Fear Conditioning and Long‐term Potentiation in the Amygdala: What Really Is the Connection?

Sah, P.; Westbrook, R. F.; Lüthi, A.

doi:10.1196/annals.1417.020

Cited by 138Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

Fear Conditioning and Long‐term Potentiation in the Amygdala: What Really Is the Connection?

Sah, P., Westbrook, R. F., Lüthi, A.·2008·Annals of the New York Academy of Sciences

DOI 10.1196/annals.1417.020

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Abstract

The cellular mechanisms that underlie learning and memory formation remain one of the most intriguing unknowns about the mammalian brain. A plethora of experimental evidence over the last 30 years has established that long‐term synaptic plasticity at excitatory synapses is the most likely mechanism that underlies learning and memory formation. Experiments done largely in acute brain slices maintained in vitro have revealed many of the molecular mechanisms in the induction and maintenance of long‐term potentiation (LTP). However, evidence directly liking LTP with learning and memory formation has not been established. Pavlovian fear conditioning is a good candidate to provide such evidence. The relations between events that produce fear conditioning are simple; these relations and their fear products involve circuits in the amygdala that are well understood, as are those circuits in the amygdala that underlie LTP. The evidence that links LTP in the amygdala with fear conditioning is reviewed.

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A large number of studies have provided convincing evidence that associative plasticity in the LA contributes to fear memory formation.
“A large number of studies have provided convincing evidence that associative plasticity in the LA contributes to fear memory formation (4, 6, 7).”
From Optical activation of lateral amygdala pyramidal cells instructs associative fear learning (2010) · cites this paper as [4]
Fear conditioning is a simple form of associative learning that provides a powerful model system to study associative plasticity and memory formation.
“Fear conditioning is a simple form of associative learning that provides a powerful model system to study associative plasticity and memory formation (1–4).”
From Optical activation of lateral amygdala pyramidal cells instructs associative fear learning (2010) · cites this paper as [4]

Emotion circuits in the brain
LeDoux, J. E. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.155 · Cited by 8,444 · see citing works
Long‐lasting potentiation of synaptic transmission in the dentate area of the unanaesthetized rabbit following stimulation of the perforant path
Bliss, T. V. P., & Gardner-Medwin, A. R. (1973) · The Journal of Physiology · doi:10.1113/jphysiol.1973.sp010274 · Cited by 7,460 · see citing works
Magnesium gates glutamate-activated channels in mouse central neurones
Nowak, L. M., Bregestovski, P. D., Ascher, P., Herbet, A., & Prochiantz, A. (1984) · Nature · doi:10.1038/307462a0 · Cited by 4,033 · see citing works
LTP and LTD
Malenka, R. C., & Bear, M. F. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.012 · Cited by 3,968 · see citing works
A model for Pavlovian learning: Variations in the effectiveness of conditioned but not of unconditioned stimuli.
Pearce, J. M., & Hall, G. (1980) · Psychological Review · doi:10.1037/0033-295x.87.6.532 · Cited by 3,023 · see citing works
The amygdala: vigilance and emotion
Davis, M., & Whalen, P. J. (2001) · Molecular Psychiatry · doi:10.1038/sj.mp.4000812 · Cited by 2,882 · see citing works
Synaptic Plasticity and Memory: An Evaluation of the Hypothesis
Martin, S. J., Grimwood, P. D., & Morris, R. G. M. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.649 · Cited by 2,794 · see citing works
AMPA Receptor Trafficking and Synaptic Plasticity
Malinow, R., & Malenka, R. C. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142758 · Cited by 2,588 · see citing works
The role of the amygdala in fear and anxiety
Davis, M. (1992) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.15.030192.002033 · Cited by 2,357 · see citing works
The Emotional Brain, Fear, and the Amygdala
LeDoux, J. (2003) · Cellular and Molecular Neurobiology · doi:10.1023/a:1025048802629 · Cited by 1,818 · see citing works
The Amygdaloid Complex: Anatomy and Physiology
SAH, P., FABER, E. S. L., LOPEZ DE ARMENTIA, M., & POWER, J. (2003) · Physiological Reviews · doi:10.1152/physrev.00002.2003 · Cited by 1,745 · see citing works
Self-citation
Predictability, surprise, attention, and conditioning
Kamin, L. J. (1967) · NASA Technical Reports Server (NASA) · Cited by 1,483 · see citing works
Fear conditioning induces associative long-term potentiation in the amygdala
Rogan, M. T., Stäubli, U. V., & LeDoux, J. E. (1997) · Nature · doi:10.1038/37601 · Cited by 1,310 · see citing works
Active propagation of somatic action potentials into neocortical pyramidal cell dendrites
Stuart, G. J., & Sakmann, B. (1994) · Nature · doi:10.1038/367069a0 · Cited by 1,289 · see citing works
NMDA receptors - their role in long-term potentiation
Collingridge, G. L., & Bliss, T. (1987) · Trends in Neurosciences · doi:10.1016/0166-2236(87)90175-5 · Cited by 1,174 · see citing works
Time, rate, and conditioning.
Gallistel, C. R., & Gibbon, J. (2000) · Psychological Review · doi:10.1037/0033-295x.107.2.289 · Cited by 1,122 · see citing works
Probability of shock in the presence and absence of cs in fear conditioning.
Rescorla, R. A. (1968) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0025984 · Cited by 1,067 · see citing works
Information Processing in Animals: Memory Mechanisms.
indicated, N. A. (1986) · Contemporary Psychology · doi:10.1037/024459 · Cited by 1,022 · see citing works
Reciprocal Connections between the Amygdala and the Hippocampal Formation, Perirhinal Cortex, and Postrhinal Cortex in Rat: A Review
Pitkänen, A., Pikkarainen, M., Nurminen, N., & Ylinen, A. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06738.x · Cited by 962 · see citing works
Contrasting properties of two forms of long-term potentiation in the hippocampus
Nicoll, R., & Malenka, R. (1995) · Nature · doi:10.1038/377115a0 · Cited by 854 · see citing works
Blocking of acquisition but not expression of conditioned fear-potentiated startle by NMDA antagonists in the amygdala
Miserendino, M. J. D., Sananes, C. B., Melia, K. R., & Davis, M. (1990) · Nature · doi:10.1038/345716a0 · Cited by 824 · see citing works
Fear conditioning enhances short-latency auditory responses of lateral amygdala neurons: Parallel recordings in the freely behaving rat
Quirk, G. J., Repa, J. C., & LeDoux, J. E. (1995) · Neuron · doi:10.1016/0896-6273(95)90092-6 · Cited by 808 · see citing works
Postsynaptic receptor trafficking underlying a form of associative learning
Rumpel, S., LeDoux, J., Zador, A., & Malinow, R. (2005) · Science · doi:10.1126/science.1103944 · Cited by 775 · see citing works
Fear conditioning induces a lasting potentiation of synaptic currents in vitro
McKernan, M. G., & Shinnick-Gallagher, P. (1997) · Nature · doi:10.1038/37605 · Cited by 771 · see citing works
Spike Timing-Dependent Plasticity: From Synapse to Perception
Dan, Y., & Poo, M.-M. (2006) · Physiological Reviews · doi:10.1152/physrev.00030.2005 · Cited by 675 · see citing works
NMDA and non-NMDA receptors are co-localized at individual excitatory synapses in cultured rat hippocampus
Bekkers, J. M., & Stevens, C. F. (1989) · Nature · doi:10.1038/341230a0 · Cited by 660 · see citing works
Synaptic plasticity at hippocampal mossy fibre synapses
Nicoll, R. A., & Schmitz, D. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1786 · Cited by 653 · see citing works
Dendritic spikes as a mechanism for cooperative long-term potentiation
Golding, N. L., Staff, N. P., & Spruston, N. (2002) · Nature · doi:10.1038/nature00854 · Cited by 623 · see citing works
Fear Conditioning Enhances Different Temporal Components of Tone-Evoked Spike Trains in Auditory Cortex and Lateral Amygdala
Quirk, G. J., Armony, J. L., & LeDoux, J. E. (1997) · Neuron · doi:10.1016/s0896-6273(00)80375-x · Cited by 563 · see citing works
Rethinking the Fear Circuit: The Central Nucleus of the Amygdala Is Required for the Acquisition, Consolidation, and Expression of Pavlovian Fear Conditioning
Wilensky, A. E., Schafe, G. E., Kristensen, M. P., & LeDoux, J. E. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4316-06.2006 · Cited by 533 · see citing works
Analysis of excitatory synaptic action in pyramidal cells using whole‐cell recording from rat hippocampal slices.
Hestrin, S., Nicoll, R. A., Perkel, D. J., & Sah, P. (1990) · The Journal of Physiology · doi:10.1113/jphysiol.1990.sp017980 · Cited by 491 · see citing works
Self-citation
Long-term potentiation in the amygdala: a mechanism for emotional learning and memory
Maren, S. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(99)01465-4 · Cited by 456 · see citing works
Somatosensory and auditory convergence in the lateral nucleus of the amygdala.
Romanski, L. M., Clugnet, M.-C., Bordi, F., & LeDoux, J. E. (1993) · Behavioral Neuroscience · doi:10.1037/0735-7044.107.3.444 · Cited by 446 · see citing works
Two different lateral amygdala cell populations contribute to the initiation and storage of memory
Repa, J. C., Muller, J., Apergis, J., Desrochers, T. M., Zhou, Y., & LeDoux, J. E. (2001) · Nature Neuroscience · doi:10.1038/89512 · Cited by 440 · see citing works
NMDA Receptors and L-Type Voltage-Gated Calcium Channels Contribute to Long-Term Potentiation and Different Components of Fear Memory Formation in the Lateral Amygdala
Bauer, E. P., Schafe, G. E., & LeDoux, J. E. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-12-05239.2002 · Cited by 438 · see citing works
Dopamine gates LTP induction in lateral amygdala by suppressing feedforward inhibition
Bissière, S., Humeau, Y., & Lüthi, A. (2003) · Nature Neuroscience · doi:10.1038/nn1058 · Cited by 415 · see citing works
Self-citation
Cellular neurophysiological approaches in the study of learning.
Kandel, E., & Spencer, W. A. (1968) · Physiological Reviews · doi:10.1152/physrev.1968.48.1.65 · Cited by 412 · see citing works
Intra-Amygdala Blockade of the NR2B Subunit of the NMDA Receptor Disrupts the Acquisition But Not the Expression of Fear Conditioning
Rodrigues, S. M., Schafe, G. E., & LeDoux, J. E. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-17-06889.2001 · Cited by 350 · see citing works
Dopamine-mediated modulation of odour-evoked amygdala potentials during pavlovian conditioning
Rosenkranz, J. A., & Grace, A. A. (2002) · Nature · doi:10.1038/417282a · Cited by 348 · see citing works
Postsynaptic Induction and PKA-Dependent Expression of LTP in the Lateral Amygdala
Huang, Y.-Y., & Kandel, E. R. (1998) · Neuron · doi:10.1016/s0896-6273(00)80524-3 · Cited by 333 · see citing works
Fear Conditioning Occludes LTP-Induced Presynaptic Enhancement of Synaptic Transmission in the Cortical Pathway to the Lateral Amygdala
Tsvetkov, E., Carlezon, W. A., Benes, F. M., Kandel, E. R., & Bolshakov, V. Y. (2002) · Neuron · doi:10.1016/s0896-6273(02)00645-1 · Cited by 321 · see citing works
N-methyl-D-aspartate receptor antagonist APV blocks acquisition but not expression of fear conditioning.
Kim, J. J., DeCola, J. P., Landeira-Fernández, J., & Fanselow, M. S. (1991) · Behavioral Neuroscience · doi:10.1037/0735-7044.105.1.126 · Cited by 295 · see citing works
LTP is accompanied by commensurate enhancement of auditory-evoked responses in a fear conditioning circuit
Rogan, M. T., & LeDoux, J. E. (1995) · Neuron · doi:10.1016/0896-6273(95)90070-5 · Cited by 292 · see citing works
Response properties of single units in areas of rat auditory thalamus that project to the amygdala
Bordi, F., & LeDoux, J. E. (1994) · Experimental Brain Research · doi:10.1007/bf00228415 · Cited by 291 · see citing works
Pain Pathways Involved in Fear Conditioning Measured with Fear-Potentiated Startle: Lesion Studies
Shi, C., & Davis, M. E. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-01-00420.1999 · Cited by 282 · see citing works
Presynaptic induction of heterosynaptic associative plasticity in the mammalian brain
Humeau, Y., Shaban, H., Bissière, S., & Lüthi, A. (2003) · Nature · doi:10.1038/nature02194 · Cited by 253 · see citing works
Self-citation
Lesions of the Basal Amygdala Block Expression of Conditioned Fear But Not Extinction
Anglada-Figueroa, D., & Quirk, G. J. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2600-05.2005 · Cited by 238 · see citing works
Long‐Term synaptic potentiation in the amygdala
Chapman, P. F., Kairiss, E. W., Keenan, C. L., & Brown, T. H. (1990) · Synapse · doi:10.1002/syn.890060306 · Cited by 234 · see citing works
Generalization of amygdala LTP and conditioned fear in the absence of presynaptic inhibition
Shaban, H., Humeau, Y., Herry, C., Casassus, G., Shigemoto, R., Ciocchi, S., Barbieri, S., van der Putten, H., Kaupmann, K., Bettler, B., et al. (2006) · Nature Neuroscience · doi:10.1038/nn1732 · Cited by 208 · see citing works
Self-citation
Synapse-specific reconsolidation of distinct fear memories in the lateral amygdala
Doyère, V., Dębiec, J., Monfils, M.-H., Schafe, G. E., & LeDoux, J. E. (2007) · Nature Neuroscience · doi:10.1038/nn1871 · Cited by 200 · see citing works
Amygdalar NMDA Receptors Are Critical for the Expression of Multiple Conditioned Fear Responses
Lee, H. J., Choi, J.-S., Brown, T. H., & Kim, J. J. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-11-04116.2001 · Cited by 195 · see citing works
Kinetics of Mg 2+ unblock of NMDA receptors: implications for spike‐timing dependent synaptic plasticity
Kampa, B. M., Clements, J., Jónás, P., & Stuart, G. J. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2003.058842 · Cited by 191 · see citing works
Differential Fear Conditioning Induces Reciprocal Changes in the Sensory Responses of Lateral Amygdala Neurons to the CS<sup>+</sup> and CS<sup>−</sup>
Collins, D. R., & Paré, D. (2000) · Learning & Memory · doi:10.1101/lm.7.2.97 · Cited by 171 · see citing works
Morphological and electrophysiological properties of principal neurons in the rat lateral amygdala in vitro.
Faber, E., Callister, R., & Sah, P. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.85.2.714 · Cited by 170 · see citing works
Self-citation
Dorsal hippocampus involvement in trace fear conditioning with long, but not short, trace intervals in mice.
Chowdhury, N., Quinn, J. J., & Fanselow, M. S. (2005) · Behavioral Neuroscience · doi:10.1037/0735-7044.119.5.1396 · Cited by 160 · see citing works
The basolateral amygdaloid complex as a cortical-like structure
Carlsen, J., & Heimer, L. (1988) · Brain Research · doi:10.1016/0006-8993(88)91418-7 · Cited by 149 · see citing works
Dendritic Spine Heterogeneity Determines Afferent-Specific Hebbian Plasticity in the Amygdala
Humeau, Y., Herry, C., Kemp, N., Shaban, H., Fourcaudot, E., Bissière, S., & Lüthi, A. (2005) · Neuron · doi:10.1016/j.neuron.2004.12.019 · Cited by 148 · see citing works
Self-citation
A Pathway-Specific Function for Different AMPA Receptor Subunits in Amygdala Long-Term Potentiation and Fear Conditioning
Humeau, Y., Reisel, D., Johnson, A. W., Borchardt, T., Jensen, V., Gebhardt, C., Bosch, V., Gass, P., Bannerman, D. M., Good, M. A., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2603-07.2007 · Cited by 147 · see citing works
Self-citation
The Role of Background Stimuli during Pavlovian Conditioning
Odling-Smee, F. J. (1975) · Quarterly Journal of Experimental Psychology · doi:10.1080/14640747508400480 · Cited by 141 · see citing works
Auditory-Evoked Spike Firing in the Lateral Amygdala and Pavlovian Fear Conditioning
Goosens, K. A., Hobin, J. A., & Maren, S. (2003) · Neuron · doi:10.1016/s0896-6273(03)00728-1 · Cited by 135 · see citing works
Development and Subunit Composition of Synaptic NMDA Receptors in the Amygdala: NR2B Synapses in the Adult Central Amygdala
de Armentia, M. L., & Sah, P. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-17-06876.2003 · Cited by 134 · see citing works
Self-citation
Involvement of cortical and thalamic auditory regions in retention of differential bradycardiac conditioning to acoustic conditioned stimuli in rabbits
Jarrell, T. W., Gentile, C. G., Romanski, L. M., McCabe, P. M., & Schneiderman, N. (1987) · Brain Research · doi:10.1016/0006-8993(87)91135-8 · Cited by 129 · see citing works
Distinct Populations of NMDA Receptors at Subcortical and Cortical Inputs to Principal Cells of the Lateral Amygdala
Weisskopf, M. G., & LeDoux, J. E. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.81.2.930 · Cited by 127 · see citing works
Injections of the NMDA Receptor Antagonist Aminophosphonopentanoic Acid into the Lateral Nucleus of the Amygdala Block the Expression of Fear-Potentiated Startle and Freezing
Fendt, M. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-11-04111.2001 · Cited by 117 · see citing works
Associations to contextual stimuli as a determinant of long-term habituation.
Marlin, N. A., & Miller, R. R. (1981) · Journal of Experimental Psychology Animal Behavior Processes · doi:10.1037/0097-7403.7.4.313 · Cited by 112 · see citing works
NMDA receptors are essential for the acquisition, but not expression, of conditional fear and associative spike firing in the lateral amygdala
Goosens, K. A., & Maren, S. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03513.x · Cited by 108 · see citing works
Auditory Fear Conditioning and Long-Term Potentiation in the Lateral Amygdala Require ERK/MAP Kinase Signaling in the Auditory Thalamus: A Role for Presynaptic Plasticity in the Fear System
Apergis-Schoute, A. M. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0096-05.2005 · Cited by 101 · see citing works
Long‐term potentiation in freely moving rats reveals asymmetries in thalamic and cortical inputs to the lateral amygdala
Doyère, V., Schafe, G. E., Sigurdsson, T., & LeDoux, J. E. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02707.x · Cited by 101 · see citing works
A different recruitment of the lateral and basolateral amygdala promotes contextual or elemental conditioned association in Pavlovian fear conditioning
Calandreau, L., Desmedt, A., Decorte, L., & Jaffard, R. (2005) · Learning & Memory · doi:10.1101/lm.92305 · Cited by 99 · see citing works
Excitatory synaptic inputs to pyramidal neurons of the lateral amygdala
Mahanty, N. K., & Sah, P. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00528.x · Cited by 69 · see citing works
Self-citation
Glutamatergic synaptic responses and long-term potentiation are impaired in the CA1 hippocampal area of calbindin D28k-deficient mice
Jouvenceau, A., Potier, B., Battini, R., Ferrari, S. M., Dutar, P., & Billard, J. (1999) · Synapse · doi:10.1002/(sici)1098-2396(19990901)33:3 · Cited by 52 · see citing works
Contribution of NR2B Subunits to Synaptic Transmission in Amygdaloid Interneurons
Szinyei, C., Stork, O., & Pape, H. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-07-02549.2003 · Cited by 49 · see citing works
Serotonin-1A antagonists attenuate the effects of nicotine withdrawal on the auditory startle response
Rasmussen, K., Kallman, M. J., & Helton, D. R. (1997) · Synapse · doi:10.1002/(sici)1098-2396(199710)27:2 · Cited by 43 · see citing works
The Overshadowing of Background Stimuli: Some Effects of Varying Amounts of Training and UCS Intensity
Odling-Smee, F. J. (1978) · Quarterly Journal of Experimental Psychology · doi:10.1080/14640747808400698 · Cited by 34 · see citing works
Embryonic development of the nervous system of the rhabdocoel flatwormMesostoma lingua (Abildgaard, 1789)
Younossi‐Hartenstein, A., Ehlers, U., & Hartenstein, V. (2000) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(20000124)416:4 · Cited by 33 · see citing works

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Johansen, J. P., Cain, C. K., Ostroff, L. E., & LeDoux, J. E. (2011) · Cell · doi:10.1016/j.cell.2011.10.009 · Cited by 1,012 · see citing works
Engineering a memory with LTD and LTP
Nabavi, S., Fox, R., Proulx, C. D., Lin, J. Y., Tsien, R. Y., & Malinow, R. (2014) · Nature · doi:10.1038/nature13294 · Cited by 980 · see citing works
Encoding of conditioned fear in central amygdala inhibitory circuits
Ciocchi, S., Herry, C., Grenier, F., Wolff, S. B. E., Letzkus, J. J., Vlachos, I., Ehrlich, I., Sprengel, R., Deisseroth, K., Stadler, M. B., et al. (2010) · Nature · doi:10.1038/nature09559 · Cited by 924 · see citing works
Self-citation
Fear conditioning, synaptic plasticity and the amygdala: implications for posttraumatic stress disorder
Mahan, A. L., & Ressler, K. J. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.06.007 · Cited by 616 · see citing works
Neuronal circuits of fear extinction
Herry, C., Ferraguti, F., Singewald, N., Letzkus, J. J., Ehrlich, I., & Lüthi, A. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07101.x · Cited by 484 · see citing works
Self-citation
Disinhibition, a Circuit Mechanism for Associative Learning and Memory
Letzkus, J. J., Wolff, S. B. E., & Lüthi, A. (2015) · Neuron · doi:10.1016/j.neuron.2015.09.024 · Cited by 401 · see citing works
Self-citation
Surviving threats: neural circuit and computational implications of a new taxonomy of defensive behaviour
LeDoux, J. E., & Daw, N. D. (2018) · Nature reviews. Neuroscience · doi:10.1038/nrn.2018.22 · Cited by 391 · see citing works
Neural ensemble dynamics underlying a long-term associative memory
Grewe, B. F., Gründemann, J., Kitch, L. J., Lecoq, J. A., Parker, J. G., Marshall, J. D., Larkin, M. C., Jercog, P. E., Grenier, F., Li, J. Z., et al. (2017) · Nature · doi:10.1038/nature21682 · Cited by 351 · see citing works
Self-citation
Neural substrates for expectation-modulated fear learning in the amygdala and periaqueductal gray
Johansen, J. P., Tarpley, J. W., LeDoux, J. E., & Blair, H. T. (2010) · Nature Neuroscience · doi:10.1038/nn.2594 · Cited by 312 · see citing works
Optical activation of lateral amygdala pyramidal cells instructs associative fear learning
Johansen, J. P., Hamanaka, H., Monfils, M. H., Behnia, R., Deisseroth, K., Blair, H. T., & LeDoux, J. E. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002418107 · Cited by 308 · see citing works
The amygdala and medial prefrontal cortex: partners in the fear circuit
Marek, R., Strobel, C., Bredy, T. W., & Sah, P. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2012.248575 · Cited by 304 · see citing works
Self-citation
Sleep deprivation causes memory deficits by negatively impacting neuronal connectivity in hippocampal area CA1
Havekes, R., Park, A. J., Tudor, J. C., Luczak, V. G., Hansen, R. T., Ferri, S. L., Bruinenberg, V. M., Poplawski, S. G., Day, J. P., Aton, S. J., et al. (2016) · eLife · doi:10.7554/elife.13424 · Cited by 292 · see citing works
Molecular and Cellular Approaches to Memory Allocation in Neural Circuits
Silva, A. J., Zhou, Y., Rogerson, T., Shobe, J. L., & Balaji, J. (2009) · Science · doi:10.1126/science.1174519 · Cited by 266 · see citing works
Neural Representations of Unconditioned Stimuli in Basolateral Amygdala Mediate Innate and Learned Responses
Gore, F., Schwartz, E. C., Brangers, B. C., Aladi, S., Stujenske, J. M., Likhtik, E., Russo, M. J., Gordon, J. A., Salzman, C. D., & Axel, R. (2015) · Cell · doi:10.1016/j.cell.2015.06.027 · Cited by 256 · see citing works
Untitled work
Doux, L. (2012) · doi:10.1016/b978-0-444-53860-4.00021-0 · Cited by 241 · see citing works
Interneurons in the basolateral amygdala
Spampanato, J. G., Polepalli, J. S., & Sah, P. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.11.006 · Cited by 205 · see citing works
Self-citation
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Pal, M. M. (2021) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2021.722323 · Cited by 194 · see citing works
Pathological circuit function underlying addiction and anxiety disorders
Lüthi, A., & Lüscher, C. (2014) · Nature Neuroscience · doi:10.1038/nn.3849 · Cited by 192 · see citing works
Self-citation
Presynaptic LTP and LTD of Excitatory and Inhibitory SynapsesPreprint
Castillo, P. E. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005728 · Cited by 169 · see citing works
An update on contextual fear memory mechanisms: Transition between Amygdala and Hippocampus
Chaaya, N., Battle, A. R., & Johnson, L. R. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.05.013 · Cited by 163 · see citing works
Fear and safety learning differentially affect synapse size and dendritic translation in the lateral amygdala
Ostroff, L. E., Cain, C. K., Bedont, J. L., Monfils, M., & LeDoux, J. E. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913384107 · Cited by 154 · see citing works
Parabrachial CGRP Neurons Establish and Sustain Aversive Taste Memories
Chen, J., Campos, C., Jarvie, B. C., & Palmiter, R. D. (2018) · Neuron · doi:10.1016/j.neuron.2018.09.032 · Cited by 157 · see citing works
Early-life stress affects the structural and functional plasticity of the medial prefrontal cortex in adolescent rats
Chocyk, A., Bobula, B., Dudys, D., Przyborowska, A., Majcher-Maślanka, I., Hess, G., & Wędzony, K. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12208 · Cited by 153 · see citing works
Targeting brain serotonin synthesis: insights into neurodevelopmental disorders with long-term outcomes related to negative emotionality, aggression and antisocial behaviour
Lesch, K., Araragi, N., Waider, J., van den Hove, D., & Gutknecht, L. (2012) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2012.0039 · Cited by 147 · see citing works
Asymmetry of brain and behavior in animals: Its development, function, and human relevance
Rogers, L. J. (2014) · genesis · doi:10.1002/dvg.22741 · Cited by 145 · see citing works
Animal models in translational studies of PTSD
Daskalakis, N. P., Yehuda, R., & Diamond, D. M. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.06.006 · Cited by 116 · see citing works
The functional profile of the human amygdala in affective processing: Insights from intracranial recordings
Murray, R. J., Brosch, T., & Sander, D. (2014) · Cortex · doi:10.1016/j.cortex.2014.06.010 · Cited by 105 · see citing works
Fear conditioning and the basolateral amygdala
Sun, Y., Gooch, H., & Sah, P. (2020) · F1000Research · doi:10.12688/f1000research.21201.1 · Cited by 104 · see citing works
Self-citation
FROM THE NEUROBIOLOGY OF EXTINCTION TO IMPROVED CLINICAL TREATMENTS
Morrison, F. G., & Ressler, K. J. (2013) · Depression and Anxiety · doi:10.1002/da.22214 · Cited by 103 · see citing works
Synapses lacking astrocyte appear in the amygdala during consolidation of pavlovian threat conditioning
Ostroff, L. E., Manzur, M. K., Cain, C. K., & LeDoux, J. E. (2013) · The Journal of Comparative Neurology · doi:10.1002/cne.23523 · Cited by 87 · see citing works
Controlling the Elements: An Optogenetic Approach to Understanding the Neural Circuits of Fear
Johansen, J. P., Wolff, S. B. E., Lüthi, A., & LeDoux, J. E. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.10.023 · Cited by 84 · see citing works
Self-citation
Aversion hot spots in the dopamine system
Verharen, J. P. H., Zhu, Y., & Lammel, S. (2020) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2020.02.002 · Cited by 79 · see citing works
Chronic intermittent ethanol and withdrawal differentially modulate basolateral amygdala AMPA-type glutamate receptor function and trafficking
Christian, D., Alexander, N. J., Diaz, M. R., Robinson, S. L., & McCool, B. A. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.02.017 · Cited by 76 · see citing works
Alcohol inhibition of the NMDA receptor function, long-term potentiation, and fear learning requires striatal-enriched protein tyrosine phosphatase
Hicklin, T. R., Wu, P. H., Radcliffe, R. A., Freund, R. K., Goebel-Goody, S. M., Correa, P. R., Proctor, W. R., Lombroso, P. J., & Browning, M. D. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1017856108 · Cited by 73 · see citing works
X‐linked mental retardation: focus on synaptic function and plasticity
Humeau, Y., Gambino, F., Chelly, J., & Vitale, N. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.05881.x · Cited by 67 · see citing works
Oxytocin signaling in basolateral and central amygdala nuclei differentially regulates the acquisition, expression, and extinction of context-conditioned fear in ratsPreprint
Campbell-Smith, E. J., Holmes, N. M., Lingawi, N. W., Panayi, M. C., & Westbrook, R. F. (2015) · Learning & memory (Cold Spring Harbor, N.Y.) · doi:10.1101/lm.036962.114 · Cited by 67 · see citing works
Self-citation
Neuropeptides at the crossroad of fear and hunger: a special focus on neuropeptide Y
Comeras, L. B., Herzog, H., & Tasan, R. O. (2019) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14179 · Cited by 63 · see citing works
NMDA receptor- and ERK-dependent histone methylation changes in the lateral amygdala bidirectionally regulate fear memory formationPreprint
Gupta, S., Jarome, T. J., Fernandez, J., & Lubin, F. D. (2014) · Learning & Memory · doi:10.1101/lm.035105.114 · Cited by 65 · see citing works
Impaired long-term potentiation and enhanced neuronal excitability in the amygdala of CaV1.3 knockout mice
McKinney, B. C., Sze, W., Lee, B., & Murphy, G. G. (2009) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2009.06.012 · Cited by 63 · see citing works
Exposure to silver impairs learning and social behaviors in adult zebrafish
Fu, C.-W., Horng, J., Tong, S., Cherng, B., Liao, B., Lin, L., & Chou, M. (2020) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2020.124031 · Cited by 60 · see citing works
Neurons in the barrel cortex turn into processing whisker and odor signals: a cellular mechanism for the storage and retrieval of associative signals
Wang, D., Zhao, J. W., Gao, Z., Chen, N., Wen, B., Lu, W., Lei, Z., Chen, C., Liu, Y., Feng, J., et al. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00320 · Cited by 54 · see citing works
ASIC-dependent LTP at multiple glutamatergic synapses in amygdala network is required for fear memory
Chiang, P., Chien, T.-C., Chen, C., Yanagawa, Y., & Lien, C. (2015) · Scientific Reports · doi:10.1038/srep10143 · Cited by 56 · see citing works
Out with the old and in with the new: Synaptic mechanisms of extinction in the amygdala
Maren, S. (2014) · Brain Research · doi:10.1016/j.brainres.2014.10.010 · Cited by 49 · see citing works
Thalamic glutamatergic afferents into the rat basolateral amygdala exhibit increased presynaptic glutamate function following withdrawal from chronic intermittent ethanol
Christian, D., Alexander, N. J., Diaz, M. R., & McCool, B. A. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.09.004 · Cited by 50 · see citing works
Synaptic NMDA receptors in basolateral amygdala principal neurons are triheteromeric proteins: physiological role of GluN2B subunits
Delaney, A., Sedlak, P. L., Autuori, E., Power, J., & Sah, P. (2012) · Journal of Neurophysiology · doi:10.1152/jn.00176.2012 · Cited by 47 · see citing works
Self-citation
Diversity of interneurons in the lateral and basal amygdala
Polepalli, J. S., Gooch, H. M., & Sah, P. (2020) · npj Science of Learning · doi:10.1038/s41539-020-0071-z · Cited by 47 · see citing works
Self-citation
Disruption of fear memory consolidation and reconsolidation by actin filament arrest in the basolateral amygdala
Rehberg, K., Bergado-Acosta, J. R., Koch, J. C., & Stork, O. (2010) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2010.04.007 · Cited by 46 · see citing works
Molecular Mechanisms of Threat Learning in the Lateral Nucleus of the Amygdala
Sears, R. M., Schiff, H. C., & LeDoux, J. E. (2014) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-420170-5.00010-6 · Cited by 44 · see citing works
Involvement of the GABAergic system in PTSD and its therapeutic significance
Huang, J., Xu, F., Yang, L.-P., Tuolihong, L., Wang, X., Du, Z., Zhang, Y., Yin, X., Li, Y.-J. D., Lu, K., et al. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1052288 · Cited by 41 · see citing works
Endogenous GluR1‐containing AMPA receptors translocate to asymmetric synapses in the lateral amygdala during the early phase of fear memory formation: An electron microscopic immunocytochemical study
Nedelescu, H., Kelso, C. M., Lázaro‐Muñoz, G., Purpura, M., Cain, C. K., LeDoux, J. E., & Aoki, C. J. (2010) · The Journal of Comparative Neurology · doi:10.1002/cne.22472 · Cited by 44 · see citing works
Activation of the Hippocampal DRD2 Alleviates Neuroinflammation, Synaptic Plasticity Damage and Cognitive Impairment After Sleep Deprivation
Gao, H., Zhang, Y., Luo, D., Xu, J., Tan, S., Li, Y., Qi, W., Zhai, Q., & Wang, Q. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03514-5 · Cited by 40 · see citing works
Stability of presynaptic vesicle pools and changes in synapse morphology in the amygdala following fear learning in adult rats
Ostroff, L. E., Cain, C. K., Jindal, N., Dar, N., & LeDoux, J. E. (2011) · The Journal of Comparative Neurology · doi:10.1002/cne.22691 · Cited by 39 · see citing works
Stress-Induced Enhancement of Mouse Amygdalar Synaptic Plasticity Depends on Glucocorticoid and ß-Adrenergic Activity
Sarabdjitsingh, R. A., Kofink, D., Karst, H., de Kloet, E. R., & Joëls, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042143 · Cited by 39 · see citing works
Amygdala Mechanisms of Pavlovian Psychostimulant Conditioning and Relapse
Buffalari, D. M., & See, R. E. (2009) · Current topics in behavioral neurosciences · doi:10.1007/7854_2009_18 · Cited by 36 · see citing works
Memory labilization in reconsolidation and extinction – Evidence for a common plasticity system?
Almeida-Corrêa, S., & Amaral, O. B. (2014) · Journal of Physiology-Paris · doi:10.1016/j.jphysparis.2014.08.006 · Cited by 36 · see citing works
Involvement of CRFR 1 in the Basolateral Amygdala in the Immediate Fear Extinction Deficit
Hollis, F., Sevelinges, Y., Grosse, J., Zanoletti, O., & Sandi, C. (2016) · eNeuro · doi:10.1523/eneuro.0084-16.2016 · Cited by 35 · see citing works
The effect of the mGlu5 negative allosteric modulator MTEP and NMDA receptor partial agonist D-cycloserine on Pavlovian conditioned fear
Handford, C. E., Tan, S. Z. K., Lawrence, A. J., & Kim, J. H. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145714000303 · Cited by 36 · see citing works
Neurotrophin signalling in amygdala-dependent cued fear learning
Meis, S., Endres, T., & Leßmann, V. (2020) · Cell and Tissue Research · doi:10.1007/s00441-020-03260-3 · Cited by 36 · see citing works
Functionally distinct amygdala subregions identified using DTI and high-resolution fMRI
Balderston, N. L., Schultz, D. H., Hopkins, L. S., & Helmstetter, F. J. (2015) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsv055 · Cited by 33 · see citing works
effects of 6-OHDA infusion into the hypothalamic paraventricular nucleus in mediating stress-induced behavioural responses and oxidative damage in rats
Ciobica, A. S. (2009) · Acta Endocrinologica (Bucharest) · doi:10.4183/aeb.2009.425 · Cited by 30 · see citing works
Hebbian reverberations in emotional memory micro circuits
Johnson, L. R., LeDoux, J. E., & Doyère, V. (2009) · Figshare · Cited by 30 · see citing works
Haploinsufficiency in Peptidylglycine α-Amidating Monooxygenase Leads to Altered Synaptic Transmission in the Amygdala and Impaired Emotional Responses
Gaier, E. D., Rodriguiz, R. M., Ma, X.-M. M., Sivaramakrishnan, S., Bousquet‐Moore, D., Wetsel, W. C., Eipper, B. A., & Mains, R. E. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.2200-10.2010 · Cited by 28 · see citing works
Offline consolidation of procedural skill learning is enhanced by negative emotional content
Javadi, A. H., Walsh, V., & Lewis, P. A. (2011) · Experimental Brain Research · doi:10.1007/s00221-010-2497-7 · Cited by 26 · see citing works
Genetic variation in 5-hydroxytryptamine transporter expression causes adaptive changes in 5-HT4 receptor levels
Jennings, K. A., Licht, C. L., Bruce, A., Lesch, K., Knudsen, G. M., & Sharp, T. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711001258 · Cited by 25 · see citing works
Negative emotion can enhance human motor cortical plasticity
Koganemaru, S., Domen, K., Fukuyama, H., & Mima, T. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.08098.x · Cited by 22 · see citing works
The L-type voltage-gated calcium channel CaV1.2 mediates fear extinction and modulates synaptic tone in the lateral amygdalaPreprint
Temme, S. J., & Murphy, G. G. (2017) · Learning & Memory · doi:10.1101/lm.045773.117 · Cited by 24 · see citing works
Pamheterozygous mice reveal essential role for Cu in amygdalar behavioral and synaptic function
Gaier, E. D., Eipper, B. A., & Mains, R. E. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12378 · Cited by 24 · see citing works
Adolescents’ Socio‐Motivational Relationships With Teachers, Amygdala Response to Teacher's Negative Facial Expressions, and Test Anxiety
Raufelder, D., Hoferichter, F., Romund, L., Golde, S., Lorenz, R. C., & Beck, A. (2015) · Journal of Research on Adolescence · doi:10.1111/jora.12220 · Cited by 22 · see citing works
Development of Threat Expression Following Infant Maltreatment: Infant and Adult Enhancement but Adolescent Attenuation
Junod, A., Opendak, M. M., LeDoux, J. E., & Sullivan, R. M. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00130 · Cited by 24 · see citing works
Protein synthesis in the basolateral amygdala complex is required for consolidation of a first-order fear memory, but not for consolidation of a higher-order fear memory
Leidl, D. M., Lay, B. P. P., Chakouch, C., Westbrook, R. F., & Holmes, N. M. (2018) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2018.04.001 · Cited by 22 · see citing works
Self-citation
Glutamate-Mediated Neuroplasticity Deficits in Mood Disorders
Reznikov, L. R., Fadel, J. R., & Reagan, L. P. (2011) · doi:10.1007/978-1-908517-18-0_2 · Cited by 20 · see citing works
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Doss, M. K., DeMarco, A., Dunsmoor, J. E., Cisler, J. M., Fonzo, G. A., & Nemeroff, C. B. (2024) · Drugs · doi:10.1007/s40265-024-02106-4 · Cited by 21 · see citing works
Hyperexcitability: From Normal Fear to Pathological Anxiety and Trauma
Rosen, J. B., & Schulkin, J. A. (2022) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2022.727054 · Cited by 19 · see citing works
Neurobiology of aversive states
Umberg, E. N., & Pothos, E. N. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.04.045 · Cited by 19 · see citing works
Imbalanced Brain Neurochemicals in Long COVID and ME/CFS: A Preliminary Study Using MRI
Thapaliya, K., Marshall‐Gradisnik, S., Eaton-Fitch, N., Eftekhari, Z., Inderyas, M., & Barnden, L. R. (2024) · The American Journal of Medicine · doi:10.1016/j.amjmed.2024.04.007 · Cited by 19 · see citing works
Effects of a True Prophylactic Treatment on Hippocampal and Amygdala Synaptic Plasticity and Gene Expression in a Rodent Chronic Stress Model of Social Defeat
Winzenried, E. T., Everett, A. C., Saito, E. R., Miller, R. M., Johnson, T., Neal, E., Boyce, Z., Smith, C., Jensen, C., Kimball, S., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241311193 · Cited by 19 · see citing works
Pharmacological rewriting of fear memories: A beacon for post-traumatic stress disorder
Uniyal, A., Singh, R., Akhtar, A., Dhaliwal, J., Kuhad, A., & Sah, S. P. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.172824 · Cited by 18 · see citing works
A novel role for the lateral habenula in fear learning
Sachella, T. E., Ihidoype, M. R., Proulx, C. D., Pafundo, D. E., Medina, J. H., Méndez, P., & Piriz, J. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-022-01294-5 · Cited by 18 · see citing works
Neuronal metabolism in learning and memory: The anticipatory activity perspective
Alexandrov, Y. I., & Pletnikov, M. V. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104664 · Cited by 18 · see citing works
Contextual Fear Memory Maintenance Changes Expression of pMAPK, BDNF and IBA-1 in the Pre-limbic Cortex in a Layer-Specific Manner
Chaaya, N., Wang, J., Jacques, A., Beecher, K., Chaaya, M., Battle, A. R., Johnson, L. R., Chehrehasa, F., Belmer, A., & Bartlett, S. E. (2021) · Frontiers in Neural Circuits · doi:10.3389/fncir.2021.660199 · Cited by 16 · see citing works
Neuropeptide S-Mediated Facilitation of Synaptic Transmission Enforces Subthreshold Theta Oscillations within the Lateral Amygdala
Meis, S., Stork, O., & Munsch, T. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018020 · Cited by 17 · see citing works
Affective memory rehearsal with temporal sequences in amygdala neurons
Reitich-Stolero, T., & Paz, R. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0542-9 · Cited by 17 · see citing works
Synapse-Specific Encoding of Fear Memory in the Amygdala
Maren, S. (2017) · Neuron · doi:10.1016/j.neuron.2017.08.020 · Cited by 16 · see citing works
Neuroscience and education: Mind the gap
Morris, J., & Sah, P. (2016) · Australian Journal of Education · doi:10.1177/0004944116652913 · Cited by 15 · see citing works
Self-citation
Inhibition of adenylyl cyclase in amygdala blocks the effect of audiogenic seizure kindling in genetically epilepsy-prone rats
Tupal, S., & Faingold, C. L. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.04.011 · Cited by 14 · see citing works
A role for midline and intralaminar thalamus in the associative blocking of Pavlovian fear conditioning
Sengupta, A., & McNally, G. P. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00148 · Cited by 14 · see citing works
The two‐step task, avoidance, and OCD
Geramita, M. A., Yttri, E. A., & Ahmari, S. E. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24594 · Cited by 11 · see citing works
Potentiation of cholinergic and corticofugal inputs to the lateral amygdala in threat learning
Asokan, M. M., Watanabe, Y. L., Kimchi, E. Y., & Polley, D. B. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113167 · Cited by 13 · see citing works
Fear and Memory: A View of the Hippocampus Through the Lens of the Amygdala
Blair, H. T., & Fanselow, M. S. (2014) · Springer eBooks · doi:10.1007/978-3-7091-1292-2_17 · Cited by 11 · see citing works
Neurobehavioral Mechanisms of Traumatic Stress in Post-traumatic Stress Disorder
Bluhm, M. D. L., & Peterson, A. L. (2014) · Current topics in behavioral neurosciences · doi:10.1007/7854_2014_307 · Cited by 11 · see citing works
Blood Pressure Variations Real-Time Reflect the Conditioned Fear Learning and Memory
Hsu, Y.-C., Yu, L., Chen, H., Lee, H.-L., Kuo, Y., & Jen, C. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032855 · Cited by 11 · see citing works
Glycyrrhizin treatment ameliorates post‐traumatic stress disorder‐like behaviours and restores circadian oscillation of intracranial serotonin
Lai, S., Shi, L., Jiang, Z., & Lin, Z. (2019) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13173 · Cited by 10 · see citing works
Stuttering Interneurons Generate Fast and Robust Inhibition onto Projection Neurons with Low Capacity of Short Term Modulation in Mouse Lateral Amygdala
Song, C., Xu, X.-B., He, Y., Liu, Z.-P., Wang, M., Zhang, X., Li, B., & Pan, B. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060154 · Cited by 10 · see citing works
Priming of LTP in amygdala and hippocampus by prior paired pulse facilitation paradigm in mice lacking brain serotonin
Gebhardt, C., Mosienko, V., Alenina, N. V., & Albrecht, D. (2018) · Hippocampus · doi:10.1002/hipo.23055 · Cited by 10 · see citing works
Bilateral phosphorylation of ERK in the lateral and centrolateral amygdala during unilateral storage of fear memories
Tarpley, J. W., Shlifer, I. G., Birnbaum, M. S., Halladay, L. R., & Blair, H. T. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.08.071 · Cited by 10 · see citing works
Localization of Contextual and Context Removed Auditory Fear Memory within the Basolateral Amygdala Complex
Chaaya, N., Jacques, A., Belmer, A., Richard, D. J., Bartlett, S. E., Battle, A. R., & Johnson, L. R. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.12.004 · Cited by 10 · see citing works
Non-Hebbian plasticity transforms transient experiences into lasting memories
Faress, I. M. G., Khalil, V., Hou, W., Moreno, A., Andersen, N., Fonseca, R., Piriz, J., Capogna, M., & Nabavi, S. (2023) · eLife · doi:10.7554/elife.91421 · Cited by 9 · see citing works
The Determining Conditions for Pavlovian Learning
Nasser, H. M., & Delamater, A. R. (2016) · Wiley eBooks · doi:10.1002/9781118650813.ch2 · Cited by 10 · see citing works
Desflurane post-treatment reduces hypoxic-ischemic brain injury via reducing transient receptor potential ankyrin 1 in neonatal rats
Zhou, T., Li, J., Cheng, A., & Zuo, Z. (2023) · Neuroscience · doi:10.1016/j.neuroscience.2023.05.007 · Cited by 7 · see citing works
Amygdalostriatal transition zone neurons encode sustained cue responses to guide defensive behaviors
Mills, F., Lee, C. R., Howe, J. R., Li, H., Keisler, M. N., Shao, S., Taschbach, F., Lemieux, M., Aloboudi, F., White, J., et al. (2026) · Neuron · doi:10.1016/j.neuron.2026.08.012 · Cited by 10 · see citing works

Authors: Sah, P., Westbrook, R. F., & Lüthi, A.
Affiliations: The University of Queensland (AU)
UNSW Sydney (AU)
Friedrich Miescher Institute (CH)
Corresponding author: Sah, P.
ORCID: Sah, P.
Westbrook, R. F.
Lüthi, A.
Venue: Annals of the New York Academy of Sciences
Publisher: Wiley
Published: 2008-05
Volume: 1129
Issue: 1
Pages: 88-95
ISSN: 0077-8923 (ISSN-L)
1749-6632
DOI: 10.1196/annals.1417.020
OpenAlex: W2041442771
Cited by: 138
References: 75
Citations by year: 2026: 2 · 2025: 3 · 2024: 7 · 2023: 11 · 2022: 5 · 2021: 5 · 2020: 7 · 2019: 6 · 2018: 6 · 2017: 4 · 2016: 4 · 2015: 8 · 2014: 17 · 2013: 8 · 2012: 10
FWCI: 0.89
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 58 d)
Locations: Annals of the New York Academy of Sciences (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: fear conditioning, long-term potentiation, amygdala, synaptic plasticity, learning and memory, excitatory synapses
MeSH terms: Amygdala, Animals, Conditioning, Psychological, Fear, Humans, Models, Biological, Long-Term Potentiation

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Fear Conditioning and Long‐term Potentiation in the Amygdala: What Really Is the Connection?

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