The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.
Molecular mechanisms of nociception
Abstract
The sensation of pain alerts us to real or impending injury and triggers appropriate protective responses. Unfortunately, pain often outlives its usefulness as a warning system and instead becomes chronic and debilitating. This transition to a chronic phase involves changes within the spinal cord and brain, but there is also remarkable modulation where pain messages are initiated - at the level of the primary sensory neuron. Efforts to determine how these neurons detect pain-producing stimuli of a thermal, mechanical or chemical nature have revealed new signalling mechanisms and brought us closer to understanding the molecular events that facilitate transitions from acute to persistent pain.
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“Therefore, it is possible that a ZnIUD would cause users less pain and bleeding compared to the CuIUD, due to the absence of localised inflammation (24,25).”
From Zinc as a non-hormonal contraceptive: a better alternative to the copper intrauterine device (IUD) (2022) · cites this paper as [24]
Citations
Cites
The capsaicin receptor: a heat-activated ion channel in the pain pathway
Caterina, M. J., Schumacher, M. A., Tominaga, M., Rosen, T. A., Levine, J. D., & Julius, D. J. (1997) · Nature · doi:10.1038/39807 · Cited by 9,132
Self-citationThe Integrative Action of the Nervous System.
Sherrington, C. (1907) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-190734120-00021 · Cited by 4,136
Neuronal plasticity: Increasing the gain in pain
Woolf, C. J., & Salter, M. W. (2000) · Science · doi:10.1126/science.288.5472.1765 · Cited by 3,781 · cited 1×
“Moreover, because expression of neurotransmitters, their receptors and other signalling molecules are dramatically altered after tissue or nerve injur”
BackgroundImpaired nociception and pain sensation in mice lacking the capsaicin receptor
Caterina, M. J., Leffler, A., Malmberg, A. B., Martin, W. J., Trafton, J., Petersen-Zeitz, K. R., Koltzenburg, M., Basbaum, A. I., & Julius, D. (2000) · Science · doi:10.1126/science.288.5464.306 · Cited by 3,544
Self-citationThe Cloned Capsaicin Receptor Integrates Multiple Pain-Producing Stimuli
Tominaga, M., Caterina, M. J., Malmberg, A. B., Rosen, T. A., Gilbert, H., Skinner, K., Raumann, B. E., Basbaum, A. I., & Julius, D. J. (1998) · Neuron · doi:10.1016/s0896-6273(00)80564-4 · Cited by 3,086
Self-citationBonica, J. J., Melzack, R., & Wall, P. D. (1999) · Cited by 2,537
Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide
Zygmunt, P. M., Petersson, J., Andersson, D. A., Chuang, H.-H., Sørgård, M., Di Marzo, V., Julius, D., & Högestätt, E. D. (1999) · Nature · doi:10.1038/22761 · Cited by 2,142
Self-citationVanilloid receptor-1 is essential for inflammatory thermal hyperalgesia
Davis, J. B., Gray, J., Gunthorpe, M. J., Hatcher, J. P., Davey, P. T., Overend, P., Harries, M. H., Latcham, J., Clapham, C. M., Atkinson, K., et al. (2000) · Nature · doi:10.1038/35012076 · Cited by 1,781
A capsaicin-receptor homologue with a high threshold for noxious heat
Caterina, M. J., Rosen, T. A., Tominaga, M., Brake, A. J., & Julius, D. J. (1999) · Nature · doi:10.1038/18906 · Cited by 1,599
Self-citationSamad, T. A., Moore, K. A., Sapirstein, A., Billet, S. E., Allchorne, A. J., Poole, S., Bonventre, J. V., & Woolf, C. J. (2001) · Nature · doi:10.1038/35068566 · Cited by 1,282
Flagged first, then by citations
Research works printed but not linked: 5
- Basbaum, A. I. & Jessell, T. M. in Principles of Neuroscience (eds Kandel, E. R., Schwartz, J. H. & Jessell, T. M.) 472–491 (McGraw-Hill, New York, 2000).
- Bevan, S. in Textbook of Pain (eds Wall, P. D. & Melzack, R.) 85–103 (Churchill-Livingstone, New York, 1999).
- Levine, J. D. & Reichling, D. B. in Textbook of Pain (eds Wall, P. D. & Melzack, R.) 59–84 (Churchill-Livingstone, New York, 1999).
- McMahon, S. B. & Bennett, D. L. H. in Textbook of Pain (eds Wall, P. D. & Melzack, R.) 105–128 (Harcourt, London, 1999).
- Fields, H. L. Pain (McGraw-Hill, New York, 1987).
Cited by
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Items 1,001–1,003 of 1,003
Acute Pain Service: Past, Present and Future
Tawfic, Q. A., & Faris, A. S. (2015) · Pain Management · doi:10.2217/pmt.14.48 · Cited by 29
Two to tango: GPCR oligomers and GPCR-TRP channel interactions in nociception
Yekkirala, A. S. (2013) · Life Sciences · doi:10.1016/j.lfs.2012.06.021 · Cited by 24
Zinc as a non-hormonal contraceptive: a better alternative to the copper intrauterine device (IUD)
Shankie-Williams, K., Lindsay, L., Murphy, C., & Dowland, S. (2022) · doi:10.1101/2022.03.24.485705 · Cited by 3
Metadata
- Authors
- Julius, D., & Basbaum, A. I.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Julius, David
- Venue
- Nature
- Published
- 2001-09
- Volume
- 413
- Issue
- 6852
- Pages
- 203-210
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1883044208
- Cited by
- 2,685
- References
- 73
- Citations by year
- 2026: 63 · 2025: 66 · 2024: 95 · 2023: 91 · 2022: 100 · 2021: 103 · 2020: 94 · 2019: 138 · 2018: 119 · 2017: 113 · 2016: 109 · 2015: 114 · 2014: 147 · 2013: 144 · 2012: 117
- FWCI
- 8.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Bristol-Myers Squibb
- National Institutes of Health
- National Institute of Mental Health
- Topics
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Keywords
- nociception, pain, chronic pain, primary sensory neurons, pain detection, thermal pain, mechanical pain, chemical pain, acute to chronic pain transition, pain signalling, molecular mechanisms
- MeSH terms
- Animals, Forecasting, Humans, Neurons, Afferent, Pain, Signal Transduction
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