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Cited by 668Nicotinic Acetylcholine Receptors StudyNeuroscience and Neuropharmacology ResearchSmoking Behavior and Cessation

The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.

Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain

Picciotto, Marina R., Zoli, Michele, Léna, Clement, Bessis, Alain, Lallemand, Yvan, LeNovère, Nicolas, Vincent, Pierre, Pich, Emilio Merlo, Brûlet, Philippe, Changeux, Jean-Pierre·1995·Nature
DOI 10.1038/374065a0
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Abstract

Nicotine affects many aspects of behaviour including learning and memory through its interaction with neuronal nicotinic acetylcholine receptors (nAChR). Functional nAChRs are pentameric proteins containing at least one type of alpha-subunit and one type of beta-subunit. The involvement of a particular neuronal nicotinic subunit in pharmacology and behaviour was examined using gene targeting to mutate beta 2, the most widely expressed nAChR subunit in the central nervous system. We report here that high-affinity binding sites for nicotine are absent from the brains of mice homozygous for the beta 2-subunit mutation. Further, electrophysiological recording from brain slices reveals that thalamic neurons from these mice do not respond to nicotine application. Finally, behavioural tests demonstrate that nicotine no longer augments the performance of beta 2-1- mice on passive avoidance, a test of associative memory. Paradoxically, mutant mice are able to perform better than their non-mutant siblings on this task.

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Crossref · 10.1038/374065a0

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Research works printed but not linked: 5

  1. Zoli, M., Le Novère, N., Hill, J. A. J. & Changeux, J.-P. J. Neurosci. (in the press).
  2. Flores, C. M., Rogers, S. W., Pabreza, L. A., Wolfe, B. B. & Kellar, K. J. Molec. Pharm. 41, 31–37 (1992).
  3. Marks, M. J. & Collins, A. C. Molec. Pharm. 22, 554–564 (1982).
  4. Decker, M. W. et al. J. pharmacol. exp. Ther. 270, 319–328 (1994).
  5. Oliverio, A. J. pharmacol. exp. Ther. 154, 350–356 (1966).

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Metadata

Authors
Picciotto, M. R., Zoli, M., Léna, C., Bessis, A., Lallemand, Y., LeNovère, N., Vincent, P., Pich, E. M., Brûlet, P., & Changeux, J.-P.
Affiliations
Centre National de la Recherche Scientifique (FR)
ORCID
Venue
Nature
Publisher
Springer Science and Business Media LLC
Published
1995-03
Volume
374
Issue
6517
Pages
65-67
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
DOI
10.1038/374065a0
OpenAlex
W1996157865
Cited by
668
References
26
Citations by year
2026: 2 · 2025: 4 · 2023: 9 · 2022: 27 · 2021: 8 · 2020: 15 · 2019: 12 · 2018: 10 · 2017: 12 · 2016: 17 · 2015: 16 · 2014: 18 · 2013: 20 · 2012: 27
FWCI
10.67
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Nature (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
Keywords
nicotinic acetylcholine receptors, beta2 subunit, avoidance learning, passive avoidance, associative memory, thalamic neurons, nicotine binding, gene targeting
MeSH terms
Animals, Avoidance Learning, Base Sequence, Brain, Cell Line, DNA, Female, Homozygote, Hypothalamus, Male, Mice, Inbred C57BL, Mice, Inbred DBA, Molecular Sequence Data, Mutation, Nicotine, Receptors, Nicotinic, Patch-Clamp Techniques, Mice

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