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Partial leptin deficiency and human adiposity
Abstract
The adipocyte-derived hormone leptin is crucial for energy homeostasis in mammals; mice and humans without it suffer from a voracious appetite and extreme obesity. The effect on energy balance of variations in plasma leptin above a minimal threshold is uncertain, however, particularly in humans. Here we examine a group of individuals who are genetically partially deficient in leptin, and show that differences in circulating leptin levels within the range found in normal human populations can directly influence the laying down of fat tissue (adiposity).
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“Mutations in the leptin pathway can be a cause of human obesity (5–7).”
From Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults (2004) · cites this paper as [5]
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Metadata
- Authors
- Farooqi, I. S., Keogh, J. M., Kamath, S., Jones, S., Gibson, W. T., Trussell, R., Jebb, S. A., Lip, G. Y. H., & O'Rahilly, S.
- Affiliations
- University of Cambridge (GB)
- Birmingham City Hospital (GB)
- MRC Elsie Widdowson Laboratory (GB)
- Alberta Children's Hospital (CA)
- Venue
- Nature
- Published
- 2001-11
- Volume
- 414
- Issue
- 6859
- Pages
- 34-35
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1527986744
- Cited by
- 407
- References
- 9
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 8 · 2023: 7 · 2022: 12 · 2021: 16 · 2020: 18 · 2019: 7 · 2018: 7 · 2017: 12 · 2016: 13 · 2015: 7 · 2014: 11 · 2013: 18 · 2012: 14
- FWCI
- 9.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- leptin, adiposity, obesity, energy homeostasis, appetite
- MeSH terms
- Adipose Tissue, Adult, Energy Metabolism, Biological Evolution, Female, Heterozygote, Humans, Male, Middle Aged, Obesity, Body Mass Index, Frameshift Mutation, Leptin
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