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An early haematopoietic defect in mice lacking the transcription factor GATA-2

Tsai, Fong-Ying, Keller, Gordon, Kuo, Frank C., Weiss, Mitchell, Chen, Jianzhou, Rosenblatt, Margery, Alt, Frederick W., Orkin, Stuart H.·1994·Nature
DOI 10.1038/371221a0
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Abstract

Blood cell development relies on the expansion and maintenance of haematopoietic stem and progenitor cells in the embryo. By gene targeting in mouse embryonic stem cells, we demonstrate that the transcription factor GATA-2 plays a critical role in haematopoiesis, particularly of an adult type. We propose that GATA-2 regulates genes controlling growth factor responsiveness or the proliferative capacity of early haematopoietic cells.

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Crossref · 10.1038/371221a0

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4 of 4 references verified0 citation errors · 0 not checkable

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Citations

Cites

Research works printed but not linked: 35

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Cited by

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Metadata

Authors
Tsai, F.-Y., Keller, G., Kuo, F. C., Weiss, M., Chen, J., Rosenblatt, M., Alt, F. W., & Orkin, S. H.
Venue
Nature
Publisher
Springer Science and Business Media LLC
Published
1994-09
Volume
371
Issue
6494
Pages
221-226
ISSN
  • 0028-0836
  • 1476-4687
DOI
10.1038/371221a0
Cited by
1,237
References
4
Language
en
Licence
www.springer.com/tdm (tdm)

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