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Targeted disruption of µ chain membrane exon causes loss of heavy-chain allelic exclusion

Kitamura, Daisuke, Rajewsky, Klaus·1992·Nature
DOI 10.1038/356154a0
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Abstract

Burnet's clonal selection theory suggests that each B lymphocyte is committed to a single antibody specificity. This is achieved by a programme of somatic rearrangements of the gene segments encoding antibody variable (V) regions, in the course of B-cell development. Evidence from immunoglobulin-transgenic mice and immunoglobulin-gene-transfected transformed pre-B cells suggest that the membrane form of the immunoglobulin heavy (H) chain of class mu (microns), expressed from a rearranged H-chain (IgH) locus, may signal allelic exclusion of the homologous IgH locus in the cell and initiation of light (L)-chain gene rearrangement in the Ig kappa loci. We report here that targeted disruption of the membrane exon of the mu chain indeed results in the loss of H-chain allelic exclusion. But, some kappa chain gene rearrangement is still observed in the absence of micron expression.

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Metadata

Authors
Kitamura, D., & Rajewsky, K.
Venue
Nature
Publisher
Springer Science and Business Media LLC
Published
1992-03
Volume
356
Issue
6365
Pages
154-156
ISSN
  • 0028-0836
  • 1476-4687
DOI
10.1038/356154a0
Cited by
254
References
0
Language
en
Licence
www.springer.com/tdm (tdm)

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