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Fear conditioning induces associative long-term potentiation in the amygdala

Rogan, Michael T., Stäubli, Ursula V., LeDoux, Joseph E.·1997·Nature

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Abstract

Long-term potentiation (LTP) is an experience-dependent form of neural plasticity believed to involve mechanisms that underlie memory formation. LTP has been studied most extensively in the hippocampus, but the relation between hippocampal LTP and memory has been difficult to establish. Here we explore the relation between LTP and memory in fear conditioning, an amygdala-dependent form of learning in which an innocuous conditioned stimulus (CS) elicits fear responses after being associatively paired with an aversive unconditioned stimulus (US). We have previously shown that LTP induction in pathways that transmit auditory CS information to the lateral nucleus of the amygdala (LA) increases auditory-evoked field potentials in this nucleus. Now we show that fear conditioning alters auditory CS-evoked responses in LA in the same way as LTP induction. The changes parallel the acquisition of CS-elicited fear behaviour, are enduring, and do not occur if the CS and US remain unpaired. LTP-like associative processes thus occur during fear conditioning, and these may underlie the long-term associative plasticity that constitutes memory of the conditioning experience.

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Background
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Authors: Rogan, M. T., Stäubli, U. V., & LeDoux, J. E.
Affiliations: New York University (US)
Corresponding author: Rogan, Michael T.
ORCID: LeDoux, Joseph E.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1997-12-01
Volume: 390
Issue: 6660
Pages: 604-607
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/37601
OpenAlex: W1703928766
Cited by: 1,310
References: 32
Citations by year: 2026: 23 · 2025: 27 · 2024: 43 · 2023: 20 · 2022: 28 · 2021: 37 · 2020: 41 · 2019: 31 · 2018: 40 · 2017: 48 · 2016: 43 · 2015: 53 · 2014: 63 · 2013: 56 · 2012: 46
FWCI: 30.17
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Keywords: long-term potentiation, fear conditioning, amygdala, lateral amygdala, associative plasticity, memory formation, auditory conditioned stimulus, neuroplasticity
MeSH terms: Amygdala, Animals, Association Learning, Conditioning, Classical, Evoked Potentials, Auditory, Fear, Memory, Long-Term Potentiation, Rats

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Fear conditioning induces associative long-term potentiation in the amygdala

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