Cited by 655Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsNeural dynamics and brain function

Synaptic plasticity in the hippocampus: LTP and LTD

Malenka, Robert C.·1994·Cell

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Crossref · 10.1016/0092-8674(94)90517-7

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26 of 26 references verified0 citation errors · 0 not checkable

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  • NMDAR-dependent LTP and LTD can be elicited by activating NMDA-type glutamate receptors, typically by coincident activity of pre- and postsynaptic neurons.

    “Long-term potentiation and long-term depression (LTP/LTD) can be elicited by activating N-methyl-D-aspartate (NMDA)-type glutamate receptors, typically by the coincident activity of pre-and postsynaptic neurons.”
  • LTP and LTD are induced by specific patterns of activity.

    “LTP and LTD are induced by specific patterns of activity (Malenka 1994).”
  • Modest activation of NMDARs leading to modest increases in postsynaptic calcium is optimal for triggering LTD, whereas much stronger activation leading to much larger increases in postsynaptic calcium is required to trigger LTP.

    “Indeed, it is now fairly well accepted that modest activation of NMDARs leading to modest increases in postsynaptic calcium are optimal for triggering LTD, whereas much stronger activation of NMDARs leading to much larger increases in postsynaptic calcium are required to trigger LTP (Malenka 1994).”

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Authors
Malenka, R. C.
Affiliations
University of California, San Francisco (US)
Corresponding author
Malenka, Robert C.
Venue
Cell
Publisher
Elsevier BV
Published
1994-08
Volume
78
Issue
4
Pages
535-538
ISSN
0092-8674 (ISSN-L)
OpenAlex
W2070094949
Cited by
655
References
26
Citations by year
2026: 8 · 2025: 5 · 2024: 13 · 2023: 15 · 2022: 15 · 2021: 14 · 2020: 22 · 2019: 19 · 2018: 19 · 2017: 13 · 2016: 18 · 2015: 19 · 2014: 18 · 2013: 17 · 2012: 15
FWCI
3.35
Type
journal article
Language
en
Open access
closed
Locations
  • Cell (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
long-term potentiation, long-term depression, synaptic plasticity, hippocampus, NMDA receptor, calcium buffering, calcium-dependent protein kinase, CaMKII, CaMKI, CaMKIV
MeSH terms
Animals, Hippocampus, Humans, Memory, Models, Neurological, Neuronal Plasticity, Signal Transduction, Long-Term Potentiation

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