Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration

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  1. Rac1 Mediates Collapse of Microvilli on Chemokine-Activated T Lymphocytes
    Ruchika Nijhara, Paula B. van Hennik, Michelle Gignac, Michael J. Kruhlak, Peter Lodewijk Hordijk, Jérôme Delon, Stephen Shaw · 2004 · The Journal of Immunology
  2. Dock6, a Dock-C subfamily guanine nucleotide exchanger, has the dual specificity for Rac1 and Cdc42 and regulates neurite outgrowth
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  3. The Rac activator Tiam1 controls efficient T-cell trafficking and route of transendothelial migration
    Audrey Gérard, Rob A. van der Kammen, Hans Janssen, Saskia I. J. Ellenbroek, John G. Collard · 2009 · Blood
  4. Genetic Analysis of Hematological Parameters in Incipient Lines of the Collaborative Cross
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  5. The anti‐apoptotic factor Bcl‐2 can functionally substitute for the B cell survival but not for the marginal zone B cell differentiation activity of BAFF
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  6. Activation of Rac1 by Paxillin-Crk-DOCK180 Signaling Complex Is Antagonized by Rap1 in Migrating NBT-II Cells
    Ana María Vallés, Maud Beuvin, Brigitte Boyer · 2004 · Journal of Biological Chemistry
  7. Mechanism of Diapedesis
    Marie–Dominique Filippi · 2015 · Advances in immunology
  8. CCR7-mediated physiological lymphocyte homing involves activation of a tyrosine kinase pathway
    Jens Volker Stein, Silvia F. Soriano, Christine M’Rini, César Nombela‐Arrieta, Gonzalo González de Buitrago, José Miguel Rodrı́guez-Frade, Mario Mellado, Jean‐Philippe Girard, Carlos Martínez‐A · 2002 · Blood
  9. Dock4 is regulated by RhoG and promotes Rac-dependent cell migration
    Kiyo Hiramoto, Masahiko Negishi, Hironori Katoh · 2006 · Experimental Cell Research
  10. Genetic, Clinical, and Laboratory Markers for DOCK8 Immunodeficiency Syndrome
    Jeremiah C. Davis, Christopher G. Dove, Helen C. Su · 2010 · Disease Markers
  11. DOCK2 is involved in the host genetics and biology of severe COVID-19
    Ho Namkoong, Ryuya Edahiro, Tomomi Takano, Hiroshi Nishihara, Yuya Shirai, Kyuto Sonehara, Hiromu Tanaka, Shuhei Azekawa, Yohei Mikami, Ho Lee et al. · 2022 · Nature
  12. Critical roles for Rac GTPases in T-cell migration to and within lymph nodes
    Mustapha Faroudi, Miroslav Hons, Agnieszka Zachacz, Céline Dumont, Ruth Lyck, Jens Volker Stein, Victor L. J. Tybulewicz · 2010 · Blood
  13. CD19 Function in Central and Peripheral B-Cell Development
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  14. The CDM protein DOCK2 in lymphocyte migration
    Karin Reif · 2002 · Trends in Cell Biology
  15. T Cell Receptor (TCR)-induced Tyrosine Phosphorylation Dynamics Identifies THEMIS as a New TCR Signalosome Component
    Claudia Brockmeyer, Wolfgang Paster, David R. Pepper, Choon Ping Tan, David C. Trudgian, Simon J. McGowan, Guo Fu, Nicholas R. J. Gascoigne, Oreste Acuto, Mogjiborahman Salek · 2010 · Journal of Biological Chemistry
  16. CXCL13 mediates prostate cancer cell proliferation through JNK signalling and invasion through ERK activation
    Christelle P El-Haibi, R. Singh, Praveen Sharma, Shailesh Singh, J. W. Lillard · 2011 · Cell Proliferation
  17. The Yaa Mutation Promoting Murine Lupus Causes Defective Development of Marginal Zone B Cells
    Hirofumi Amano, Eri Amano, Thomas Moll, Dragan Marinković, Nabila Ibnou-Zekri, Eduardo Martínez-Soria, Isabelle Semac, Thomas Wirth, Lars Nitschke, Shozo Izui · 2003 · The Journal of Immunology
  18. The Recirculating B Cell Pool Contains Two Functionally Distinct, Long-Lived, Posttransitional, Follicular B Cell Populations
    Annaiah Cariappa, Cristian Boboilă, Stewart T. Moran, Haoyuan Liu, Hai Ning Shi, Shiv S Pillai · 2007 · The Journal of Immunology
  19. Rho GTPases: Masters of T lymphocyte migration and activation
    Pablo Rougerie, Jérôme Delon · 2011 · Immunology Letters
  20. Dock180–ELMO Cooperation in Rac Activation
    Mingjian Lu, Kodi S. Ravichandran · 2006 · Methods in enzymology on CD-ROM/Methods in enzymology
  21. DOCK8 deficiency
    Helen C. Su, Huie Jing, Qian Zhang · 2011 · Annals of the New York Academy of Sciences
  22. Blockade of Inflammatory Responses by a Small-Molecule Inhibitor of the Rac Activator DOCK2
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    Stephen Geoffrey Ward, Federica M. Marelli‐Berg · 2009 · Biochemical Journal
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  25. I’m coming to GEF you: Regulation of RhoGEFs during cell migration
    Silvia M. Goicoechea, Sahezeel S. Awadia, Rafael García‐Mata · 2014 · Cell Adhesion & Migration
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  27. DOCK2 associates with CrkL and regulates Rac1 in human leukemia cell lines
    Hiroshi Nishihara, Masae Maeda, Atsushi Oda, Masumi Tsuda, Hirofumi Sawa, Kazuo Nagashima, Shinya Tanaka · 2002 · Blood
  28. The Transcription Factor Fli-1 Modulates Marginal Zone and Follicular B Cell Development in Mice
    Xian K. Zhang, Omar Moussa, Amanda C. LaRue, Sarah G. Bradshaw, Ivan D. Molano, Demetri D. Spyropoulos, Gary S. Gilkeson, Dennis K. Watson · 2008 · The Journal of Immunology
  29. Immune regulatory functions of DOCK family proteins in health and disease
    Nishikimi, Akihiko, Kukimoto-Niino, Mutsuko, Yokoyama, Shigeyuki, Fukui, Yoshinori · 2013 · Experimental Cell Research
  30. Striking Immune Phenotypes in Gene-Targeted Mice Are Driven by a Copy-Number Variant Originating from a Commercially Available C57BL/6 Strain
    Vinay S. Mahajan, Ezana Demissie, Hamid Mattoo, Vinay Viswanadham, Ajit P Varki, Robert W. Morris, Shiv S Pillai · 2016 · Cell Reports
  31. Spontaneous mutation of the Dock2 gene in Irf5 − / − mice complicates interpretation of type I interferon production and antibody responses
    Whitney E. Purtha, Melissa K. Swiecki, Marco Colonna, Michael S. Diamond, Deepta Bhattacharya · 2012 · Proceedings of the National Academy of Sciences
  32. Transcriptional control of B cell development and function
    Boris Bartholdy, Patrick Matthias · 2003 · Gene
  33. Rac GTPases play critical roles in early T-cell development
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  34. Chemotactic cell movement during development
    Dirk Dormann · 2003 · Current Opinion in Genetics & Development
  35. DOCK2 regulates chemokine-triggered lateral lymphocyte motility but not transendothelial migration
    Ziv Shulman, Ronit Pasvolsky, Eilon Woolf, Valentin Grabovsky, Sara W. Feigelson, Noam Erez A, Yoshinori Fukui, Ronen Alon · 2006 · Blood
  36. Synergism between NF-κB1/p50 and Notch2 during the Development of Marginal Zone B Lymphocytes
    Stewart T. Moran, Annaiah Cariappa, Haoyuan Liu, Beth Muir, Dennis C. Sgroi, Cristian Boboilă, Shiv S Pillai · 2007 · The Journal of Immunology
  37. FTY720-Enhanced T Cell Homing Is Dependent on CCR2, CCR5, CCR7, and CXCR4: Evidence for Distinct Chemokine Compartments
    Adam Charles Yopp, Shuang Fu, Shaun Honig, Gwendalyn J. Randolph, Yaozhong Ding, Nancy R Krieger, Jonathan S. Bromberg · 2004 · The Journal of Immunology
  38. L-Plastin Regulates Polarization and Migration in Chemokine-Stimulated Human T Lymphocytes
    Michael Freeley, Francis O’Dowd, Toby Paul, Dmitry Kashanin, Anthony Mitchell Davies, Dermot P Kelleher, Aideen Long · 2012 · The Journal of Immunology
  39. Differential requirement for DOCK2 in migration of plasmacytoid dendritic cells versus myeloid dendritic cells
    Kazuhito Gotoh, Yoshihiko Tanaka, Akihiko Nishikimi, Ayumi Inayoshi, Munechika Enjoji, Ryoichi Takayanagi, Takehiko Sasazuki, Yoshinori Fukui · 2008 · Blood
  40. CCL21 mediates CD4+ T-cell costimulation via a DOCK2/Rac-dependent pathway
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  41. Structural basis for mutual relief of the Rac guanine nucleotide exchange factor DOCK2 and its partner ELMO1 from their autoinhibited forms
    Hanawa-Suetsugu, Kyoko, Kukimoto-Niino, Mutsuko, Mishima-Tsumagari, Chiemi, Akasaka, Ryogo, Ohsawa, Noboru, Sekine, Shun-ichi, Ito, Takuhiro, Tochio, Naoya, Koshiba, Seizo, Kigawa, Takanori et al. · 2012 · Proceedings of the National Academy of Sciences
  42. CRK proteins selectively regulate T cell migration into inflamed tissues
    Yanping Huang, Fiona Clarke, Mobin A Karimi, Nathan H. Roy, Edward K. Williamson, Mariko Okumura, Kazuhiro Mochizuki, Emily J. H. Chen, Tae‐Ju Park, Gudrun Fiona Debes et al. · 2015 · Journal of Clinical Investigation
  43. T helper type 2 differentiation and intracellular trafficking of the interleukin 4 receptor-α subunit controlled by the Rac activator Dock2
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  44. Zizimin2: a novel, DOCK180‐related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes
    Nishikimi, Akihiko, Meller, Nahum, Uekawa, Natsuko, Isobe, Ken-ichi, Schwartz, Martin A., Maruyama, Mitsuo · 2005 · FEBS Letters
  45. Immune pathology associated with altered actin cytoskeleton regulation
    Dilki C. Wickramarachchi, Argyrios N. Theofilopoulos, Dwight H. Kono · 2009 · Autoimmunity
  46. High-resolution measurements of the multilayer ultra-structure of articular cartilage and their translational potential
    Bo He, Jianping Wu, T.B. Kirk, John A. Carrino, Chuan Xiang, Jiake Xu · 2014 · Arthritis Research & Therapy
  47. Cell Migration Is Regulated by Platelet-Derived Growth Factor Receptor Endocytosis
    Kenji Kawada, Geeta Upadhyay, Sébastien Ferrandon, Sailajah Janarthanan, Matthew Hall, Jean‐Pierre Vilardaga, Vijay Yajnik · 2009 · Molecular and Cellular Biology
  48. Nef Proteins from Diverse Groups of Primate Lentiviruses Downmodulate CXCR4 To Inhibit Migration to the Chemokine Stromal Derived Factor 1
    Kasia Hrecka, Tomek Swigut, Michael Schindler, Frank Kirchhoff, Jacek Skowroński · 2005 · Journal of Virology
  49. Structural Basis of Membrane Targeting by the Dock180 Family of Rho Family Guanine Exchange Factors (Rho-GEFs)
    Premkumar, Lakshmanane, Bobkov, Andrey A., Patel, Manishha, Jaroszewski, Lukasz, Bankston, Laurie A., Stec, Boguslaw, Vuori, Kristiina, Côté, Jean-Francois, Liddington, Robert C. · 2010 · Journal of Biological Chemistry
  50. Chemoattractant Receptor Signaling and the Control of Lymphocyte Migration
    John H. Kehrl · 2006 · Immunologic Research
  51. Human hyper-IgE syndrome: singular or plural?
    Zhang, Qian, Boisson, Bertrand, Béziat, Vivien, Puel, Anne, Casanova, Jean-Laurent · 2018 · Mammalian Genome
  52. Crk-Associated Substrate Lymphocyte Type Is Required for Lymphocyte Trafficking and Marginal Zone B Cell Maintenance
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  53. DOCK2 and DOCK5 Act Additively in Neutrophils To Regulate Chemotaxis, Superoxide Production, and Extracellular Trap Formation
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  54. Duplication of the SLIT3 Locus on 5q35.1 Predisposes to Major Depressive Disorder
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  55. Targeting Ras-Driven Cancer Cell Survival and Invasion through Selective Inhibition of DOCK1
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  56. T lymphocytes on the move: chemokines, PI 3-kinase and beyond
    Stephen Geoffrey Ward · 2006 · Trends in Immunology
  57. IRF5-mediated signaling and implications for SLE
    Elisa Lazzari, Caroline Anne Jefferies · 2014 · Clinical Immunology
  58. Gut-adipose tissue axis in hepatic fat accumulation in humans
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  59. Integrin Regulation of Lymphocyte Trafficking: Lessons from Structural and Signaling Studies
    Tatsuo Kinashi · 2007 · Advances in immunology
  60. Phosphatidylinositol 3,4,5-Triphosphate-Dependent Rac Exchanger 1 (P-Rex-1), a Guanine Nucleotide Exchange Factor for Rac, Mediates Angiogenic Responses to Stromal Cell-Derived Factor-1/Chemokine Stromal Cell Derived Factor-1 (SDF-1/CXCL-12) Linked to Rac Activation, Endothelial Cell Migration, and in Vitro Angiogenesis
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  61. PI3Kp110-, Src-, FAK-dependent and DOCK2-independent migration and invasion of CXCL13-stimulated prostate cancer cells
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