The DOI matches its Crossref record; 19 of the 21 references it cites were found in a registry or an index.
Synaptic plasticity in a cerebellum-like structure depends on temporal order
Abstract
Cerebellum-like structures in fish appear to act as adaptive sensory processors, in which learned predictions about sensory input are generated and subtracted from actual sensory input, allowing unpredicted inputs to stand out. Pairing sensory input with centrally originating predictive signals, such as corollary discharge signals linked to motor commands, results in neural responses to the predictive signals alone that are 'negative images' of the previously paired sensory responses. Adding these 'negative images' to actual sensory inputs minimizes the neural response to predictable sensory features. At the cellular level, sensory input is relayed to the basal region of Purkinje-like cells, whereas predictive signals are relayed by parallel fibres to the apical dendrites of the same cells. The generation of negative images could be explained by plasticity at parallel fibre synapses. We show here that such plasticity exists in the electrosensory lobe of mormyrid electric fish and that it has the necessary properties for such a model: it is reversible, anti-hebbian (excitatory postsynaptic potentials (EPSPs) are depressed after pairing with a postsynaptic spike) and tightly dependent on the sequence of pre- and postsynaptic events, with depression occurring only if the postsynaptic spike follows EPSP onset within 60 ms.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“An implication here, for which there is some evidence, 66 is that increases in the phasic activity of midbrain dopaminergic neurons will result in increased dopamine release at target sites, such as has been inferred to occur in patients with schizophrenia.67,68”
From Schizophrenia, myelination, and delayed corollary discharges: a hypothesis (2012) · cites this paper as [67]
Citations
Cites
Hebb, D. O. (2005) · doi:10.4324/9781410612403 · Cited by 9,825
Regulation of Synaptic Efficacy by Coincidence of Postsynaptic APs and EPSPs
Markram, H., Lübke, J., Frotscher, M., & Sakmann, B. (1997) · Science · doi:10.1126/science.275.5297.213 · Cited by 3,832
Ito, M. (1989) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.12.030189.000505 · Cited by 1,167
Huerta, P. T., & Lisman, J. E. (1995) · Neuron · doi:10.1016/0896-6273(95)90094-2 · Cited by 673
Gustafsson, B., Wigstrom, H., Abraham, W., & Huang, Y. (1987) · The Journal of Neuroscience · doi:10.1523/jneurosci.07-03-00774.1987 · Cited by 583
Associative long-term depression in the hippocampus induced by hebbian covariance
Stanton, P. K., & B, T. J. S. A. (1989) · Nature · doi:10.1038/339215a0 · Cited by 461
Sakurai, M. (1987) · The Journal of Physiology · doi:10.1113/jphysiol.1987.sp016881 · Cited by 391
The Generation and Subtraction of Sensory Expectations within Cerebellum-Like Structures
Bell, C., Bodznick, D., Montgomery, J. C., & Bastian, J. (2008) · Brain Behavior and Evolution · doi:10.1159/000113352 · Cited by 244
Self-citationAn Efference Copy Which Is Modified by Reafferent Input
Bell, C. C. (1981) · Science · doi:10.1126/science.7291985 · Cited by 244
Self-citationDebanne, D., Gähwiler, B. H., & Thompson, S. M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.3.1148 · Cited by 233
Chen, C., & Thompson, R. F. (1995) · Learning & Memory · doi:10.1101/lm.2.3-4.185 · Cited by 192
Montgomery, J. C., & Bodznick, D. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90007-8 · Cited by 183
Ekerot, C. ‐., & Kano, M. (1989) · Neuroscience Research · doi:10.1016/0168-0102(89)90065-5 · Cited by 140
Bastian, J. (1995) · Journal of Comparative Physiology A · doi:10.1007/bf00197753 · Cited by 119
Storage of a sensory pattern by anti-Hebbian synaptic plasticity in an electric fish.
Bell, C. C., Caputi, A. A., Grant, K., & Serrier, J. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.10.4650 · Cited by 117
Self-citationHirano, T. (1991) · Synapse · doi:10.1002/syn.890070408 · Cited by 116
Neural simulations of adaptive reafference suppression in the elasmobranch electrosensory system
Nelson, M. E., & Paulin, M. G. (1995) · Journal of Comparative Physiology A · doi:10.1007/bf00187631 · Cited by 50
Strack, S., Wadzinski, B. E., & Ebner, F. F. (1996) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19961104)375:1 · Cited by 35
Self-citationHashemzadeh-Gargari, H., Colbert, C., & Levy, W. (1991) · Neuroscience Letters · doi:10.1016/0304-3940(91)90365-z · Cited by 13
Flagged first, then by citations
2 of the 21 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Montgomery, J., Coombs, S., Conley, R. & Bodznick, D. Hindbrain sensory processing in lateral line, electrosensory, and auditory systems: a comparative overview of anatomical and functional similarities. Aud. Neurosci. 1, 207–231 (1995).
- Grant, K. et al. Projection neurons of the mormyrid electrosensory lateral line lobe. J. Comp. Neurol. 375, 18–42 (1996). · DOI
Cited by
Sorted by citations
Bi, G.-Q., & Poo, M.-M. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-24-10464.1998 · Cited by 4,744
Competitive Hebbian learning through spike-timing-dependent synaptic plasticity
Song, S., Miller, K. D., & Abbott, L. F. (2000) · Nature Neuroscience · doi:10.1038/78829 · Cited by 2,794
Synaptic plasticity: taming the beast
Abbott, L. F., & Nelson, S. B. (2000) · Nature Neuroscience · doi:10.1038/81453 · Cited by 2,263
Spike Timing–Dependent Plasticity: A Hebbian Learning Rule
Caporale, N., & Dan, Y. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.31.060407.125639 · Cited by 1,997
Computational principles of movement neuroscience
Wolpert, D. M., & Ghahramani, Z. (2000) · Nature Neuroscience · doi:10.1038/81497 · Cited by 2,122
Metadata
- Authors
- Bell, C. C., Han, V. Z., Sugawara, Y., & Grant, K.
- Affiliations
- Legacy Good Samaritan Medical Center (US)
- Centre National de la Recherche Scientifique (FR)
- Teikyo University (JP)
- ORCID
- Han, Victor Z.
- Venue
- Nature
- Published
- 1997-05
- Volume
- 387
- Issue
- 6630
- Pages
- 278-281
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2075075476
- Cited by
- 620
- References
- 21
- Citations by year
- 2026: 8 · 2025: 9 · 2024: 13 · 2023: 31 · 2022: 16 · 2021: 13 · 2020: 13 · 2019: 16 · 2018: 25 · 2017: 14 · 2016: 23 · 2015: 19 · 2014: 21 · 2013: 29 · 2012: 21
- FWCI
- 6.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- synaptic plasticity, anti-Hebbian plasticity, negative image, corollary discharge, predictive signals, parallel fiber synapses, excitatory postsynaptic potentials
- MeSH terms
- Animals, Cerebellum, Electric Fish, Evoked Potentials, Models, Neurological, Neuronal Plasticity, Synapses, Time Factors, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
