Dufort, A., Staffa, A., Domenech, P., Reed, M. B., & Behr, M. A. (2015) · Journal of Bacteriology · doi:10.1128/jb.00922-15 · Cited by 25
Evidence that phosphorylation of threonine in the GT motif triggers activation of PknA, a eukaryotic‐type serine/threonine kinase from Mycobacterium tuberculosis
Ravala, S. K., Singh, S., Yadav, G. S., Kumar, S., Karthikeyan, S., & Chakraborti, P. K. (2015) · FEBS Journal · doi:10.1111/febs.13230 · Cited by 25
A proteomic view of mycobacteria
de Souza, G. A., & Wiker, H. G. (2011) · PROTEOMICS · doi:10.1002/pmic.201100043 · Cited by 25
Mechanisms of Action and Resistance of Antimycobacterial Agents
Karakousis, P. C. (2009) · Humana Press eBooks · doi:10.1007/978-1-59745-180-2_24 · Cited by 25
Introduction to Evolutionary Genomics
Saitou, N. (2018) · Computational biology · doi:10.1007/978-3-319-92642-1 · Cited by 25
Analysis of gene gain and loss in the evolution of predatory bacteria
Li, N., Wang, K., Williams, H. N., Sun, J., Ding, C., Leng, X., & Dong, K. (2016) · Gene · doi:10.1016/j.gene.2016.10.039 · Cited by 23
Natural environmental water sources in endemic regions of northeastern Brazil are potential reservoirs of viable Mycobacterium leprae
Arraes, M. L. B. D. M., de Holanda, M. V., Lima, L. N. G. C., Sabadia, J. A. B., Duarte, C. R., de Almeida, R. L. F., Kendall, C., Kerr, L. R. F. S., & Frota, C. C. (2017) · Memórias do Instituto Oswaldo Cruz · doi:10.1590/0074-02760170117 · Cited by 25
Mycobacterium leprae-Specific Antibodies in Multibacillary Leprosy Patients Decrease During and After Treatment With Either the Regular 12 Doses Multidrug Therapy (MDT) or the Uniform 6 Doses MDT
Hungria, E. M., Bührer-Sékula, S., Oliveira, R. M., Aderaldo, L. C., Pontes, M. A. D. A., Cruz, R. C. D. S., Gonçalves, H. D. S., Penna, M. L. F., Penna, G. O., & Stefani, M. M. A. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00915 · Cited by 25
Bacteriocyte-associated gammaproteobacterial symbionts of the Adelges nordmannianae/piceae complex (Hemiptera: Adelgidae)
Toenshoff, E. R., Penz, T., Narzt, T., Collingro, A., Schmitz‐Esser, S., Pfeiffer, S., Klepal, W., Wagner, M., Weinmaier, T., Rattei, T., et al. (2011) · The ISME Journal · doi:10.1038/ismej.2011.102 · Cited by 25
Long Simple Sequence Repeats in Host-Adapted Pathogens Localize Near Genes Encoding Antigens, Housekeeping Genes, and Pseudogenes
Guo, X., & Mrázek, J. (2008) · Journal of Molecular Evolution · doi:10.1007/s00239-008-9166-5 · Cited by 25
The Two Chorismate Mutases from both Mycobacterium tuberculosis and Mycobacterium smegmatis : Biochemical Analysis and Limited Regulation of Promoter Activity by Aromatic Amino Acids
Schneider, C. Z., Parish, T., Basso, L. A., & Santos, D. S. (2007) · Journal of Bacteriology · doi:10.1128/jb.01332-07 · Cited by 25
Vaccination with the ML0276 Antigen Reduces Local Inflammation but Not Bacterial Burden during Experimental M ycobacterium leprae Infection
Raman, V. S., O’Donnell, J. A., Bailor, H. R., Goto, W., Lahiri, R., Gillis, T. P., Reed, S. G., & Duthie, M. S. (2009) · Infection and Immunity · doi:10.1128/iai.00508-09 · Cited by 25
Mycobacterium tuberculosis Rv1395 Is a Class III Transcriptional Regulator of the AraC Family Involved in Cytochrome P450 Regulation
Recchi, C., Sclavi, B., Rauzier, J., Gicquel, B., & Reyrat, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305963200 · Cited by 25
Cross‐Reaction Between Mammalian Cell Entry (Mce) Proteins of Mycobacterium tuberculosis
Harboe, M., Christensen, A., Ahmad, S., Ulvund, G., Harkness, R. E., Mustafa, A. S., & Wiker, H. G. (2002) · Scandinavian Journal of Immunology · doi:10.1046/j.1365-3083.2002.01172.x · Cited by 25
A polymorphic region in Mycobacterium abscessus contains a novel insertion sequence element b bThe GenBank accession number for the sequence reported in this paper is AF513500.
Howard, S. T., Byrd, T. F., & Lyons, C. R. (2002) · Microbiology · doi:10.1099/00221287-148-10-2987 · Cited by 25
Molecular Basis of the Defective Heat Stress Response inMycobacterium leprae
Williams, D. L., Pittman, T. L., Deshotel, M., Oby-Robinson, S., Smith, I., & Husson, R. N. (2007) · Journal of Bacteriology · doi:10.1128/jb.00601-07 · Cited by 25
Buchnera Bacteria And Other Symbionts Of Aphids
Douglas, A. E. (2003) · Contemporary topics in entomology series · doi:10.1201/9780203009918.ch2 · Cited by 25
How do monomorphic bacteria evolve? The Mycobacterium tuberculosis complex and the awkward population genetics of extreme clonality
Stritt, C., & Gagneux, S. (2023) · Peer Community Journal · doi:10.24072/pcjournal.322 · Cited by 24
Classification and Taxonomy of Actinobacteria
Mohammadipanah, F., & Dehhaghi, M. (2017) · Springer eBooks · doi:10.1007/978-3-319-60339-1_4 · Cited by 24
Genome-wide re-sequencing of multidrug-resistant Mycobacterium leprae Airaku-3
Singh, P., Benjak, A., Carat, S., Kai, M., Busso, P., Avanzi, C., Paniz‐Mondolfi, A., Peter, C., Harshman, K., Rougemont, J., et al. (2014) · Clinical Microbiology and Infection · doi:10.1111/1469-0691.12609 · Cited by 24
Self-citation
The rise and fall of deleterious mutation
Balbi, K. J., & Feil, E. J. (2007) · Research in Microbiology · doi:10.1016/j.resmic.2007.09.005 · Cited by 24
Genome dynamics and evolution of Salmonella Typhi strains from the typhoid-endemic zones
Baddam, R., Kumar, N., Shaik, S., Lankapalli, A. K., & Ahmed, N. (2014) · Scientific Reports · doi:10.1038/srep07457 · Cited by 23
Outer membrane pore protein prediction in mycobacteria using genomic comparison
Mah, N., Perez‐Iratxeta, C., & Andrade-Navarro, M. A. (2010) · Microbiology · doi:10.1099/mic.0.040089-0 · Cited by 25
Genetic Variation in Toll-Interacting Protein Is Associated With Leprosy Susceptibility and Cutaneous Expression of Interleukin 1 Receptor Antagonist
Shah, J. A., Berrington, W. R., Vary, J. C., Wells, R. D., Peterson, G. J., Kunwar, C. B., Khadge, S., Hagge, D. A., & Hawn, T. R. (2015) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiv570 · Cited by 25
Structural and functional analysis of the solute-binding protein UspC from Mycobacterium tuberculosis that is specific for amino sugars
Fullam, E., Prokeš, I., Fütterer, K., & Besra, G. S. (2016) · Open Biology · doi:10.1098/rsob.160105 · Cited by 24
A Molecular Perspective of Microbial Pathogenicity
Relman, D. A., & Falkow, S. (2015) · Elsevier eBooks · doi:10.1016/b978-1-4557-4801-3.00001-1 · Cited by 26
Bacterial Type II Topoisomerases and Target-Mediated Drug Resistance
Gibson, E. G., Ashley, R. E., Kerns, R. J., & Osheroff, N. (2018) · Springer eBooks · doi:10.1007/978-3-319-78538-7_16 · Cited by 25
High resolution CryoEM structure of the ring-shaped virulence factor EspB from Mycobacterium tuberculosis
Piton, J., Pojer, F., Wakatsuki, S., Gati, C., & Cole, S. T. (2020) · Journal of Structural Biology X · doi:10.1016/j.yjsbx.2020.100029 · Cited by 25
Self-citation
Surviving the Macrophage: Tools and Tricks Employed by Mycobacterium tuberculosis
Jayachandran, R., Dasgupta, S. B., & Pieters, J. (2012) · Current topics in microbiology and immunology · doi:10.1007/82_2012_273 · Cited by 24
Transmission of leprosy in Qiubei County, Yunnan, China: Insights from an 8-year molecular epidemiology investigation
Weng, X., Heiden, J. V., Xing, Y., Liu, J., & Vissa, V. (2010) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2010.11.014 · Cited by 24
Gene Arrangements and Phylogeny in the Class Proteobacteria
Kunisawa, T. (2001) · Journal of Theoretical Biology · doi:10.1006/jtbi.2001.2396 · Cited by 24
Mycobacterium tuberculosisgenome-wide screen exposes multiple CD8+ T cell epitopes
Hammond, A. S., Klein, M. R., Corrah, T., Fox, A., Jaye, A., Mcadam, K. P. W. J., & Brookes, R. H. (2005) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2005.02751.x · Cited by 24
Genotypic analysis ofMycobacterium lepraeisolates from Japan and other Asian countries reveals a global transmission pattern of leprosy
Matsuoka, M., López-Roa, R. I., Budiawan, T., Kyaw, K., & Chae, G. (2006) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2006.00346.x · Cited by 24
Genomic analyses of microbial virulence
Sassetti, C. M. (2002) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(02)00281-3 · Cited by 24
Study of the Properties of a Channel-forming Protein of the Cell Wall of the Gram-positive Bacterium Mycobacterium phlei
Rieß, F. G., Dörner, U., Schiffler, B., & Benz, R. (2001) · The Journal of Membrane Biology · doi:10.1007/s00232-001-0037-x · Cited by 24
Reconsidering the Antiquity of Leprosy
Pinhasi, R., Foley, R., & Donoghue, H. D. (2006) · Science · doi:10.1126/science.312.5775.846a · Cited by 24
Mycobacterium leprae virulence-associated peptides are indicators of exposure to M. leprae in Brazil, Ethiopia and Nepal
Bobosha, K., Tang, S. T., Schip, J. J. V. D. P.-V., Bekele, Y., Martins, M. V. S. B., Lund, O., Franken, K. L. M. C., Khadge, S., Pontes, M. A. D. A., Gonçalves, H. D. S., et al. (2012) · Memórias do Instituto Oswaldo Cruz · doi:10.1590/s0074-02762012000900018 · Cited by 23
A systematic review of Mycobacterium leprae DNA gyrase mutations and their impact on fluoroquinolone resistance
Chauffour, A., Morel, F., Reibel, F., Petrella, S., Mayer, C., Cambau, E., & Aubry, A. (2021) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2021.07.007 · Cited by 23
Sensitivity of Mycobacterium leprae to Telacebec
Lahiri, R., Adams, L. B., Thomas, S. S., & Pethe, K. (2022) · Emerging infectious diseases · doi:10.3201/2803.210394 · Cited by 23
Modeling nontuberculous mycobacterial infections in zebrafish
Johansen, M. D., Spaink, H. P., Oehlers, S. H., & Kremer, L. (2023) · Trends in Microbiology · doi:10.1016/j.tim.2023.11.011 · Cited by 22
Multiple loci variable number tandem repeat (VNTR) analysis (MLVA) of Mycobacterium leprae isolates amplified from European archaeological human remains with lepromatous leprosy
Taylor, G. M., & Donoghue, H. D. (2011) · Microbes and Infection · doi:10.1016/j.micinf.2011.05.003 · Cited by 23
Functional characterization of a small heat shock protein from Mycobacterium leprae
Nirmala, L., Rehna, E. A. A., Sugathan, S., Jayapal, J. M., Shankernarayan, N. P., & Dharmalingam, K. (2008) · BMC Microbiology · doi:10.1186/1471-2180-8-208 · Cited by 23
The respiratory tract as a hypothetical route of infection of cattle with Mycobacterium avium subspecies paratuberculosis
Corner, L., Pfeiffer, D. U., & ABBOTT, K. (2004) · Australian Veterinary Journal · doi:10.1111/j.1751-0813.2004.tb12652.x · Cited by 23
A Mycobacterial smc Null Mutant Is Proficient in DNA Repair and Long-Term Survival
Güthlein, C., Wanner, R. M., Sander, P., Böttger, E. C., & Springer, B. (2007) · Journal of Bacteriology · doi:10.1128/jb.01315-07 · Cited by 23
Pyruvate Decarboxylase, the Target for Omeprazole in Metronidazole-Resistant and Iron-Restricted Tritrichomonas foetus
Šuťák, R., Tachezy, J., Kulda, J., & Hrdý, I. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.6.2185-2189.2004 · Cited by 23
The low-affinity phosphate transporter PitA is dispensable for in vitro growth of Mycobacterium smegmatis
Gebhard, S., Ekanayaka, N., & Cook, G. M. (2009) · BMC Microbiology · doi:10.1186/1471-2180-9-254 · Cited by 23
The Contribution of Genomics to the Study of Q Fever
D’Amato, F., Eldin, C., & Raoult, D. (2016) · Future Microbiology · doi:10.2217/fmb.15.137 · Cited by 23
Draft Genome Sequence of New Leprosy Agent Mycobacterium lepromatosis
Han, X. Y., Mistry, N. A., Thompson, E. J., Tang, H.-L., Khanna, K., & Zhang, L. (2015) · Genome Announcements · doi:10.1128/genomea.00513-15 · Cited by 23
Energetics of Respiration and Oxidative Phosphorylation in Mycobacteria
Cook, G. M., Hards, K., Vilchèze, C., Hartman, T. E., & Berney, M. (2015) · ASM Press eBooks · doi:10.1128/9781555818845.ch20 · Cited by 23
ICDS database: interrupted CoDing sequences in prokaryotic genomes
Perrodou, E. (2005) · Nucleic Acids Research · doi:10.1093/nar/gkj060 · Cited by 23
Sterol 14α-demethylase activity in Streptomyces coelicolor A3(2) is associated with an unusual member of the CYP51 gene family
Lamb, D. C., Fowler, K., Kieser, T., Manning, N. J., Podust, L. M., Waterman, M. R., Kelly, D. E., & Kelly, S. L. (2002) · Biochemical Journal · doi:10.1042/bj20011380 · Cited by 23
The microbial physiologist's guide to the leprosy genome
Wheeler, P. R. (2001) · Leprosy Review · doi:10.5935/0305-7518.20010048 · Cited by 23
Self-citation

Authors: Cole, S. T., Eiglmeier, K., Parkhill, J., James, K. D., Thomson, N. R., Wheeler, P. R., Honoré, N., Garnier, T., Churcher, C., Harris, D., Mungall, K., Basham, D., Brown, D., Chillingworth, T., Connor, R., Davies, R. M., Devlin, K., Duthoy, S., Feltwell, T., Fraser, A., Hamlin, N., Holroyd, S., Hornsby, T., Jagels, K., Lacroix, C., Maclean, J., Moule, S., Murphy, L., Oliver, K., Quail, M. A., Rajandream, M.-A., Rutherford, K. M., Rutter, S., Seeger, K., Simon, S., Simmonds, M., Skelton, J., Squares, R., Squares, S., Stevens, K., Taylor, K., Whitehead, S., Woodward, J. R., & Barrell, B. G.
Affiliations: Institut Pasteur (FR)
Wellcome Sanger Institute (GB)
Animal and Plant Health Agency (GB)
Corresponding author: Cole, S. T.
ORCID: Cole, S. T.
Eiglmeier, K.
Parkhill, J.
Thomson, N. R.
Harris, D.
Davies, R. M.
Feltwell, T.
Lacroix, C.
Murphy, L.
Oliver, K.
Quail, M. A.
Rutherford, K. M.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2001-02
Volume: 409
Issue: 6823
Pages: 1007-1011
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/35059006
OpenAlex: W2164217177
Cited by: 1,777
References: 50
Citations by year: 2026: 22 · 2025: 32 · 2024: 34 · 2023: 30 · 2022: 38 · 2021: 41 · 2020: 49 · 2019: 50 · 2018: 51 · 2017: 55 · 2016: 64 · 2015: 75 · 2014: 80 · 2013: 63 · 2012: 79
FWCI: 94.38
Type: journal article
Language: en
Open access: green
infoscience.epfl.ch
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
Funders: New York Community Trust
Wellcome Trust
Topics: Health Sciences › Medicine › Infectious Diseases › Leprosy Research and Treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Research on Leishmaniasis Studies
Keywords: Mycobacterium leprae, leprosy, genome reduction, reductive evolution, pseudogenes, gene decay, Mycobacterium tuberculosis, recombination, gene deletion, siderophore production, electron transport chain
MeSH terms: Animals, Armadillos, DNA, Bacterial, Energy Metabolism, Multigene Family, Humans, Leprosy, Molecular Sequence Data, Mycobacterium leprae, Genome, Bacterial, Sequence Analysis, DNA, Evolution, Molecular, Gene Transfer, Horizontal

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Massive gene decay in the leprosy bacillus.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks