Circadian oscillation of a mammalian homologue of the Drosophila period gene

Tei, Hajime, Okamura, Hitoshi, Shigeyoshi, Yasufumi, Fukuhara, Chiaki, Ozawa, Ritsuko, Hirose, Matsumi, Sakaki, Yoshiyuki·1997·Nature
DOI 10.1038/39086

Cited by (787)

Items 101–200 of 787

  1. How Temperature Changes Reset a Circadian Oscillator
    Yi Liu, Martha W. Merrow, Jennifer Loros, Jay Dunlap · 1998 · Science
  2. Rhythmic PER Abundance Defines a Critical Nodal Point for Negative Feedback within the Circadian Clock Mechanism
    Rongmin Chen, Aaron E. Schirmer, Yongjin Lee, Hyeong-Min Lee, Vivek Kumar, Seung Hee Yoo, Joseph S. Takahashi, Choogon Lee · 2009 · Molecular Cell
  3. Genetic and Molecular Analysis of Circadian Rhythms in Neurospora
    Jennifer Loros, Jay Dunlap · 2001 · Annual Review of Physiology
  4. Circadian Regulation of a Drosophila Homolog of the Mammalian Clock Gene: PER and TIM Function as Positive Regulators
    Kiho Bae, Choogon Lee, David J. Sidote, Keng-yu Chuang, Isaac Edery · 1998 · Molecular and Cellular Biology
  5. A new mammalian period gene predominantly expressed in the suprachiasmatic nucleus
    Toru Takumi, Chiaki Matsubara, Yasufumi Shigeyoshi, Kouji Taguchi, Kazuhiro Yagita, Yoshiro Maebayashi, Yoko Sakakida, Ko Okumura, Naoyuki Takashima, Hitoshi Okamura · 1998 · Genes to Cells
  6. The circadian clock within the heart: potential influence on myocardial gene expression, metabolism, and function
    Martin Elliot Young · 2005 · American Journal of Physiology-Heart and Circulatory Physiology
  7. Molecular analysis of avian circadian clock genes
    Takashi Yoshimura, Yoshikazu Suzuki, Eri Makino, Tomohiro Suzuki, Asato Kuroiwa, Yoichi Matsuda, Takao NAMIKAWA, Shizufumi Ebihara · 2000 · Molecular Brain Research
  8. The intrinsic circadian clock within the cardiomyocyte
    David J. Durgan, Margaret A. Hotze, Tara M. Tomlin, Oluwaseun Egbejimi, Christophe Graveleau, E. Dale Abel, Chad A. Shaw, Molly S. Bray, Paul E. Hardin, Martin Elliot Young · 2005 · American Journal of Physiology-Heart and Circulatory Physiology
  9. Changing the dosing schedule minimizes the disruptive effects of interferon on clock function
    Shigehiro Ohdo, Satoru Koyanagi, Hinako Suyama, Shun Higuchi, Hironori Aramaki · 2001 · Nature Medicine
  10. Inversion of the circadian rhythm of melatonin in the Smith-Magenis syndrome
    Hélène De Leersnyder, Marie‐Christine de Blois, Bruno Claustrat, Serge Pierrick Romana, Urs Albrecht, Jürgen‐Christoph von Kleist-Retzow, Bruno Delobel, Géraldine Viot, Stanislas Lyonnet, Michel J. J. Vekemans et al. · 2001 · The Journal of Pediatrics
  11. SCN Efferents to Peripheral Tissues: Implications for Biological Rhythms
    Timothy J. Bartness, C. Kay Song, Gregory E. Demas · 2001 · Journal of Biological Rhythms
  12. Systems Biology of Mammalian Circadian Clocks
    Hideki Ukai, Hiroki R. Ueda · 2010 · Annual Review of Physiology
  13. Nonphotic Entrainment by 5-HT1A/7Receptor Agonists Accompanied by ReducedPer1andPer2mRNA Levels in the Suprachiasmatic Nuclei
    Kazumasa Horikawa, Shin-ichi Yokota, Kazuyuki Fuji, Masashi Akiyama, Takahiro Moriya, Hitoshi Okamura, Shigenobu Shibata · 2000 · Journal of Neuroscience
  14. Noninvasive method for assessing the human circadian clock using hair follicle cells
    Makoto Akashi, Haruhiko Soma, Takuro Yamamoto, Asuka Tsugitomi, Shiko Yamashita, Takuya Yamamoto, Eisuke Nishida, Akio Yasuda, James K. Liao, Koichi Node · 2010 · Proceedings of the National Academy of Sciences
  15. Pathophysiology of seasonal affective disorder: a review.
    2000 · PubMed Central
  16. Dimerization and nuclear entry of mPER proteins in mammalian cells
    Kazuhiro Yagita, Shun Yamaguchi, Filippo Tamanini, Gijsbertus T. J. van der Horst, Jan H.J. Hoeijmakers, Akira Yasui, Jennifer Loros, Jay Dunlap, Hitoshi Okamura · 2000 · Genes & Development
  17. The influence of circadian rhythms on the kinetics of drugs in humans
    Massimo Baraldo · 2008 · Expert Opinion on Drug Metabolism & Toxicology
  18. Functional redundancy of cryptochromes and classical photoreceptors for nonvisual ocular photoreception in mice.
    Selby, Christopher P., Thompson, Carol, Schmitz, Therese M., Van Gelder, Russell N., Sancar, Aziz · 2000 · Proceedings of the National Academy of Sciences
  19. Circadian Rhythms and Hormonal Homeostasis: Pathophysiological Implications
    Davide Gnocchi, Giovannella Bruscalupi · 2017 · Biology
  20. THE MOLECULAR CONTROL OF CIRCADIAN BEHAVIORAL RHYTHMS AND THEIR ENTRAINMENT IN DROSOPHILA
    Michael W. Young · 1998 · Annual Review of Biochemistry
  21. Daily Electrical Silencing in the Mammalian Circadian Clock
    Mino D. C. Belle, Casey O. Diekman, Daniel B. Forger, Hugh David Piggins · 2009 · Science
  22. Roles in dimerization and blue light photoresponse of the PAS and LOV domains of Neurospora crassa white collar proteins
    Paola Ballario, Claudio Talora, Daniela Galli, Hartmut Linden, Giuseppe Macino · 1998 · Molecular Microbiology
  23. The Network of Time: Understanding the Molecular Circadian System
    Till Roenneberg, Martha W. Merrow · 2003 · Current Biology
  24. A Clockwork Explosion!
    Steven M. Reppert · 1998 · Neuron
  25. Decoding photoperiodic time through Per1 and ICER gene amplitude
    Sophie Messager, Alexander Ross, Perry Barrett, Peter J. Morgan · 1999 · Proceedings of the National Academy of Sciences
  26. Clock genes outside the suprachiasmatic nucleus involved in manifestation of locomotor activity rhythm in rats
    Satoru Masubuchi, Sato Honma, Hiroshi Abe, Kouji Ishizaki, Masakazu Namihira, Masaaki Ikeda, Ken‐ichi Honma · 2000 · European Journal of Neuroscience
  27. An Inherited Functional Circadian Clock in Zebrafish Embryos
    Franck Delaunay, Christine Thisse, Oriane Marchand, Vincent Laudet, Bernard Thisse · 2000 · Science
  28. Physical interactions among circadian clock proteins KaiA, KaiB and KaiC in cyanobacteria
    Hideo Iwasaki, Yasuhito Taniguchi, Masahiro Ishiura, Takao Kondo · 1999 · The EMBO Journal
  29. Molecular Analysis of Mammalian Timeless
    Mark J. Zylka, Lauren P. Shearman, Joel D. Levine, Xiaowei Jin, David R. Weaver, Steven M. Reppert · 1998 · Neuron
  30. Histone Deacetylase Inhibition by Gut Microbe-Generated Short-Chain Fatty Acids Entrains Intestinal Epithelial Circadian Rhythms
    Jibraan A. Fawad, Deborah Luzader, Gabriel F. Hanson, Thomas J. Moutinho, Craig A. McKinney, Paul Mitchell, Kathleen Brown-Steinke, Ajay Kumar, Miri Park, Suengwon Lee et al. · 2020 · Gastroenterology
  31. Differential regulation of mPER1 and mTIM proteins in the mouse suprachiasmatic nuclei: new insights into a core clock mechanism
    Hastings, Michael H., Field, Manu D., Maywood, Elizabeth S., Weaver, David R., Reppert, Steven M. · 1999 · The Journal of Neuroscience
  32. Estrogen differentially regulates expression of <i>Per1</i> and <i>Per2</i> genes between central and peripheral clocks and between reproductive and nonreproductive tissues in female rats
    Nakamura, Takahiro J., Moriya, Takahiro, Inoue, Shin, Shimazoe, Takao, Watanabe, Shigenori, Ebihara, Shizufumi, Shinohara, Kazuyuki · 2005 · Journal of Neuroscience Research
  33. Shift Work or Food Intake during the Rest Phase Promotes Metabolic Disruption and Desynchrony of Liver Genes in Male Rats
    Roberto Salgado‐Delgado, Nadia Saderi, María del Carmen Basualdo, Natalí N. Guerrero‐Vargas, Carolina Escobar, Ruud M. Buijs · 2013 · PLoS ONE
  34. Invited Review: Regulation of mammalian circadian clock genes
    Urs Albrecht · 2002 · Journal of Applied Physiology
  35. Synchronization of the Molecular Clockwork by Light- and Food-Related Cues in Mammals
    Étienne Challet, Ivette Caldelas, C. Graff, Paul Pévet · 2003 · Biological Chemistry
  36. The 5′ upstream region of mPer1 gene contains two promoters and is responsible for circadian oscillation
    Shun Yamaguchi, Shigeru Mitsui, S. Miyake, Lili Yan, Hiroyasu Onishi, Kazuhiro Yagita, Misao Suzuki, Shigenobu Shibata, Masaki Kobayashi, Hitoshi Okamura · 2000 · Current Biology
  37. Electric light, particularly at night, disrupts human circadian rhythmicity: is that a problem?
    Richard G. Stevens, Yong Lian Zhu · 2015 · Philosophical Transactions of the Royal Society B Biological Sciences
  38. Cellular Circadian Pacemaking and the Role of Cytosolic Rhythms
    Michael Harvey Hastings, Elizabeth Susan Maywood, John Stuart O'Neill · 2008 · Current Biology
  39. Non-cyclic and Developmental Stage-Specific Expression of Circadian Clock Proteins During Murine Spermatogenesis1
    John David Alvarez, Dechun Chen, Elizabeth Storer, Amita Sehgal · 2003 · Biology of Reproduction
  40. Transcriptionally Active Heterodimer Formation of an Arnt-like PAS Protein, Arnt3, with HIF-1a, HLF, and Clock
    Sho Takahata, Kazuhiro Sogawa, Akira Kobayashi, Masatsugu Ema, Junsei Mimura, Nobuhiro Ozaki, Yoshiaki Fujii‐Kuriyama · 1998 · Biochemical and Biophysical Research Communications
  41. Human casein kinase Iδ phosphorylation of human circadian clock proteins period 1 and 2
    Fernando Camacho, M. Cilio, Yixuan Guo, David M. Virshup, K. Patel, Olga Khorkova, Scot D. Styren, B. Morse, Zhengbin Yao, George A. Keesler · 2001 · FEBS Letters
  42. Electrophysiology of the suprachiasmatic circadian clock
    Timothy M. Brown, Hugh David Piggins · 2007 · Progress in Neurobiology
  43. Implications of circadian gene expression in kidney, liver and the effects of fasting on pharmacogenomic studies
    Yasuhiro Kita, Masahide Shiozawa, Jin Weihong, Rebecca R. Majewski, Joseph C. Besharse, Andrew Seth Greene, Howard J. Jacob · 2002 · Pharmacogenetics
  44. Methylome analysis and integrative profiling of human HCCs identify novel protumorigenic factors
    Olaf Neumann, Miriam Kesselmeier, Robert Geffers, Rossella Pellegrino, Bernhard Radlwimmer, Katrin Hoffmann, Volker Ehemann, Peter Schemmer, Peter Schirmacher, Justo Lorenzo Bermejo et al. · 2012 · Hepatology
  45. Circadian profile of Per gene mRNA expression in the suprachiasmatic nucleus, paraventricular nucleus, and pineal body of aged rats
    Makoto Asai, Yuko Yoshinobu, Satoshi Kaneko, Akiko Mori, Takato Nikaido, Takahiro Moriya, Masashi Akiyama, Shigenobu Shibata · 2001 · Journal of Neuroscience Research
  46. Interactivating Feedback Loops within the Mammalian Clock: BMAL1 Is Negatively Autoregulated and Upregulated by CRY1, CRY2, and PER2
    Wangjie Yu, Masahiko Nomura, Masaaki Ikeda · 2002 · Biochemical and Biophysical Research Communications
  47. E-box function in a period gene repressed by light
    Daniela Vallone, Srinivas Babu Gondi, David Whitmore, Nicholas Simon Foulkes · 2004 · Proceedings of the National Academy of Sciences
  48. Machine Learning Helps Identify CHRONO as a Circadian Clock Component
    Ron C. Anafi, Yool Lee, Trey K. Sato, Anand Venkataraman, Chidambaram Ramanathan, İbrahim Halil Kavaklı, Michael E. Hughes, Julie E. Baggs, Jacqueline Growe, Andrew C. Liu et al. · 2014 · PLoS Biology
  49. The regulation of neuroendocrine function: Timing is everything
    Lance J. Kriegsfeld, Rae Silver · 2006 · Hormones and Behavior
  50. Chronotherapeutic strategy: Rhythm monitoring, manipulation and disruption☆
    Shigehiro Ohdo · 2010 · Advanced Drug Delivery Reviews
  51. Two Decades of Circadian Time
    Michael Harvey Hastings, Elizabeth Susan Maywood, Akhilesh B. Reddy · 2008 · Journal of Neuroendocrinology
  52. The Human and Mouse Period1 Genes: Five Well-Conserved E-Boxes Additively Contribute to the Enhancement of mPer1 Transcription
    Akiko Hida, Nobuya Koike, Matsumi Hirose, Masahira Hattori, Yoshiyuki Sakaki, Hajime Tei · 2000 · Genomics
  53. Robust Circadian Rhythmicity of Per1 and Per2 Mutant Mice in Constant Light, and Dynamics of Per1 and Per2 Gene Expression under Long and Short Photoperiods
    Stephan Steinlechner, Birgit Jacobmeier, Frank Scherbarth, Haiko Dernbach, Friederike Kruse, Urs Albrecht · 2002 · Journal of Biological Rhythms
  54. The circadian cycle of mPER clock gene products in the suprachiasmatic nucleus of the Siberian hamster encodes both daily and seasonal time
    Barbara Nuesslein‐Hildesheim, John O’Brien, Francis J. P. Ebling, Elizabeth Susan Maywood, Michael Harvey Hastings · 2000 · European Journal of Neuroscience
  55. Asynchronous oscillations of two zebrafish CLOCK partners reveal differential clock control and function
    Nicolas Cermakian, David Whitmore, Nicholas Simon Foulkes, Paolo Sassone‐Corsi · 2000 · Proceedings of the National Academy of Sciences
  56. Photic and circadian expression of luciferase in mPeriod1 - luc transgenic mice in vivo
    Lisa D. Wilsbacher, Shin Yamazaki, Erik D. Herzog, Eun-Joo Song, Laurel A. Radcliffe, Michikazu Abe, Gene D. Block, Edward L. Spitznagel, Michael Menaker, Joseph S. Takahashi · 2001 · Proceedings of the National Academy of Sciences
  57. takeout , a Novel Drosophila Gene under Circadian Clock Transcriptional Regulation
    W. Venus So, Lea Sarov‐Blat, Carolyn K. Kotarski, Michael J. McDonald, Ravi Allada, Michael Rosbash · 2000 · Molecular and Cellular Biology
  58. Comparative analysis of circadian clock genes in insects
    Federica Sandrelli, Rodolfo Costa, C. P. Kyriacou, Ezio Rosato · 2008 · Insect Molecular Biology
  59. Call it worm sleep
    Trojanowski, Nicholas F., Raizen, David M. · 2016 · Trends in Neurosciences
  60. Hypoxia affects expression of circadian genes PER1 and CLOCK in mouse brain
    Dmitri Chilov, Thomas Höfer, Christian Bauer, Roland H. Wenger, Max Gassmann · 2001 · The FASEB Journal
  61. A molecular perspective of human circadian rhythm disorders
    Nicolas Cermakian, Diane B. Boivin · 2003 · Brain Research Reviews
  62. Immortal Time: Circadian Clock Properties of Rat Suprachiasmatic Cell Lines
    David J. Earnest, Fong-Qi Liang, Matt Ratcliff, Vincent M. Cassone · 1999 · Science
  63. Circadian clock‐protein expression in cyanobacteria: rhythms and phase setting
    Yanwen Xu, Tetsuya Mori, Carl Hirschie Johnson · 2000 · The EMBO Journal
  64. Integrative Physiology and Functional Genomics of Epithelial Function in a Genetic Model Organism
    Julian A. T. Dow, Shireen A. Davies · 2003 · Physiological Reviews
  65. Expression of the Circadian Clock Genes clock and period1 in Human Skin
    Susana B. Zanello, David M. Jackson, Michael F. Holick · 2000 · Journal of Investigative Dermatology
  66. Circadian profile and photic regulation of clock genes in the suprachiasmatic nucleus of a diurnal mammal arvicanthis ansorgei
    Ivette Caldelas, V.-J Poirel, Bruno Sicard, Paul Pévet, Étienne Challet · 2003 · Neuroscience
  67. Mouse mutagenesis-systematic studies of mammalian gene function
    S.D.M. Brown · 1998 · Human Molecular Genetics
  68. Molecular Cloning and Characterization of the HumanCLOCKGene: Expression in the Suprachiasmatic Nuclei
    Thomas D. L. Steeves, David P. King, Yaliang Zhao, Ashvin M. Sangoram, Fenghe Du, Anne M. Bowcock, Robert Y. Moore, Joseph S. Takahashi · 1999 · Genomics
  69. The need for a simple animal model to understand sleep
    Joan C. Hendricks, Amita Sehgal, Allan I Pack · 2000 · Progress in Neurobiology
  70. Response of the Timeless Protein to Light Correlates with Behavioral Entrainment and Suggests a Nonvisual Pathway for Circadian Photoreception
    Zhaohai Yang, Mark M. Emerson, Henry S. Su, Amita Sehgal · 1998 · Neuron
  71. Methamphetamine‐induced, suprachiasmatic nucleus‐independent circadian rhythms of activity and <i>mPer</i> gene expression in the striatum of the mouse
    Iijima, Michihiko, Nikaido, Takato, Akiyama, Masashi, Moriya, Takahiro, Shibata, Shigenobu · 2002 · European Journal of Neuroscience
  72. The role of circadian rhythmicity in reproduction
    Kennaway, David J. · 2005 · Human Reproduction Update
  73. Downregulation of circadian clock genes in chronic myeloid leukemia: Alternative methylation pattern of hPER3
    Ming‐Yu Yang, Jan‐Gowth Chang, Pai‐Mei Lin, Kai‐Ping Tang, Yen‐Hsu Chen, Hugo You‐Hsien Lin, Ta‐Chih Liu, Hui‐Hua Hsiao, Yi‐Chang Liu, Sheng‐Fung Lin · 2006 · Cancer Science
  74. Rhythmic expression of NocturninmRNA in multiple tissues of the mouse
    Yunxia Wang, David Osterbur, Pam L. Megaw, Gianluca Tosini, Chiaki Fukuhara, Carla B. Green, Joseph C. Besharse · 2001 · BMC Developmental Biology
  75. Role of the PAS Domain in Regulation of Dimerization and DNA Binding Specificity of the Dioxin Receptor
    I. Pongratz, Camilla Antonsson, M. Whitelaw, L. Poellinger · 1998 · Molecular and Cellular Biology
  76. Interactions between metabolism and circadian clocks: reciprocal disturbances
    Julien Delezie, Étienne Challet · 2011 · Annals of the New York Academy of Sciences
  77. Differential Response of Period 1 Expression within the Suprachiasmatic Nucleus
    Wataru Nakamura · 2005 · Journal of Neuroscience
  78. The brain's master circadian clock: Implications and opportunities for therapy of sleep disorders
    Phyllis C. Zee, Prasanth Manthena · 2006 · Sleep Medicine Reviews
  79. Disruption of mCry2 restores circadian rhythmicity in mPer2 mutant mice
    Henrik Oster, Akira Yasui, Gijsbertus T.J. van der Horst, Urs Albrecht · 2002 · Genes & Development
  80. Lipids around the Clock: Focus on Circadian Rhythms and Lipid Metabolism
    Gnocchi, Davide, Pedrelli, Matteo, Hurt-Camejo, Eva, Parini, Paolo · 2015 · Biology
  81. From circadian rhythms to clock genes in depression
    Fred William Turek · 2007 · International Clinical Psychopharmacology
  82. Rapid Resetting of the Mammalian Circadian Clock
    Jonathan D. Best, Elizabeth Susan Maywood, Karen L. Smith, Michael Harvey Hastings · 1999 · Journal of Neuroscience
  83. Peripheral clocks and their role in circadian timing: insights from insects
    Jadwiga Maria Giebultowicz · 2001 · Philosophical Transactions of the Royal Society B Biological Sciences
  84. Glucocorticoid hormones are both a major circadian signal and major stress signal: How this shared signal contributes to a dynamic relationship between the circadian and stress systems
    Robert L. Spencer, Lauren E. Chun, Matthew J. Hartsock, Elizabeth R. Woodruff · 2017 · Frontiers in Neuroendocrinology
  85. View of a mouse clock gene ticking
    Shun Yamaguchi, Masaki Kobayashi, Shigeru Mitsui, Yoshiki Ishida, Gijsbertus T. J. van der Horst, Misao Suzuki, Shigenobu Shibata, Hitoshi Okamura · 2001 · Nature
  86. Developmental Transitions in C. elegans Larval Stages
    Ann E. Rougvie, Eric G. Moss · 2013 · Current topics in developmental biology/Current Topics in Developmental Biology
  87. Molecular Mechanism and Cellular Distribution of Insect Circadian Clocks
    Jadwiga Maria Giebultowicz · 2000 · Annual Review of Entomology
  88. Distribution of the rhythm-related genes rPERIOD1, rPERIOD2, and rCLOCK, in the rat brain
    K.-R. Shieh · 2003 · Neuroscience
  89. Circadian and Photic Regulation of Phosphorylation of ERK1/2 and Elk-1 in the Suprachiasmatic Nuclei of the Syrian Hamster
    Andrew N. Coogan, Hugh David Piggins · 2003 · Journal of Neuroscience
  90. Neuroanatomical studies of period gene expression in the hawkmoth, Manduca sexta
    Sarah K. Wise, Norman T. Davis, Elizabeth Tyndale, Jocelyne Noveral, Mary Grace Folwell, Vahe Bedian, Ivette F. Emery, Kathleen King Siwicki · 2002 · The Journal of Comparative Neurology
  91. Circadian rhythms and molecular noise
    Didier Gonze, Albert Goldbeter · 2006 · Chaos An Interdisciplinary Journal of Nonlinear Science
  92. A Molecular Rhythm Mediating Circadian Clock Output in Drosophila
    Gerard P. McNeil, Xiaolan Zhang, Ginka Genova, F. Rob Jackson · 1998 · Neuron
  93. Circadian variation of cell proliferation and cell cycle protein expression in man: Clinical implications
    Georg A. Bjarnason, Richard C. Jordan · 2000 · Springer eBooks
  94. Searching for Genes Underlying Behavior: Lessons from Circadian Rhythms
    Joseph S. Takahashi, Kazuhiro Shimomura, Vivek Kumar · 2008 · Science
  95. The Suprachiasmatic Nucleus is a Functionally Heterogeneous Timekeeping Organ
    Rae Silver, William J. Schwartz · 2005 · Methods in enzymology on CD-ROM/Methods in enzymology
  96. Rhythmic regulation of membrane potential and potassium current persists in SCN neurons in the absence of environmental input
    Sandra J. Kuhlman, Douglas G. McMahon · 2004 · European Journal of Neuroscience
  97. Molecular Circadian Oscillators: An Alternative Hypothesis
    Till Roenneberg, Martha W. Merrow · 1998 · Journal of Biological Rhythms
  98. A novel E4BP4 element drives circadian expression of mPeriod2
    T. Ohno, Yoshiaki Onishi, Norio Ishida · 2006 · Nucleic Acids Research
  99. Impaired daily glucocorticoid rhythm in Per1 Brd mice
    Robert Dallmann, Chadi Touma, Rupert Palme, Urs Albrecht, Stephan Steinlechner · 2006 · Journal of Comparative Physiology A
  100. Sensitized Increase of Period Gene Expression in the Mouse Caudate/Putamen Caused by Repeated Injection of Methamphetamine
    Takato Nikaido, Masashi Akiyama, Takahiro Moriya, Shigenobu Shibata · 2001 · Molecular Pharmacology