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An early haematopoietic defect in mice lacking the transcription factor GATA-2
Abstract
Blood cell development relies on the expansion and maintenance of haematopoietic stem and progenitor cells in the embryo. By gene targeting in mouse embryonic stem cells, we demonstrate that the transcription factor GATA-2 plays a critical role in haematopoiesis, particularly of an adult type. We propose that GATA-2 regulates genes controlling growth factor responsiveness or the proliferative capacity of early haematopoietic cells.
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“Reports on the role of GATA-2 in eosinophil differentiation and function have shown that it can have positive, as well as negative regulatory functions. 8 -14”
From RhoH is a negative regulator of eosinophilopoiesis (2016) · cites this paper as [8]
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Metadata
- Authors
- Tsai, F.-Y., Keller, G., Kuo, F. C., Weiss, M., Chen, J., Rosenblatt, M., Alt, F. W., & Orkin, S. H.
- Venue
- Nature
- Published
- 1994-09
- Volume
- 371
- Issue
- 6494
- Pages
- 221-226
- ISSN
- 0028-0836
- 1476-4687
- Cited by
- 1,237
- References
- 4
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
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