A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity

Weggen, Sascha, Eriksen, Jason L., Das, Pritam, Sagi, Sarah A., Wang, Rong, Pietrzik, Claus U., Findlay, Kirk A., Smith, Tawnya E., Murphy, Michael P., Bulter, Thomas, Kang, David E., Marquez-Sterling, Numa, Golde, Todd E., Koo, Edward H.·2001·Nature

DOI 10.1038/35102591

Cited by (1,001)

Items 701–800 of 1,001

The anti-inflammatory and cholinesterase inhibitor bifunctional compound IBU-PO protects from β-amyloid neurotoxicity by acting on Wnt signaling components
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Purine derivatives as potent γ-secretase modulators
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Steroids as γ‐secretase modulators
Joo In Jung, Thomas B. Ladd, Thomas L. Kukar, Ashleigh R. Price, Brenda D. Moore, Edward H. Koo, Todd Eliot Golde, Kevin M. Felsenstein · 2013 · The FASEB Journal
Design of Pyridopyrazine-1,6-dione γ-Secretase Modulators that Align Potency, MDR Efflux Ratio, and Metabolic Stability
Martin Pettersson, Douglas S. Johnson, John M. Humphrey, Todd W. Butler, Christopher W. am Ende, Benjamin A. Fish, Michael Green, Gregory W. Kauffman, Patrick B. Mullins, Christopher J. O’Donnell et al. · 2015 · ACS Medicinal Chemistry Letters
Insights into the Pathophysiology of Alzheimer’s Disease and Potential Therapeutic Targets: A Current Perspective
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The Mitochondrial Secret(ase) of Alzheimer's Disease
Kisha J. Young, James P. Bennett · 2010 · Journal of Alzheimer s Disease
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Inhibition of Amyloidogenesis by Nonsteroidal Anti-inflammatory Drugs and Their Hybrid Nitrates
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Substrate Sequence Influences γ-Secretase Modulator Activity, Role of the Transmembrane Domain of the Amyloid Precursor Protein
Sarah A. Sagi, Christian B. Lessard, Kellen Diamond Winden, Hiroko Maruyama, Jeremy C. Koo, Sascha Weggen, Thomas L. Kukar, Todd Eliot Golde, Edward H. Koo · 2011 · Journal of Biological Chemistry
Dynamics of Aβ42 Reduction in Plasma, CSF and Brain of Rats Treated with the γ-Secretase Modulator, GSM-10h
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Aβ38 in the Brains of Patients with Sporadic and Familial Alzheimer's Disease and Transgenic Mouse Models
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DP‐155, a Lecithin Derivative of Indomethacin, is a Novel Nonsteroidal Antiinflammatory Drug for Analgesia and Alzheimer's Disease Therapy
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Dynamic Nature of presenilin1/γ-Secretase: Implication for Alzheimer’s Disease Pathogenesis
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The role of microglia in Alzheimer’s disease: friend or foe?
Dale Schenk, Ted A. Yednock · 2002 · Neurobiology of Aging
R-flurbiprofen improves tau, but not Aß pathology in a triple transgenic model of Alzheimer's disease
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Design, Synthesis, and Pharmacological Evaluation of a Novel Series of Pyridopyrazine-1,6-dione γ-Secretase Modulators
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Modification of Behavior With 50% Nitrous Oxide/Oxygen Conscious Sedation Over Repeated Visits for Dental Treatment A 3-Year Prospective Study
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The Protective Effect of Rho-Associated Kinase Inhibitor on Aluminum-Induced Neurotoxicity in Rat Cortical Neurons
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Translational Medicine Lessons from Flurizan's Failure in Alzheimer's Disease (AD) Trial: Implication for Future Drug Discovery and Development for AD
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NSAID-derived γ-secretase modulation requires an acidic moiety on the carbazole scaffold
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Iminoheterocycles as γ-secretase modulators
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Common anti-inflammatory drugs are potentially therapeutic for Parkinson’s disease?
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Current Opinion on the Role of Neurogenesis in the Therapeutic Strategies for Alzheimer Disease, Parkinson Disease, and Ischemic Stroke; Considering Neuronal Voiding Function
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Nonsteroidal Anti-Inflammatory Drugs and Their Neuroprotective Role After an Acute Spinal Cord Injury: A Systematic Review of Animal Models
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Fluorinated piperidine acetic acids as γ-secretase modulators
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Naproxen Reduces Excitotoxic Neurodegeneration in Vivo with an Extended Therapeutic Window
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How Predictive of Dementia are Peripheral Inflammatory Markers in the elderly?
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Design, Synthesis, and Evaluation of a Novel Series of Oxadiazine Gamma Secretase Modulators for Familial Alzheimer’s Disease
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Carlos A. Saura · 2010 · Frontiers in Aging Neuroscience
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Emerging therapeutics for Alzheimer’s disease
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Is there a Future for Cyclo-Oxygenase Inhibitors in Alzheimer???s Disease?
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A Novel Phospholipid Derivative of Indomethacin, DP-155 [Mixture of 1-Steroyl and 1-Palmitoyl-2-{6-[1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indolyl acetamido]hexanoyl}-sn-glycero-3-phosophatidyl Choline], Shows Superior Safety and Similar Efficacy in Reducing Brain Amyloid β in an Alzheimer’s Disease Model
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Pathogenic Aβ generation in familial Alzheimer’s disease: novel mechanistic insights and therapeutic implications
Johannes Trambauer, Akio Fukumori, Harald Steiner · 2020 · Current Opinion in Neurobiology
Etiology and management of Alzheimer’s disease: Potential role of gut microbiota modulation with probiotics supplementation
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Immunotherapy in Alzheimer's Disease: Where Do We Stand? Where Should We Go?
Rommy von Bernhardi M. · 2010 · Journal of Alzheimer s Disease
γ‐Secretase modulators do not induce Aβ‐rebound and accumulation of β‐C‐terminal fragment
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Synergistic Interactions between Alzheimer’s Aβ40 and Aβ42 on the Surface of Primary Neurons Revealed by Single Molecule Microscopy
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Discovery of Notch-Sparing γ-Secretase Inhibitors
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De Novo and Molecular Target-Independent Discovery of Orally Bioavailable Lead Compounds for Neurological Disorders
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Modulation of Gamma-Secretase for the Treatment of Alzheimer's Disease
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Discovery of fused 5,6-bicyclic heterocycles as γ-secretase modulators
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Cholesterol independent effect of LXR agonist TO‐901317 on gamma‐secretase
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Discovery of BIIB042, a Potent, Selective, and Orally Bioavailable γ-Secretase Modulator
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The γ-Secretase Modulator CHF5074 Reduces the Accumulation of Native Hyperphosphorylated Tau in a Transgenic Mouse Model of Alzheimer’s Disease
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Reduction of Nuclear Peroxisome Proliferator-Activated Receptor γ Expression in Methamphetamine-Induced Neurotoxicity and Neuroprotective Effects of Ibuprofen
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Processing of Amyloid Precursor Protein as a Biochemical Link Between Atherosclerosis and Alzheimers Disease
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Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity
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