The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Induction of gadd45β by NF-κB downregulates pro-apoptotic JNK signalling
Abstract
In addition to coordinating immune and inflammatory responses, NF-kappaB/Rel transcription factors control cell survival. Normally, NF-kappaB dimers are sequestered in the cytoplasm by binding to inhibitory IkappaB proteins, and can be activated rapidly by signals that induce the sequential phosphorylation and proteolysis of IkappaBs. Activation of NF-kappaB antagonizes apoptosis or programmed cell death by numerous triggers, including the ligand engagement of 'death receptors' such as tumour-necrosis factor (TNF) receptor. The anti-apoptotic activity of NF-kappaB is also crucial to oncogenesis and to chemo- and radio-resistance in cancer. Cytoprotection by NF-kappaB involves the activation of pro-survival genes; however, its basis remains poorly understood. Here we report that NF-kappaB complexes downregulate the c-Jun amino-terminal kinase (JNK) cascade, thus establishing a link between the NF-kappaB and the JNK pathways. This link involves the transcriptional upregulation of gadd45beta/myd118 (ref. 4), which downregulates JNK signalling induced by the TNF receptor (TNF-R). This NF-kappaB-dependent inhibition of the JNK pathway is central to the control of cell death. Our findings define a protective mechanism that is mediated by NF-kappaB complexes and establish a role for the persistent activation of JNK in the apoptotic response to TNF-alpha.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“However, in the absence of NF-κB, this JNK activation is greatly extended, allowing for increased cell death 57, 58.”
From Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes (2010) · cites this paper as [58]
Citations
Cites
NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses
Ghosh, S., May, M. J., & Kopp, E. B. (1998) · Annual Review of Immunology · doi:10.1146/annurev.immunol.16.1.225 · Cited by 5,182
Mammalian MAP kinase signalling cascades
Chang, L., & Karin, M. (2001) · Nature · doi:10.1038/35065000 · Cited by 5,118
Signal transduction by the JNK group of MAP kinases
Davis, R. J. (2000) · Cell · doi:10.1016/s0092-8674(00)00116-1 · Cited by 4,237
An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death
Beg, A. A., & Baltimore, D. (1996) · Science · doi:10.1126/science.274.5288.782 · Cited by 3,047
Wang, C.-Y., Mayo, M., Korneluk, R., Goeddel, D., & Baldwin, A. (1998) · Science · doi:10.1126/science.281.5383.1680 · Cited by 2,950
Suppression of TNF-α-Induced Apoptosis by NF-κB
Antwerp, D. J. V., Martin, S. J., Kafri, T., Green, D. R., & Verma, I. M. (1996) · Science · doi:10.1126/science.274.5288.787 · Cited by 2,581
Biochemical Pathways of Caspase Activation During Apoptosis
Budihardjo, I. I., Oliver, H., Lutter, M. L., Luo, X., & Wang, X. (1999) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.15.1.269 · Cited by 2,577
Control of oncogenesis and cancer therapy resistance by the transcription factor NF-κB
Baldwin, A. S. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11991 · Cited by 1,427
ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis
Tobiume, K., Matsuzawa, A., Takahashi, T., Nishitoh, H., Morita, K., Takeda, K., Minowa, O., Miyazono, K., Noda, T., & Ichijo, H. (2001) · EMBO Reports · doi:10.1093/embo-reports/kve046 · Cited by 1,211
Chu, Z.-L., McKinsey, T. A., Liu, L., Gentry, J. J., Malim, M. H., & Ballard, D. W. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.19.10057 · Cited by 872
Cited by
Sorted by citations
Items 301–400 of 730
Yamamoto, Y., Moore, R., Flavell, R. A., Lu, B., & Negishi, M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010121 · Cited by 57
Kim, J. H., Qu, A., Reddy, J. K., Gao, B., & Gonzalez, F. J. (2013) · Hepatology · doi:10.1002/hep.26683 · Cited by 57
Mauro, C., Crescenzi, E., Mattia, R. D., Pacifico, F., Mellone, S., Salzano, S., de Luca, C., D'adamio, L., Palumbo, G. A., Formisano, S., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502181200 · Cited by 57
NF-κB in the crosshairs: Rethinking an old riddle
Bennett, J., Capece, D., Begalli, F., Verzella, D., D’Andrea, D., Tornatore, L., & Franzoso, G. (2017) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2017.12.020 · Cited by 58
Self-citationTNF-α signaling in Fanconi anemia
Du, W., Erden, O., & Pang, Q. (2013) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2013.06.005 · Cited by 64
Shanmugam, R., Jayaprakasan, V., Gökmen‐Polar, Y., Kelich, S. L., Miller, K. D., Yip-Schneider, M., Liang Cheng, C., Bhat‐Nakshatri, P., Sledge, G. W., Nakshatri, H., et al. (2006) · The Prostate · doi:10.1002/pros.20482 · Cited by 56
Inhibitor of κB Kinase Beta Regulates Gastric Carcinogenesis via Interleukin-1α Expression
Sakamoto, K., Hikiba, Y., Nakagawa, H., Hayakawa, Y., Yanai, A., Akanuma, M., Ogura, K., Hirata, Y., Kaestner, K. H., Omata, M., et al. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.03.047 · Cited by 56
Kim, S. G., Gao, Z.-G., Soltysiak, K. A., Chang, T., Brodie, C., & Jacobson, K. A. (2003) · Cellular and Molecular Neurobiology · doi:10.1023/a:1023696806609 · Cited by 55
Zhang, L., Blackwell, K., Shi, Z., & Habelhah, H. (2010) · Journal of Molecular Biology · doi:10.1016/j.jmb.2010.01.008 · Cited by 55
Overexpression of p65/RelA potentiates curcumin-induced apoptosis in HCT116 human colon cancer cells
Collett, G. P., & Campbell, F. C. (2006) · Carcinogenesis · doi:10.1093/carcin/bgi368 · Cited by 55
Piperlongumine inhibits proliferation and survival of Burkitt lymphoma in vitro
Han, S., Son, D.-J., Yun, H., Kamberos, N. L., & Janz, S. (2012) · Leukemia Research · doi:10.1016/j.leukres.2012.11.009 · Cited by 54
Conze, D. B., Zhao, Y., & Ashwell, J. D. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000518 · Cited by 54
Cho, H. J., Park, S.-M., Hwang, E. M., Baek, K. E., Kim, I., Nam, I.-K., Im, M.-J., Park, S.-H., Bae, S., Park, J., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.091413 · Cited by 54
Gupta, S. K., Gupta, M., Hoffman‐Liebermann, B., & Liebermann, D. A. (2006) · Oncogene · doi:10.1038/sj.onc.1209555 · Cited by 54
Mihm, M., Baker, P. J., Fleming, L. M., Monteiro, A., & O’Shaughnessy, P. J. (2008) · Reproduction · doi:10.1530/rep-06-0193 · Cited by 53
Liu, Y., Zhou, G., Wang, Z., Guo, X., Xu, Q., Huang, Q., & Su, L. (2015) · Scientific Reports · doi:10.1038/srep13547 · Cited by 53
Fas-induced apoptosis in B cells
Mizuno, T., Zhong, X., & Rothstein, T. L. (2003) · APOPTOSIS · doi:10.1023/a:1025534223168 · Cited by 52
Yuan, Z., Feldman, R. I., Sun, M., Olashaw, N., Coppola, D., Sussman, G. E., Shelley, S. A., Nicosia, S. V., & Cheng, J. Q. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203636200 · Cited by 52
RetractedDifferential Roles of JNK in ConA/GalN and ConA-Induced Liver Injury in Mice
Ni, H., Chen, X., Ding, W., Schuchmann, M., & Yin, X. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.080358 · Cited by 51
Dose dependent effects of cadmium on tumor angiogenesis
Wei, T., Jia, J., Wada, Y., Kapron, C. M., & Liu, J. (2017) · Oncotarget · doi:10.18632/oncotarget.16572 · Cited by 51
Angiotensin II Signaling Promotes Follicle Growth and Dominance in Cattle
Ferreira, R., Gasperin, B., Rovani, M., Santos, J., Barreta, M., Bohrer, R., Price, C., & Bayard Dias Gonçalves, P. (2011) · Endocrinology · doi:10.1210/en.2011-1146 · Cited by 51
Computationally Identifying Novel NF-κB-Regulated Immune Genes in the Human GenomePreprint
Liu, R., McEachin, R. C., & States, D. J. (2003) · Genome Research · doi:10.1101/gr.911803 · Cited by 51
Terasaki, H., Kase, S., Shirasawa, M., Otsuka, H., Hisatomi, T., Sonoda, S., Ishida, S., Ishibashi, T., & Sakamoto, T. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069994 · Cited by 52
IKKβ Is Essential for Adipocyte Survival and Adaptive Adipose Remodeling in Obesity
Park, S., Liu, Z., Sui, Y., Helsley, R. N., Zhu, B., Powell, D. K., Kern, P. A., & Zhou, C. (2016) · Diabetes · doi:10.2337/db15-1156 · Cited by 52
Guillermet‐Guibert, J., Saint‐Laurent, N., Davenne, L., Rochaix, P., Cuvillier, O., Culler, M. D., Pradayrol, L., Buscail, L., Susini, C., & Bousquet, C. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401939 · Cited by 50
Zerbini, L. F., & Libermann, T. A. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-1475 · Cited by 50
Gene expression profiling of macrophages following mice treatment with an immunomodulator medication
de Oliveira, C. C., de Oliveira, S. M., Góes, V. M., Probst, C., Krieger, M. A., & Buchi, D. D. F. (2008) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21713 · Cited by 49
Chemosensitization by erythropoietin through inhibition of the NF-κB rescue pathway
Carvalho, G., Lefaucheur, C., Cherbonnier, C., Métivier, D., Chapel, A., Pallardy, M. J., Bourgeade, M., Charpentier, B., Hirsch, F., & Kroemer, G. (2004) · Oncogene · doi:10.1038/sj.onc.1208205 · Cited by 50
Recent Advances in Understanding NF-κB Regulation
Boone, D. L., Lee, E. G., Libby, S., Gibson, P. J., Chien, M., Chan, F., Madonia, M., Burkett, P. R., & Ma, A. I. (2002) · Inflammatory Bowel Diseases · doi:10.1097/00054725-200205000-00008 · Cited by 49
Chen, J., Wang, F., & Chen, W. (2014) · Molecular Biology Reports · doi:10.1007/s11033-014-3329-9 · Cited by 48
Scudiero, I., Zotti, T., Ferravante, A., Vessichelli, M., Reale, C., Masone, M. C., Leonardi, A., Vito, P., & Stilo, R. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.300137 · Cited by 48
NF-κB signaling maintains the survival of cadmium-exposed human renal glomerular endothelial cells
Zhang, H., Li, L., Wang, Y., Dong, F., Chen, X., Liu, F., Xu, D., Yi, F., Kapron, C. M., & Liu, J. (2016) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2016.2640 · Cited by 48
Ralph, G. S., Parham, S., Lee, S. R., Beard, G. L., Craigon, M., Ward, N., White, J. R., Barber, R. D., Rayner, W., Kingsman, S. M., et al. (2004) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000110532.48786.46 · Cited by 48
Regulation of mature T lymphocyte proliferation and differentiation by Par‐4
Lafuente, M. J., Martı́n, P., Garcı́a-Cao, I., Díaz-Meco, M. T., Serrano, M., & Moscat, J. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg460 · Cited by 48
Gadd45β forms a Homodimeric Complex that Binds Tightly to MKK7
Tornatore, L., Marasco, D., Dathan, N. A., Vitale, R. M., Benedetti, E., Papa, S., Franzoso, G., Ruvo, M., & Monti, S. M. (2008) · Journal of Molecular Biology · doi:10.1016/j.jmb.2008.01.074 · Cited by 48
Self-citationAging does not reduce the hepatocyte proliferative response of mice to the primary mitogen TCPOBOP
Ledda‐Columbano, G. M., Pibiri, M., Cossu, C., Molotzu, F., Locker, J. D., & Columbano, A. (2004) · Hepatology · doi:10.1002/hep.1840400429 · Cited by 49
NF-κB Promotes Survival during Mitotic Cell Cycle Arrest
Mistry, P., Deacon, K., Mistry, S. C., Blank, J. L., & Patel, R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310413200 · Cited by 48
Major, M. B., & Jones, D. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311517200 · Cited by 48
Kim, J. H., Kim, M. J., Choi, K., & Son, J. (2016) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2016.07.033 · Cited by 47
E3 ubiquitin ligase Mule ubiquitinates Miz1 and is required for TNFα-induced JNK activation
Yang, Y., Do, H., Tian, X., Zhang, C., Liu, X., Dada, L. A., Sznajder, J. I., & Liu, J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913690107 · Cited by 47
Mora, A. L., Corn, R. A., Stanic, A. K., Goenka, S., Aronica, M. A., Stanley, S. A., Ballard, D. W., Joyce, S., & Boothby, M. R. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401257 · Cited by 47
Zhang, L., Blackwell, K., Altaeva, A., Shi, Z., & Habelhah, H. (2010) · Molecular Biology of the Cell · doi:10.1091/mbc.e10-06-0556 · Cited by 47
Farah, M., Parhar, K. K. S., Moussavi, M., Eivemark, S., & Salh, B. S. (2003) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00205.2003 · Cited by 47
Rubira, R. J. G., Camacho, S. A., Martin, C. S., Mejía-Salazar, J. R., Gómez, F. R., da Silva, R. R., Oliveira, O. N., Aléssio, P., & Constantino, C. J. L. (2019) · Sensors · doi:10.3390/s20010015 · Cited by 46
The many faces of tumor necrosis factor signaling in the intestinal epithelium
Delgado, M. E., & Brunner, T. (2019) · Genes and Immunity · doi:10.1038/s41435-019-0057-0 · Cited by 45
NF-κB is Required for Survival of Immature Auditory Hair Cells In Vitro
Nagy, I., Monge, A., Albinger‐Hegyi, A., Schmid, S., & Bodmer, D. (2005) · Journal of the Association for Research in Otolaryngology · doi:10.1007/s10162-005-0006-7 · Cited by 45
Nemo‐like kinase suppresses a wide range of transcription factors, including nuclear factor‐kB
Yasuda, J., Yokoo, H., Yamada, T., Kitabayashi, I., Sekiya, T., & Ichikawa, H. (2004) · Cancer Science · doi:10.1111/j.1349-7006.2004.tb03170.x · Cited by 45
Chen, X., Ding, W., Ni, H., Gao, W., Shi, Y., Gambotto, A. A., Fan, J., Beg, A. A., & Yin, X. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01166-06 · Cited by 45
Shimada, K., Nakamura, M., Ishida, E., Kishi, M., Yonehara, S., & Konishi, N. (2002) · Molecular Carcinogenesis · doi:10.1002/mc.10084 · Cited by 45
Statins can modulate effectiveness of antitumor therapeutic modalities
Jakóbisiak, M., & Gołąb, J. (2009) · Medicinal Research Reviews · doi:10.1002/med.20162 · Cited by 44
Transcriptional signatures throughout development: the effects of mouse embryo manipulation in vitro
Feuer, S. K., Liu, X.-W., Donjacour, A., Simbulan, R., Maltepe, E., & Rinaudo, P. (2017) · Reproduction · doi:10.1530/rep-16-0473 · Cited by 33
Role of NF-κB/RelA and MAPK Pathways in Keratinocytes in Response to Sulfur Mustard
Rebholz, B., Kehe, K., Ruzicka, T., & Rupec, R. A. (2008) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5701234 · Cited by 44
RbAp48 is a Target of Nuclear Factor-κB Activity in Thyroid Cancer
Pacifico, F., Paolillo, M., Chiappetta, G., Crescenzi, E., Arena, S., Scaloni, A., Monaco, M., Vascotto, C., Tell, G., Formisano, S., et al. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-2199 · Cited by 44
Landgren, H., Blixt, Å., & Carlsson, P. (2008) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-2243 · Cited by 44
Zhao, X., Zhou, J., Liang, W., Sheng, Q., Lü, L., Chen, T., Chen, J., Tan, K., & Lv, Z. (2021) · Cell & Bioscience · doi:10.1186/s13578-021-00530-7 · Cited by 43
Sousa, K. M., Mira, H., Hall, A. C., Jansson-Sjöstrand, L., Kusakabe, M., & Arenas, E. (2006) · Stem Cells · doi:10.1634/stemcells.2006-0238 · Cited by 43
Smith, M. R., Jin, F., & Joshi, I. D. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-0982 · Cited by 44
Potential Sabotage of Host Cell Physiology by Apicomplexan Parasites for Their Survival Benefits
Chakraborty, S., Roy, S., Mistry, H., Murthy, S., George, N., Bhandari, V., & Sharma, P. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01261 · Cited by 42
Gu, M., Donato, M., Guo, M., Wary, N. K., Miao, Y., Mao, S., Saito, T., Otsuki, S., Wang, L., Harper, R. L., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.aba6480 · Cited by 42
Blackwell, N. M., Sembi, P., Newson, J., Lawrence, T., Gilroy, D. W., & Kabouridis, P. S. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20467 · Cited by 42
Burn injury induces elevated inflammatory traffic: the role of NF-κB
George, B., Vasu, S. T., & Bhatia, N. (2020) · Inflammation Research · doi:10.1007/s00011-020-01426-x · Cited by 41
Inhibition of NF-κB promotes autophagy via JNK signaling pathway in porcine granulosa cells
Gao, H., Lin, L., Haq, I. U., & Zeng, S. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.03.101 · Cited by 41
JNK: a killer on a transcriptional leash
Franzoso, G., Zazzeroni, F., & Papa, S. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401154 · Cited by 41
Self-citationSchichl, Y. M., Resch, U., Lemberger, C. E., Stichlberger, D., & de Martin, R. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.254888 · Cited by 40
Rae, C. J., Langa, S., Tucker, S. J., & MacEwan, D. J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701437104 · Cited by 40
Smith, G. B., & Mocarski, E. S. (2005) · Journal of Virology · doi:10.1128/jvi.79.23.14923-14932.2005 · Cited by 40
Castrillo, A., Través, P. G., Martín‐Sanz, P., Parkinson, S. J., Parker, P. J., & Boscá, L. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.4.1196-1208.2003 · Cited by 40
Nakano, R., Kitanaka, T., Namba, S., Kitanaka, N., Suwabe, Y., Konno, T., Yamazaki, J., Nakayama, T., & Sugiya, H. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.579266 · Cited by 40
C/EBPβ Mediates TNF‐α‐Induced Cancer Cell Migration by Inducing MMP Expression Dependent on p38 MAPK
Xia, P., Zhang, R., & Ge, G. (2015) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25219 · Cited by 39
Liu, X., Happel, C., & Ziegelbauer, J. M. (2016) · Journal of Virology · doi:10.1128/jvi.02045-16 · Cited by 39
Identification of Spt5 Target Genes in Zebrafish Development Reveals Its Dual Activity In Vivo
Krishnan, K., Salomonis, N., & Guo, S. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003621 · Cited by 39
Larsen, C. M., Døssing, M. G., Papa, S., Franzoso, G., Billestrup, N., & Mandrup-Poulsen, T. R. (2006) · Diabetologia · doi:10.1007/s00125-006-0164-0 · Cited by 39
Self-citationZhang, C., Wang, J., Lü, G., Li, J., Lu, X., Mantion, G., Vuitton, D. A., Wen, H., & Lin, R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030127 · Cited by 40
TNFR1 determines progression of chronic liver injury in the IKKγ/Nemo genetic model
Cubero, F. J., Singh, A. P., Borkham‐Kamphorst, E., Nevzorova, Y. A., Masaoudi, M. A., Haas, U., Boekschoten, M. V., Gaßler, N., Weiskirchen, R., Müller, M. M., et al. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.112 · Cited by 38
Chang, M. X., Wang, Y. P., & Nie, P. (2008) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2008.11.007 · Cited by 38
Hesling, C., Oliveira, C. C., Castilho, B. A., & Zanchin, N. I. T. (2007) · Experimental Cell Research · doi:10.1016/j.yexcr.2007.06.024 · Cited by 38
Regulation and Phenotype of an Innate Th1 Cell: Role of Cytokines and the p38 Kinase Pathway
Yu, J. J., Tripp, C. S., & Russell, J. H. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.11.6112 · Cited by 38
Global transcriptome analysis to identify critical genes involved in the pathology of osteoarthritis
Zhang, X., Bu, Y., Zhu, B., Zhao, Q., Lv, Z., Li, B., & Liu, J. (2018) · Bone and Joint Research · doi:10.1302/2046-3758.74.bjr-2017-0245.r1 · Cited by 37
Lim, K., Yong, Z. W. E., Wang, H., Tan, T. Z., Huang, R. Y., Yamamoto, D., Inaki, N., Hazawa, M., Wong, R. W.-C., Oshima, H., et al. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.012943 · Cited by 38
c-Jun N-terminal kinases as potential therapeutic targets
Salh, B. S. (2007) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.11.10.1339 · Cited by 38
Gene therapy for thyroid cancer
Barzon, L., Pacenti, M., Boscaro, M., & Palù, G. (2004) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.4.8.1225 · Cited by 37
Recent Advances in Understanding the Role of IKKβ in Cardiometabolic Diseases
Hernandez, R., & Zhou, C. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.752337 · Cited by 38
Lipke, A. B., Matute‐Bello, G., Herrero, R., Kurahashi, K., Wong, V. A., Mongovin, S. M., & Martin, T. R. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903191 · Cited by 36
Emerging Complexity of Protein Ubiquitination in the NF- B Pathway
Habelhah, H. (2010) · Genes & Cancer · doi:10.1177/1947601910382900 · Cited by 36
GADD45β Loss Ablates Innate Immunosuppression in Cancer
Verzella, D., Bennett, J., Fischietti, M., Thotakura, A. K., Recordati, C., Pasqualini, F., Capece, D., Vecchiotti, D., D'Andrea, D., Francesco, B. D., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-17-1833 · Cited by 36
Self-citationCharacterization of Transcriptional Regulation During Negative Selection In Vivo
DeRyckere, D., Mann, D. L., & DeGregori, J. V. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.2.802 · Cited by 36
Effect of age on molecular signaling of TNF-α-induced apoptosis in human lymphocytes
Gupta, S., Chiplunkar, S., Kim, C., Yel, L., & Gollapudi, S. V. S. (2003) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(03)00028-9 · Cited by 36
A possible role for the loss of CD27–CD70 interaction in myelomagenesis
Katayama, Y., Sakai, A., Oue, N., Asaoku, H., Otsuki, T., Shiomomura, T., Masuda, R., Hino, N., Takimoto, Y., Imanaka, F., et al. (2003) · British Journal of Haematology · doi:10.1046/j.1365-2141.2003.04069.x · Cited by 36
The NF-κB Pharmacopeia: Novel Strategies to Subdue an Intractable Target
Verzella, D., Cornice, J., Arboretto, P., Vecchiotti, D., Nolfi, M. D. V., Capece, D., Zazzeroni, F., & Franzoso, G. (2022) · Biomedicines · doi:10.3390/biomedicines10092233 · Cited by 36
Self-citationLis, R., Touboul, C., Halabi, N. M., Madduri, A. S., Querleu, D., Mezey, J. G., Malek, J. A., Suhre, K., & Rafii, A. (2014) · Journal of Translational Medicine · doi:10.1186/1479-5876-12-59 · Cited by 35
Divakaran, V. G., Evans, S., Topkara, V. K., Diwan, A., Burchfield, J. S., Gao, F., Dong, J., Tzeng, H.-P., Sivasubramanian, N., Barger, P. M., et al. (2013) · Circulation Heart Failure · doi:10.1161/circheartfailure.112.000080 · Cited by 35
The ERK5/NF-κB signaling pathway targets endometrial cancer proliferation and survival
Diéguez-Martínez, N., Espinosa-Gil, S., Yoldi, G., Megías‐Roda, E., Bolinaga-Ayala, I., Viñas-Casas, M., Görgişen, G., Domingo-Ortí, I., Perez‐Montoyo, H., Bayascas, J. R., et al. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04541-6 · Cited by 35
Yang, Z., Qu, Y., Zhang, Q., Wei, M., Liu, C., Chen, X., Yan, M., Zhu, Z., Liu, B., Chen, G., et al. (2011) · International Journal of Cancer · doi:10.1002/ijc.26331 · Cited by 35
Zhang, D., Song, L., Li, J., Wu, K., & Huang, C. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602821200 · Cited by 34
Schmitz, I. (2013) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-8289-5_4 · Cited by 34
Liu, J., Yan, J. R., Jiang, S., Wen, J., Chen, L., Zhao, Y., & Lin, A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1105176108 · Cited by 34
Gadd45β is a pro-survival factor associated with stress-resistant tumors
Engelmann, A., Speidel, D., Bornkamm, G. W., Deppert, W., & Stocking, C. (2007) · Oncogene · doi:10.1038/sj.onc.1210772 · Cited by 34
Pacák, K., Sirová, M., Giubellino, A., Lencesova, L., Csáderová, L., Lauková, M., Hudecová, S., & Križanová, O. (2012) · International Journal of Cancer · doi:10.1002/ijc.27524 · Cited by 34
Tang, Z., Wu, Y., Gao, S., & Shen, H. (2007) · Journal of Surgical Research · doi:10.1016/j.jss.2007.03.061 · Cited by 33
Zanotto‐Filho, A., Gelain, D. P., Schröder, R., Souza, L. F., Pasquali, M. A. D. B., Klamt, F., & Moreira, J. C. F. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.12.010 · Cited by 33
Metadata
- Authors
- De Smaele, E., Zazzeroni, F., Papa, S., Nguyen, D. U., Jin, R., Jones, J., Cong, R., & Franzoso, G.
- Affiliations
- University of Chicago (US)
- Corresponding author
- Franzoso, Guido
- Venue
- Nature
- Published
- 2001-11
- Volume
- 414
- Issue
- 6861
- Pages
- 308-313
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1563090311
- Cited by
- 732
- References
- 30
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 14 · 2023: 11 · 2022: 12 · 2021: 16 · 2020: 10 · 2019: 16 · 2018: 24 · 2017: 12 · 2016: 25 · 2015: 16 · 2014: 18 · 2013: 29 · 2012: 22
- FWCI
- 22.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Keywords
- NF-κB, GADD45B, JNK signaling, apoptosis, TNF receptor, TNF-α, cell survival, transcriptional regulation, IκB, death receptors, anti-apoptotic signaling
- MeSH terms
- GADD45 Proteins, Animals, Antigens, Differentiation, Cell Line, Cell Survival, Cycloheximide, Gene Expression Regulation, Protein Synthesis Inhibitors, Tumor Necrosis Factor-alpha, NF-kappa B, 3T3 Cells, Apoptosis, Receptors, Tumor Necrosis Factor, Mitogen-Activated Protein Kinases, MAP Kinase Signaling System, JNK Mitogen-Activated Protein Kinases, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review