Circadian oscillation of a mammalian homologue of the Drosophila period gene
Tei, Hajime, Okamura, Hitoshi, Shigeyoshi, Yasufumi, Fukuhara, Chiaki, Ozawa, Ritsuko, Hirose, Matsumi, Sakaki, Yoshiyuki·1997·Nature
DOI 10.1038/39086
Cited by (787)
Items 201–300 of 787
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- Effects of Irradiance and Stimulus Duration on Early Gene Expression (Fos) in the Suprachiasmatic Nucleus: Temporal Summation and ReciprocityOuria Dkhissi‐Benyahya, Bruno Sicard, Howard Michael Cooper · 2000 · Journal of Neuroscience
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- Molecular clocks: mastering time by gene regulationPaolo Sassone‐Corsi · 1998 · Nature
- Ataxin-2: From RNA Control to Human Health and DiseaseLauren Ostrowski, Amanda C. Hall, Karim Mekhail · 2017 · Genes
- Theoretical models for circadian rhythms in Neurospora and DrosophilaDidier Gonze, Jean‐Christophe Leloup, Albert Goldbeter · 2000 · Comptes Rendus de l Académie des Sciences - Series III - Sciences de la Vie
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- Unraveling the mechanisms of the vertebrate circadian clock: zebrafish may light the wayMatthew P. Pando, Paolo Sassone‐Corsi · 2002 · BioEssays
- MT1 melatonin receptor mRNA expression exhibits a circadian variation in the rat suprachiasmatic nucleiVincent‐Joseph Poirel, Mireille Masson‐Pévet, Paul Pévet, François Gauer · 2002 · Brain Research
- SCOP, a novel gene product expressed in a circadian manner in rat suprachiasmatic nucleusKimiko Shimizu, Masato Okada, Atsuko Takano, Katsuya Nagai · 1999 · FEBS Letters
- Light pollution, reproductive function and cancer risk.Marie Stiborová, Vaclav Martínek, Heinz H. Schmeiser, Eva Frei · 2006 · PubMed
- Genome-Wide Analysis of Light- and Temperature-Entrained Circadian Transcripts in Caenorhabditis elegansAlexander M. van der Linden, Matthew Beverly, Sebastián Kadener, Joseph Rodriguez, Sara M. Wasserman, Michael Rosbash, Piali Sengupta · 2010 · PLoS Biology
- Neuropeptide Y rapidly reduces Period 1 and Period 2 mRNA levels in the hamster suprachiasmatic nucleusChiaki Fukuhara, Judy McKinley Brewer, James C. Dirden, Eric L. Bittman, Gianluca Tosini, Mary E. Harrington · 2001 · Neuroscience Letters
- The Neurobiology of Circadian RhythmsPatricia J. Sollars, Gary E. Pickard · 2015 · Psychiatric Clinics of North America
- Circadian time keeping: the daily ups and downs of genes, cells, and organismsUeli Schibler · 2006 · Progress in brain research
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- Independence of Genetic Geographical Variation between Photoperiodic Diapause, Circadian Eclosion Rhythm, and Thr-Gly Repeat Region of the Period Gene in Drosophila littoralisPekka Lankinen, Päivi Forsman · 2006 · Journal of Biological Rhythms
- Phosphorylation of the Cryptochrome 1 C-terminal Tail Regulates Circadian Period LengthPeng Gao, Seung Hee Yoo, Kyung Jong Lee, Clark Rosensweig, Joseph S. Takahashi, Benjamin P. Chen, Carla B. Green · 2013 · Journal of Biological Chemistry
- Expression of the Per1 gene in the hamster: Brain atlas and circadian characteristics in the suprachiasmatic nucleusShuzo Yamamoto, Yasufumi Shigeyoshi, Yoshiki Ishida, Tsuyoshi Fukuyama, Shun Yamaguchi, Kazuhiro Yagita, Takahiro Moriya, Shigenobu Shibata, Naoyuki Takashima, Hitoshi Okamura · 2001 · The Journal of Comparative Neurology
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- Genetic variation of clock genes and cancer risk: a field synopsis and meta-analysisClara Benna, Charlotte Helfrich‐Förster, Senthilkumar Rajendran, Halenya Monticelli, Pierluigi Pilati, Donato Nitti, Simone Mocellin M. D · 2017 · Oncotarget
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- The humanPER1gene is transcriptionally regulated by multiple signaling pathwaysDirk Motzkus, Erik Maronde, Uwe Grunenberg, Cheng Chi Lee, Wolf‐Georg Forssmann, Urs Albrecht · 2000 · FEBS Letters
- The Human PER1 Gene is Inducible by Interleukin-6Dirk Motzkus, Urs Albrecht, Erik Maronde · 2002 · Journal of Molecular Neuroscience
- Molecular coevolution within a Drosophila clock geneAlexandre Afrânio Peixoto, J. Michael Hennessy, Ian Townson, Gaiti Hasan, Michael Rosbash, Rodolfo Costa, Charalambos Panayiotis Kyriacou · 1998 · Proceedings of the National Academy of Sciences
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- Cylindrically Etched Carbon-Fiber Microelectrodes for Low-Noise Amperometric Recording of Cellular SecretionAlbert Schulte, Robert Hsiu-Ping Chow · 1998 · Analytical Chemistry
- MULTIPLE OSCILLATORS IN THE SUPRACHIASMATIC NUCLEUSTetsuo Shirakawa, Sato Honma, Ken‐ichi Honma · 2001 · Chronobiology International
- Flexible phase adjustment of circadian albumin D site-binding protein (Dbp) gene expression by CRYPTOCHROME1Markus Stratmann, Frédéric Stadler, Filippo Tamanini, Gijsbertus T. J. van der Horst, Jürgen A. Ripperger · 2010 · Genes & Development
- Circadian Clocks in the Cnidaria: Environmental Entrainment, Molecular Regulation, and Organismal OutputsAdam M. Reitzel, Ann M. Tarrant, Oren Levy · 2013 · Integrative and Comparative Biology
- Effects of light at night on laboratory animals and research outcomes.Kathryn M Emmer, Kathryn L.G. Russart, William H. Walker, Randy J Nelson, A. Courtney DeVries · 2018 · Behavioral Neuroscience
- A mammalian ortholog of Drosophila timeless, highly expressed in SCN and retina, forms a complex with mPER1Toru Takumi, Yasuko Nagamine, Shigeru Miyake, Chiaki Matsubara, Kouji Taguchi, Seiichi Takekida, Yoko Sakakida, Kazuko Nishikawa, Toshihiko Kishimoto, Shin‐ichiro Niwa et al. · 1999 · Genes to Cells
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- Identification of the mammalian homologues of the Drosophila timeless gene, Timeless11Nobuya Koike, Akiko Hida, Rika Numano, Matsumi Hirose, Yoshiuki Sakaki, Hajime Tei · 1998 · FEBS Letters
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