The DOI matches its Crossref record.
Postsynaptic contribution to long-term potentiation revealed by the analysis of miniature synaptic currents
Abstract
Miniature excitatory synaptic currents were recorded from CA1 pyramidal cells in hippocampal slices to study the site of the persistent change in synaptic efficacy during long-term potentiation. Induction of long-term potentiation produced a large increase in the amplitude of these currents. Such a change in amplitude suggests an increase in postsynaptic transmitter sensitivity.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“For instance, the size of “quantal” miniature EPSCs increases after LTP (364, 365).”
From Synaptic memory and CaMKII (2023) · cites this paper as [365]
Citations
Cites
No references could be resolved yet.
Research works printed but not linked: 34
- Bliss, T. V. P. & Lømo, T. J. Physiol., Lond. 232, 331–356 (1973). · DOI · Paper page
- Bliss, T. V. P. & Lynch, M. A. in Long-Term Potentiation: From Biophysics to Behavior (eds Landfield, P. W. & Deadwyler, S. A.) 3–72 (Liss, New York, 1988).
- Nicoll, R. A., Kauer, J. A. & Malenka, R. C. Neuron 1, 97–103 (1988). · DOI · Paper page
- Wigström, H., Gustafsson, B., Huang, Y.-Y. & Abraham, W. C. Acta physiol. scand. 126, 317–319 (1986). · DOI
- Malinow, R. & Miller, J. P. Nature 320, 529–530 (1986). · DOI
- Kelso, S. R., Ganong, A. H. & Brown, T. H. Proc. natn. Acad. Sci. U.S.A. 83, 5326–5330 (1986). · DOI
- Sastry, B. R., Goh, J. W. & Auyeung, A. Science 232, 988–990 (1986). · DOI
- Dolphin, A. C., Errington, M. L. & Bliss, T. V. P. Nature 297, 496–498 (1982). · DOI
- Kauer, J. A., Malenka, R. C. & Nicoll, R. A. Neuron 1, 911–917 (1988). · DOI · Paper page
- Muller, D., Joly, M. & Lynch, G. Science 242, 1694–1697 (1988). · DOI
- Davies, S. N., Lester, R. A. J., Reymann, K. G. & Collingridge, G. L. Nature 338, 500–503 (1989). · DOI
- Voronin, L. L., Kuhnt, U. & Hess, G. Neurophysiology 22, 341–347 (1990). · DOI
- Malinow, R. & Tsien, R. W. Nature 346, 177–180 (1990). · DOI
- Bekkers, J. M. & Stevens, C. F. Nature 346, 724–729 (1990). · DOI
- Malinow, R. Science 252, 722–724 (1991). · DOI
- Foster, T. C. & McNaughton, B. L. Hippocampus 1, 79–91 (1991). · DOI
- Edwards, F. Nature 350, 271–272 (1991). · DOI · Paper page
- Korn, H. & Faber, D. S. Trends in Neurosci. 14, 439–445 (1991). · DOI
- Del Castillo, J. & Katz, B. J. Physiol. Lond. 124, 560–573 (1954). · DOI
- Redman, S. Physiol. Rev. 70, 165–198 (1990). · DOI
- Katz, B. Nerve, Muscle and Synapse (McGraw-Hill, New York, 1966).
- Bekkers, J. M., Richerson, G. B. & Stevens, C. F. Proc. natn. Acad. Sci. U.S.A. 87, 5359–5362 (1990). · DOI
- Van der Kloot, W. Prog. Neurobiol. 36, 93–130 (1991). · DOI
- Barrett, E. F. & Stevens, C. F. J. Physiol., Lond. 227, 691–708 (1972). · DOI
- Rahamimoff, R. & Yaari, Y. J. Physiol., Lond. 228, 241–257 (1973). · DOI
- Fatt, P. & Katz, B. J. Physiol., Lond. 117, 109–128 (1952). · DOI
- Collingridge, G. L., Kehl, S. J. & McLennan, H. J. Physiol., Lond. 334, 33–46 (1983). · DOI · Paper page
- Kauer, J. A., Malenka, R. C. & Nicoll, R. A. Nature 334, 250–252 (1988). · DOI · Paper page
- Thibault, O. et al. Brain Res. 476, 170–173 (1989). · DOI
- Malenka, R. C. Neuron 6, 53–60 (1991). · DOI · Paper page
- Asztely, F., Hanse, E., Wigström, H. & Gustafsson, B. Brain Res. 558, 153–156 (1991). · DOI
- Elmqvist, D. & Quastel, D. M. J. J. Physiol., Lond. 177, 463–482 (1965). · DOI
- Coleman, P. A. & Miller, R. F. J. Neurophysiol. 61, 218–230 (1989). · DOI
- Blanton, M. G., Lo Turco, J. J. & Kriegstein, A. R. J. Neurosci. Meth. 30, 203–210 (1989). · DOI
Cited by
Sorted by citations
Items 301–327 of 327
Colmers, W., McQuiston, A., Kombian, S., & Klapstein, G. J. (1993) · Birkhäuser Boston eBooks · doi:10.1007/978-1-4684-6825-0_6 · Cited by 2
Vadakkan, K. I. (2016) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/085589 · Cited by 1
“The propagation of potentials through the IPLs can also explain how mEPSP size is increased after LTP induction (Manabe et al., 1992), which is currently thought to occur either by an increase in the number or function of AMPA receptors at the postsynaptic terminals of the recording neuron (Malenka and Nicoll, 1999).”
BackgroundA reassessment of NMDA receptor-dependent presynaptic homeostatic plasticity
Chen, X., Dou, T., Zhang, J., Hong, Y., & Nicoll, R. A. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2617982123 · Cited by 2
Self-citation‘Mini analysis’ is an unreliable reporter of synaptic changesPreprint
Greger, I., & Watson, J. (2024) · bioRxiv · doi:10.1101/2024.10.26.620084 · Cited by 1
“This approach has been previously employed as such for an experimental control (Malgaroli and Tsien, 1992; Manabe et al., 1992), and to dissect synaptic parameters (Chen et al., 2015).”
BackgroundMethodSynaptic Triad in the Neostriatum
Klug, J. R., Deutch, A. Y., Colbran, R. J., & Winder, D. J. (2011) · Frontiers in neuroscience · doi:10.1201/b11284-5 · Cited by 2
Bishop, W. B. (2001) · IEEE Transactions on Biomedical Engineering · doi:10.1109/10.923785 · Cited by 1
“Presently there is no consensus regarding the source of the LTP response; some studies suggest that the LTP response is exclusively based on presynaptic events [11], others suggest postsynaptic origins [10], and still others indicate that LTP is the result of combined presynaptic and postsynaptic events [5].”
BackgroundAnalysis of Synaptic Plasticity with the Slice Patch-Clamp Recording Technique
Manabe, T. (2012) · Springer protocols handbooks/Springer protocols · doi:10.1007/978-4-431-53993-3_9 · Cited by 1
Self-citationActivity-Dependent Increases in Quantal Size at the Drosophila NMJ
Powers, A. S., Gajic, P., Rittereiser, E., Dasrat, K., & Lnenicka, G. A. (2025) · Journal of Developmental Biology · doi:10.3390/jdb13040038
“LTP produced by high-frequency, brief (seconds) synaptic activity involves a greater postsynaptic response to a single vesicle of transmitter (quantal size) triggered by an increase in postsynaptic Ca 2+ [7,8].”
EPHierStats: a statistical tool to model the hierarchical relationships in electrophysiological data
Kolpakova, J., Marvel-Zuccola, J., Futai, K., Martin, G. E., & van der Vinne, V. (2022) · bioRxiv · doi:10.1101/2022.03.23.485501
“A typically employed statistical test to assess changes in the distribution of values is the two-sample Kolmogorov-Smirnov test [Massey, 1951; Manabe et al., 1992].”
MethodFunctional spreading of hyperexcitability induced by human and synthetic intracellular Aβ oligomersPreprint
Fernández-Pérez, E. J., Muñoz, B., Bascuñán, D., Peters, C., Riffo-Lepe, N., Espinoza, M. P., Morgan, P. J., Filippi, C., Bourboulou, R., Sengupta, U., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.10.16.332445
Mechanics of CaMKII-actin networksPreprint
Khan, S., Molloy, J., & Downing, K. (2018) · bioRxiv · doi:10.1101/308353
“The basal 594 dendritic spine free-calcium level is sub-nanomolar so calmodulin is in its apo-form and CaMKII-actin 595 networks are stable and not susceptible to forces due to macromolecular crowding or episodic myosin 596 motor activation triggered by miniature synaptic currents (66).”
BackgroundBessiron, T. (2014) · theses.fr (ABES) · doi:10.70675/269f9366z9470z434ezba5ez71916f09e312
“In addition, variations in mEPSC frequency or amplitude induced by different pharmacological manipulations give insight into the respective preor postsynaptic nature of these changes (Malgaroli and Tsien, 1992; Manabe et al., 1992).”
BackgroundEstimating a hidden Bernoulli parameter by sequential Bayesian analysis
Bishop, W. B. (2001) · Signal Processing · doi:10.1016/s0165-1684(01)00086-x
Neural stem cell transplantation : neuroprotection and LTP-induced facilitation of neurogenesis
Cho, T. (2011) · doi:10.14288/1.0072116
“by changes in AMPAR function or number (Kauer et al., 1988b; Malenka et al., 1988; Muller et al., 1988; Davies et al., 1989; Manabe et al., 1992).”
BackgroundIntroductory Review: Synaptic Plasticity and Modulation
Yoshioka, T., & Kuba, K. (2000) · Springer eBooks · doi:10.1007/978-4-431-66973-9_36
Jia, Z., Lu, Y. M., Agopyan, N., & Roder, J. (1999) · Techniques in the behavioral and neural sciences · doi:10.1016/s0921-0709(99)80029-7
Physiological consequences of astrocyte-to-neuron signaling
Sanzgiri, R. P. (1998) · doi:10.31274/rtd-180813-10807
Mechanisms of transmitter release and synaptic plasticity at excitatory synapses in the hippocampus
Reid, C. (1998) · doi:10.25911/5d69081f7e2c9
“Variance-mean technique vs other methods Previous investigations of the locus of LTP expression have used a change in the amplitude distribution of mEPSCs to indicate a postsynaptic site (Manabe et al., 1992), or a change in their frequency of occurrence to indicate a presynaptic site (Malgaroli and Tsien, 1992).”
BackgroundMethodNeurotransmitter Release and Synaptic Plasticity
Huang, E. P., & Stevens, C. F. (1997) · Advances in organ biology · doi:10.1016/s1569-2590(08)60185-8 · Cited by 1
Neurotrophins and TRK Receptors in Hippocampal Development
Collazo, D., & McKay, R. D. G. (1995) · Springer eBooks · doi:10.1007/978-1-4615-1929-4_12
Membrane Fusion in the Exocytotic Release of Neurotransmitters
Oliveira, C., Almeida, M. T., & de Lima, M. D. (1995) · Springer eBooks · doi:10.1007/978-3-642-79547-3_20
Juurlink, B., Krone, P. H., Kulyk, W., Verge, V., & Doucette, J. R. (1995) · Altschul Symposia Series · doi:10.1007/978-1-4615-1929-4
Jones, O. T., Koncz, E., & So, A. P. (1994) · doi:10.1016/b978-0-12-668330-1.50012-0
Hashemi-Sakhtsari, A. (n.d.) · doi:10.1037/e448942006-001
“…from the presynaptic terminal is involved (Bliss et al., 1990; Malinow, 1991; Schuman and Madison, 1991; Malgaroli and Tsien, 1992), while others refer to a postsynaptic changes in glutamate AMP A receptors (Davies et al., 1989; Manabe et al., 1992; Staubli et al., 1992; Maren et al., 1993).”
BackgroundMethodInfluential
Metadata
- Authors
- Manabe, T., Renner, P., & Nicoll, R. A.
- Affiliations
- University of California, San Francisco (US)
- Venue
- Nature
- Published
- 1992-01
- Volume
- 355
- Issue
- 6355
- Pages
- 50-55
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1970096704
- Cited by
- 366
- References
- 35
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 6 · 2023: 1 · 2022: 5 · 2021: 7 · 2020: 4 · 2019: 2 · 2018: 8 · 2017: 3 · 2016: 6 · 2015: 6 · 2014: 6 · 2013: 4 · 2012: 3
- FWCI
- 22.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- long-term potentiation, miniature synaptic currents, CA1 pyramidal neurons, hippocampus, synaptic efficacy, excitatory synaptic transmission
- MeSH terms
- Animals, Electric Stimulation, Evoked Potentials, Hippocampus, Pyramidal Tracts, Quinoxalines, Synapses, Tetrodotoxin, N-Methylaspartate, 6-Cyano-7-nitroquinoxaline-2,3-dione, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
