Cited by 1,443Genomics and Chromatin DynamicsProtein Kinase Regulation and GTPase SignalingSignaling Pathways in Disease

The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.

Nuclear protein CBP is a coactivator for the transcription factor CREB

Kwok, Roland P. S., Lundblad, James R., Chrivia, John C., Richards, Jane P., Bächinger, Hans Peter, Brennan, Richard G., Roberts, Stefan G. E., Green, Michael R., Goodman, Richard H.·1994·Nature

DOI 10.1038/370223a0

Open this paper in CoChat — free account

Abstract

The transcription factor CREB binds to a DNA element known as the cAMP-regulated enhancer (CRE). CREB is activated through phosphorylation by protein kinase A (PKA), but precisely how phosphorylation stimulates CREB function is unknown. One model is that phosphorylation may allow the recruitment of coactivators which then interact with basal transcription factors. We have previously identified a nuclear protein of M(r)265K, CBP, that binds specifically to the PKA-phosphorylated form of CREB. We have used fluorescence anisotropy measurements to define the equilibrium binding parameters of the phosphoCREB:CBP interaction and report here that CBP can activate transcription through a region in its carboxy terminus. The activation domain of CBP interacts with the basal transcription factor TFIIB through a domain that is conserved in the yeast coactivator ADA-1 (ref. 8). Consistent with its role as a coactivator, CBP augments the activity of phosphorylated CREB to activate transcription of cAMP-responsive genes.

Integrity signals

Registry

Crossref · 10.1038/370223a0

Cites

19 of 19 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133
Gonzalez, G. A., & Montminy, M. (1989) · Cell · doi:10.1016/0092-8674(89)90013-5 · Cited by 2,464
Phosphorylated CREB binds specifically to the nuclear protein CBP
Chrivia, J. C., Kwok, R. P. S., Lamb, N., Hagiwara, M., Montminy, M. R., & Goodman, R. H. (1993) · Nature · doi:10.1038/365855a0 · Cited by 2,052
Self-citation
Eukaryotic proteins expressed in Escherichia coli: an improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase.
Guan, K., & Dixon, J. (1991) · Analytical Biochemistry · doi:10.1016/0003-2697(91)90534-z · Cited by 1,735
Identification of a cyclic-AMP-responsive element within the rat somatostatin gene.
Montminy, M., Sevarino, K. A., Wagner, J. A., Mandel, G., & Goodman, R. H. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.18.6682 · Cited by 1,385
Self-citation
A cluster of phosphorylation sites on the cyclic AMP-regulated nuclear factor CREB predicted by its sequence
Gonzalez, G. A., Yamamoto, K. K., Fischer, W. H., Karr, D., Menzel, P., Biggs, W., Vale, W., & Montminy, M. (1989) · Nature · doi:10.1038/337749a0 · Cited by 875
A cyclic AMP- and phorbol ester-inducible DNA element
Comb, M. J., Birnberg, N. C., Seasholtz, A. F., Herbert, E., & Goodman, H. M. (1986) · Nature · doi:10.1038/323353a0 · Cited by 741
Cyclic AMP-Responsive DNA-Binding Protein: Structure Based on a Cloned Placental cDNA
Hoeffler, J. P., Meyer, T. E., Yun, Y., Jameson, J. L., & Habener, J. F. (1988) · Science · doi:10.1126/science.2974179 · Cited by 731
Transcription activation by the adenovirus E1a protein
Lillie, J. W., & Green, M. R. (1989) · Nature · doi:10.1038/338039a0 · Cited by 617
Self-citation
Genetic isolation of ADA2: A potential transcriptional adaptor required for function of certain acidic activation domains
Berger, S. L., Piña, B., Silverman, N., Marcus, G. A., Agapite, J., Regier, J. L., Triezenberg, S. J., & Guarente, L. (1992) · Cell · doi:10.1016/0092-8674(92)90100-q · Cited by 435
Drosophila TAFII40 interacts with both a VP16 activation domain and the basal transcription factor TFIIB.
Goodrich, J., Hoey, T., Thut, C., Admon, A., & Tjian, R. (1993) · Cell · doi:10.1016/0092-8674(93)90386-5 · Cited by 417

Show all 19 references

Research works printed but not linked: 1

Gonzalez, G. A. & Montminy, M. R. Cell 59, 675–680 (1989). · DOI

Sorted by citations

Items 301–400 of 1,000

Cooperation of Sp1 and p300 in the induction of the CDK inhibitor p21WAF1/CIP1 during NGF-mediated neuronal differentiation
Billon, N., Carlisi, D., Datto, M., van Grunsven, L. A., Watt, A. J., Wang, X., & Rudkin, B. B. (1999) · Oncogene · doi:10.1038/sj.onc.1202712 · Cited by 150
Role of NMDA Receptor-Mediated Glutamatergic Signaling in Chronic and Acute Neuropathologies
Carvajal, F. J., Mattison, H. A., & Cerpa, W. F. (2016) · Neural Plasticity · doi:10.1155/2016/2701526 · Cited by 154
The Transcription Coactivator Cbp Is a Dynamic Component of the Promyelocytic Leukemia Nuclear Body
Boisvert, F., Kruhlak, M. J., Box, A. K., Hendzel, M. J., & Bazett‐Jones, D. P. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.152.5.1099 · Cited by 155
A chromatin link to caste identity in the carpenter ant Camponotus floridanusPreprint
Simola, D. F., Ye, C., Mutti, N. S., Dolezal, K., Bonasio, R., Liebig, J., Reinberg, D., & Berger, S. L. (2012) · Genome Research · doi:10.1101/gr.148361.112 · Cited by 150
Cell-type-specific binding of the transcription factor CREB to the cAMP-response element
Cha‐Molstad, H., Keller, D. M., Yochum, G. S., Impey, S., & Goodman, R. H. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405587101 · Cited by 149
Self-citation
HIV transcriptional activation by the accessory protein, VPR, is mediated by the p300 co-activator
Felzien, L. K., Woffendin, C., Hottiger, M. O., Subbramanian, R. A., Cohen, É. A., & Nabel, G. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.9.5281 · Cited by 148
Mechanisms of lung neutrophil activation after hemorrhage or endotoxemia: roles of reactive oxygen intermediates, NF-kappa B, and cyclic AMP response element binding protein.
Shenkar, R., & Abraham, E. H. (1999) · PubMed · Cited by 148
Prostate cancer: molecular biology of early progression to androgen independence.
Sadar, M. D., Hussain, M., & Bruchovsky, N. (1999) · Endocrine Related Cancer · doi:10.1677/erc.0.0060487 · Cited by 148
Regulation of the human P450scc gene by steroidogenic factor 1 is mediated by CBP/p300
Monté, D., DeWitte, F., & Hum, D. W. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.8.4585 · Cited by 147
Functional Characterization of Transcription Regulators That Interact with the Electrophile Response Element
Zhu, M., & Fahl, W. E. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5944 · Cited by 148
Multiple protein kinase A-regulated events are required for transcriptional induction by cAMP.
Brindle, P. K., Nakajima, T., & Montminy, M. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.23.10521 · Cited by 144
Interactions between the Class II Transactivator and CREB Binding Protein Increase Transcription of Major Histocompatibility Complex Class II Genes
Fontes, J. D., Kanazawa, S., Jean, D., & Peterlin, B. M. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.1.941 · Cited by 144
Calcium and cAMP Signals Differentially Regulate cAMP-responsive Element-binding Protein Function via a Rap1-Extracellular Signal-regulated Kinase Pathway
Grewal, S., Fass, D. M., Yao, H. W., Ellig, C. L., Goodman, R. H., & Stork, P. A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004728200 · Cited by 145
Self-citation
Inhibition of p300 Histone Acetyltransferase by Viral Interferon Regulatory Factor
Li, M., Damania, B., Alvarez, X., Ogryzko, V., Ozato, K., & Jung, J. U. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.21.8254-8263.2000 · Cited by 142
Regulation of Gene Expression by cGMP-dependent Protein Kinase
Gudi, T., Huvar, I., Meinecke, M., Lohmann, S. M., Boss, G. R., & Pilz, R. B. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.9.4597 · Cited by 144
Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator
Ko, L., Cardona, G. R., & Chin, W. W. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.11.6212 · Cited by 144
Interaction between the HPV E7 oncoprotein and the transcriptional coactivator p300
Bernat, A., Avvakumov, N., Mymryk, J. S., & Banks, L. (2003) · Oncogene · doi:10.1038/sj.onc.1206896 · Cited by 145
Transcriptional coactivators in yeast and beyond
Guarente, L. (1995) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)89120-3 · Cited by 143
A CRE-like sequence that binds CREB and contributes to cAMP-dependent regulation of the proximal promoter of the human aromatase P450 (CYP19) gene
Michael, M. D., Michael, L. F., & Simpson, E. R. (1997) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(97)00178-0 · Cited by 141
The Role of Coactivators and Corepressors in the Biology and Mechanism of Action of Steroid Hormone Receptors
Edwards, D. P. (2000) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1023/a:1009503029176 · Cited by 142
Induction of Meiosis in Saccharomyces cerevisiae Depends on Conversion of the Transcriptional Repressor Ume6 to a Positive Regulator by Its Regulated Association with the Transcriptional Activator Ime1
Rubin-Bejerano, I., Mandel, S. A., Robzyk, K., & Kassir, Y. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.5.2518 · Cited by 140
p300 Mediates Transcriptional Stimulation by the Basic Helix-Loop-Helix Activators of the Insulin Gene
Qiu, Y., Sharma, A., & Stein, R. W. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.5.2957 · Cited by 139
Transcriptional Induction by Double-stranded RNA Is Mediated by Interferon-stimulated Response Elements without Activation of Interferon-stimulated Gene Factor 3
Bandyopadhyay, S. K., Leonard, G. T., Bandyopadhyay, T., Stark, G. R., & Sen, G. C. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.33.19624 · Cited by 140
Relative binding affinities of OmpR and OmpR-phosphate at the ompF and ompC regulatory sites 1 1Edited by R. Ebright
Head, C., Tardy, A., & Kenney, L. J. (1998) · Journal of Molecular Biology · doi:10.1006/jmbi.1998.1985 · Cited by 140
p300/cAMP-responsive Element-binding Protein Interactions with Ets-1 and Ets-2 in the Transcriptional Activation of the Human Stromelysin Promoter
Jayaraman, G., Srinivas, R., Duggan, C. R., Ferreira, E., Swaminathan, S., Somasundaram, K., Williams, J. T., Hauser, C. A., Kurkinen, M. T., Dhar, R., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.24.17342 · Cited by 140
CBP/p300 histone acetyl-transferase activity is important for the G1/S transition
Ait‐Si‐Ali, S., Polesskaya, A., Filleur, S., Ferreira, R., Duquet, A., Robin, P., Vervisch, A., Trouche, D., Cabon, F., & Harel‐Bellan, A. (2000) · Oncogene · doi:10.1038/sj.onc.1203562 · Cited by 145
The basic helix-loop-helix protein BETA2 interacts with p300 to coordinate differentiation of secretin-expressing enteroendocrine cellsPreprint
Mutoh, H., Naya, F. J., Tsai, M., & Leiter, A. B. (1998) · Genes & Development · doi:10.1101/gad.12.6.820 · Cited by 141
PCAF Interacts with Tax and Stimulates Tax Transactivation in a Histone Acetyltransferase-Independent Manner
Jiang, H., Lu, H., Schiltz, R. L., Pise-Masison, C. A., Ogryzko, V. V., Nakatani, Y., & Brady, J. N. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.12.8136 · Cited by 144
Modulation of cytokine‐induced HIV gene expression by competitive binding of transcription factors to the coactivator p300
Hottiger, M. O., Felzien, L. K., & Nabel, G. J. (1998) · The EMBO Journal · doi:10.1093/emboj/17.11.3124 · Cited by 137
Histone Lysine and Genomic Targets of Histone Acetyltransferases in Mammals
Voss, A. K., & Thomas, T. (2018) · BioEssays · doi:10.1002/bies.201800078 · Cited by 141
CCAAT/Enhancer-binding Protein Family Members Recruit the Coactivator CREB-binding Protein and Trigger Its Phosphorylation
Kovács, K. A., Steinmann, M., Magistretti, P. J., Halfon, O., & Cardinaux, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303147200 · Cited by 135
Steroidogenic Factor-1 Contains a Carboxy-Terminal Transcriptional Activation Domain That Interacts with Steroid Receptor Coactivator-1
Ito, M., Yu, R. N., & Jameson, J. L. (1998) · Molecular Endocrinology · doi:10.1210/mend.12.2.0059 · Cited by 137
Identification and Characterization of RRM-containing Coactivator Activator (CoAA) as TRBP-interacting Protein, and Its Splice Variant as a Coactivator Modulator (CoAM)
Iwasaki, T., Chin, W. W., & Ko, L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101517200 · Cited by 136
Loss of CBP acetyltransferase activity by PHD finger mutations in Rubinstein-Taybi syndrome
Kalkhoven, E. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg039 · Cited by 143
Identification of Two RNA-binding Proteins Associated with Human Telomerase RNA
Le, S., Sternglanz, R., & Greider, C. W. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.3.999 · Cited by 137
17β-Estradiol Stimulates the Growth of Human Keratinocytes by Inducing Cyclin D2 Expression
Kanda, N., & Watanabe, S. (2004) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2004.12645.x · Cited by 159
Molecular Mechanisms of Transforming Growth Factor- Signaling
Hu, P. P.-C., Datto, M., & Wang, X. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.3.0333 · Cited by 137
Mitogen-Regulated RSK2-CBP Interaction Controls Their Kinase and Acetylase Activities
Mérienne, K., Pannetier, S., Harel‐Bellan, A., & Sassone‐Corsi, P. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.20.7089-7096.2001 · Cited by 136
Simple histone acetylation plays a complex role in the regulation of gene expression
Fukuda, H. (2006) · Briefings in Functional Genomics and Proteomics · doi:10.1093/bfgp/ell032 · Cited by 133
Molecular Mechanism of Hypoxia-inducible Factor 1α-p300 Interaction
Gu, J., Milligan, J., & Huang, E. L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009522200 · Cited by 129
Calcium regulation of gene expression in neurons: the mode of entry matters
Gallin, W. J., & Greenberg, M. E. (1995) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(95)80050-6 · Cited by 130
Targeting CREB-binding protein (CBP) loss of function as a therapeutic strategy in neurological disorders
Rouaux, C., Loeffler, J., & Boutillier, A. (2004) · Biochemical Pharmacology · doi:10.1016/j.bcp.2004.05.035 · Cited by 132
Acetylation of adenovirus E1A regulates binding of the transcriptional corepressor CtBP
Zhang, Q., Yao, H. W., Vo, N., & Goodman, R. H. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.011283598 · Cited by 129
Self-citation
Nuclear Receptor Coactivators Modulate Hormone-Dependent Gene Expression in Brain and Female Reproductive Behavior in Rats
Molenda‐Figueira, H. A., Griffin, A. L., Auger, A. P., McCarthy, M. M., & Tetel, M. J. (2002) · Endocrinology · doi:10.1210/endo.143.2.8659 · Cited by 128
p300/CBP is required for transcriptional induction by interleukin-4 and interacts with Stat6
Gingras, S., Simard, J., Groner, B., & Pfitzner, E. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.13.2722 · Cited by 129
miR-34b Targets Cyclic AMP–Responsive Element Binding Protein in Acute Myeloid Leukemia
Pigazzi, M., Manara, E., Baron, E., & Basso, G. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-3404 · Cited by 130
Akt2 Regulates All Akt Isoforms and Promotes Resistance to Hypoxia through Induction of miR-21 upon Oxygen Deprivation
Polytarchou, C., Iliopoulos, D., Hatziapostolou, M., Kottakis, F., Maroulakou, I. G., Struhl, K., & Tsichlis, P. N. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-0365 · Cited by 132
Expression of aromatase in the ovary: Down-regulation of mRNA by the ovulatory luteinizing hormone surge
Fitzpatrick, S. L., Carlone, D. L., Robker, R. L., & Richards, J. S. (1997) · Steroids · doi:10.1016/s0039-128x(96)00181-x · Cited by 128
Self-citation
The role of NR4A transcription factors in memory formation
Hawk, J. D., & Abel, T. G. (2011) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2011.02.001 · Cited by 136
CBP, a transcriptional coactivator and acetyltransferase
McManus, K. J., & Hendzel, M. J. (2001) · Biochemistry and Cell Biology · doi:10.1139/o01-076 · Cited by 127
Mechanisms of Lung Neutrophil Activation After Hemorrhage or Endotoxemia: Roles of Reactive Oxygen Intermediates, NF-κB, and Cyclic AMP Response Element Binding Protein
Shenkar, R., & Abraham, E. H. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.2.954 · Cited by 127
Regulation of inducible gene expression by the transcription factor NF-κB
Ghosh, S. (1999) · Immunologic Research · doi:10.1007/bf02786486 · Cited by 126
Transactivation and growth suppression by the gut-enriched Kruppel-like factor (Kruppel-like factor 4) are dependent on acidic amino acid residues and protein-protein interaction
Geiman, D. E. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.5.1106 · Cited by 127
CBP/p300 Integrates Raf/Rac-Signaling Pathways in the Transcriptional Induction of NF-ATc during T Cell Activation
Avots, A., Buttmann, M., Chuvpilo, S. A., Escher, C., Smola, U., Bannister, A. J., Rapp, U. R., Kouzarides, T., & Serfling, E. (1999) · Immunity · doi:10.1016/s1074-7613(00)80051-5 · Cited by 125
Phosphorylation by p44 MAP Kinase/ERK1 Stimulates CBP Histone Acetyl Transferase Activity in Vitro
Ait‐Si‐Ali, S., Carlisi, D., Ramírez-Clavijo, S. R., Upegui-Gonzalez, L.-C., Duquet, A., Robin, P., Rudkin, B. B., Harel‐Bellan, A., & Trouche, D. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1132 · Cited by 126
MicroRNA‐182 targets cAMP‐responsive element‐binding protein 1 and suppresses cell growth in human gastric adenocarcinoma
Kong, W., Bai, R., Liu, T., Cai, C., Liu, M., Li, X., & Tang, H. (2012) · FEBS Journal · doi:10.1111/j.1742-4658.2012.08519.x · Cited by 124
How the Rb tumor suppressor structure and function was revealed by the study of Adenovirus and SV40
DeCaprio, J. A. (2009) · Virology · doi:10.1016/j.virol.2008.12.010 · Cited by 126
Immunity, Inflammation, and Remodeling in the Airway Epithelial Barrier: Epithelial-Viral-Allergic Paradigm
Holtzman, M. J., Morton, J. D., Shornick, L. P., Tyner, J. W., O’Sullivan, M. P., Antao, A. B., Lo, M. S., Castro, M., & Walter, M. J. (2002) · Physiological Reviews · doi:10.1152/physrev.00020.2001 · Cited by 121
E1A directly binds and regulates the P/CAF acetyltransferase
Reid, J. L., Bannister, A. J., Zegerman, P., Martínez‐Balbás, M. A., & Kouzarides, T. (1998) · The EMBO Journal · doi:10.1093/emboj/17.15.4469 · Cited by 124
Opposing effects of corepressor and coactivators in determining the dose-response curve of agonists, and residual agonist activity of antagonists, for glucocorticoid receptor-regulated gene expression.
Szapary, D., Huang, Y., & Simons, S. (1999) · Molecular Endocrinology · doi:10.1210/mend.13.12.0384 · Cited by 118
Recruitment of p300 by C/EBPβ triggers phosphorylation of p300 and modulates coactivator activity
Schwartz, C., Schachtrup, K., Mink, S., Schmolke, M., Budde, B., Wenning, D., & Klempnauer, K.-H. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg076 · Cited by 122
Human T-Cell Leukemia Virus Type 1 Tax Requires Direct Access to DNA for Recruitment of CREB Binding Protein to the Viral Promoter
Lenzmeier, B. A., Giebler, H. A., & Nyborg, J. K. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.2.721 · Cited by 122
Human Immunodeficiency Virus Type 1 (HIV-1) Accessory Protein Vpr Induces Transcription of the HIV-1 and Glucocorticoid-Responsive Promoters by Binding Directly to p300/CBP Coactivators
Kino, T., Gragerov, A., Slobodskaya, O. R., Tsopanomichalou, M., Chrousos, G. P., & Pavlakis, G. N. (2002) · Journal of Virology · doi:10.1128/jvi.76.19.9724-9734.2002 · Cited by 121
Regulation of Gene Expression by HTLV-I Tax Protein
Bex, F., & Gaynor, R. B. (1998) · Methods · doi:10.1006/meth.1998.0646 · Cited by 121
Synergistic Activation of the Inhibin -Promoter by Steroidogenic Factor-1 and Cyclic Adenosine 3',5'-Monophosphate
Ito, M., Park, Y., Weck, J., Mayo, K. E., & Jameson, J. L. (2000) · Molecular Endocrinology · doi:10.1210/mend.14.1.0410 · Cited by 118
Differential Transcriptional Activation by Human T-Cell Leukemia Virus Type 1 Tax Mutants Is Mediated by Distinct Interactions with CREB Binding Protein and p300
Bex, F., Yin, M.-J., Burny, A., & Gaynor, R. B. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.4.2392 · Cited by 121
Distinct roles for P-CREB and LEF-1 in TCR alpha enhancer assembly and activation on chromatin templates in vitro.
Mayall, T. P., Sheridan, P. L., Montminy, M. R., & Jones, K. A. (1997) · Genes & Development · doi:10.1101/gad.11.7.887 · Cited by 118
Coactivation of the CLOCK–BMAL1 complex by CBP mediates resetting of the circadian clock
Lee, Y., Lee, J., Kwon, I., Nakajima, Y., Ohmiya, Y., Son, G. H., Lee, K. H., & Kim, K. (2010) · Journal of Cell Science · doi:10.1242/jcs.070300 · Cited by 116
Yeast SUB1 is a suppressor of TFIIB mutations and has homology to the human co‐activator PC4.
Knaus, R., Pollock, R., & Guarente, L. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00544.x · Cited by 118
Creb-Binding Protein (Cbp/P300) and RNA Polymerase II Colocalize in Transcriptionally Active Domains in the Nucleus
von Mikecz, A. H., Zhang, S., Montminy, M., Tan, E. M., & Hemmerich, P. H. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.150.1.265 · Cited by 120
The versatile functions of the transcriptional coactivators p300 and CBP and their roles in disease.
Janknecht, R. (2002) · PubMed · doi:10.14670/hh-17.657 · Cited by 117
Phosphorylation of p300 at Serine 89 by Protein Kinase C
Yuan, L. W., & Gambee, J. E. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m007832200 · Cited by 119
Structural and Functional Analysis of Yeast Putative Adaptors
Candau, R., & Berger, S. L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.9.5237 · Cited by 117
Mechanisms That Mediate Negative Regulation of the Thyroid-stimulating Hormone α Gene by the Thyroid Hormone Receptor
Tagami, T., Park, Y., & Jameson, J. L. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.32.22345 · Cited by 121
The role of the cyclic AMP-responsive element binding protein (CREB) in hypoxic-ischemic brain damage and repair
Walton, M. R., Sirimanne, E. S., Williams, C., Gluckman, P. D., & Dragunow, M. (1996) · Molecular Brain Research · doi:10.1016/s0169-328x(96)00144-1 · Cited by 118
cAMP-response-element-binding-protein-binding protein (CBP) and p300 are transcriptional co-activators of early growth response factor-1 (Egr-1)
Silverman, E. S., Du, J., WILLIAMS, A. J., Wadgaonkar, R., Drazen, J. M., & Collins, T. (1998) · Biochemical Journal · doi:10.1042/bj3360183 · Cited by 114
Analysis of the Structural Properties of cAMP-responsive Element-binding Protein (CREB) and Phosphorylated CREB
Richards, J. P., Bächinger, H. P., Goodman, R. H., & Brennan, R. G. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.23.13716 · Cited by 118
Self-citation
Conditional MLL‐CBP targets GMP and models therapy‐related myeloproliferative disease
Wang, J., Iwasaki, H., Krivtsov, A. V., Febbo, P. G., Thorner, A. R., Ernst, P., Anastasiadou, E., Kutok, J. L., Kogan, S. C., Zinkel, S. S., et al. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600521 · Cited by 116
Retinoid Receptors and Their Coregulators
Wei, L. (2003) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.43.100901.140301 · Cited by 116
The CBP co-activator stimulates E2F1/DP1 activity
Trouche, D. (1996) · Nucleic Acids Research · doi:10.1093/nar/24.21.4139 · Cited by 120
p300 and p300/cAMP-responsive Element-binding Protein Associated Factor Interact with Human T-cell Lymphotropic Virus Type-1 Tax in a Multi-histone Acetyltransferase/Activator-Enhancer Complex
Harrod, R., Kuo, Y., Tang, Y., Yao, Y., Vassilev, A. P., Nakatani, Y., & Giam, C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.16.11852 · Cited by 121
Kinase interaction domain of kinase-associated protein phosphatase, a phosphoprotein-binding domain
Li, J., Smith, G. P., & Walker, J. C. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.14.7821 · Cited by 114
Cloning and characterization of hTAFII18, hTAFII20 and hTAFII28: three subunits of the human transcription factor TFIID.
Mengus, G., May, M., Jacq, X., Staub, A., Tora, L., Chambon, P., & Davidson, I. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07138.x · Cited by 115
Identification and Characterization of a Low Oxygen Response Element Involved in the Hypoxic Induction of a Family ofSaccharomyces cerevisiae Genes
Vasconcelles, M. J., Jiang, Y., McDaid, K., Gilooly, L., Wretzel, S., Porter, D. L., Martin, C. E., & Goldberg, M. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009546200 · Cited by 114
Transcriptional Regulation of the Genes Encoding the Cytochrome P-450 Steroid Hydroxylases
Parker, K. L., & Schimmer, B. P. (1995) · Vitamins and hormones · doi:10.1016/s0083-6729(08)61044-4 · Cited by 114
Characterization of Human Activating Transcription Factor 4, a Transcriptional Activator That Interacts with Multiple Domains of cAMP-responsive Element-binding Protein (CREB)-binding Protein (CBP)
Liang, G., & Hai, T. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.38.24088 · Cited by 114
Drosophila CBP is required for dorsal–dependent twist gene expression
Akimaru, H., Hou, D., & Ishii, S. (1997) · Nature Genetics · doi:10.1038/ng1097-211 · Cited by 116
Regulation of Lef-mediated Transcription and p53-dependent Pathway by Associating β-Catenin with CBP/p300
Miyagishi, M., Fujii, R., Hatta, M., Yoshida, E., Araya, N., Nagafuchi, A., Ishihara, S., Nakajima, T., & Fukamizu, A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.c000258200 · Cited by 113
Shaping synaptic plasticity: The role of activity‐mediated epigenetic regulation on gene transcription
Cortés‐Mendoza, J., de León‐Guerrero, S. D., Pedraza‐Alva, G., & Pérez‐Martínez, L. (2013) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2013.04.003 · Cited by 117
Ca2+‐dependent block of CREB–CBP transcription by repressor DREAM
Ledo, F., Kremer, L., Mellström, B., & Naranjo, J. R. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf440 · Cited by 113
The role of Kaposi's sarcoma-associated herpesvirus/human herpesvirus-8 regulator of transcription activation (RTA) in control of gene expression
West, J. T., & Wood, C. A. (2003) · Oncogene · doi:10.1038/sj.onc.1206555 · Cited by 113
A coactivator trap identifies NONO (p54 nrb ) as a component of the cAMP-signaling pathway
Amelio, A. L., Miraglia, L. J., Conkright, J. J., Mercer, B. A., Batalov, S., Cavett, V. J., Orth, A. P., Caldwell-Busby, J., Hogenesch, J. B., & Conkright, M. D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707999105 · Cited by 115
Transcription‐dependent neuronal plasticity
Bading, H. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01565.x · Cited by 114
Physical and functional interactions between the transcription factor PU.1 and the coactivator CBP
Yamamoto, H., Kihara-Negishi, F., Yamada, T., Hashimoto, Y., & Oikawa, T. (1999) · Oncogene · doi:10.1038/sj.onc.1202427 · Cited by 113
Genomic occupancy of the transcriptional co-activators p300 and CBP
Holmqvist, P.-H., & Mannervik, M. (2012) · Transcription · doi:10.4161/trns.22601 · Cited by 113
Functional and Subcellular Changes in the A-Kinase-Signaling Pathway: Relation to Aromatase and Sgk Expression during the Transition of Granulosa Cells to Luteal Cells
González, I., Alliston, T. N., Buse, P., Firestone, G. L., & Richards, J. S. (1999) · Molecular Endocrinology · doi:10.1210/me.13.8.1318 · Cited by 111
Self-citation
Signal integration at the c-fos promoter
Janknecht, R., Cahill, M. A., & Nordheim, A. (1995) · Carcinogenesis · doi:10.1093/carcin/16.3.443 · Cited by 112
The Transcriptional Activity of cAMP Response Element-binding Protein-binding Protein Is Modulated by the Latency Associated Nuclear Antigen of Kaposi's Sarcoma-associated Herpesvirus
Lim, C., Gwack, Y., Hwang, S., Kim, S.-H., & Choe, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102431200 · Cited by 110
Coregulators: From Whence Came These “Master Genes”
O’Malley, B. W. (2007) · Molecular Endocrinology · doi:10.1210/me.2007-0012 · Cited by 110
Binding of p53 to the KIX Domain of CREB Binding Protein
Orden, K. V., Giebler, H. A., Lemasson, I., Gonzales, M. S., & Nyborg, J. K. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.37.26321 · Cited by 111

Authors: Kwok, R. P. S., Lundblad, J. R., Chrivia, J. C., Richards, J. P., Bächinger, H. P., Brennan, R. G., Roberts, S. G. E., Green, M. R., & Goodman, R. H.
Affiliations: Oregon Health & Science University (US)
ORCID: Brennan, Richard G.
Roberts, Stefan G. E.
Green, Michael R.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1994-07
Volume: 370
Issue: 6486
Pages: 223-226
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/370223a0
OpenAlex: W1964337986
Cited by: 1,443
References: 19
Citations by year: 2026: 3 · 2025: 10 · 2024: 15 · 2023: 10 · 2022: 16 · 2021: 15 · 2020: 15 · 2019: 7 · 2018: 18 · 2017: 21 · 2016: 22 · 2015: 13 · 2014: 21 · 2013: 29 · 2012: 36
FWCI: 30.10
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Research Explorer (The University of Manchester) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Keywords: CBP, CREB, transcriptional coactivator, transcriptional activation, protein kinase A phosphorylation, TFIIB, protein-protein interaction
MeSH terms: Animals, Base Sequence, Binding Sites, DNA, Enhancer Elements, Genetic, Fluorescence Polarization, Molecular Sequence Data, Nuclear Proteins, Phosphorylation, Protein Binding, Recombinant Fusion Proteins, Somatostatin, Transcription Factors, Transcription, Genetic, Tumor Cells, Cultured, Trans-Activators, Zinc Fingers, PC12 Cells, Cyclic AMP Response Element-Binding Protein, Transcription Factor TFIIB, CREB-Binding Protein, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Nuclear protein CBP is a coactivator for the transcription factor CREB

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks