Potential of Medicinal Plants as Neuroprotective and Therapeutic Properties Against Amyloid-β-Related Toxicity, and Glutamate-Induced Excitotoxicity in Human Neural Cells
Open accessAbstract
Alzheimer's disease (AD) and Parkinson's disease (PD) are notorious neurodegenerative diseases amongst the general population. Being age-associated diseases, the prevalence of AD and PD is forecasted to rapidly escalate with the progressive aging population of the world. These diseases are complex and multifactorial. Among different events, amyloid β peptide (Aβ) induced toxicity is a well-established pathway of neuronal cell death, which plays a vital function in AD. Glutamate, the major excitatory transmitter, acts as a neurotoxin when present in excess at the synapses; this latter mechanism is termed excitotoxicity. It is hypothesised that glutamate-induced excitotoxicity contributes to the pathogenesis of AD and PD. No cure for AD and PD is currently available and the currently approved drugs available to treat these diseases have limited effectiveness and pose adverse effects. Indeed, plants have been a major source for the discovery of novel pharmacologically active compounds for distinct pathological conditions. Diverse plant species employed for brain-related disorders in traditional medicine are being explored to determine the scientific rationale behind their uses. Herein, we present a comprehensive review of plants and their constituents that have shown promise in reversing the (i) amyloid-β -related toxicity in AD models and (ii) glutamate-induced excitotoxicity in AD and PD models. This review summarizes information regarding the phytochemistry, biological and cellular activities, and clinical trials of several plant species in view to provide adequate scientific baseline information that could be used in the drug development process, thereby providing effective leads for AD and PD.
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Many plant extracts showed multitarget effects in Alzheimer's disease treatment by addressing amyloid plaques, tau aggregation, oxidative stress, inflammation, cholinergic dysfunction, and excitotoxicity, while generally demonstrating safety and low toxicity or no toxicity in studies.
“Moreover, many plant extracts showed multitarget effects in AD treatment by addressing amyloid plaques, tau aggregation, oxidative stress, inflammation, cholinergic dysfunction, and excitotoxicity, while generally demonstrating safety and low toxicity or no toxicity in studies [18,21,22].”
From Cholinesterase Inhibitors from Plants and Their Potential in Alzheimer’s Treatment: Systematic Review (2025) · cites this paper as [22]
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- Authors
- Lobine, D., Sadeer, N., Jugreet, S., Suroowan, S., Keenoo, B. S., Imran, M., Venugopala, K. N., Ibrahim, F. M., Zengin, G., & Mahomoodally, M. F.
- Affiliations
- University of Mauritius (MU)
- University of Lahore (PK)
- King Faisal University (SA)
- National Research Centre (EG)
- Physiology and Biochemistry Research Laboratory, Department of Biology, Science Faculty, Selcuk University, Konya,Turkey
- Corresponding author
- Mahomoodally, Mohamad Fawzi
- ORCID
- Venue
- Current Neuropharmacology
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2021-09
- Volume
- 19
- Issue
- 9
- Pages
- 1416-1441
- ISSN
- 1570-159X (ISSN-L)
- PMC
- PMC8762182
- OpenAlex
- W3154601305
- Cited by
- 32
- References
- 181
- Citations by year
- 2026: 10 · 2025: 10 · 2024: 9 · 2023: 1 · 2022: 1 · 2021: 1
- FWCI
- 3.37
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by-nc
- Locations
- Current Neuropharmacology (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
- Keywords
- medicinal plants, neuroprotection, amyloid-beta toxicity, glutamate excitotoxicity, Alzheimer's disease, Parkinson's disease, neurodegenerative diseases, phytochemistry, traditional medicine, phytochemicals, drug development
- MeSH terms
- Aged, Alzheimer Disease, Humans, Parkinson Disease, Plants, Medicinal, Amyloid beta-Peptides, Glutamic Acid
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