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Partial leptin deficiency and human adiposity
Abstract
The adipocyte-derived hormone leptin is crucial for energy homeostasis in mammals; mice and humans without it suffer from a voracious appetite and extreme obesity. The effect on energy balance of variations in plasma leptin above a minimal threshold is uncertain, however, particularly in humans. Here we examine a group of individuals who are genetically partially deficient in leptin, and show that differences in circulating leptin levels within the range found in normal human populations can directly influence the laying down of fat tissue (adiposity).
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“Mutations in the leptin pathway can be a cause of human obesity (5–7).”
From Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults (2004) · cites this paper as [5]
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Cites
Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
Congenital leptin deficiency is associated with severe early-onset obesity in humans
Montague, C. T., Farooqi, I. S., Whitehead, J. P., Soos, M. A., Rau, H., Wareham, N. J., Sewter, C. P., Digby, J. E., Mohammed, S. N., Hurst, J. A., et al. (1997) · Nature · doi:10.1038/43185 · Cited by 2,936
Self-citationEffects of Recombinant Leptin Therapy in a Child with Congenital Leptin Deficiency
Farooqi, I. S., Jebb, S. A., Langmack, G., Lawrence, E., Cheetham, C. H., Prentice, A. M., Hughes, I. A., McCamish, M. A., & O'Rahilly, S. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909163411204 · Cited by 1,998
Self-citationHeymsfield, S. B., Greenberg, A. S., Fujioka, K., Dixon, R. M., Kushner, R., Hunt, T., Lubina, J. A., Patane, J., Self, B., Hunt, P., et al. (1999) · JAMA · doi:10.1001/jama.282.16.1568 · Cited by 1,422
Body mass index as a measure of body fatness: age- and sex-specific prediction formulas
Deurenberg, P., Weststrate, J., & Seidell, J. C. (1991) · British Journal of Nutrition · doi:10.1079/bjn19910073 · Cited by 1,397
What's in a Name? In Search of Leptin's Physiologic Role
Flier, J. S. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.5.4779 · Cited by 576
Havel, P. J. (2000) · Proceedings of The Nutrition Society · doi:10.1017/s0029665100000410 · Cited by 330
Relatively low plasma leptin concentrations precede weight gain in Pima Indians
Ravussin, É., Pratley, R. E., Maffei, M., Wang, H., Friedman, J. M., Bennett, P. H., & Bogardus, C. (1997) · Nature Medicine · doi:10.1038/nm0297-238 · Cited by 240
Metabolic fluctuation during a muscle contraction cycle
Chung, Y., Sharman, R. B., Carlsen, R. C., Unger, S. W., Larson, D. E., & Jue, T. (1998) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1998.274.3.c846 · Cited by 73
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- Flier, J. S. J. Clin. Endocrinol. Metab. 83, 1407–1413 (1998).
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da Fonseca, A. C. P., Abreu, G. D. M., Zembrzuski, V. M., Campos, M., Carneiro, J. R. I., Neto, J. F. N., Magno, F. C. C. M., Rosado, E. L., Bozza, P. T., de Cabello, G. M. K., et al. (2020) · Eating and Weight Disorders - Studies on Anorexia Bulimia and Obesity · doi:10.1007/s40519-020-00946-z · Cited by 28
Cao, Y., Liu, X., Zhang, L., Wu, Y., You, C., Li, H., Duan, H., Huang, J., & Lv, P. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.3c18905 · Cited by 27
Adipocyte biology and adipocytokines
Haque, W. A., & Garg, A. (2004) · Clinics in Laboratory Medicine · doi:10.1016/j.cll.2004.01.007 · Cited by 27
Microarray gene expression profiling in obesity and insulin resistance
Permana, P. A., Parigi, A. D., & Tataranni, P. A. (2003) · Nutrition · doi:10.1016/j.nut.2003.09.023 · Cited by 27
Dietary fiber improves lipid homeostasis and modulates adipocytokines in hamsters
Hung, S., Bartley, G. E., Young, S. A., Albers, D. R., Dielman, D., Anderson, W. H. K., & YOKOYAMA, W. H. (2009) · Journal of Diabetes · doi:10.1111/j.1753-0407.2009.00034.x · Cited by 26
Association of Long‐term Change in Waist Circumference With Insulin Resistance
Park, K., Lee, D., Erickson, D. J., Himes, J. H., Shikany, J. M., & Jacobs, D. R. (2009) · Obesity · doi:10.1038/oby.2009.252 · Cited by 27
ABDOMINAL OBESITY STUDY GROUP, von Eyben, F. E., Kroustrup, J. P., Larsen, J. F., & Celis, J. E. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1329.063 · Cited by 27
Neuropeptide gene polymorphisms and human behavioural disorders
Inui, A. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1252 · Cited by 25
SERPINE 1 Links Obesity and Diabetes: A Pilot Study
Kaur, P., Reis, M. D., Couchman, G. R., Forjuoh, S. N., & Greene, J. F. (2010) · Journal of Proteomics & Bioinformatics · doi:10.4172/jpb.1000139 · Cited by 25
Genetic Contributions to Body Weight in Mice: Relationship of Exploratory Behavior to Weight
Zhang, S., & Gershenfeld, H. K. (2003) · Obesity Research · doi:10.1038/oby.2003.114 · Cited by 25
Becetti, I., Bwenyi, E. L., de Araújo, I. E., Ard, J. D., Cryan, J. F., Farooqi, I. S., Ferrario, C. R., Gluck, M. E., Holsen, L. M., Kenny, P. J., et al. (2023) · American Journal of Clinical Nutrition · doi:10.1016/j.ajcnut.2023.05.003 · Cited by 26
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Tschöp, M. H., & Friedman, J. M. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.adh4453 · Cited by 25
Foster, S. R., Omoruyi, F. O., Bustamante, J. J., Alexander-Lindo, R. L., & Dilworth, L. (2016) · International Journal of Experimental Pathology · doi:10.1111/iep.12210 · Cited by 24
Cintra, D. E., Ropelle, E. R., & Pauli, J. R. (2007) · Revista de Neurología · doi:10.33588/rn.4511.2006612 · Cited by 24
Monogenic human obesity syndromes
Farooqi, I. S. (2006) · Progress in brain research · doi:10.1016/s0079-6123(06)53006-7 · Cited by 24
Self-citationGene expression profiles of adipose tissue of high-fat diet-induced obese rats by cDNA microarrays
Qiu, J., Cheng, R., Zhou, X., Zhu, J., Zhu, C., Qin, D., Kou, C., & Guo, X. (2010) · Molecular Biology Reports · doi:10.1007/s11033-010-0021-6 · Cited by 23
Bünger, L., Forsting, J., McDonald, K. L., Horvat, S., Duncan, J. S., Hochscheid, S., Baile, C. A., Hill, W. G., & Speakman, J. R. (2002) · The FASEB Journal · doi:10.1096/fj.02-0111fje · Cited by 25
Buettner, R., Bollheimer, L., Zietz, B., Drobnik, W., Lackner, K. J., Schmitz, G., Schölmerich, J., & Palitzsch, K.-D. (2002) · Journal of Endocrinology · doi:10.1677/joe.0.1750745 · Cited by 23
Rance, K. A., Johnstone, A. M., Murison, S. D., Duncan, J. S., Wood, S. G., & Speakman, J. R. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803535 · Cited by 22
Mutschler, J., Abbruzzese, E., Wiedemann, K., von der Goltz, C., Dinter, C., Mobascher, A., Thiele, H., Diaz-Lacava, A. N., Dahmen, N., Gallinat, J., et al. (2013) · Annals of Nutrition and Metabolism · doi:10.1159/000346799 · Cited by 20
Furusawa, T., Naka, I., Yamauchi, T., Natsuhara, K., Kimura, R., Nakazawa, M., Ishida, T., Nishida, N., Eddie, R., Ohtsuka, R., et al. (2010) · American Journal of Human Biology · doi:10.1002/ajhb.21124 · Cited by 20
Wu, Z. L., Wang, Z. J., Keller, P., & Zheng, Q. (2015) · Macromolecular Rapid Communications · doi:10.1002/marc.201500533 · Cited by 21
Serum leptin activity in obese and lean patients
Friedman‐Einat, M., Camoin, L., Faltin, Z., Rosenblum, C. I., Kaliouta, V., Eshdat, Y., & Strosberg, A. D. (2003) · Regulatory Peptides · doi:10.1016/s0167-0115(02)00259-8 · Cited by 20
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Crerand, C. E., Wadden, T. A., Sarwer, D. B., Fabricatore, A. N., Kuehnel, R. H., Gibbons, L. M., Brock, J., & Williams, N. N. (2006) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2006.03.012 · Cited by 20
Current knowledge in the neurophysiologic modulation of obesity
Angelopoulos, N., Goula, A., & Tolis, G. (2005) · Metabolism · doi:10.1016/j.metabol.2005.04.005 · Cited by 20
Murray, P. G., Read, A., Banerjee, I., Whatmore, A. J., Pritchard, L. E., Davies, R. A., Brennand, J. C., White, A. E., Ross, R. J. M., & Clayton, P. (2011) · European Journal of Endocrinology · doi:10.1530/eje-10-0656 · Cited by 20
Nutrition and Bone Growth in Pediatrics
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Shabana, S., & Hasnain, S. (2015) · Biochemical Genetics · doi:10.1007/s10528-015-9700-2 · Cited by 19
Santos, J. L., & Cortés, V. (2020) · Obesity Reviews · doi:10.1111/obr.13114 · Cited by 19
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de Luis, D. A., Sagrado, M. G., Conde, R., Aller, R., & Izaola, O. (2008) · Nutrition · doi:10.1016/j.nut.2007.11.001 · Cited by 19
Fuke, T., Yoshizaki, T., Kondo, M., Morino, K., Obata, T., Ugi, S., Nishio, Y., Maeda, S., Kashiwagi, A., & Maegawa, H. (2010) · International Journal of Obesity · doi:10.1038/ijo.2009.295 · Cited by 19
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Rodrigues, A. M., Suplicy, H. L., & Radominski, R. B. (2003) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302003000400012 · Cited by 19
Casper, R. C. (2022) · Frontiers in Psychology · doi:10.3389/fpsyg.2022.885274 · Cited by 19
Medical semiology of patients with monogenic obesity: A systematic review
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Hu, L., Wang, W., Pan, A., Duan, W., Mei, X., & Zhou, M. (2024) · Optics & Laser Technology · doi:10.1016/j.optlastec.2024.111565 · Cited by 18
Sertié, R. A. L., Kang, M., ANTIPENKO, J. P., Liu, X., Maianu, L., Habegger, K. M., & Garvey, W. T. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117764 · Cited by 18
Koerber-Rosso, I., Brandt, S., von Schnurbein, J., Fischer‐Posovszky, P., Hoegel, J. J., Rabenstein, H., Siebert, R., & Wabitsch, M. (2021) · Molecular and Cellular Pediatrics · doi:10.1186/s40348-021-00119-7 · Cited by 18
Dey, S., Samadder, A., & Nandi, S. (2021) · Current Drug Targets · doi:10.2174/1389450123666211216150355 · Cited by 19
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Franks, P. W., Loos, R. J. F., Brage, S., O’Rahilly, S., Wareham, N. J., & Ekelund, U. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01022.2006 · Cited by 18
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Metabolic syndrome, cardiovascular disease and type-2 diabetes.
Bano, K. A., & Batool, A. (2007) · PubMed · Cited by 18
Narro, L., Thomas, M. G., Silver, G. A., Rozeboom, K. J., & Keisler, D. H. (2003) · Domestic Animal Endocrinology · doi:10.1016/s0739-7240(02)00239-4 · Cited by 18
Hong, C., Tsai, P.-J., Cheng, C.-Y., Chou, C.-K., Jheng, H., Chuang, Y.-C., Yang, C.-N., Lin, Y.-T., Hsu, C.-W., Cheng, I. H.-J., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015333 · Cited by 17
Shawky, R. M., & Sadik, D. I. (2011) · Egyptian Journal of Medical Human Genetics · doi:10.1016/j.ejmhg.2011.08.005 · Cited by 18
Lustig, R. H., & Weiss, R. (2008) · Elsevier eBooks · doi:10.1016/b978-141604090-3.50024-7 · Cited by 17
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Pigeyre, M., & Meyre, D. (2017) · Contemporary Endocrinology · doi:10.1007/978-3-319-68192-4_8 · Cited by 16
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Martins, M. N. C., Telles, M. M., Zemdegs, J. C. S., de Andrade, I. S., Ribeiro, E. B., & Miranda, A. (2008) · Regulatory Peptides · doi:10.1016/j.regpep.2008.11.013 · Cited by 14
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Shirako, S., Kojima, Y., Hasegawa, T., Yoshikawa, T., Matsumura, Y., Ikeda, K., Nobuya, I., & Sato, K. (2020) · Journal of Food Bioactives · doi:10.31665/jfb.2020.12251 · Cited by 13
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Никанорова, А. А., Алексеевич, Б. Н., Пшенникова, В. Г., Сергеевич, Н. С., Gotovtsev, N. N., Romanov, G. P., Solovyev, A. V., Семеновна, К. С., Sazonov, N. N., & Федорова, С. А. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094657 · Cited by 11
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Young, S. A., Hung, S., Anderson, W. H. K., Albers, D. R., Langhorst, M. L., & YOKOYAMA, W. H. (2011) · Journal of Diabetes · doi:10.1111/j.1753-0407.2011.00157.x · Cited by 10
Borer, K. T. (2021) · Nutrients · doi:10.3390/nu13113812 · Cited by 12
Lunsky, I. O., & Meyre, D. (2018) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2018.10.002 · Cited by 11
Asai, A., Nagao, M., Hayakawa, K., Miyazawa, T., Sugihara, H., & Oikawa, S. (2020) · Diabetologia · doi:10.1007/s00125-020-05191-8 · Cited by 10
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Leptin mRNA expression in the rat mammary gland at different activation stages
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Matarese, G., Procaccini, C., Pucino, V., & Christos, M. (2014) · Springer eBooks · doi:10.1007/978-3-319-09915-6 · Cited by 10
Chen, J., Xie, Z., & Bin, Z. (2020) · Laboratory Medicine · doi:10.1093/labmed/lmaa037 · Cited by 9
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da Fonseca, A. C. P., Bozza, P. T., & Cabello, P. H. (2020) · Springer eBooks · doi:10.1007/978-3-030-53370-0_8 · Cited by 7
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Khadilkar, V. V., Gogate, N., Gangodkar, P. V., Ranade, S., Lohiya, N. N., Ragte, T., Patil, K. N., Pilankar, A., Anand, S. P., Bapat, A. C., et al. (2020) · The Indian Journal of Pediatrics · doi:10.1007/s12098-019-03129-6 · Cited by 7
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Staník, J., Kratzsch, J., Landgraf, K., Scheuermann, K., Spielau, U., Gausche, R., Gašperíková, D., Kieß, W., & Körner, A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0178107 · Cited by 7
Zhu, J., Qiu, J., Magrane, G., Abedalthagafi, M., Zanko, A., Golabi, M., & Chehab, F. F. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052353 · Cited by 7
Energy Balance and Body Weight Homeostasis
Dulloo, A. G. (2005) · Wiley eBooks · doi:10.1002/9780470987087.ch5 · Cited by 7
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Are gastrointestinal signals the principal guides to human appetite and energy balance?
Borer, K. T. (2023) · Medical Research Archives · doi:10.18103/mra.v11i1.3548 · Cited by 6
Genetic Factors for Overweight and CAD
Brönner, G., Erdmann, J., Mayer, B., Hinney, A., & Hebebrand, J. (2006) · Herz · doi:10.1007/s00059-006-2797-7 · Cited by 6
Donini, L. M., CANNELLA, C., & Savina, C. (2009) · Elsevier eBooks · doi:10.1533/9781845695484.1.43 · Cited by 6
Pandey, S. K., Baruah, J., Paw, M., Sarma, N., Begum, T., & Lal, M. (2022) · Industrial Crops and Products · doi:10.1016/j.indcrop.2022.115057 · Cited by 6
Immunoneutralization and anti-idiotype production: two-sided applications of leptin
Fanti, B. A. D. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02201-9 · Cited by 6
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Metadata
- Authors
- Farooqi, I. S., Keogh, J. M., Kamath, S., Jones, S., Gibson, W. T., Trussell, R., Jebb, S. A., Lip, G. Y. H., & O'Rahilly, S.
- Affiliations
- University of Cambridge (GB)
- Birmingham City Hospital (GB)
- MRC Elsie Widdowson Laboratory (GB)
- Alberta Children's Hospital (CA)
- Venue
- Nature
- Published
- 2001-11
- Volume
- 414
- Issue
- 6859
- Pages
- 34-35
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1527986744
- Cited by
- 407
- References
- 9
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 8 · 2023: 7 · 2022: 12 · 2021: 16 · 2020: 18 · 2019: 7 · 2018: 7 · 2017: 12 · 2016: 13 · 2015: 7 · 2014: 11 · 2013: 18 · 2012: 14
- FWCI
- 9.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- leptin, adiposity, obesity, energy homeostasis, appetite
- MeSH terms
- Adipose Tissue, Adult, Energy Metabolism, Biological Evolution, Female, Heterozygote, Humans, Male, Middle Aged, Obesity, Body Mass Index, Frameshift Mutation, Leptin
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