Cited by 407Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic DiseasesHypothalamic control of reproductive hormones

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Partial leptin deficiency and human adiposity

Farooqi, I. Sadaf, Keogh, Julia M., Kamath, Sri, Jones, Sarah, Gibson, William T., Trussell, Rebecca, Jebb, Susan A., Lip, Gregory Y. H., O'Rahilly, Stephen·2001·Nature

DOI 10.1038/35102112

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Abstract

The adipocyte-derived hormone leptin is crucial for energy homeostasis in mammals; mice and humans without it suffer from a voracious appetite and extreme obesity. The effect on energy balance of variations in plasma leptin above a minimal threshold is uncertain, however, particularly in humans. Here we examine a group of individuals who are genetically partially deficient in leptin, and show that differences in circulating leptin levels within the range found in normal human populations can directly influence the laying down of fat tissue (adiposity).

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Authors: Farooqi, I. S., Keogh, J. M., Kamath, S., Jones, S., Gibson, W. T., Trussell, R., Jebb, S. A., Lip, G. Y. H., & O'Rahilly, S.
Affiliations: University of Cambridge (GB)
Birmingham City Hospital (GB)
MRC Elsie Widdowson Laboratory (GB)
Alberta Children's Hospital (CA)
ORCID: Farooqi, I. Sadaf
Keogh, Julia M.
Jones, Sarah
Gibson, William T.
Jebb, Susan A.
Lip, Gregory Y. H.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2001-11
Volume: 414
Issue: 6859
Pages: 34-35
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/35102112
OpenAlex: W1527986744
Cited by: 407
References: 9
Citations by year: 2026: 3 · 2025: 8 · 2024: 8 · 2023: 7 · 2022: 12 · 2021: 16 · 2020: 18 · 2019: 7 · 2018: 7 · 2017: 12 · 2016: 13 · 2015: 7 · 2014: 11 · 2013: 18 · 2012: 14
FWCI: 9.97
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords: leptin, adiposity, obesity, energy homeostasis, appetite
MeSH terms: Adipose Tissue, Adult, Energy Metabolism, Biological Evolution, Female, Heterozygote, Humans, Male, Middle Aged, Obesity, Body Mass Index, Frameshift Mutation, Leptin

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