Fear conditioning enhances short-latency auditory responses of lateral amygdala neurons: Parallel recordings in the freely behaving rat
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The lateral nucleus of the amygdala (LA) is the first site in the amygdala where the plasticity underlying fear conditioning could occur. We simultaneously recorded from multiple LA neurons in freely moving rats during fear conditioning trials in which tones were paired with foot shocks. Conditioning significantly increased the magnitude of tone-elicited responses (often within the first several trials), converted unresponsive cells into tone-responsive ones, and altered functional couplings between LA neurons. The effects of conditioning were greatest on the shortest latency (less than 15 ms) components of the tone-elicited responses, consistent with the hypothesis that direct projections from the auditory thalamus to LA are an important link in the circuitry through which rapid behavioral responses are controlled in the presence of conditioned fear stimuli.
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Lateral amygdala cells develop robust responses to shock-predictive cues, corresponding to freezing behavior when the cues are presented.
“These cells develop robust responses to shock-predictive cues, corresponding to freezing behavior when the cues are presented71.”
From Resolving the neural circuits of anxiety (2015) · cites this paper as [71]
Several lines of indirect evidence support the idea that this plasticity occurs as a result of a Hebbian mechanism through which depolarization of LA pyramidal neurons by the shock US coincident with weaker activation of the same cells by auditory CS inputs results in fear learning.
“Several lines of indirect evidence support the idea that this plasticity occurs as a result of a Hebbian mechanism through which depolarization of LA pyramidal neurons by the shock US coincident with weaker activation of the same cells by auditory CS inputs results in fear learning (8–18).”
From Optical activation of lateral amygdala pyramidal cells instructs associative fear learning (2010) · cites this paper as [12]
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- Authors
- Quirk, G. J., Repa, J. C., & LeDoux, J. E.
- Affiliations
- New York University (US)
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 1995-11
- Volume
- 15
- Issue
- 5
- Pages
- 1029-1039
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2063575722
- Cited by
- 808
- References
- 69
- Citations by year
- 2026: 17 · 2025: 15 · 2024: 24 · 2023: 11 · 2022: 22 · 2021: 25 · 2020: 22 · 2019: 16 · 2018: 25 · 2017: 28 · 2016: 37 · 2015: 42 · 2014: 34 · 2013: 46 · 2012: 35
- FWCI
- 8.99
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Neuron (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5k02mh000956-07)
- National Institute of Mental Health (MH 46516, MH 00956, R01MH046516, MH38774)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- fear conditioning, lateral amygdala, auditory responses, short-latency responses, neuroplasticity, parallel recording, auditory thalamus, functional coupling, footshock
- MeSH terms
- Acoustic Stimulation, Amygdala, Animals, Behavior, Animal, Conditioning, Psychological, Electrophysiology, Fear, Male, Neuronal Plasticity, Neurons, Thalamus, Rats, Sprague-Dawley, Rats
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