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Cited by 620Neuroscience and Neuropharmacology ResearchNeural dynamics and brain functionMemory and Neural Mechanisms

The DOI matches its Crossref record; 19 of the 21 references it cites were found in a registry or an index.

Synaptic plasticity in a cerebellum-like structure depends on temporal order

Bell, Curtis C., Han, Victor Z., Sugawara, Yoshiko, Grant, Kirsty·1997·Nature
DOI 10.1038/387278a0
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Abstract

Cerebellum-like structures in fish appear to act as adaptive sensory processors, in which learned predictions about sensory input are generated and subtracted from actual sensory input, allowing unpredicted inputs to stand out. Pairing sensory input with centrally originating predictive signals, such as corollary discharge signals linked to motor commands, results in neural responses to the predictive signals alone that are 'negative images' of the previously paired sensory responses. Adding these 'negative images' to actual sensory inputs minimizes the neural response to predictable sensory features. At the cellular level, sensory input is relayed to the basal region of Purkinje-like cells, whereas predictive signals are relayed by parallel fibres to the apical dendrites of the same cells. The generation of negative images could be explained by plasticity at parallel fibre synapses. We show here that such plasticity exists in the electrosensory lobe of mormyrid electric fish and that it has the necessary properties for such a model: it is reversible, anti-hebbian (excitatory postsynaptic potentials (EPSPs) are depressed after pairing with a postsynaptic spike) and tightly dependent on the sequence of pre- and postsynaptic events, with depression occurring only if the postsynaptic spike follows EPSP onset within 60 ms.

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Research works printed but not linked: 2

  1. Montgomery, J., Coombs, S., Conley, R. & Bodznick, D. Hindbrain sensory processing in lateral line, electrosensory, and auditory systems: a comparative overview of anatomical and functional similarities. Aud. Neurosci. 1, 207–231 (1995).
  2. Grant, K. et al. Projection neurons of the mormyrid electrosensory lateral line lobe. J. Comp. Neurol. 375, 18–42 (1996). · DOI

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Metadata

Authors
Bell, C. C., Han, V. Z., Sugawara, Y., & Grant, K.
Affiliations
  • Legacy Good Samaritan Medical Center (US)
  • Centre National de la Recherche Scientifique (FR)
  • Teikyo University (JP)
ORCID
Han, Victor Z.
Venue
Nature
Publisher
Springer Science and Business Media LLC
Published
1997-05
Volume
387
Issue
6630
Pages
278-281
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
DOI
10.1038/387278a0
OpenAlex
W2075075476
Cited by
620
References
21
Citations by year
2026: 8 · 2025: 9 · 2024: 13 · 2023: 31 · 2022: 16 · 2021: 13 · 2020: 13 · 2019: 16 · 2018: 25 · 2017: 14 · 2016: 23 · 2015: 19 · 2014: 21 · 2013: 29 · 2012: 21
FWCI
6.30
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Nature (publishedVersion)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
synaptic plasticity, anti-Hebbian plasticity, negative image, corollary discharge, predictive signals, parallel fiber synapses, excitatory postsynaptic potentials
MeSH terms
Animals, Cerebellum, Electric Fish, Evoked Potentials, Models, Neurological, Neuronal Plasticity, Synapses, Time Factors, In Vitro Techniques

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