Synaptic plasticity in the hippocampus: LTP and LTD
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NMDAR-dependent LTP and LTD can be elicited by activating NMDA-type glutamate receptors, typically by coincident activity of pre- and postsynaptic neurons.
“Long-term potentiation and long-term depression (LTP/LTD) can be elicited by activating N-methyl-D-aspartate (NMDA)-type glutamate receptors, typically by the coincident activity of pre-and postsynaptic neurons.”
From NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD). (2012) · cites this paper as Malenka 1994
LTP and LTD are induced by specific patterns of activity.
“LTP and LTD are induced by specific patterns of activity (Malenka 1994).”
From NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD). (2012) · cites this paper as Malenka 1994
Modest activation of NMDARs leading to modest increases in postsynaptic calcium is optimal for triggering LTD, whereas much stronger activation leading to much larger increases in postsynaptic calcium is required to trigger LTP.
“Indeed, it is now fairly well accepted that modest activation of NMDARs leading to modest increases in postsynaptic calcium are optimal for triggering LTD, whereas much stronger activation of NMDARs leading to much larger increases in postsynaptic calcium are required to trigger LTP (Malenka 1994).”
From NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD). (2012) · cites this paper as Malenka 1994
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- Authors
- Malenka, R. C.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Malenka, Robert C.
- ORCID
- Malenka, Robert C.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1994-08
- Volume
- 78
- Issue
- 4
- Pages
- 535-538
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2070094949
- Cited by
- 655
- References
- 26
- Citations by year
- 2026: 8 · 2025: 5 · 2024: 13 · 2023: 15 · 2022: 15 · 2021: 14 · 2020: 22 · 2019: 19 · 2018: 19 · 2017: 13 · 2016: 18 · 2015: 19 · 2014: 18 · 2013: 17 · 2012: 15
- FWCI
- 3.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- long-term potentiation, long-term depression, synaptic plasticity, hippocampus, NMDA receptor, calcium buffering, calcium-dependent protein kinase, CaMKII, CaMKI, CaMKIV
- MeSH terms
- Animals, Hippocampus, Humans, Memory, Models, Neurological, Neuronal Plasticity, Signal Transduction, Long-Term Potentiation
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