Cited by 662T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisImmune Response and Inflammation

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Differential production of interferon-γ and interleukin-4 in response to Th1- and Th2-stimulating pathogens by γδ T cells in vivo

Ferrick, David A., Schrenzel, Mark D., Mulvania, Thera, Hsieh, Beryl, Ferlin, Walter G., Lepper, Heather·1995·Nature

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Abstract

Exposure to various pathogens can stimulate at least two patterns of cytokine production by CD4-positive T cells. Responses that result in secretion of interferon-gamma (IFN-gamma), lymphotoxin and interleukin-2 (IL-2) are classified as T-helper-1 (Th1); CD4+ T-cell production of IL-4, IL-5, IL-9, IL-10 and IL-13 is called a T-helper-2 response (Th2). Differentiation of CD4+ T cells into either Th1 or Th2 cells is influenced by the cytokine milieu in which the initial antigen priming occurs. Here we use flow cytometry to identify the presence of intracellular cytokines (cytoflow) and analyse T-cell production of IFN-gamma and IL-4 from mice infected with Listeria monocytogenes or Nippostrongylus brasiliensis. We show that T cells bearing gamma delta receptors discriminate early in infection between these two pathogens by producing cytokines associated with the appropriate T-helper response. Our results demonstrate that gamma delta T cells are involved in establishing primary immune responses.

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Authors: Ferrick, D. A., Schrenzel, M. D., Mulvania, T., Hsieh, B., Ferlin, W. G., & Lepper, H.
Affiliations: University of California, Davis (US)
ORCID: Ferlin, Walter G.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1995-01
Volume: 373
Issue: 6511
Pages: 255-257
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/373255a0
OpenAlex: W1895680870
Cited by: 662
References: 30
Citations by year: 2026: 2 · 2025: 5 · 2024: 4 · 2023: 5 · 2022: 7 · 2021: 2 · 2020: 6 · 2019: 3 · 2018: 6 · 2017: 6 · 2016: 7 · 2015: 6 · 2014: 12 · 2013: 12 · 2012: 14
FWCI: 29.29
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: γδ T cells, interferon-gamma, IL-4, Th1 response, Th2 immune response, Listeria monocytogenes, Nippostrongylus brasiliensis, primary immune response, intracellular cytokine production, CD4+ T cells, pathogen discrimination, cytokine milieu
MeSH terms: Animals, Flow Cytometry, Interferon-gamma, Listeriosis, Mice, Inbred C3H, Nippostrongylus, Peritoneum, Spleen, Interleukin-4, Receptors, Antigen, T-Cell, gamma-delta, Strongylida Infections, Th1 Cells, Th2 Cells, Mice

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Differential production of interferon-γ and interleukin-4 in response to Th1- and Th2-stimulating pathogens by γδ T cells in vivo

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