Cited by 2,685Pain Mechanisms and TreatmentsIon Channels and ReceptorsIon channel regulation and function

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Molecular mechanisms of nociception

Julius, David, Basbaum, Allan I.·2001·Nature

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Abstract

The sensation of pain alerts us to real or impending injury and triggers appropriate protective responses. Unfortunately, pain often outlives its usefulness as a warning system and instead becomes chronic and debilitating. This transition to a chronic phase involves changes within the spinal cord and brain, but there is also remarkable modulation where pain messages are initiated - at the level of the primary sensory neuron. Efforts to determine how these neurons detect pain-producing stimuli of a thermal, mechanical or chemical nature have revealed new signalling mechanisms and brought us closer to understanding the molecular events that facilitate transitions from acute to persistent pain.

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The capsaicin receptor: a heat-activated ion channel in the pain pathway
Caterina, M. J., Schumacher, M. A., Tominaga, M., Rosen, T. A., Levine, J. D., & Julius, D. J. (1997) · Nature · doi:10.1038/39807 · Cited by 9,132
Self-citation
The Integrative Action of the Nervous System.
Sherrington, C. (1907) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-190734120-00021 · Cited by 4,136
Neuronal plasticity: Increasing the gain in pain
Woolf, C. J., & Salter, M. W. (2000) · Science · doi:10.1126/science.288.5472.1765 · Cited by 3,781 · cited 1×
“Moreover, because expression of neurotransmitters, their receptors and other signalling molecules are dramatically altered after tissue or nerve injur”
Background
Impaired nociception and pain sensation in mice lacking the capsaicin receptor
Caterina, M. J., Leffler, A., Malmberg, A. B., Martin, W. J., Trafton, J., Petersen-Zeitz, K. R., Koltzenburg, M., Basbaum, A. I., & Julius, D. (2000) · Science · doi:10.1126/science.288.5464.306 · Cited by 3,544
Self-citation
The Cloned Capsaicin Receptor Integrates Multiple Pain-Producing Stimuli
Tominaga, M., Caterina, M. J., Malmberg, A. B., Rosen, T. A., Gilbert, H., Skinner, K., Raumann, B. E., Basbaum, A. I., & Julius, D. J. (1998) · Neuron · doi:10.1016/s0896-6273(00)80564-4 · Cited by 3,086
Self-citation
Textbook of pain
Bonica, J. J., Melzack, R., & Wall, P. D. (1999) · Cited by 2,537
Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide
Zygmunt, P. M., Petersson, J., Andersson, D. A., Chuang, H.-H., Sørgård, M., Di Marzo, V., Julius, D., & Högestätt, E. D. (1999) · Nature · doi:10.1038/22761 · Cited by 2,142
Self-citation
Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia
Davis, J. B., Gray, J., Gunthorpe, M. J., Hatcher, J. P., Davey, P. T., Overend, P., Harries, M. H., Latcham, J., Clapham, C. M., Atkinson, K., et al. (2000) · Nature · doi:10.1038/35012076 · Cited by 1,781
A capsaicin-receptor homologue with a high threshold for noxious heat
Caterina, M. J., Rosen, T. A., Tominaga, M., Brake, A. J., & Julius, D. J. (1999) · Nature · doi:10.1038/18906 · Cited by 1,599
Self-citation
Interleukin-1β-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity
Samad, T. A., Moore, K. A., Sapirstein, A., Billet, S. E., Allchorne, A. J., Poole, S., Bonventre, J. V., & Woolf, C. J. (2001) · Nature · doi:10.1038/35068566 · Cited by 1,282

Show all 73 references

Research works printed but not linked: 5

Basbaum, A. I. & Jessell, T. M. in Principles of Neuroscience (eds Kandel, E. R., Schwartz, J. H. & Jessell, T. M.) 472–491 (McGraw-Hill, New York, 2000).
Bevan, S. in Textbook of Pain (eds Wall, P. D. & Melzack, R.) 85–103 (Churchill-Livingstone, New York, 1999).
Levine, J. D. & Reichling, D. B. in Textbook of Pain (eds Wall, P. D. & Melzack, R.) 59–84 (Churchill-Livingstone, New York, 1999).
McMahon, S. B. & Bennett, D. L. H. in Textbook of Pain (eds Wall, P. D. & Melzack, R.) 105–128 (Harcourt, London, 1999).
Fields, H. L. Pain (McGraw-Hill, New York, 1987).

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Background
Effect Sizes in Experimental Pain Produced by Gender, Genetic Variants and Sensitization Procedures
Doehring, A., Küsener, N., Flühr, K., Neddermeyer, T. J., Schneider, G., & Lötsch, J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017724 · Cited by 64
“Pain is a complex and multi-factorial [1] trait and influenced by various and heterogeneous factors such as gender [2], genetic [3] or environmental causes [4].”
Background
Connections between nerve endings and epidermal cells: are they synapses?
Château, Y., & Misery, L. (2004) · Experimental Dermatology · doi:10.1111/j.0906-6705.2004.00158.x · Cited by 64
Periganglionic inflammation elicits a distally radiating pain hypersensitivity by promoting COX-2 induction in the dorsal root ganglion
Amaya, F., Samad, T. A., Barrett, L. B., Broom, D. C., & Woolf, C. J. (2009) · Pain · doi:10.1016/j.pain.2008.11.013 · Cited by 64
“Peripheral inflammation induces a local inflammatory hyperalgesia that is due both to the sensitization of nociceptor peripheral terminals at the site of the inflammation (peripheral sensitization) [27] and of dorsal horn neurons (central sensitization) [60], both of which involve COX-2 induction, the former locally i…”
Background
Interaction between Protein Kinase Cμ and the Vanilloid Receptor Type 1
Wang, Y., Kedei, N., Wang, M., Wang, Q. J., Huppler, A. R., Tóth, A., Tran, R., & Blumberg, P. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m410331200 · Cited by 64
The Interplay between Chronic Pain, Opioids, and the Immune System
Malafoglia, V., Ilari, S., Vitiello, L., Tenti, M., Balzani, E., Muscoli, C., Raffaeli, W., & Bonci, A. (2021) · The Neuroscientist · doi:10.1177/10738584211030493 · Cited by 64
“Opioid release is triggered by several endogenous factors, including temperature, low pH, proteolytic activity, or local inflammatory factors (Julius and Basbaum 2001).”
Background
The α7 nicotinic ACh receptor agonist compound B and positive allosteric modulator PNU‐120596 both alleviate inflammatory hyperalgesia and cytokine release in the rat
Munro, G., Hansen, R., Erichsen, H. K., Timmermann, D. B., Christensen, J., & Hansen, H. H. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.02003.x · Cited by 63
“…trauma or injury to cutaneous tissues, tissue acidification, combined with the local release of peptides, cytokines and prostanoids, initiates and contributes to neurogenic inflammatory processes, which act to lower the threshold of activation of peripheral nociceptors (Julius and Basbaum, 2001).”
Background
Airway effects of repeated exposures to ozone-initiated limonene oxidation products as model of indoor air mixtures
Wolkoff, P., Clausen, P. A., Larsen, S. T., Hammer, M., & Nielsen, G. D. (2011) · Toxicology Letters · doi:10.1016/j.toxlet.2011.12.008 · Cited by 63
“As the NOEL is from a protective reflex (Alarie, 1973; Julius and Basbaun, 2001), a factor is needed for extrapolation from the mouse NOEL to a NOEL estimate in humans.”
Background
5-HT acts on nociceptive primary afferents through an indirect mechanism to induce hyperalgesia in the subcutaneous tissue
Oliveira, M. C. G., Pelegrini-da-Silva, A., Parada, C. A., & Tambeli, C. H. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2006.12.021 · Cited by 63
Antinociceptive activity of fractions from Couroupita guianensis Aubl. leaves
Pinheiro, M. M. G., Fernandes, S. B. D. O., Fingolo, C. E., Kuster, R. M., Matheus, M. E., Boylan, F., & Fernandes, P. D. (2009) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2009.10.025 · Cited by 63
Neuromodulation, Specialized Proresolving Mediators, and Resolution of Pain
Tao, X., Lee, M. S., Donnelly, C. R., & Ji, R. (2020) · Neurotherapeutics · doi:10.1007/s13311-020-00892-9 · Cited by 63
Pharmacogenetics of new analgesics
Lötsch, J., & Geißlinger, G. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.01074.x · Cited by 62
“Consistent with the multifactorial nature of pain (Julius and Basbaum, 2001), translational and genetic research have identified several new analgesic targets (Backonja and Woolf, 2010), for which analgesics are being developed (Table 1).”
Background
Persistent mechanical allodynia positively correlates with an increase in activated microglia and increased P ‐p38 mitogen‐activated protein kinase activation in streptozotocin‐induced diabetic rats
Cheng, K.-F., Wang, H., Chuang, Y. ‐., Chou, C.-W., Tu, H., Yu, Y. ‐., Chang, L., & Lai, C. (2013) · European Journal of Pain · doi:10.1002/j.1532-2149.2013.00356.x · Cited by 62
“A thermosensitive transient receptor potential cation channel is sensitized by inflammatory mediators, localized ischaemia or tissue acidification (Julius and Basbaum, 2001) through sensitization of Aδ- and C-fibre nociceptors.”
Background
Curcumin Attenuates CFA Induced Thermal Hyperalgesia by Modulation of Antioxidant Enzymes and Down Regulation of TNF-α, IL-1β and IL-6
Singh, A. K., & Vinayak, M. (2014) · Neurochemical Research · doi:10.1007/s11064-014-1489-6 · Cited by 62
“The acidic nature of the inflammatory soup is also involved [26].”
Background
Modulation of Ion Channels and Synaptic Transmission by a Human Sensory Neuron-Specific G-Protein-Coupled Receptor, SNSR4/mrgX1, Heterologously Expressed in Cultured Rat Neurons
Chen, H., & Ikeda, S. R. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0990-04.2004 · Cited by 62
“8), an ATP-gated ion channel (P2X3 receptor), and a nonselective cationic channel (vanilloid receptor VR1) activated by capsaicin, noxious heat, and extracellular protons (Julius and Basbaum, 2001).”
Background
Expression and Function of Proton-Sensing G-Protein-Coupled Receptors in Inflammatory Pain
Chen, Y., Huang, C.-W., Lin, C.-S., Chang, W., & Sun, W. (2009) · Molecular Pain · doi:10.1186/1744-8069-5-39 · Cited by 62
Effects of bee venom peptidergic components on rat pain-related behaviors and inflammation
Chen, Y.-N., Li, K.-C., Li, Z., Shang, G.-W., Liu, D. N., Lu, Z.-M., Zhang, J.-W., Ji, Y.-H., Gao, G.-D., & Chen, J. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2005.11.022 · Cited by 62
Antinociceptive Properties of the Hydroalcoholic Extract and the Flavonoid Rutin Obtained fromPolygala paniculataL. in Mice
Lapa, F. D. R., Gadotti, V. M., Missau, F. C., Pizzolatti, M. G., Marques, M. C. A., Dafré, A. L., Farina, M., Rodrigues, A. L. S., & Santos, A. R. S. (2009) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2008.00365.x · Cited by 62
Role of leak potassium channels in pain signaling
Li, X., & Toyoda, H. (2015) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2015.08.007 · Cited by 59
Local Anesthetics Suppress Nerve Growth Factor-Mediated Neurite Outgrowth by Inhibition of Tyrosine Kinase Activity of TrkA
Takatori, M., Kuroda, Y., & Hirose, M. (2006) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000194334.69103.50 · Cited by 61
“In addition to the important factor for sympathetic sprouting, NGF, which is released by mast cells, fibroblasts, and other cell types at sites of injury and inflammation, is also important for nociception and long-lasting pain in conditions of inflammation and induces peripheral sensitization in the primary sensory n…”
Background
Sex-specificity and estrogen-dependence of kappa opioid receptor-mediated antinociception and antihyperalgesia
Lawson, K. P., Nag, S., Thompson, A. D., & Mokha, S. S. (2010) · Pain · doi:10.1016/j.pain.2010.09.018 · Cited by 61
“It is known that C- and Ad-fibers mediate the transmission of heat stimuli, whereas thinly myelinated Ad-fibers transmit mechanical stimulation [30].”
Atorvastatin attenuates neuropathic pain in rat neuropathy model by down-regulating oxidative damage at peripheral, spinal and supraspinal levels
Pathak, N. N., Balaganur, V., Lingaraju, M. C., Kant, V., Latief, N., More, A. S., Kumar, D., Kumar, D., & Tandan, S. K. (2014) · Neurochemistry International · doi:10.1016/j.neuint.2014.01.014 · Cited by 61
“Such pain can be characterized by hyperalgesia and allodynia (Julius and Basbaum, 2001).”
Background
Mechanism underlying anti-hyperalgesic and anti-allodynic properties of anomalin in both acute and chronic inflammatory pain models in mice through inhibition of NF-κB, MAPKs and CREB signaling cascades
Khan, S., Shehzad, O., Chun, J., & Kim, Y. S. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.07.039 · Cited by 61
“Inflammatory pain is induced by different chemical mediators released during an inflammatory process, which cause nociceptive sensitization (Julius and Basbaum, 2001).”
Background
Analgo-Sedation of Patients with Burns Outside the Operating Room
Gregoretti, C., Decaroli, D., Piacevoli, Q., Mistretta, A., Barzaghi, N., Luxardo, N., Tosetti, I., Tedeschi, L., Burbi, L., Navalesi, P., et al. (2012) · Drugs · doi:10.2165/0003495-200868170-00003 · Cited by 55
Observing Anti-inflammatory and Anti-nociceptive Activities of Glycyrrhizin Through Regulating COX-2 and Pro-inflammatory Cytokines Expressions in Mice
Wang, H., Li, Y., Niu, Y.-T., Zheng, J., Wu, J. H., Shi, G., Ma, L., Niu, Y., Sun, T., & Yu, J. (2015) · Inflammation · doi:10.1007/s10753-015-0212-3 · Cited by 60
“Inflammatory pain is primarily due to the sensitization of specific classes of nociceptive neurons by the direct action of inflammatory mediators [1].”
In vivo birthdating by BAPTISM reveals that trigeminal sensory neuron diversity depends on early neurogenesis
Caron, S. J. C., Prober, D. A., Choy, M., & Schier, A. F. (2008) · Development · doi:10.1242/dev.023200 · Cited by 61
“Somatosensory organs recognize a wide range of stimuli such as noxious chemicals, pressure and temperature (for a review, see Julius and Basbaum, 2001).”
Background
Decubital shoulder ulcers in sows: a review of classification, pain and welfare consequences
Herskin, M. S., Bonde, M., Jørgensen, E., & Jensen, K. H. (2010) · animal · doi:10.1017/s175173111000203x · Cited by 61
“The presence of infection will, in general, increase pain related to any lesion (e.g. review by Dray, 1995; Gregory, 1998; Julius and Basbaum, 2001) leading to spontaneous pain and hyperalgesia in the lesion as well as in the surrounding tissue.”
Background
Pain following hysterectomy: epidemiological and clinical aspects.
Brandsborg, B. (2012) · PubMed · Cited by 60
Involvement of phosphorylated Ca2+/calmodulin-dependent protein kinase II and phosphorylated extracellular signal-regulated protein in the mouse formalin pain model
Choi, S.-S., Seo, Y., Shim, E., Kwon, M.-S., Lee, J., Ham, Y.-O., & Suh, H. (2006) · Brain Research · doi:10.1016/j.brainres.2006.06.048 · Cited by 61
Macrophages and microglia in inflammation and neuroinflammation underlying different pain states
Ouyang, C., Luo, X., & Ji, R. (2023) · Medical Review · doi:10.1515/mr-2023-0034 · Cited by 67
“Nociceptors are a diverse group of neurons that can be characterized by factors such as their myelination level, soma size, electrophysiological properties, and molecular markers [14 – 18].”
Background
Botulinum Toxin Type A for the Treatment of Neuropathic Pain in Neuro-Rehabilitation
Intiso, D., Basciani, M., Santamato, A., Intiso, M. B. D., & Rienzo, F. D. (2015) · Toxins · doi:10.3390/toxins7072454 · Cited by 60
“They are located at the free nerve endings of unmyelinated C fibers and lightly myelinated Aδ fibers [22].”
Background
Perioperative Pain Management in the Neurosurgical Patient
Lai, L. T., Ortiz-Cardona, J. R., & Bendo, A. A. (2012) · Anesthesiology Clinics · doi:10.1016/j.anclin.2012.05.004 · Cited by 60
The development of peripheral cold neural circuits based on TRPM8 expression
Takashima, Y., Ma, L., & McKemy, D. D. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.05.039 · Cited by 60
Capsaicin for Neuropathic Pain: Linking Traditional Medicine and Molecular Biology
Haanpää, M. L., & Treede, R. (2012) · European Neurology · doi:10.1159/000339944 · Cited by 60
Mu-opioid receptor knockout prevents changes in delta-opioid receptor trafficking induced by chronic inflammatory pain
Morinville, A., Cahill, C. M., Kieffer, B. L., Collier, B., & Beaudet, A. (2004) · Pain · doi:10.1016/j.pain.2004.01.011 · Cited by 60
“Plastic changes have been documented to occur in the spinal cord in response to persistent inflammatory pain (Julius and Basbaum, 2001).”
Astrocytes—Multitaskers in chronic pain
Hansen, R. B., & Malcangio, M. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.03.023 · Cited by 61
Assessment of the Potential Role of Muscle Spindle Mechanoreceptor Afferents in Chronic Muscle Pain in the Rat Masseter Muscle
Lund, J. P., Sadeghi, S., Athanassiadis, T., Salas, N. C., Auclair, F., Thivierge, B., Arsenault, I., Rompre, P. H., Westberg, K.-G., & Kolta, A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011131 · Cited by 60
Modulation of Pain in Osteoarthritis
Hancock, C. M., & Riegger‐Krugh, C. (2008) · Clinical Journal of Pain · doi:10.1097/ajp.0b013e31815e5418 · Cited by 60
Comparison of quadriceps inactivation between nerve and muscle stimulation
Place, N., Casartelli, N. C., Item‐Glatthorn, J. F., & Maffiuletti, N. A. (2010) · Muscle & Nerve · doi:10.1002/mus.21776 · Cited by 60
“discomfort, which varies considerably between individuals,(29) is mainly mediated by Ad and C fibers.(30) Ab fibers are recruited at very low levels of stimulation, such as at detection threshold, contrary to smaller Ad and C fibers, which are”
Background
Antinociceptive actions of honokiol and magnolol on glutamatergic and inflammatory pain
Lin, Y.-R., Chen, H., Lin, Y., Ko, C.-H., & Chan, M. (2009) · Journal of Biomedical Science · doi:10.1186/1423-0127-16-94 · Cited by 60
“It is believed that substance P induced signaling pathway is involved in the inflammatory process and in the transmission of sensory nociceptive information [30,35, 36 ].”
Background
Diosmin reduces chronic constriction injury-induced neuropathic pain in mice
Bertozzi, M. M., Rossaneis, A. C., Fattori, V., Longhi-Balbinot, D. T., de Freitas, A., Cunha, F. Q., Alves-Filho, J. C., Cunha, T. M., Casagrande, R., & Verri, W. A., Jr. (2017) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2017.06.014 · Cited by 63
Dorsal Root Ganglion Neuron Types and Their Functional Specialization
Emery, E. C., & Ernfors, P. (2018) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780190860509.013.4 · Cited by 63
TRPV2, a capsaicin receptor homologue, is expressed predominantly in the neurotrophin-3-dependent subpopulation of primary sensory neurons
Tamura, S., Morikawa, Y., & Senba, E. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.09.021 · Cited by 61
Airway effects of inhaled quaternary ammonium compounds in mice
Larsen, S. T., Verder, H., & Nielsen, G. D. (2012) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2011.00851.x · Cited by 57

Authors: Julius, D., & Basbaum, A. I.
Affiliations: University of California, San Francisco (US)
Corresponding author: Julius, David
ORCID: Julius, David
Basbaum, Allan I.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2001-09
Volume: 413
Issue: 6852
Pages: 203-210
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/35093019
OpenAlex: W1883044208
Cited by: 2,685
References: 73
Citations by year: 2026: 63 · 2025: 66 · 2024: 95 · 2023: 91 · 2022: 100 · 2021: 103 · 2020: 94 · 2019: 138 · 2018: 119 · 2017: 113 · 2016: 109 · 2015: 114 · 2014: 147 · 2013: 144 · 2012: 117
FWCI: 8.09
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: Bristol-Myers Squibb
National Institutes of Health
National Institute of Mental Health
Topics: Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Keywords: nociception, pain, chronic pain, primary sensory neurons, pain detection, thermal pain, mechanical pain, chemical pain, acute to chronic pain transition, pain signalling, molecular mechanisms
MeSH terms: Animals, Forecasting, Humans, Neurons, Afferent, Pain, Signal Transduction

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